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Michael M. Shen
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Journal Articles

Abstract LB217: Novel organoid models of lineage plasticity in castration resistant prostate cancer

Jinqiu Lu, Michael M. Shen
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB217.
https://doi.org/10.1158/1538-7445.AM2024-LB217
Published: 05 April 2024
View article titled, Abstract LB217: Novel organoid models of lineage plasticity in castration resistant prostate cancer
Journal Articles

Abstract 6545: Reversing lineage plasticity and drug resistance in lethal prostate cancer

Alessandro Vasciaveo, Jia J. Li, Dimitrios Karagiannis, Xiao Chen, Andrea Califano, Chao Lu, Michael M. Shen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6545.
https://doi.org/10.1158/1538-7445.AM2024-6545
Published: 22 March 2024
View article titled, Abstract 6545: Reversing lineage plasticity and drug resistance in lethal prostate cancer
Journal Articles

Abstract 7546: Targeting NSD2 to reverse lineage plasticity and drug resistance in neuroendocrine prostate cancer and subtypes of mCRPC

Jia J. Li, Alessandro Vasciaveo, Dimitrios Karagiannis, Xiao Chen, Chen Yu, Andrea Califano, Chao Lu, Michael M. Shen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7546.
https://doi.org/10.1158/1538-7445.AM2024-7546
Published: 22 March 2024
View article titled, Abstract 7546: Targeting NSD2 to reverse lineage plasticity and drug resistance in neuroendocrine prostate cancer and subtypes of mCRPC
Journal Articles

Abstract IA012: Modeling prostate cancer metastasis in genetically engineered mouse models

Cory Abate-Shen, Arianna Giacobbe, Aleksandar Obradovic, Alessandro Vasciaveo, Florencia Picech, Kacey Ronaldson-Bouchard, Gordana Vunjak-Novakovic, Michael M. Shen, Andrea Califano, Peter Sims
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): IA012.
https://doi.org/10.1158/1538-7445.PRCA2023-IA012
Published: 02 June 2023
View article titled, Abstract IA012: Modeling prostate cancer metastasis in genetically engineered mouse models
Journal Articles

Editor's Note: Activator Protein-1 Transcription Factors Are Associated with Progression and Recurrence of Prostate Cancer

Xuesong Ouyang, Walter J. Jessen, Hikmat Al-Ahmadie, Angel M. Serio, Yong Lin, Weichung-Joseph Shih, Victor E. Reuter, Peter T. Scardino, Michael M. Shen, Bruce J. Aronow, Andrew J. Vickers, William L. Gerald, Cory Abate-Shen
Journal: Cancer Research
Cancer Res (2023) 83 (7): 1161.
https://doi.org/10.1158/0008-5472.CAN-23-0515
Published: 04 April 2023
View article titled, Editor's Note: Activator Protein-1 Transcription Factors Are Associated with Progression and Recurrence of Prostate Cancer
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Journal Articles

Editor's Note: Dual Targeting of the Akt/mTOR Signaling Pathway Inhibits Castration-Resistant Prostate Cancer in a Genetically Engineered Mouse Model

Nicola Floc'h, Carolyn Waugh Kinkade, Takashi Kobayashi, Alvaro Aytes, Celine Lefebvre, Antonina Mitrofanova, Robert D. Cardiff, Andrea Califano, Michael M. Shen, Cory Abate-Shen
Journal: Cancer Research
Cancer Res (2023) 83 (7): 1160.
https://doi.org/10.1158/0008-5472.CAN-23-0516
Published: 04 April 2023
View article titled, Editor's Note: Dual Targeting of the Akt/mTOR Signaling Pathway Inhibits Castration-Resistant Prostate Cancer in a Genetically Engineered Mouse Model
Open the PDF for Editor's Note: Dual Targeting of the Akt/mTOR Signaling Pathway Inhibits Castration-Resistant Prostate Cancer in a Genetically Engineered Mouse Model in another window
Journal Articles

Abstract 5931: Characterizing tumor heterogeneity through bulk and single cell analysis of patient derived bladder cancer models

Ziyu Chen, Xinran Tang, Eliyahu Havasov, Andrew Mcpherson, Carissa Chu, John R. Christin, Michael F. Berger, Nikolaus D. Schultz, Elisa de Stanchina, Michael M. Shen, Hikmat Al-Ahmadie, Kwanghee Kim, Gopa Iyer, David B. Solit
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5931.
https://doi.org/10.1158/1538-7445.AM2023-5931
Published: 04 April 2023
View article titled, Abstract 5931: Characterizing tumor heterogeneity through bulk and single cell analysis of patient derived bladder cancer models
Journal Articles

Abstract 472: HER2 as a therapeutic target in bladder cancer

Xinran Tang, Ziyu Chen, Jasmine Thomas, Karan Nagar, John Christin, Naryan Rustgi, Sizhi Gao, Carissa Chu, Elisa De Stanchina, Michael F. Berger, Jonathan A. Coleman, Michael M. Shen, Hikmat A. Al-Ahmadie, Gopakumar V. Iyer, Kwanghee Kim, David B. Solit
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 472.
https://doi.org/10.1158/1538-7445.AM2023-472
Published: 04 April 2023
View article titled, Abstract 472: HER2 as a therapeutic target in bladder cancer
Journal Articles

Abstract 1596: Genomic heterogeneity as a barrier to precision oncology in urothelial cancer

Ziyu Chen, Timothy N. Clinton, Soonbum Park, Andrew T. Lenis, Mark Donoghue, Jonathan E. Rosenberg, Bajorin F. Dean, Min Y. Teo, Bernard H. Bochner, Irina Ostrovnaya, Eugene J. Pietzak, Gopakumar V. Iyer, Sizhi Gao, Wenhuo Hu, Michael M. Shen, Michael F. Berger, Hikmat A. Al-Ahmadie, Corinne T. Abate-Shen, David B. Solit
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1596.
https://doi.org/10.1158/1538-7445.AM2022-1596
Published: 15 June 2022
View article titled, Abstract 1596: Genomic heterogeneity as a barrier to precision oncology in urothelial cancer
Journal Articles

Abstract 2807: HER3 is an actionable target in advanced prostate cancer

Susana Miranda, Veronica Gil, Ruth Riisnaes, Bora Gurel, Mariantonietta D’Ambrosio, Alessandro Vasciaveo, Mateus Crespo, Ana Ferreira, Daniela Brina, Martina Troiani, Adam Sharp, Beshara Sheehan, Rossitza Christova, George Seed, Ines Figueiredo, Maryou Lambros, David Dolling, Jan Rekowski, Abdullah Alajati, Matthew Clarke, Rita Pereira, Penny Flohr, Gemma Fowler, Gunther Boysen, Semini Sumanasuriya, Diletta Bianchini, Pasquale Rescigno, Caterina Aversa, Nina Tunariu, Christina Guo, Alec Paschalis, Claudia Bertan, Lorenzo Buroni, Jian Ning, Suzanne Carreira, Paul Workman, Amanda Swain, Andrea Califano, Michael M. Shen, Andrea Alimonti, Antje Neeb, SU2C/PCF International Prostate Cancer Dream Team, Jonathan Welti, Wei Yuan, Johann de Bono
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2807.
https://doi.org/10.1158/1538-7445.AM2022-2807
Published: 15 June 2022
View article titled, Abstract 2807: HER3 is an actionable target in advanced prostate cancer
Journal Articles

HER3 Is an Actionable Target in Advanced Prostate Cancer

Veronica Gil, Susana Miranda, Ruth Riisnaes, Bora Gurel, Mariantonietta D’Ambrosio, Alessandro Vasciaveo, Mateus Crespo, Ana Ferreira, Daniela Brina, Martina Troiani, Adam Sharp, Beshara Sheehan, Rossitza Christova, George Seed, Ines Figueiredo, Maryou Lambros, David Dolling, Jan Rekowski, Abdullah Alajati, Matthew Clarke, Rita Pereira, Penny Flohr, Gemma Fowler, Gunther Boysen, Semini Sumanasuriya, Diletta Bianchini, Pasquale Rescigno, Caterina Aversa, Nina Tunariu, Christina Guo, Alec Paschalis, Claudia Bertan, Lorenzo Buroni, Jian Ning, Suzanne Carreira, Paul Workman, Amanda Swain, Andrea Califano, Michael M. Shen, Andrea Alimonti, Antje Neeb, PCF/SU2C International Prostate Cancer Dream Team, Jonathan Welti, Wei Yuan, Johann de Bono
Journal: Cancer Research
Cancer Res (2021) 81 (24): 6207–6218.
https://doi.org/10.1158/0008-5472.CAN-21-3360
Published: 15 December 2021
View article titled, HER3 Is an Actionable Target in Advanced Prostate Cancer
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Includes: Supplementary data
Journal Articles

Novel Mouse Models of Bladder Cancer Identify a Prognostic Signature Associated with Risk of Disease Progression

Soonbum Park, Lijie Rong, Tomasz B. Owczarek, Matteo Di Bernardo, Rivka L. Shoulson, Chee-Wai Chua, Jaime Y. Kim, Amir Lankarani, Prithi Chakrapani, Talal Syed, James M. McKiernan, David B. Solit, Michael M. Shen, Hikmat A. Al-Ahmadie, Cory Abate-Shen
Journal: Cancer Research
Cancer Res (2021) 81 (20): 5161–5175.
https://doi.org/10.1158/0008-5472.CAN-21-1254
Published: 15 October 2021
View article titled, Novel Mouse Models of Bladder Cancer Identify a Prognostic Signature Associated with Risk of Disease Progression
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Includes: Multimedia, Supplementary data
Journal Articles

CRISPR/Cas9-Mediated Point Mutation in Nkx3.1 Prolongs Protein Half-Life and Reverses Effects Nkx3.1 Allelic Loss

Cai Bowen, Maho Shibata, Hailan Zhang, Sarah K. Bergren, Michael M. Shen, Edward P. Gelmann
Journal: Cancer Research
Cancer Res (2020) 80 (21): 4805–4814.
https://doi.org/10.1158/0008-5472.CAN-20-1742
Published: 03 November 2020
View article titled, CRISPR/Cas9-Mediated Point Mutation in <em>Nkx3.1</em> Prolongs Protein Half-Life and Reverses Effects <em>Nkx3.1</em> Allelic Loss
Open the PDF for CRISPR/Cas9-Mediated Point Mutation in <em>Nkx3.1</em> Prolongs Protein Half-Life and Reverses Effects <em>Nkx3.1</em> Allelic Loss in another window
Includes: Supplementary data
Journal Articles

Abstract 4387: Alterations of TP53 mediate resistance to abiraterone in castration-resistant prostate cancer

Min Zou, Roxanne Toivanen, Antonina Mitrofanova, Michael M. Shen, Cory Abate-Shen
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4387.
https://doi.org/10.1158/1538-7445.AM2016-4387
Published: 15 July 2016
View article titled, Abstract 4387: Alterations of TP53 mediate resistance to abiraterone in castration-resistant prostate cancer
Journal Articles

Abstract 2873: A molecular signature predictive of indolent prostate cancer

Shazia Irshad, Mukesh Bansal, Clementine L. Magnen, Risham Dillon, Mireia Castillo-Martin, Tian Zheng, Alvaro Aytes, Sven Wenske, Paolo Guarnieri, Pavel Sumazin, Mitchell Benson, Michael M. Shen, Andrea Califano, Cory Abate-Shen
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2873.
https://doi.org/10.1158/1538-7445.AM2014-2873
Published: 01 October 2014
View article titled, Abstract 2873: A molecular signature predictive of indolent prostate cancer
Journal Articles

Abstract A36: Identification of master regulators driving advanced prostate cancer and treatment response through the assembly of mouse and human prostate cancer interactomes

Alvaro Aytes, Antonina Mitrofanova, Celine Lefebvre, Michael M. Shen, Andrea Califano, Cory Abate-Shen
Journal: Cancer Research
Cancer Res (2012) 72 (4_Supplement): A36.
https://doi.org/10.1158/1538-7445.PRCA2012-A36
Published: 09 May 2013
View article titled, Abstract A36: Identification of master regulators driving advanced prostate cancer and treatment response through the assembly of mouse and human prostate cancer interactomes
Journal Articles

B-Raf Activation Cooperates with PTEN Loss to Drive c-Myc Expression in Advanced Prostate Cancer

Jingqiang Wang, Takashi Kobayashi, Nicolas Floc'h, Carolyn Waugh Kinkade, Alvaro Aytes, David Dankort, Celine Lefebvre, Antonina Mitrofanova, Robert D. Cardiff, Martin McMahon, Andrea Califano, Michael M. Shen, Cory Abate-Shen
Journal: Cancer Research
Cancer Res (2012) 72 (18): 4765–4776.
https://doi.org/10.1158/0008-5472.CAN-12-0820
Published: 16 September 2012
View article titled, B-Raf Activation Cooperates with PTEN Loss to Drive c-Myc Expression in Advanced Prostate Cancer
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Includes: Supplementary data
Journal Articles

Dual Targeting of the Akt/mTOR Signaling Pathway Inhibits Castration-Resistant Prostate Cancer in a Genetically Engineered Mouse Model

Nicolas Floc'h, Carolyn Waugh Kinkade, Takashi Kobayashi, Alvaro Aytes, Celine Lefebvre, Antonina Mitrofanova, Robert D. Cardiff, Andrea Califano, Michael M. Shen, Cory Abate-Shen
Journal: Cancer Research
Cancer Res (2012) 72 (17): 4483–4493.
https://doi.org/10.1158/0008-5472.CAN-12-0283
Published: 30 August 2012
View article titled, Dual Targeting of the Akt/mTOR Signaling Pathway Inhibits Castration-Resistant Prostate Cancer in a Genetically Engineered Mouse Model
Open the PDF for Dual Targeting of the Akt/mTOR Signaling Pathway Inhibits Castration-Resistant Prostate Cancer in a Genetically Engineered Mouse Model in another window
Includes: Supplementary data
Journal Articles

Abstract LB-405: Identification of master regulators driving advanced prostate cancer and treatment response through the assembly of mouse and human prostate cancer interactomes

Alvaro Aytes, Antonina Mitrofanova, Celine Lefebvre, Carolyn W. Kinkade, Michael M. Shen, Andrea Califano, Cory Abate-Shen
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): LB-405.
https://doi.org/10.1158/1538-7445.AM2012-LB-405
Published: 15 April 2012
View article titled, Abstract LB-405: Identification of master regulators driving advanced prostate cancer and treatment response through the assembly of mouse and human prostate cancer interactomes
Journal Articles

Abstract SY22-01: Interrogating gene expression programs from preclinical analyses of genetically engineered mouse models

Cory Abate-Shen, Alvaro Aytes Meneses, Carolyn W. Kinkade, Antonina Mitrofanova, Celine Lefebvre, Chee Wai Chua, Mireia Castillo-Martin, Edward Gelmann, Michael M. Shen, Andrea Califano
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): SY22-01.
https://doi.org/10.1158/1538-7445.AM2011-SY22-01
Published: 15 April 2011
View article titled, Abstract SY22-01: Interrogating gene expression programs from preclinical analyses of genetically engineered mouse models