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Michael T. Lewis
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Journal Articles

Abstract 739: Patient-derived xenografts allow deconvolution and prediction of chemotherapy responses

Free
Jonathan T. Lei, Lacey E. Dobrolecki, Chen Huang, Ramakrishnan R. Srinivasan, Suhas V. Vasaikar, Alaina N. Lewis, Christina Sallas, Na Zhao, Jin Cao, John D. Landua, Chang I. Moon, Yuxing Liao, Susan G. Hilsenbeck, C K. Osborne, Mothaffar F. Rimawi, Matthew J. Ellis, Varduhi Petrosyan, Bo Wen, Kai Li, Alexander B. Saltzman, Antrix Jain, Anna Malovannaya, Gerburg M. Wulf, Elisabetta Marangoni, Shunqiang Li, Daniel C. Kraushaar, Tao Wang, Senthil Damodaran, Xiaofeng Zheng, Funda Meric-Bernstam, Gloria V. Echeverria, Meenakshi Anurag, Xi Chen, Bryan E. Welm, Alana L. Welm, Bing Zhang, Michael T. Lewis
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 739.
https://doi.org/10.1158/1538-7445.AM2025-739
Published: 21 April 2025
View articletitled, Abstract 739: Patient-derived xenografts allow deconvolution and prediction of chemotherapy responses
Journal Articles

Abstract 2906: Functional and therapeutic significance of DNA ligase I (LIG1) depletion in triple-negative breast cancer (TNBC)

Free
Anh M. Tran Huynh, Sumimasa Arimura, Lacey E. Dobrolecki, Mariah J. Berner, Xuxu Gou, Junkai Wang, Michael T. Lewis, Jason Mills, Jun Xu, Gloria V. Echeverria, Susan M. Rosenberg, Christopher J. Lord, Simon Powell, Jonathan T. Lei, Matthew J. Ellis, Meenakshi Anurag
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2906.
https://doi.org/10.1158/1538-7445.AM2025-2906
Published: 21 April 2025
View articletitled, Abstract 2906: Functional and therapeutic significance of DNA ligase I (LIG1) depletion in triple-negative breast cancer (TNBC)
Journal Articles

Abstract 5427: Targeting mitochondrial protein translation in chemo-refractory triple negative breast cancer

Free
Mariah J. Berner, Steven W. Wall, Mokryun L. Baek, Audra Lane, Allison S. Greer, Karen Wang, Lacey Dobrolecki, Bing Zhang, Jonathan T. Lei, Michael T. Lewis, Gloria V. Echeverria
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5427.
https://doi.org/10.1158/1538-7445.AM2025-5427
Published: 21 April 2025
View articletitled, Abstract 5427: Targeting mitochondrial protein translation in chemo-refractory triple negative breast cancer
Journal Articles

Lineage Tracing and Single-Cell RNA Sequencing Reveal a Common Transcriptional State in Breast Cancer Tumor–Initiating Cells Characterized by IFN/STAT1 Activity

Open Access
Eric P. Souto, Ping Gong, John D. Landua, Ramakrishnan Rajaram Srinivasan, Abhinaya Ganesan, Lacey E. Dobrolecki, Stephen C. Purdy, Xingxin Pan, Michael Zeosky, Anna Chung, S. Stephen Yi, Heide L. Ford, Michael T. Lewis
Journal: Cancer Research
Cancer Res (2025) 85 (8): 1390–1409.
https://doi.org/10.1158/0008-5472.CAN-23-4022
Published: 15 April 2025
View articletitled, Lineage Tracing and Single-Cell RNA Sequencing Reveal a Common Transcriptional State in Breast Cancer Tumor–Initiating Cells Characterized by IFN/STAT1 Activity
Open the PDF for Lineage Tracing and Single-Cell RNA Sequencing Reveal a Common Transcriptional State in Breast Cancer Tumor–Initiating Cells Characterized by IFN/STAT1 Activity in another window
Includes: Supplementary data
Journal Articles

A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis

Open Access
Brian S. White, Xing Yi Woo, Soner Koc, Todd Sheridan, Steven B. Neuhauser, Shidan Wang, Yvonne A. Evrard, Li Chen, Ali Foroughi pour, John D. Landua, R. Jay Mashl, Sherri R. Davies, Bingliang Fang, Maria Gabriela Raso, Kurt W. Evans, Matthew H. Bailey, Yeqing Chen, Min Xiao, Jill C. Rubinstein, Brian J. Sanderson, Michael W. Lloyd, Sergii Domanskyi, Lacey E. Dobrolecki, Maihi Fujita, Junya Fujimoto, Guanghua Xiao, Ryan C. Fields, Jacqueline L. Mudd, Xiaowei Xu, Melinda G. Hollingshead, Shahanawaz Jiwani, Saul Acevedo, PDXNet Consortium, Brandi N. Davis-Dusenbery, Peter N. Robinson, Jeffrey A. Moscow, James H. Doroshow, Nicholas Mitsiades, Salma Kaochar, Chong-xian Pan, Luis G. Carvajal-Carmona, Alana L. Welm, Bryan E. Welm, Ramaswamy Govindan, Shunqiang Li, Michael A. Davies, Jack A. Roth, Funda Meric-Bernstam, Yang Xie, Meenhard Herlyn, Li Ding, Michael T. Lewis, Carol J. Bult, Dennis A. Dean, II, Jeffrey H. Chuang
Journal: Cancer Research
Cancer Res (2024) 84 (13): 2060–2072.
https://doi.org/10.1158/0008-5472.CAN-23-1349
Published: 02 July 2024
View articletitled, A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis
Open the PDF for A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis in another window
Includes: Supplementary data
Journal Articles

Abstract 3371: PRMT blockade induces defective DNA replication stress response via ATR suppression and synergizes with PARP inhibition

Free
Deepa Bisht, Yang Li, Lacey E. Dobrolecki, Christina Sallas, Xudong Zhang, Travis D. Kerr, Yalong Wang, Sharad Awasthi, Babita Kaundal, Siqi Wu, Weiyi Peng, Marc L. Mendillo, Yiling Lu, Collene R. Jeter, Guang Peng, Jinsong Liu, Shannon N. Westin, Anil K. Sood, Michael T. Lewis, Jishnu Das, S. Stephen Yi, Mark T. Bedford, Daniel J. McGrail, Nidhi Sahni
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3371.
https://doi.org/10.1158/1538-7445.AM2024-3371
Published: 22 March 2024
View articletitled, Abstract 3371: PRMT blockade induces defective DNA replication stress response via ATR suppression and synergizes with PARP inhibition
Journal Articles

Kinome Reprogramming Is a Targetable Vulnerability in ESR1 Fusion-Driven Breast Cancer

Open Access
Xuxu Gou, Beom-Jun Kim, Meenakshi Anurag, Jonathan T. Lei, Meggie N. Young, Matthew V. Holt, Diana Fandino, Craig T. Vollert, Purba Singh, Mohammad A. Alzubi, Anna Malovannaya, Lacey E. Dobrolecki, Michael T. Lewis, Shunqiang Li, Charles E. Foulds, Matthew J. Ellis
Journal: Cancer Research
Cancer Res (2023) 83 (19): 3237–3251.
https://doi.org/10.1158/0008-5472.CAN-22-3484
Published: 02 October 2023
View articletitled, Kinome Reprogramming Is a Targetable Vulnerability in ESR1 Fusion-Driven Breast Cancer
Open the PDF for Kinome Reprogramming Is a Targetable Vulnerability in ESR1 Fusion-Driven Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 5011: Targeting kinome reprogramming in ESR1 fusion-driven breast cancer

Free
Xuxu Gou, Beom-Jun Kim, Meenakshi Anurag, Jonathan T. Lei, Meggie N. Young, Matthew V. Holt, Diana Fandino, Craig T. Vollert, Purba Singh, Mohammad A. Alzubi, Anna Malovannaya, Lacey E. Dobrolecki, Michael T. Lewis, Shunqiang Li, Matthew J. Ellis, Charles E. Foulds
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5011.
https://doi.org/10.1158/1538-7445.AM2023-5011
Published: 04 April 2023
View articletitled, Abstract 5011: Targeting kinome reprogramming in ESR1 fusion-driven breast cancer
Journal Articles

Abstract 5407: A pan-cancer PDX histology image repository with genomic and pathological annotations for deep learning analysis

Free
Brian S. White, Xing Yi Woo, Soner Koc, Todd Sheridan, Steven B. Neuhauser, Shidan Wang, Yvonne A. Evrard, John David Landua, R Jay Mashl, Sherri R. Davies, Bingliang Fang, Maria Gabriela Raso, Kurt W. Evans, Matthew H. Bailey, Yeqing Chen, Min Xiao, Jill Rubinstein, Ali Foroughi pour, Lacey Elizabeth Dobrolecki, Maihi Fujita, Junya Fujimoto, Guanghua Xiao, Ryan C. Fields, Jacqueline L. Mudd, Xiaowei Xu, Melinda G. Hollingshead, Shahanawaz Jiwani, PDXNet consortium, Tiffany A. Wallace, Jeffrey A. Moscow, James H. Doroshow, Nicholas Mitsiades, Salma Kaochar, Chong-xian Pan, Moon S. Chen, Luis G. Carvajal-Carmona, Alana L. Welm, Bryan E. Welm, Ramaswamy Govindan, Shunqiang Li, Michael A. Davies, Jack A. Roth, Funda Meric-Bernstam, Yang Xie, Meenhard Herlyn, Li Ding, Michael T. Lewis, Carol J. Bolt, Dennis A. Dean, Jeffrey H. Chuang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5407.
https://doi.org/10.1158/1538-7445.AM2023-5407
Published: 04 April 2023
View articletitled, Abstract 5407: A pan-cancer PDX histology image repository with genomic and pathological annotations for deep learning analysis
Journal Articles

Abstract P6-12-04: An Inducible Lineage Tracing System for the Identification of Tumor-Initiating Cells

Free
Eric P. Souto, Michael T. Lewis
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P6-12-04.
https://doi.org/10.1158/1538-7445.SABCS22-P6-12-04
Published: 01 March 2023
View articletitled, Abstract P6-12-04: An Inducible Lineage Tracing System for the Identification of Tumor-Initiating Cells
Journal Articles

Abstract P2-23-01: Patient-derived xenografts allow deconvolution of single agent and combination chemotherapy responses in triple-negative breast cancer

Free
Jonathan T. Lei, Chen Huang, Ramakrishnan R. Srinivasan, Suhas Vasaikar, Lacey E. Dobrolecki, Alaina N. Lewis, Na Zhao, Jin Cao, Susan G. Hilsenbeck, C. Kent Osborne, Mothaffar Rimawi, Matthew J. Ellis, Varduhi Petrosyan, Alexander B. Saltzman, Anna Malovannaya, John D. Landua, Bo Wen, Antrix Jain, Gerburg M. Wulf, Shunqiang Li, Daniel C. Kraushaar, Tao Wang, Xi Chen, Gloria V. Echeverria, Meenakshi Anurag, Bing Zhang, Michael T. Lewis
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P2-23-01.
https://doi.org/10.1158/1538-7445.SABCS22-P2-23-01
Published: 01 March 2023
View articletitled, Abstract P2-23-01: Patient-derived xenografts allow deconvolution of single agent and combination chemotherapy responses in triple-negative breast cancer
Journal Articles

Abstract PD5-01: PD5-01 Genomic and epigenomic BRCA alterations predict adaptive resistance and response to platinum-based therapy in triple negative breast cancer and ovarian carcinoma

Free
Francesca Menghi, Kalyan Banda, Pooja Kumar, Robert Straub, Lacey E. Dobrolecki, Isabel Rodriguez, Susan E. Yost, Harshpreet Chandok, Marc Radke, George Somlo, Yuan Yuan, Michael T. Lewis, Elizabeth Swisher, Edison Liu
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): PD5-01.
https://doi.org/10.1158/1538-7445.SABCS22-PD5-01
Published: 01 March 2023
View articletitled, Abstract PD5-01: PD5-01 Genomic and epigenomic BRCA alterations predict adaptive resistance and response to platinum-based therapy in triple negative breast cancer and ovarian carcinoma
Journal Articles

Abstract P6-11-15: Lipid accumulation in residual triple negative breast cancer cells surviving chemotherapy treatment

Free
Katherine E. Pendleton, Mokryun L. Baek, Junegoo Lee, Lin Tan, Hannah L. Johnson, Lacey E. Dobrolecki, James P. Barrish, Michael T. Lewis, Philip L. Lorenzi, Fabio Stossi, Gloria V. Echeverria
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P6-11-15.
https://doi.org/10.1158/1538-7445.SABCS22-P6-11-15
Published: 01 March 2023
View articletitled, Abstract P6-11-15: Lipid accumulation in residual triple negative breast cancer cells surviving chemotherapy treatment
Journal Articles

Abstract P6-11-10: Investigating the role of mitochondrial protein translation in the metabolic adaptation of chemoresistant triple negative breast cancer

Free
Mariah J. Berner, Lily Baek, Junegoo Lee, Philip L. Lorenzi, Mei Leng, Alexander B. Saltzman, Anna Malovannaya, Lacey E. Dobrolecki, Christina Sallas, Michael T. Lewis, Gloria V. Echeverria
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P6-11-10.
https://doi.org/10.1158/1538-7445.SABCS22-P6-11-10
Published: 01 March 2023
View articletitled, Abstract P6-11-10: Investigating the role of mitochondrial protein translation in the metabolic adaptation of chemoresistant triple negative breast cancer
Journal Articles

Abstract 1689: Heterogeneity of tumor-initiating cell related signaling revealed by lentiviral signaling reporters in breast cancer patient-derived xenografts

Free
John Landua, Ping Gong, Michael T. Lewis
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1689.
https://doi.org/10.1158/1538-7445.AM2022-1689
Published: 15 June 2022
View articletitled, Abstract 1689: Heterogeneity of tumor-initiating cell related signaling revealed by lentiviral signaling reporters in breast cancer patient-derived xenografts
Journal Articles

Abstract 3169: Inducible lineage tracing system for the identification of tumor-initiating cells

Free
Eric P. Souto, Michael T. Lewis
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3169.
https://doi.org/10.1158/1538-7445.AM2022-3169
Published: 15 June 2022
View articletitled, Abstract 3169: Inducible lineage tracing system for the identification of tumor-initiating cells
Journal Articles

Abstract 1202: A repository of PDX histology images for exploring spatial heterogeneity and cancer dynamics

Free
Brian S. White, Xingyi Woo, Soner Koc, Todd Sheridan, Steven B. Neuhauser, Akshat M. Savaliya, Lacey E. Dobrolecki, John D. Landua, Matthew H. Bailey, Maihi Fujita, Kurt W. Evans, Bingliang Fang, Junya Fujimoto, Maria Gabriela Raso, Shidan Wang, Guanghua Xiao, Yang Xie, Sherri R. Davies, Ryan C. Fields, R Jay Mashl, Jacqueline L. Mudd, Yeqing Chen, Min Xiao, Xiaowei Xu, Melinda G. Hollingshead, Shahanawaz Jiwani, PDXNet Consortium, Yvonne A. Evrard, Tiffany A. Wallace, Jeffrey A. Moscow, James H. Doroshow, Nicholas Mitsiades, Salma Kaochar, Chong-xian Pan, Moon S. Chen, Luis G. Carvajal-Carmona, Alana L. Welm, Bryan E. Welm, Michael T. Lewis, Ramaswamy Govindan, Li Ding, Shunqiang Li, Meenhard Herlyn, Michael A. Davies, Jack A. Roth, Funda Meric-Bernstam, Carol J. Bult, Brandi Davis-Dusenbery, Dennis A. Dean, Jeffrey H. Chuang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1202.
https://doi.org/10.1158/1538-7445.AM2022-1202
Published: 15 June 2022
View articletitled, Abstract 1202: A repository of PDX histology images for exploring spatial heterogeneity and cancer dynamics
Journal Articles

Abstract 6384: Morphological and functional plasticity of mitochondria promotes chemotherapy resistance in triple negative breast cancer

Free
Lily Baek, Junegoo Lee, Mariah J. Berner, Katherine E. Pendleton, Emily B. Goff, Karen Wang, James P. Barrish, Bora Lim, Philip J. Lorenzi, Weston Porter, Michael T. Lewis, Gloria V. Echeverria
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6384.
https://doi.org/10.1158/1538-7445.AM2022-6384
Published: 15 June 2022
View articletitled, Abstract 6384: Morphological and functional plasticity of mitochondria promotes chemotherapy resistance in triple negative breast cancer
Journal Articles

Abstract 1010: LIG1 deletion predicts chemotherapy resistance, chromosomal instability, and poor prognosis in triple negative breast cancer

Free
Meenakshi Anurag, Eric Jaehnig, Jonathan Lei, Beom-Jun Kim, Anh Minh Tran Huynh, Yongchao Dou, Tanmayi Vashist, Erik Bergstrom, Xuxu Gou, Viktoriya Korchina, Donna Marie Muzny, Kristen Otte, Harshavardhan Doddapaneni, Lacey Dobrolecki, Gloria Vittone Echeverria, Bora Lim, Mothaffar Rimawi, Karsten Krug, Ian Hageman, Henry Rodriguez, Ana I. Robles, Tara Hiltke, Kent Osborne, Michael Gillette, George Miles, Steven Carr, Michael T Lewis, Bing Zhang, Foluso Ademuyiwa, Shankha Satpathy, Matthew J. Ellis
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1010.
https://doi.org/10.1158/1538-7445.AM2022-1010
Published: 15 June 2022
View articletitled, Abstract 1010: LIG1 deletion predicts chemotherapy resistance, chromosomal instability, and poor prognosis in triple negative breast cancer
Journal Articles

Abstract PR009: Investigating dynamics of the mitochondrial network in triple negative breast cancer chemotherapy resistance

Free
Lily Baek, Mariah Berner, Junegoo Lee, Katherine Pendleton, Karen Wang, Emily B. Goff, James P. Barrish, Bora Lim, Michael T. Lewis, Philip L. Lorenzi, Weston Porter, Gloria V. Echeverria
Journal: Cancer Research
Cancer Res (2022) 82 (10_Supplement): PR009.
https://doi.org/10.1158/1538-7445.EVODYN22-PR009
Published: 15 May 2022
View articletitled, Abstract PR009: Investigating dynamics of the mitochondrial network in triple negative breast cancer chemotherapy resistance