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Michael Roth
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Journal Articles

Abstract 3975: Clonal emergence of resistance to methotrexate in osteosarcoma barcoded PDX cells

Giuseppe Longo, Sylvester Jusu, Zhongting Zhang, Zhaohui Xu, Wendong Zhang, Michael Roth, Rui Yang, Douglas Harrison, Jonathan Gill, Richard Gorlick
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3975.
DOI: https://doi.org/10.1158/1538-7445.AM2022-3975
Published: 15 June 2022
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Journal Articles

Abstract 3794: Comprehensive clonal and molecular profiling of primary tumors and distant lung metastases in an amputation model of osteosarcoma

Sylvester Jusu, Sankaranarayanan Kannan, Sahil Seth, Michael D. Peoples, Zhongting Zhang, Wendong Zhang, Zhaohui Xu, Yifei Wang, Xin Zhou, Yizheng Tu, Giuseppe Longo, Michael Roth, Jonathan B. Gill, Richard Gorlick
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3794.
DOI: https://doi.org/10.1158/1538-7445.AM2022-3794
Published: 15 June 2022
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Journal Articles

Abstract 2016: Preclinical evaluation of uPARAP (MRC2) antibody-drug conjugates (ADCE-003,010,011) in osteosarcoma pdx models

Yifei Wang, Wendong Zhang, Zhongting Zhang, Xiangjun Tian, Rossana Lazcano, Pooja Hingorani, Michael Roth, Jonathan Gill, Douglas Harrison, Zhaohui Xu, Jing Wang, Niels Behrendt, Christoffer F. Nielsen, Lars H. Engelholm, Richard Gorlick
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2016.
DOI: https://doi.org/10.1158/1538-7445.AM2022-2016
Published: 15 June 2022
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Journal Articles

Abstract LB252: Evaluation of the pan-class I phosphoinositide 3-kinase (PI3K) inhibitor copanlisib in the Pediatric Preclinical Testing Consortium osteosarcoma in vivo models

Douglas Harrison, Jonathan Gill, Pooja Hingorani, Michael Roth, Wendong Zhang, Beverly Teicher, Eric J. Earley, Stephen W. Erickson, Gregory Gatto, Raushan T. Kurmasheva, Peter J. Houghton, Malcolm A. Smith, Edward A. Kolb, Richard Gorlick
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB252.
DOI: https://doi.org/10.1158/1538-7445.AM2021-LB252
Published: 01 July 2021
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Journal Articles

Abstract LB008: Integrative surfaceome profiling identifies immunotherapeutic targets in osteosarcomas (OS); Preclinical testing of BT1769, an MT1-MMP-targeted Bicycle Toxin Conjugate, in OS by the Pediatric Preclinical Testing Consortium (PPTC)

Yifei Wang, Wendong Zhang, Zhongting Zhang, Xiangjun Tian, Rossana N. Lazcano Segura, Pooja Hingorani, Michael Roth, Jonathan Gill, Douglas Harrison, Zhaohui Xu, Jing Wang, Eric J. Earley, Stephen W. Erickson, Edward A. Kolb, Malcolm A. Smith, Peter Houghton, Raushan Kurmasheva, Tara Gelb, Philip Huxley, Johanna Lahdenranta, Gemma Mudd, Richard Gorlick
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB008.
DOI: https://doi.org/10.1158/1538-7445.AM2021-LB008
Published: 01 July 2021
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Journal Articles

Abstract 5415: Profiling cancer testis antigens in osteosarcomas

Zhongting Zhang, Yifei Wang, Wendong Zhang, Zhaohui Xu, Xin Zhou, Michael Roth, Jonathan Gill, Douglas Harrison, Pooja Hingorani, Sylvester Jusu, Sankar Kannan, Xiangjun Tian, Jing Wang, Rossana N Segura Lazcano, Alexander Lazar, Richard Gorlick
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5415.
DOI: https://doi.org/10.1158/1538-7445.AM2020-5415
Published: 15 August 2020
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Journal Articles

Abstract 5405: Integrative surfaceome profiling identifies MMP14, MRC2 and CD276 as candidate immunotherapeutic target in osteosarcomas

Yifei Wang, Zhongting Zhang, Wendong Zhang, Zhaohui Xu, Xin Zhou, Michael Roth, Jonathan Gill, Douglas Harrison, Pooja Hingorani, Sankar Kannan, Sylvester Jusu, Xiangjun Tian, Jing Wang, Rossana Lazcano, Alexander Lazar, Richard Gorlick
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5405.
DOI: https://doi.org/10.1158/1538-7445.AM2020-5405
Published: 15 August 2020
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Journal Articles

Abstract LB-217: Preclinical evaluation of trastuzumab deruxtecan (T-DXd; DS-8201a), a HER2 antibody-drug conjugate, in pediatric solid tumors by the Pediatric Preclinical Testing Consortium (PPTC)

Pooja Hingorani, Wendong Zhang, Raushan Kurmasheva, Zhongting Zhang, Yifei Wang, Zhaohui Xu, Michael Roth, Jonathan Gill, Douglas Harrison, Stephen Erickson, Edward A. Kolb, Malcolm Smith, Peter Houghton, Richard Gorlick
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-217.
DOI: https://doi.org/10.1158/1538-7445.AM2020-LB-217
Published: 15 August 2020
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Journal Articles

Abstract 4396: A bioinformatics approach for cancer immunotherapeutic target identification by evaluating surfaceome gene and protein expression (CITIESGAPE) in tumor and pan-normal tissues

Xiangjun Tian, Jing Wang, Yifei Wang, Zhongting Zhang, Michael Roth, Jonathan B. Gill, Richard Gorlick
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4396.
DOI: https://doi.org/10.1158/1538-7445.AM2020-4396
Published: 15 August 2020
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Journal Articles

Abstract 1291: Notch2 inhibition as a therapeutic intervention in osteosarcoma

Sankaranarayanan Kannan, John A. Livingston, Michael Roth, Jonathan Benjamin, Yifei Wang, Zhongting Zhang, Wendong Zhang, Chia-Chin Wu, Hannah Beird, Andrew Futreal, Richard Gorlick
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1291.
DOI: https://doi.org/10.1158/1538-7445.AM2019-1291
Published: 01 July 2019
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Journal Articles

Abstract 82: Transforming of human osteoblasts with the combination of hTERT (T), SV40Tag (S) and c-Myc: Changes in phenotype and tumorigenesis capability

Zhongting Zhang, Yifei Wang, Wendong Zhang, Michael Roth, Jonathan Benjamin Gill, Zhaohui Xu, Xiangjun Tian, Jing Wang, Richard Gorlick
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 82.
DOI: https://doi.org/10.1158/1538-7445.AM2019-82
Published: 01 July 2019
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Journal Articles

Abstract 3655: Mapping the osteogenic lineage and identification of the cell of origin of osteosarcoma through high-dimensional analysis

Yifei Wang, Sankaranarayanan Kannan, Zhongting Zhang, Wendong Zhang, Michael Roth, Jonathan B. Gill, Zhaohui Xu, Xiangjun Tian, Jing Wang, Richard Gorlick
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3655.
DOI: https://doi.org/10.1158/1538-7445.AM2019-3655
Published: 01 July 2019
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Journal Articles

Abstract 2866: Surfaceome profiling in osteosarcoma: Identification of the candidate immunotherapeutic target

Yifei Wang, Zhongting Zhang, Sankaranarayanan Kannan, Wendong Zhang, Michael Roth, Jonathan B. Gill, Zhaohui Xu, Xiangjun Tian, Jing Wang, Richard Gorlick
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2866.
DOI: https://doi.org/10.1158/1538-7445.AM2019-2866
Published: 01 July 2019
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Journal Articles

Abstract 5872: Pediatric Preclinical Testing Consortium (PPTC) of eribulin in osteosarcoma (OS) patient-derived xenograft (PDX) models

Wendong Zhang, E. Anders Kolb, Richard Gorlick, Michael Roth, Jonathan Gill, Sudie Rowshan, Stephen Erickson, Raushan Kurmasheva, Peter Houghton, Beverly Teicher, Malcolm A. Smith
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5872.
DOI: https://doi.org/10.1158/1538-7445.AM2018-5872
Published: 01 July 2018
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Journal Articles

Abstract 2664: Identification of two small molecules with small cell lung cancer growth inhibition response profiles different from etoposide/topotecan

Allison A. Mootz, Michael Peyton, Paul Yenerall, Kimberley Avila, Kenneth Huffman, Tomohiro Haruki, Mahboubeh Papari-Zareei, Victor Stastny, Luc Girard, Elizabeth McMillan, Michael Roth, John MacMillan, Bruce Posner, Michael White, Gazdar Adi, John Minna
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2664.
DOI: https://doi.org/10.1158/1538-7445.AM2018-2664
Published: 01 July 2018
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Journal Articles

Abstract 699: Clinical feasibility of chemotherapy monitoring for bone sarcoma patients with diffuse optical spectroscopic imaging

Hannah M. Peterson, Bang H. Hoang, David Geller, Richard Gorlick, Rui Yang, Jeremy Berger, Janet Tingling, Michael Roth, Jonathan Gill, Darren Roblyer
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 699.
DOI: https://doi.org/10.1158/1538-7445.AM2017-699
Published: 01 July 2017
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Abstract 920: ICAM-1(CD54) is involved in the osteogenic differentiation of mesenchymal stem cells and affects the progression of osteosarcoma cells

Yidan Zhang, Sajida Piperdi, Nikolas Zaphiros, Pratistha Koirala, Tingting Ren, Michael Roth, Jonathan Gill, Bang Hoang, David Geller, Rui Yang, Wendong Zhang, Xiuquan Du, Jinghang Zhang, Richard Gorlick
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 920.
DOI: https://doi.org/10.1158/1538-7445.AM2017-920
Published: 01 July 2017
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Journal Articles

Abstract 1950: Introducing c-Myc into transformed human mesenchymal stem cells and osteoblasts to recapitulate the osteosarcoma phenotype

Sajida Piperdi (Thein), Wendong Zhang, Daria Ivenitsky, Yidan Zhang, Yunjia Zhang, David S. Geller, Bang Hoang, Rui Yang, Jonathan B. Gill, Michael Roth, Richard Gorlick
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1950.
DOI: https://doi.org/10.1158/1538-7445.AM2017-1950
Published: 01 July 2017
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Abstract 2125: Flavokawain A, a kava chalcone, inhibits growth and invasion of human osteosarcoma cells by targeting Skp2

Yidan Zhang, Wendong Zhang, Nikolas Zaphiros, Xiuquan Du, Pratistha Koirala, Michael Roth, Jonathan Gill, Sajida Piperdi, David Geller, Rui Yang, Jinghang Zhang, Richard Gorlick, Xiaolin Zi, Tao Ji, Bang H. Hoang
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2125.
DOI: https://doi.org/10.1158/1538-7445.AM2017-2125
Published: 01 July 2017
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Abstract 2731: Identifying circulating tumor DNA in patients with osteosarcoma

David M. Barris, Michael Fremed, Robert Durbin, Xusheng Zhang, Sajida Piperdi, Wendong Zhang, Shahina Maqbool, Jonathan Gill, Michael Roth, Bang Hoang, David Geller, Richard Gorlick, Daniel Weiser
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2731.
DOI: https://doi.org/10.1158/1538-7445.AM2017-2731
Published: 01 July 2017
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