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Michael R. Boyd
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Journal Articles

A Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth and Induces Antitumor Immunity in Gastrointestinal Cancer

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Jeremy B. Foote, Tyler E. Mattox, Adam B. Keeton, Xi Chen, Forrest T. Smith, Kristy Berry, Thomas W. Holmes, Junwei Wang, Chung-hui Huang, Antonio Ward, Amit K. Mitra, Veronica Ramirez-Alcantara, Cherlene Hardy, Karianne G. Fleten, Kjersti Flatmark, Karina J. Yoon, Sujith Sarvesh, Ganji P. Nagaraju, Dhana Sekhar Reddy Bandi, Yulia Y. Maxuitenko, Jacob Valiyaveettil, Julienne L. Carstens, Donald J. Buchsbaum, Jennifer Yang, Gang Zhou, Elmar Nurmemmedov, Ivan Babic, Vadim Gaponeko, Hazem Abdelkarim, Michael R. Boyd, Greg Gorman, Upender Manne, Sejong Bae, Bassel F. El-Rayes, Gary A. Piazza
Journal: Cancer Research
Cancer Res (2025) 85 (5): 956–972.
https://doi.org/10.1158/0008-5472.CAN-24-0323
Published: 03 March 2025
View articletitled, A Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth and Induces Antitumor Immunity in Gastrointestinal Cancer
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Includes: Supplementary data
Journal Articles

Abstract 2731: A novel PDE10/beta-catenin inhibitor, MCI-048, suppresses lung tumorigenesis to block metastasis

Free
Bing Zhu, Veronica Ramirez-Alcantara, Antonio Ward, Kristy Berry, Adam B. Keeton, Michael R. Boyd, Yulia Maxuitenko, Xi Chen, Gary A. Piazza
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2731.
https://doi.org/10.1158/1538-7445.AM2019-2731
Published: 01 July 2019
View articletitled, Abstract 2731: A novel PDE10/beta-catenin inhibitor, MCI-048, suppresses lung tumorigenesis to block metastasis
Journal Articles

Abstract 2707: A novel RAS inhibitor, MCI-062, inhibits colon tumor growth in vivo and activates antitumor immunity

Free
Adam B. Keeton, Antonio Ward, Xi Chen, Jacob Valiyaveettil, Bing Zhu, Veronica Ramirez-Alcantara, Yulia Maxuitenko, Kristy Berry, Tyler E. Mattox, Michael R. Boyd, Gary A. Piazza
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2707.
https://doi.org/10.1158/1538-7445.AM2019-2707
Published: 01 July 2019
View articletitled, Abstract 2707: A novel RAS inhibitor, MCI-062, inhibits colon tumor growth in vivo and activates antitumor immunity
Journal Articles

Abstract 3864: A novel PDE10/β-catenin pathway inhibitor, MCI-030, for the treatment of colorectal cancer

Free
Antonio B. Ward, Xi Chen, Jacob Valiyaveettil, Kevin Lee, Wen-Chi L. Chang, Yulia Maxuitenko, Veronica Ramirez-Alcantara, Kristy Berry, Luciana Madeira da Silva, Bing Zhu, Tyler Mattox, Michael R. Boyd, Adam B. Keeton, Margie L. Clapper, Harry S. Cooper, Gary A. Piazza
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3864.
https://doi.org/10.1158/1538-7445.AM2019-3864
Published: 01 July 2019
View articletitled, Abstract 3864: A novel PDE10/β-catenin pathway inhibitor, MCI-030, for the treatment of colorectal cancer
Journal Articles

Abstract 5159: Characterization of a novel class of RAS inhibitory compounds with potent anti-tumor activity

Free
Antonio Ward, Xi Chen, Jacob Valiyaveettil, Bing Zhu, Veronica Ramirez-Alcantara, Kevin J. Lee, Ashley Lindsey, Kristy Berry, Tyler E. Mattox, Kate McConnell, Michael R. Boyd, Gary A. Piazza, Adam B. Keeton
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5159.
https://doi.org/10.1158/1538-7445.AM2017-5159
Published: 01 July 2017
View articletitled, Abstract 5159: Characterization of a novel class of RAS inhibitory compounds with potent anti-tumor activity
Journal Articles

Abstract B23: DC070-547, a novel Ras inhibitor potently and selectivity inhibits colon tumor growth in vitro and in vivo

Free
Veronica Ramirez-Alcantara, Adam B. Keeton, Bing Zhu, Kevin J. Lee, Joshua Canzoneri, Ashley S. Lindsey, Luciana Madeira da Silva Barnes, Kristy Berry, Jacob Valiyaveettil, Xi Chen, Michael R. Boyd, Gary Piazza
Journal: Cancer Research
Cancer Res (2017) 77 (3_Supplement): B23.
https://doi.org/10.1158/1538-7445.CRC16-B23
Published: 31 January 2017
View articletitled, Abstract B23: DC070-547, a novel Ras inhibitor potently and selectivity inhibits colon tumor growth in vitro and in vivo
Journal Articles

Abstract 1238: A novel Ras inhibitor potently and selectively suppresses lung tumor cell growth by blocking Ras-Raf binding

Free
Bing Zhu, Xi Chen, Veronica Ramirez-Alcantara, Kevin Lee, Jacob Valiyaveettil, Joshua Canzoneri, Sara Sigler, Kristy Berry, Ashley Lindsey, Adam Keeton, Michael R. Boyd, Gary A. Piazza
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1238.
https://doi.org/10.1158/1538-7445.AM2016-1238
Published: 15 July 2016
View articletitled, Abstract 1238: A novel Ras inhibitor potently and selectively suppresses lung tumor cell growth by blocking Ras-Raf binding
Journal Articles

Abstract 326: Discovery and in vitro and in vivo characterization of a novel, small-molecule Ras inhibitor class

Free
Adam B. Keeton, Bing Zhu, Kevin J. Lee, Joshua C. Canzoneri, Sara C. Sigler, Ashley S. Lindsey, Veronica Ramirez-Alcantara, Luciana Barnes, Tyler E. Mattox, Kate McConnell, Kristy L. Berry, Jacob Valiyaveettil, Xi Chen, Michael R. Boyd, Gary A. Piazza
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 326.
https://doi.org/10.1158/1538-7445.AM2016-326
Published: 15 July 2016
View articletitled, Abstract 326: Discovery and in vitro and in vivo characterization of a novel, small-molecule Ras inhibitor class
Journal Articles

Abstract 701: A novel class of Ras selective inhibitors

Free
Joshua C. Canzoneri, Xi Chen, Adam B. Keeton, Kevin Lee, Bernard Gary, Ethan B. Butler, William E. Grizzle, Landon Wilson, Stephen Barnes, Michael R. Boyd, Gary A. Piazza
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 701.
https://doi.org/10.1158/1538-7445.AM2015-701
Published: 01 August 2015
View articletitled, Abstract 701: A novel class of Ras selective inhibitors
Journal Articles

Abstract 4360: Validation of phosphodiesterase 10A as a cancer target

Free
Kevin Lee, Nan Li, Xi Chen, Bing Zhu, Larry Yet, Luciana Madeira da Silva, Suzanne Russo, Adam B. Keeton, Michael R. Boyd, Gary A. Piazza
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4360.
https://doi.org/10.1158/1538-7445.AM2015-4360
Published: 01 August 2015
View articletitled, Abstract 4360: Validation of phosphodiesterase 10A as a cancer target
Journal Articles

Phase I and Pharmacological Study of the Pulmonary Cytotoxin 4-Ipomeanol on a Single Dose Schedule in Lung Cancer Patients: Hepatotoxicity Is Dose Limiting in Humans

Free
Eric K. Rowinsky, Dennis A. Noe, David S. Ettinger, Michaele C. Christian, Barbara G. Lubejko, Elliot K. Fishman, Susan E. Sartorius, Michael R. Boyd, Ross C. Donehower
Journal: Cancer Research
Cancer Res (1993) 53 (8): 1794–1801.
Published: 01 April 1993
View articletitled, Phase I and Pharmacological Study of the Pulmonary Cytotoxin 4-Ipomeanol on a Single Dose Schedule in Lung Cancer Patients: Hepatotoxicity Is Dose Limiting in Humans
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Journal Articles

Multidrug-resistant Phenotype of Disease-oriented Panels of Human Tumor Cell Lines Used for Anticancer Drug Screening

Free
Lin Wu, Anne M. Smythe, Sherman F. Stinson, Leslie A. Mullendore, Anne Monks, Dominic A. Scudiero, Kenneth D. Paull, Antonis D. Koutsoukos, Lawrence V. Rubinstein, Michael R. Boyd, Robert H. Shoemaker
Journal: Cancer Research
Cancer Res (1992) 52 (11): 3029–3034.
Published: 01 June 1992
View articletitled, Multidrug-resistant Phenotype of Disease-oriented Panels of Human Tumor Cell Lines Used for Anticancer Drug Screening
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Journal Articles

Evaluation of Metastatic Human Tumor Burden and Response to Therapy in a Nude Mouse Xenograft Model Using a Molecular Probe for Repetitive Human DNA Sequences

Free
Robert H. Shoemaker, Anne M. Smythe, Lin Wu, Michael S. Balaschak, Michael R. Boyd
Journal: Cancer Research
Cancer Res (1992) 52 (10): 2791–2796.
Published: 01 May 1992
View articletitled, Evaluation of Metastatic Human Tumor Burden and Response to Therapy in a Nude Mouse Xenograft Model Using a Molecular Probe for Repetitive Human DNA Sequences
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Journal Articles

Practical Spontaneous Metastasis Model for in Vivo Therapeutic Studies Using a Human Melanoma

Free
Robert H. Shoemaker, Donald J. Dykes, Jacqueline Plowman, Steadman D. Harrison, Jr., Daniel P. Griswold, Jr., Betty J. Abbott, Joseph G. Mayo, Oystein Fodstad, Michael R. Boyd
Journal: Cancer Research
Cancer Res (1991) 51 (11): 2837–2841.
Published: 01 June 1991
View articletitled, Practical Spontaneous Metastasis Model for in Vivo Therapeutic Studies Using a Human Melanoma
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Journal Articles

Tetrazolium-based Assays for Cellular Viability: A Critical Examination of Selected Parameters Affecting Formazan Production

Free
David T. Vistica, Philip Skehan, Dominic Scudiero, Anne Monks, Angela Pittman, Michael R. Boyd
Journal: Cancer Research
Cancer Res (1991) 51 (10): 2515–2520.
Published: 01 May 1991
View articletitled, Tetrazolium-based Assays for Cellular Viability: A Critical Examination of Selected Parameters Affecting Formazan Production
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Journal Articles

Evidence for Prostanoid Biosynthesis as a Biochemical Feature of Certain Subclasses of Non-Small Cell Carcinomas of the Lung as Determined in Established Cell Lines Derived from Human Lung Tumors

Free
Walter C. Hubbard, Michael C. Alley, Glenn N. Gray, Karen C. Green, Theodore L. McLemore, Michael R. Boyd
Journal: Cancer Research
Cancer Res (1989) 49 (4): 826–832.
Published: 01 February 1989
View articletitled, Evidence for Prostanoid Biosynthesis as a Biochemical Feature of Certain Subclasses of Non-Small Cell Carcinomas of the Lung as Determined in Established Cell Lines Derived from Human Lung Tumors
Open the PDF for Evidence for Prostanoid Biosynthesis as a Biochemical Feature of Certain Subclasses of Non-Small Cell Carcinomas of the Lung as Determined in Established Cell Lines Derived from Human Lung Tumors in another window
Journal Articles

Evaluation of a Soluble Tetrazolium/Formazan Assay for Cell Growth and Drug Sensitivity in Culture Using Human and Other Tumor Cell Lines

Free
Dominic A. Scudiero, Robert H. Shoemaker, Kenneth D. Paull, Anne Monks, Siobhan Tierney, Thomas H. Nofziger, Michael J. Currens, Donna Seniff, Michael R. Boyd
Journal: Cancer Research
Cancer Res (1988) 48 (17): 4827–4833.
Published: 01 September 1988
View articletitled, Evaluation of a Soluble Tetrazolium/Formazan Assay for Cell Growth and Drug Sensitivity in Culture Using Human and Other Tumor Cell Lines
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Journal Articles

Profiles of Prostaglandin Biosynthesis in Sixteen Established Cell Lines Derived from Human Lung, Colon, Prostate, and Ovarian Tumors

Free
Walter C. Hubbard, Michael C. Alley, Theodore L. McLemore, Michael R. Boyd
Journal: Cancer Research
Cancer Res (1988) 48 (17): 4770–4775.
Published: 01 September 1988
View articletitled, Profiles of Prostaglandin Biosynthesis in Sixteen Established Cell Lines Derived from Human Lung, Colon, Prostate, and Ovarian Tumors
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Journal Articles

Extrapulmonary, Tissue-specific Metastasis Formation in Nude Mice Injected with FEMX-I Human Melanoma Cells

Free
Øystein Fodstad, Inge Kjønniksen, Steinar Aamdal, Jahn M. Nesland, Michael R. Boyd, Alexander Pihl
Journal: Cancer Research
Cancer Res (1988) 48 (15): 4382–4388.
Published: 01 August 1988
View articletitled, Extrapulmonary, Tissue-specific Metastasis Formation in Nude Mice Injected with FEMX-I Human Melanoma Cells
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Journal Articles

Profiles of Prostaglandin Biosynthesis in Normal Lung and Tumor Tissue from Lung Cancer Patients

Free
Theodore L. McLemore, Walter C. Hubbard, Charles L. Litterst, Mark C. Liu, Stephan Miller, Noreen A. McMahon, Joseph C. Eggleston, Michael R. Boyd
Journal: Cancer Research
Cancer Res (1988) 48 (11): 3140–3147.
Published: 01 June 1988
View articletitled, Profiles of Prostaglandin Biosynthesis in Normal Lung and Tumor Tissue from Lung Cancer Patients
Open the PDF for Profiles of Prostaglandin Biosynthesis in Normal Lung and Tumor Tissue from Lung Cancer Patients in another window