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Michael Ohh
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Journal Articles

Abstract 670: Distinct biochemical properties of KRAS Q61H mutant render cancer cells resistant to SHP2 inhibitors

Teklab Gebregiworgis, Yoshihito Kano, Michael Ohh, Christopher B. Marshall, Mitsuhiko Ikura
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 670.
https://doi.org/10.1158/1538-7445.AM2022-670
Published: 15 June 2022
View articletitled, Abstract 670: Distinct biochemical properties of KRAS Q61H mutant render cancer cells resistant to SHP2 inhibitors
Journal Articles

NRAS Status Determines Sensitivity to SHP2 Inhibitor Combination Therapies Targeting the RAS–MAPK Pathway in Neuroblastoma

Ivette Valencia-Sama, Yagnesh Ladumor, Lynn Kee, Teresa Adderley, Gabriella Christopher, Claire M. Robinson, Yoshihito Kano, Michael Ohh, Meredith S. Irwin
Journal: Cancer Research
Cancer Res (2020) 80 (16): 3413–3423.
https://doi.org/10.1158/0008-5472.CAN-19-3822
Published: 14 August 2020
View articletitled, NRAS Status Determines Sensitivity to SHP2 Inhibitor Combination Therapies Targeting the RAS–MAPK Pathway in Neuroblastoma
Open the PDF for NRAS Status Determines Sensitivity to SHP2 Inhibitor Combination Therapies Targeting the RAS–MAPK Pathway in Neuroblastoma in another window
Includes: Supplementary data
Journal Articles

Abstract 3123: Targeting SHP2 and RAS MAPK pathway in neuroblastoma

Ivette Valencia-Sama, Teresa Adderley, Lynn Kee, Gabriella Christopher, Yoshihito Kano, Michael Ohh, Meredith Irwin
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3123.
https://doi.org/10.1158/1538-7445.AM2019-3123
Published: 01 July 2019
View articletitled, Abstract 3123: Targeting SHP2 and RAS MAPK pathway in neuroblastoma
Journal Articles

Abstract 4360: Altering the regulation of KRAS GTPase cycle via Src and SHP2 creates a potential therapeutic vulnerability for pancreatic cancer

Teklab Gebregiworgis, Christopher B. Marshall, Yoshihito Kano, Nikolina Radulovich, Ming-Sound Tsao, Michael Ohh, Mitsuhiko Ikura
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4360.
https://doi.org/10.1158/1538-7445.AM2018-4360
Published: 01 July 2018
View articletitled, Abstract 4360: Altering the regulation of KRAS GTPase cycle via Src and SHP2 creates a potential therapeutic vulnerability for pancreatic cancer
Journal Articles

Abstract A31: eIF4F links translation to energy stress response in cancer

Laura Hulea, Marie Cargnello, Simon-Pierre Gravel, Young Im, Shannon McLaughlan, Yunhua Zhao, Jenna Ching, Yutian Cai, Ola Larsson, Michael Ohh, Josie Ursini-Siegel, Julie St-Pierre, Michael Pollak, Ivan Topisirovic
Journal: Cancer Research
Cancer Res (2017) 77 (6_Supplement): A31.
https://doi.org/10.1158/1538-7445.Transcontrol16-A31
Published: 14 March 2017
View articletitled, Abstract A31: eIF4F links translation to energy stress response in cancer
Journal Articles

Abstract B13: Novel treatment strategy for pancreatic cancer by targeting the ‘undruggable’ Ras oncoprotein

Yoshihito Kano, Severa Bunda, Jen Jen Yeh, Zhong-Yin Zhang, Michael Ohh
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): B13.
https://doi.org/10.1158/1538-7445.PANCA16-B13
Published: 14 December 2016
View articletitled, Abstract B13: Novel treatment strategy for pancreatic cancer by targeting the ‘undruggable’ Ras oncoprotein
Journal Articles

Abstract B1: Chemotherapy induces NEDP1‐mediated destabilization of MDM2

Ian R. Watson, Bryan K. Li, Olga Roche, Alvaro Blanch, Michael Ohh, Meredith S. Irwin
Journal: Cancer Research
Cancer Res (2009) 69 (23_Supplement): B1.
https://doi.org/10.1158/0008-5472.FBCR09-B1
Published: 28 October 2014
View articletitled, Abstract B1: Chemotherapy induces NEDP1‐mediated destabilization of MDM2
Journal Articles

Inhibition of SRC Corrects GM-CSF Hypersensitivity That Underlies Juvenile Myelomonocytic Leukemia

Severa Bunda, Michelle W. Kang, Stephanie S. Sybingco, Julie Weng, Helene Favre, Danielle H. Shin, Meredith S. Irwin, Mignon L. Loh, Michael Ohh
Journal: Cancer Research
Cancer Res (2013) 73 (8): 2540–2550.
https://doi.org/10.1158/0008-5472.CAN-12-3425
Published: 15 April 2013
View articletitled, Inhibition of SRC Corrects GM-CSF Hypersensitivity That Underlies Juvenile Myelomonocytic Leukemia
Open the PDF for Inhibition of SRC Corrects GM-CSF Hypersensitivity That Underlies Juvenile Myelomonocytic Leukemia in another window
Includes: Supplementary data
Journal Articles

Abstract 1973: Caveolin-1 promotes cell proliferation, EGFR activation and tumor growth in kidney cancer

Chao Ying (Sarah) Xu, Yi Wang, Olga Roche, Eduardo Moriyama, Michael Ohh
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1973.
https://doi.org/10.1158/1538-7445.AM2011-1973
Published: 15 April 2011
View articletitled, Abstract 1973: Caveolin-1 promotes cell proliferation, EGFR activation and tumor growth in kidney cancer
Journal Articles

Abstract 459: Caveolin-1 mediated signaling and proliferation is regulated through the oxygen sensing pathway

Chao Ying Xu, Yi Wang, Olga Roche, Michael Ohh
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 459.
https://doi.org/10.1158/1538-7445.AM10-459
Published: 15 April 2010
View articletitled, Abstract 459: Caveolin-1 mediated signaling and proliferation is regulated through the oxygen sensing pathway
Journal Articles

Suppression of Hypoxia-Inducible Factor 2α Restores p53 Activity via Hdm2 and Reverses Chemoresistance of Renal Carcinoma Cells

Andrew M. Roberts, Ian R. Watson, Andrew J. Evans, David A. Foster, Meredith S. Irwin, Michael Ohh
Journal: Cancer Research
Cancer Res (2009) 69 (23): 9056–9064.
https://doi.org/10.1158/0008-5472.CAN-09-1770
Published: 30 November 2009
View articletitled, Suppression of Hypoxia-Inducible Factor 2α Restores p53 Activity via Hdm2 and Reverses Chemoresistance of Renal Carcinoma Cells
Open the PDF for Suppression of Hypoxia-Inducible Factor 2α Restores p53 Activity via Hdm2 and Reverses Chemoresistance of Renal Carcinoma Cells in another window
Includes: Supplementary data
Journal Articles

von Hippel-Lindau Tumor Suppressor Protein Regulates the Assembly of Intercellular Junctions in Renal Cancer Cells through Hypoxia-Inducible Factor–Independent Mechanisms

Maria J. Calzada, Miguel A. Esteban, Monica Feijoo-Cuaresma, Maria C. Castellanos, Salvador Naranjo-Suárez, Elisa Temes, Fernando Méndez, Maria Yánez-Mo, Michael Ohh, Manuel O. Landázuri
Journal: Cancer Research
Cancer Res (2006) 66 (3): 1553–1560.
https://doi.org/10.1158/0008-5472.CAN-05-3236
Published: 01 February 2006
View articletitled, von Hippel-Lindau Tumor Suppressor Protein Regulates the Assembly of Intercellular Junctions in Renal Cancer Cells through Hypoxia-Inducible Factor–Independent Mechanisms
Open the PDF for von Hippel-Lindau Tumor Suppressor Protein Regulates the Assembly of Intercellular Junctions in Renal Cancer Cells through Hypoxia-Inducible Factor–Independent Mechanisms in another window
Journal Articles

Characterization of a von Hippel Lindau Pathway Involved in Extracellular Matrix Remodeling, Cell Invasion, and Angiogenesis

Ghada Kurban, Valérie Hudon, Eric Duplan, Michael Ohh, Arnim Pause
Journal: Cancer Research
Cancer Res (2006) 66 (3): 1313–1319.
https://doi.org/10.1158/0008-5472.CAN-05-2560
Published: 01 February 2006
View articletitled, Characterization of a von Hippel Lindau Pathway Involved in Extracellular Matrix Remodeling, Cell Invasion, and Angiogenesis
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Journal Articles

The von Hippel-Lindau Tumor Suppressor Protein Sensitizes Renal Cell Carcinoma Cells to Tumor Necrosis Factor-Induced Cytotoxicity By Suppressing the Nuclear Factor-κB-Dependent Antiapoptotic Pathway

Heng Qi, Michael Ohh
Journal: Cancer Research
Cancer Res (2003) 63 (21): 7076–7080.
Published: 11 November 2003
View articletitled, The von Hippel-Lindau Tumor Suppressor Protein Sensitizes Renal Cell Carcinoma Cells to Tumor Necrosis Factor-Induced Cytotoxicity By Suppressing the Nuclear Factor-κB-Dependent Antiapoptotic Pathway
Open the PDF for The von Hippel-Lindau Tumor Suppressor Protein Sensitizes Renal Cell Carcinoma Cells to Tumor Necrosis Factor-Induced Cytotoxicity By Suppressing the Nuclear Factor-κB-Dependent Antiapoptotic Pathway in another window