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Michael M. Gottesman
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Journal Articles

Abstract LB-066: A high-throughput screen of an annotated small molecule library identifies substrates of P-glycoprotein

Tobie D. Lee, Olivia W. Lee, Kyle R. Brimacombe, Min Shen, Lu Chen, Rajarshi Guha, Bethelihem Tebase, Robert W. Robey, Suresh V. Ambudkar, Michael M. Gottesman, Matthew D. Hall
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-066.
https://doi.org/10.1158/1538-7445.AM2018-LB-066
Published: 01 July 2018
View article titled, Abstract LB-066: A high-throughput screen of an annotated small molecule library identifies substrates of P-glycoprotein
Journal Articles

Abstract 4040: Short-term romidepsin treatment combined with clotrimazole or bifonazole leads to decreased mitochondrial hexokinase 2 and apoptosis in cancer cells

Robert W. Robey, Andrew J. McDonald, Hanna Kozlowski, Michael M. Gottesman, Susan E. Bates
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4040.
https://doi.org/10.1158/1538-7445.AM2017-4040
Published: 01 July 2017
View article titled, Abstract 4040: Short-term romidepsin treatment combined with clotrimazole or bifonazole leads to decreased mitochondrial hexokinase 2 and apoptosis in cancer cells
Journal Articles

Mathematical Modeling Reveals That Changes to Local Cell Density Dynamically Modulate Baseline Variations in Cell Growth and Drug Response

James M. Greene, Doron Levy, Sylvia P. Herrada, Michael M. Gottesman, Orit Lavi
Journal: Cancer Research
Cancer Res (2016) 76 (10): 2882–2890.
https://doi.org/10.1158/0008-5472.CAN-15-3232
Published: 12 May 2016
View article titled, Mathematical Modeling Reveals That Changes to Local Cell Density Dynamically Modulate Baseline Variations in Cell Growth and Drug Response
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Includes: Multimedia, Supplementary data
Journal Articles

Say No to DMSO: Dimethylsulfoxide Inactivates Cisplatin, Carboplatin, and Other Platinum Complexes

Matthew D. Hall, Katherine A. Telma, Ki-Eun Chang, Tobie D. Lee, James P. Madigan, John R. Lloyd, Ian S. Goldlust, James D. Hoeschele, Michael M. Gottesman
Journal: Cancer Research
Cancer Res (2014) 74 (14): 3913–3922.
https://doi.org/10.1158/0008-5472.CAN-14-0247
Published: 14 July 2014
View article titled, Say No to DMSO: Dimethylsulfoxide Inactivates Cisplatin, Carboplatin, and Other Platinum Complexes
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Includes: Supplementary data
Journal Articles

MDR1 Synonymous Polymorphisms Alter Transporter Specificity and Protein Stability in a Stable Epithelial Monolayer

King Leung Fung, James Pan, Shinobu Ohnuma, Paul E. Lund, Jessica N. Pixley, Chava Kimchi-Sarfaty, Suresh V. Ambudkar, Michael M. Gottesman
Journal: Cancer Research
Cancer Res (2014) 74 (2): 598–608.
https://doi.org/10.1158/0008-5472.CAN-13-2064
Published: 16 January 2014
View article titled, <em>MDR1</em> Synonymous Polymorphisms Alter Transporter Specificity and Protein Stability in a Stable Epithelial Monolayer
Open the PDF for <em>MDR1</em> Synonymous Polymorphisms Alter Transporter Specificity and Protein Stability in a Stable Epithelial Monolayer in another window
Includes: Supplementary data
Journal Articles

The Role of Cell Density and Intratumoral Heterogeneity in Multidrug Resistance

Orit Lavi, James M. Greene, Doron Levy, Michael M. Gottesman
Journal: Cancer Research
Cancer Res (2013) 73 (24): 7168–7175.
https://doi.org/10.1158/0008-5472.CAN-13-1768
Published: 16 December 2013
View article titled, The Role of Cell Density and Intratumoral Heterogeneity in Multidrug Resistance
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Includes: Supplementary data
Journal Articles

Abstract 954: Multidrug resistance transcriptome analysis highlights compounds that sensitize resistant hepatocellular carcinoma through increased histone acetylation.

Jean-Pierre Gillet, Jesper B. Andersen, James P. Madigan, Sudhir Varma, Chung-Pu Wu, Anna M. Calcagno, Suresh V. Ambudkar, Snorri S. Thorgeirsson, Michael M. Gottesman
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 954.
https://doi.org/10.1158/1538-7445.AM2013-954
Published: 15 April 2013
View article titled, Abstract 954: Multidrug resistance transcriptome analysis highlights compounds that sensitize resistant hepatocellular carcinoma through increased histone acetylation.
Journal Articles

Abstract 944: The effect of endogenous peroxidase activity on cell culture-based drug activity screening.

Joshua Bakhsheshian, Alexandra D.T. Kwit, Kyle R. Brimacombe, Matthew D. Hall, Michael M. Gottesman
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 944.
https://doi.org/10.1158/1538-7445.AM2013-944
Published: 15 April 2013
View article titled, Abstract 944: The effect of endogenous peroxidase activity on cell culture-based drug activity screening.
Journal Articles

Abstract 989: Mild ER stress increases human ABC transporter expression and drug transport function in polarized cell monolayers.

King Leung Fung, Jessica Pixley, Darrell J. Talbert, Khyati Kapoor, Suresh Ambudkar, Michael M. Gottesman
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 989.
https://doi.org/10.1158/1538-7445.AM2013-989
Published: 15 April 2013
View article titled, Abstract 989: Mild ER stress increases human ABC transporter expression and drug transport function in polarized cell monolayers.
Journal Articles

Abstract B12: The miR-15 family and miR-155 mediate WEE1 and CHEK1 effects on cisplatin-resistance in cancer cells

Lynn M. Pouliot, Jennifer Bai, Matthew D. Hall, Scott E. Martin, Michael M. Gottesman
Journal: Cancer Research
Cancer Res (2012) 72 (2_Supplement): B12.
https://doi.org/10.1158/1538-7445.NONRNA12-B12
Published: 03 April 2013
View article titled, Abstract B12: The miR-15 family and miR-155 mediate WEE1 and CHEK1 effects on cisplatin-resistance in cancer cells
Journal Articles

Cisplatin Sensitivity Mediated by WEE1 and CHK1 Is Mediated by miR-155 and the miR-15 Family

Lynn M. Pouliot, Yu-Chi Chen, Jennifer Bai, Rajarshi Guha, Scott E. Martin, Michael M. Gottesman, Matthew D. Hall
Journal: Cancer Research
Cancer Res (2012) 72 (22): 5945–5955.
https://doi.org/10.1158/0008-5472.CAN-12-1400
Published: 14 November 2012
View article titled, Cisplatin Sensitivity Mediated by WEE1 and CHK1 Is Mediated by miR-155 and the miR-15 Family
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Includes: Supplementary data
Journal Articles

Impact of Intertumoral Heterogeneity on Predicting Chemotherapy Response of BRCA1-Deficient Mammary Tumors

Sven Rottenberg, Marieke A. Vollebergh, Bas de Hoon, Jorma de Ronde, Philip C. Schouten, Ariena Kersbergen, Serge A.L. Zander, Marina Pajic, Janneke E. Jaspers, Martijn Jonkers, Martin Lodén, Wendy Sol, Eline van der Burg, Jelle Wesseling, Jean-Pierre Gillet, Michael M. Gottesman, Joost Gribnau, Lodewyk Wessels, Sabine C. Linn, Jos Jonkers, Piet Borst
Journal: Cancer Research
Cancer Res (2012) 72 (9): 2350–2361.
https://doi.org/10.1158/0008-5472.CAN-11-4201
Published: 30 April 2012
View article titled, Impact of Intertumoral Heterogeneity on Predicting Chemotherapy Response of BRCA1-Deficient Mammary Tumors
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Includes: Supplementary data
Journal Articles

Abstract 843: Influx of thiosemicarbazone NSC73306 is mediated by the cisplatin and copper transporter SLC31A1 (CTR1)

King Leung Fung, Abisola K. Tepede, Kristen M. Pluchino, Matthew D. Hall, Michael M. Gottesman
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 843.
https://doi.org/10.1158/1538-7445.AM2012-843
Published: 15 April 2012
View article titled, Abstract 843: Influx of thiosemicarbazone NSC73306 is mediated by the cisplatin and copper transporter SLC31A1 (CTR1)
Journal Articles

Abstract 2624: Elevated expression of phosphorylated mitogen activated protein kinase kinase (MEK) as a mechanism of resistance to the histone deacetylase inhibitor romidepsin in HUT 78 cutaneous T-cell lymphoma cells

Arup R. Chakraborty, Robert W. Robey, Nathan Collie, Jean-Pierre Gillet, Richard L. Piekarz, Michael M. Gottesman, Susan E. Bates
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2624.
https://doi.org/10.1158/1538-7445.AM2011-2624
Published: 15 April 2011
View article titled, Abstract 2624: Elevated expression of phosphorylated mitogen activated protein kinase kinase (MEK) as a mechanism of resistance to the histone deacetylase inhibitor romidepsin in HUT 78 cutaneous T-cell lymphoma cells
Journal Articles

Abstract LB-51: Correlation of expression of MDR-associated genes with outcome in primary ovarian serous carcinoma

Jean-Pierre Gillet, Anna Maria Calcagno, Sudhir Varma, Ben Davidson, Mari Bunkholt Elstrand, Ram Ganapathi, Anil K. Sood, Suresh V. Ambudkar, Michael V. Seiden, Bo R. Rueda, Michael M. Gottesman
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): LB-51.
https://doi.org/10.1158/1538-7445.AM10-LB-51
Published: 15 April 2010
View article titled, Abstract LB-51: Correlation of expression of MDR-associated genes with outcome in primary ovarian serous carcinoma
Journal Articles

Abstract LB-261: Cancer stem cell characteristics exhibited by doxorubicin-selected drug-resistant breast cancer cells

Anna Maria Calcagno, Crystal D. Salcido, Jean-Pierre Gillet, Chung-Pu Wu, Jennifer M. Fostel, Melanie Mumau, Michael M. Gottesman, Lyuba Varticovski, Suresh V. Ambudkar
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): LB-261.
https://doi.org/10.1158/1538-7445.AM10-LB-261
Published: 15 April 2010
View article titled, Abstract LB-261: Cancer stem cell characteristics exhibited by doxorubicin-selected drug-resistant breast cancer cells
Journal Articles

Abstract 3533: Resistance is useless: Development of the MDR1-selective agent NSC73306

Matthew D. Hall, Misty D. Handley, Kristen Pluchino, Kyle R. Brimacombe, Michael M. Gottesman
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3533.
https://doi.org/10.1158/1538-7445.AM10-3533
Published: 15 April 2010
View article titled, Abstract 3533: Resistance is useless: Development of the MDR1-selective agent NSC73306
Journal Articles

Identification of Compounds Selectively Killing Multidrug-Resistant Cancer Cells

Dóra Türk, Matthew D. Hall, Benjamin F. Chu, Joseph A. Ludwig, Henry M. Fales, Michael M. Gottesman, Gergely Szakács
Journal: Cancer Research
Cancer Res (2009) 69 (21): 8293–8301.
https://doi.org/10.1158/0008-5472.CAN-09-2422
Published: 28 October 2009
View article titled, Identification of Compounds Selectively Killing Multidrug-Resistant Cancer Cells
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Includes: Supplementary data
Journal Articles

Building Scientific Progress without Borders: Nanobiology and Nanomedicine in China and the U.S.

Paul C. Wang, Robert P. Blumenthal, Yuliang Zhao, Julie A. Schneider, Nancy Miller, Piotr Grodzinski, Michael M. Gottesman, Sally Tinkle, Kuan Wang, Chen Wang, Xing-Jie Liang
Journal: Cancer Research
Cancer Res (2009) 69 (13): 5294–5295.
https://doi.org/10.1158/0008-5472.CAN-09-0563
Published: 01 July 2009
View article titled, Building Scientific Progress without Borders: Nanobiology and Nanomedicine in China and the U.S.
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Includes: Supplementary data
Journal Articles

Silent Polymorphisms Speak: How They Affect Pharmacogenomics and the Treatment of Cancer

Zuben E. Sauna, Chava Kimchi-Sarfaty, Suresh V. Ambudkar, Michael M. Gottesman
Journal: Cancer Research
Cancer Res (2007) 67 (20): 9609–9612.
https://doi.org/10.1158/0008-5472.CAN-07-2377
Published: 17 October 2007
View article titled, Silent Polymorphisms Speak: How They Affect Pharmacogenomics and the Treatment of Cancer
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