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Michael Ostrowski
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Journal Articles

Abstract A044: Persistence of fetal splanchnic gene signature defines a tumor-restraining fibroblast subtype in pancreatic cancer

Lu Han, Tom Walter, Joseph Beaudet, Caroline Everett, Gustavo Leone, Michael Ostrowski
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): A044.
https://doi.org/10.1158/1538-7445.PANCREATIC24-A044
Published: 15 September 2024
View article titled, Abstract A044: Persistence of fetal splanchnic gene signature defines a tumor-restraining fibroblast subtype in pancreatic cancer
Journal Articles

Abstract A060: Dysregulation of PTEN expression in a subset of Cancer Associated Fibroblasts by Tumor Secreted Factors in PDAC

Ivo N. Woogeng, Lu Han, Samaneh Saberi, Cameron Bumbleburg, Joseph Beaudet, Sudarshana Sharma, Michael Ostrowski
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): A060.
https://doi.org/10.1158/1538-7445.PANCREATIC24-A060
Published: 15 September 2024
View article titled, Abstract A060: Dysregulation of PTEN expression in a subset of Cancer Associated Fibroblasts by Tumor Secreted Factors in PDAC
Journal Articles

Abstract 1595: Persistence of fetal gene signatures along the mesenchymal lineage trajectory defines heterogeneity and function of pancreatic cancer associated fibroblasts

Lu Han, Tom Walter, Joseph Beaudet, Caroline Everett, Kun Fang, Michael Zimmermann, Angela Mathison, Raul Urrutia, Victor Jin, Gustavo Leone, Michael Ostrowski
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1595.
https://doi.org/10.1158/1538-7445.AM2024-1595
Published: 22 March 2024
View article titled, Abstract 1595: Persistence of fetal gene signatures along the mesenchymal lineage trajectory defines heterogeneity and function of pancreatic cancer associated fibroblasts
Journal Articles

Abstract A045: Persistence of the splanchnic gene signature along the mesenchymal cell trajectory during pancreatic cancer progression

Lu Han, Tom Walter, Joseph Beaudet, Caroline Everett, Julia Piermattei, Alex Adams, Kun Fang, Michael Zimmermann, Angela Mathison, Raul Urrutia, Victor Jin, Gustavo Leone, Michael Ostrowski
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): A045.
https://doi.org/10.1158/1538-7445.PANCA2023-A045
Published: 16 January 2024
View article titled, Abstract A045: Persistence of the splanchnic gene signature along the mesenchymal cell trajectory during pancreatic cancer progression
Journal Articles

Abstract C041: Oncostatin-M and transforming growth factor-beta promote loss of PTEN in PDAC cancer associated fibroblasts

Ivo N. Woogeng, Lu Han, Samaneh Saberi, Cameron Bumbleburg, Joseph Beaudet, Sudarshana Sharma, Michael Ostrowski
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): C041.
https://doi.org/10.1158/1538-7445.PANCA2023-C041
Published: 16 January 2024
View article titled, Abstract C041: Oncostatin-M and transforming growth factor-beta promote loss of PTEN in PDAC cancer associated fibroblasts
Journal Articles

Abstract C032: The involvement of the splanchnic program at the cellular and molecular levels in pancreatic cancer associated fibroblasts

Tom Walter, Lu Han, Michael Ostrowski
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): C032.
https://doi.org/10.1158/1538-7445.PANCA2023-C032
Published: 16 January 2024
View article titled, Abstract C032: The involvement of the splanchnic program at the cellular and molecular levels in pancreatic cancer associated fibroblasts
Journal Articles

Abstract 1344: myCAFs and iCAFs have similar lineage

Thomas S. Walter, Lu Han, Michael Ostrowski
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1344.
https://doi.org/10.1158/1538-7445.AM2023-1344
Published: 04 April 2023
View article titled, Abstract 1344: myCAFs and iCAFs have similar lineage
Journal Articles

Abstract 5847: The splanchnic mesenchyme is the main tissue origin of fibroblasts in the pancreas during homeostasis and tumorigenesis

Lu Han, Yongxia Wu, Kun Fang, Sean Sweeney, Ulyss Roesner, Melodie Parrish, Khushbu Patel, Tom Walter, Julia Piermattei, Anthony Trimboli, Julia Lefler, Cynthia Timmers, Xue-Zhong Yu, Victor Jin, Michael Zimmermann, Angela Mathison, Raul Urrutia, Michael Ostrowski, Gustavo Leone
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5847.
https://doi.org/10.1158/1538-7445.AM2023-5847
Published: 04 April 2023
View article titled, Abstract 5847: The splanchnic mesenchyme is the main tissue origin of fibroblasts in the pancreas during homeostasis and tumorigenesis
Journal Articles

Abstract 3645: The splanchnic mesenchyme is the main tissue origin of fibroblasts in the pancreas during homeostasis and tumorigenesis

Lu Han, Yongxia Wu, Melodie Parrish, Khushbu Patel, Tony Trimboli, Julia Lefler, Xuezhong Yu, Michael Zimmermann, Angela Mathison, Raul Urrutia, Michael Ostrowski, Gustavo Leone
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3645.
https://doi.org/10.1158/1538-7445.AM2022-3645
Published: 15 June 2022
View article titled, Abstract 3645: The splanchnic mesenchyme is the main tissue origin of fibroblasts in the pancreas during homeostasis and tumorigenesis
Journal Articles

Abstract PR-013: The splanchnic mesenchyme during fetal development is the major source of pancreatic cancer associated fibroblasts

Lu Han, Yongxia Wu, Melodie Parrish, Khushbu Patel, Xuezhong Yu, Michael Ostrowski, Gustavo Leone
Journal: Cancer Research
Cancer Res (2021) 81 (22_Supplement): PR-013.
https://doi.org/10.1158/1538-7445.PANCA21-PR-013
Published: 15 November 2021
View article titled, Abstract PR-013: The splanchnic mesenchyme during fetal development is the major source of pancreatic cancer associated fibroblasts
Journal Articles

Abstract PO-114: STAT3 in cancer-associated fibroblasts promotes an immunosuppressive tumor microenvironment

Julia E. Lefler, Michael Ostrowski, Catherine MarElia-Bennett
Journal: Cancer Research
Cancer Res (2021) 81 (22_Supplement): PO-114.
https://doi.org/10.1158/1538-7445.PANCA21-PO-114
Published: 15 November 2021
View article titled, Abstract PO-114: STAT3 in cancer-associated fibroblasts promotes an immunosuppressive tumor microenvironment
Journal Articles

Abstract PR001: The splanchnic mesenchyme during fetal development is the major source of pancreatic cancer associated fibroblasts

Lu Han, Yongxia Xu, Sean Sweeney, Ulyss Roesner, Melodie Parrish, Khushbu Patel, Xuezhong Yu, Michael Ostrowski, Gustavo Leone
Journal: Cancer Research
Cancer Res (2021) 81 (5_Supplement): PR001.
https://doi.org/10.1158/1538-7445.TME21-PR001
Published: 01 March 2021
View article titled, Abstract PR001: The splanchnic mesenchyme during fetal development is the major source of pancreatic cancer associated fibroblasts
Journal Articles

Abstract PO-051: The splanchnic mesenchyme during fetal development is the major source of pancreatic cancer associated fibroblasts

Lu Han, Yongxia Wu, Sean Sweeney, Ulyss Roesner, Khushbu Patel, Melodie Parrish, Xuezhong Yu, Cynthia Timmers, Michael Ostrowski, Gustavo Leone
Journal: Cancer Research
Cancer Res (2020) 80 (22_Supplement): PO-051.
https://doi.org/10.1158/1538-7445.PANCA20-PO-051
Published: 13 November 2020
View article titled, Abstract PO-051: The splanchnic mesenchyme during fetal development is the major source of pancreatic cancer associated fibroblasts
Journal Articles

Abstract PO-032: Targeting the KRAS dimerization interface enhances T-cell mediated anti-tumor response in vivo

Imran Khan, Julia Lefler, Catherine Marelia, Mariyam Zuberi, Eric Denbaum, Akiko Koide, Cynthia Timmers, Michael Ostrowski, Shohei Koide, John O’Bryan
Journal: Cancer Research
Cancer Res (2020) 80 (22_Supplement): PO-032.
https://doi.org/10.1158/1538-7445.PANCA20-PO-032
Published: 13 November 2020
View article titled, Abstract PO-032: Targeting the KRAS dimerization interface enhances T-cell mediated anti-tumor response in vivo
Journal Articles

Abstract 2644: Oncostatin M in pancreatic cancer tumor microenvironment

Daenique H. Jengelley, Melissa L. Fishel, Michael Ostrowski, Teresa A. Zimmers
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2644.
https://doi.org/10.1158/1538-7445.AM2020-2644
Published: 15 August 2020
View article titled, Abstract 2644: Oncostatin M in pancreatic cancer tumor microenvironment
Journal Articles

Abstract C28: Platelet-derived growth factor receptor-β (PDGFRβ) in the breast metastatic tumor microenvironment

Gina Sizemore, Anisha Mathur, Katie Thies, Chelsea Bolyard, Steven Sizemore, Raleigh Kladney, Anthony Trimboli, Balveen Kaur, Gustavo Leone, Michael Ostrowski
Journal: Cancer Research
Cancer Res (2016) 76 (15_Supplement): C28.
https://doi.org/10.1158/1538-7445.TME16-C28
Published: 28 July 2016
View article titled, Abstract C28: Platelet-derived growth factor receptor-β (PDGFRβ) in the breast metastatic tumor microenvironment
Journal Articles

Abstract P6-16-02: Oncolytic viral therapy enhances the survival of mice in a novel model of breast cancer brain metastases

W Hans Meisen, Samuel Dubin, Steven Sizemore, Haritha Mathsyaraja, Katie Thies, Norm Lehman, Peter Boyer, Alena C Jaime-Ramirez, J Bradley Elder, Kimerly Powell, Michael Ostrowski, Balveen Kaur
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): P6-16-02.
https://doi.org/10.1158/1538-7445.SABCS14-P6-16-02
Published: 01 May 2015
View article titled, Abstract P6-16-02: Oncolytic viral therapy enhances the survival of mice in a novel model of breast cancer brain metastases
Journal Articles

RAGE Mediates S100A7-Induced Breast Cancer Growth and Metastasis by Modulating the Tumor Microenvironment

Mohd W. Nasser, Nissar Ahmad Wani, Dinesh K. Ahirwar, Catherine A. Powell, Janani Ravi, Mohamad Elbaz, Helong Zhao, Laura Padilla, Xiaoli Zhang, Konstantin Shilo, Michael Ostrowski, Charles Shapiro, William E. Carson, III, Ramesh K. Ganju
Journal: Cancer Research
Cancer Res (2015) 75 (6): 974–985.
https://doi.org/10.1158/0008-5472.CAN-14-2161
Published: 12 March 2015
View article titled, RAGE Mediates S100A7-Induced Breast Cancer Growth and Metastasis by Modulating the Tumor Microenvironment
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Includes: Supplementary data
Journal Articles

Abstract 2843: Tumor macrophages utilize ATF3 to promote breast cancer metastasis

Chris C. Wolford, Stephen McConoughey, Xin Yin, Anand Merchant, Marino E. Leon, Sandra O'Toole, Rob Sutherland, Michael Ostrowski, Tsonwin Hai
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2843.
https://doi.org/10.1158/1538-7445.AM2011-2843
Published: 15 April 2011
View article titled, Abstract 2843: Tumor macrophages utilize ATF3 to promote breast cancer metastasis
Journal Articles

Abstract 2841: Inducible modulation of NF-kappaB in macrophages reveals that timing of intervention may be critical to therapeutic outcome during mammary tumorigenesis

Whitney Barham, Linda Connelly, Halina M. Onishko, Lianyi Chen, Taylor Sherrill, Tahera Zabuawala, Michael Ostrowski, Timothy Blackwell, Fiona Yull
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2841.
https://doi.org/10.1158/1538-7445.AM2011-2841
Published: 15 April 2011
View article titled, Abstract 2841: Inducible modulation of NF-kappaB in macrophages reveals that timing of intervention may be critical to therapeutic outcome during mammary tumorigenesis