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Michael L. Freeman
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Journal Articles

Nucleophosmin Plays a Role in Repairing DNA Damage and Is a Target for Cancer Treatment

Open Access
Konjeti R. Sekhar, Michael L. Freeman
Journal: Cancer Research
Cancer Res (2023) 83 (10): 1573–1580.
https://doi.org/10.1158/0008-5472.CAN-22-3631
Published: 15 May 2023
View articletitled, Nucleophosmin Plays a Role in Repairing DNA Damage and Is a Target for Cancer Treatment
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Includes: Supplementary data
Journal Articles

Abstract 6164: Small-molecule targeting of the NPM1/Rad51 repair pathway for the radiosensitization of cancer

Free
Konjeti R. Sekhar, Geri Traver, Peter A. Crooks, Michael L. Freeman
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6164.
https://doi.org/10.1158/1538-7445.AM2020-6164
Published: 15 August 2020
View articletitled, Abstract 6164: Small-molecule targeting of the NPM1/Rad51 repair pathway for the radiosensitization of cancer
Journal Articles

Abstract 3934: Bcl2-expressing quiescent type B neural stem cells in the SVZ are resistant to concurrent temozolomide/X-irradiation

Free
Brent D. Cameron, Geri Traver, Joseph T. Roland, Daniel Dean, Levi Johnson, Kelli L. Boyd, Rebecca A. Ihrie, Jialiang Wang, Michael L. Freeman
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3934.
https://doi.org/10.1158/1538-7445.AM2019-3934
Published: 01 July 2019
View articletitled, Abstract 3934: Bcl2-expressing quiescent type B neural stem cells in the SVZ are resistant to concurrent temozolomide/X-irradiation
Journal Articles

Abstract 3189: Targeting NPM1 for controlling growth of Ewing sarcoma

Free
Geri Traver, Konjeti R. Sekhar, Narsimha R. Renthala, Peter A. Crooks, Maxwell Ofori, Michael L. Freeman
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3189.
https://doi.org/10.1158/1538-7445.AM2018-3189
Published: 01 July 2018
View articletitled, Abstract 3189: Targeting NPM1 for controlling growth of Ewing sarcoma
Journal Articles

Abstract 3050: Proteotoxic isolevuglandins are a central feature of radiation-induced pulmonary injury

Free
Stacy Mont, Sean S. Davies, L Jackson Roberts, Raymond L. Mernaugh, W Hayes McDonald, Brahm H. Segal, Jonathan A. Kropski, Timothy S. Blackwell, Konjeti R. Sekhar, James J. Galligan, Lawrence J. Marnett, Michael L. Freeman
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3050.
https://doi.org/10.1158/1538-7445.AM2016-3050
Published: 15 July 2016
View articletitled, Abstract 3050: Proteotoxic isolevuglandins are a central feature of radiation-induced pulmonary injury
Journal Articles

Abstract 4905: Targeting NPM1 for the radiosensitization of NSCLC

Free
Konjeti R. Sekhar, Mouadh Benamar, Amudhan Venkateswaran, Narsimha R. Penthala, Peter A. Crooks, Stephen R. Hann, Ling Geng, Ramesh Balusu, Tarek Abbas, Michael L. Freeman
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4905.
https://doi.org/10.1158/1538-7445.AM2014-4905
Published: 01 October 2014
View articletitled, Abstract 4905: Targeting NPM1 for the radiosensitization of NSCLC
Journal Articles

The NADH Oxidase ENOX1, a Critical Mediator of Endothelial Cell Radiosensitization, Is Crucial for Vascular Development

Free
Amudhan Venkateswaran, Konjeti R. Sekhar, Daniel S. Levic, David B. Melville, Travis A. Clark, Witold M. Rybski, Alexandra J. Walsh, Melissa C. Skala, Peter A. Crooks, Ela W. Knapik, Michael L. Freeman
Journal: Cancer Research
Cancer Res (2014) 74 (1): 38–43.
https://doi.org/10.1158/0008-5472.CAN-13-1981
Published: 05 January 2014
View articletitled, The NADH Oxidase ENOX1, a Critical Mediator of Endothelial Cell Radiosensitization, Is Crucial for Vascular Development
Open the PDF for The NADH Oxidase ENOX1, a Critical Mediator of Endothelial Cell Radiosensitization, Is Crucial for Vascular Development in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract 384: NADH oxidase, Enox1 activity, is required for vasculogenesis in Zebrafish.

Free
Amudhan Venkateswaran, Daniel S. Levic, David B. Melville, Konjeti R. Sekhar, Alexandra J. Walsh, Melissa C. Skala, Peter A. Crooks, Ela W. Knapik, Michael L. Freeman
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 384.
https://doi.org/10.1158/1538-7445.AM2013-384
Published: 15 April 2013
View articletitled, Abstract 384: NADH oxidase, Enox1 activity, is required for vasculogenesis in Zebrafish.
Journal Articles

Abstract 5091: Increased susceptibility of Nrf2 deficient mice to radiation-induced pulmonary fibrosis

Free
Elizabeth L. Travis, Girish Rachakonda, Xinhui Zhou, Konjeti R. Sekhar, Katrina E. Korhonen, Michael L. Freeman
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5091.
https://doi.org/10.1158/1538-7445.AM2011-5091
Published: 15 April 2011
View articletitled, Abstract 5091: Increased susceptibility of Nrf2 deficient mice to radiation-induced pulmonary fibrosis
Journal Articles

Oxidative Stress Plays a Critical Role in Inactivating Mutant BRAF by Geldanamycin Derivatives

Free
Yayoi Fukuyo, Masahiro Inoue, Takuma Nakajima, Ryuji Higashikubo, Nobuko T. Horikoshi, Clayton Hunt, Anny Usheva, Michael L. Freeman, Nobuo Horikoshi
Journal: Cancer Research
Cancer Res (2008) 68 (15): 6324–6330.
https://doi.org/10.1158/0008-5472.CAN-07-6602
Published: 01 August 2008
View articletitled, Oxidative Stress Plays a Critical Role in Inactivating Mutant BRAF by Geldanamycin Derivatives
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Includes: Supplementary data
Journal Articles

Activating Transcription Factor 3 Is a Novel Repressor of the Nuclear Factor Erythroid-Derived 2–Related Factor 2 (Nrf2)–Regulated Stress Pathway

Free
Stephan L. Brown, Konjeti R. Sekhar, Girish Rachakonda, Soumya Sasi, Michael L. Freeman
Journal: Cancer Research
Cancer Res (2008) 68 (2): 364–368.
https://doi.org/10.1158/0008-5472.CAN-07-2170
Published: 15 January 2008
View articletitled, Activating Transcription Factor 3 Is a Novel Repressor of the Nuclear Factor Erythroid-Derived 2–Related Factor 2 (Nrf2)–Regulated Stress Pathway
Open the PDF for Activating Transcription Factor 3 Is a Novel Repressor of the Nuclear Factor Erythroid-Derived 2–Related Factor 2 (Nrf2)–Regulated Stress Pathway in another window
Journal Articles

Novel Chemical Enhancers of Heat Shock Increase Thermal Radiosensitization through a Mitotic Catastrophe Pathway

Free
Konjeti R. Sekhar, Vijayakumar N. Sonar, Venkatraj Muthusamy, Soumya Sasi, Andrei Laszlo, Jamil Sawani, Nobuo Horikoshi, Ryuji Higashikubo, Robert G. Bristow, Michael J. Borrelli, Peter A. Crooks, James R. Lepock, Joseph L. Roti Roti, Michael L. Freeman
Journal: Cancer Research
Cancer Res (2007) 67 (2): 695–701.
https://doi.org/10.1158/0008-5472.CAN-06-3212
Published: 18 January 2007
View articletitled, Novel Chemical Enhancers of Heat Shock Increase Thermal Radiosensitization through a Mitotic Catastrophe Pathway
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Includes: Supplementary data
Journal Articles

Smad3 suppresses Nrf2-mediated expression of GCLC.

Free
Andrei V. Bakin, Konjeti R. Sekhar, Cammie Rinehart, Michael J. Meredith, Carlos L. Arteaga, Michael L. Freeman
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 806.
Published: 01 April 2004
View articletitled, Smad3 suppresses Nrf2-mediated expression of GCLC.
Journal Articles

The Antiangiogenic Agent SU5416 Down-Regulates Phorbol Ester-Mediated Induction of Cyclooxygenase 2 Expression by Inhibiting Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activity

Free
Debabrata Saha, Konjeti R. Sekhar, Carolyn Cao, Jason D. Morrow, Hak Choy, Michael L. Freeman
Journal: Cancer Research
Cancer Res (2003) 63 (20): 6920–6927.
Published: 28 October 2003
View articletitled, The Antiangiogenic Agent SU5416 Down-Regulates Phorbol Ester-Mediated Induction of Cyclooxygenase 2 Expression by Inhibiting Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activity
Open the PDF for The Antiangiogenic Agent SU5416 Down-Regulates Phorbol Ester-Mediated Induction of Cyclooxygenase 2 Expression by Inhibiting Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activity in another window
Journal Articles

NADPH Oxidase Activity Is Essential for Keap1/Nrf2-mediated Induction of GCLC in Response to 2-Indol-3-yl-methylenequinuclidin-3-ols

Free
Konjeti R. Sekhar, Peter A. Crooks, Vijayakumar N. Sonar, David B. Friedman, Jeff Y. Chan, Michael J. Meredith, Joseph H. Starnes, Kathy R. Kelton, Samantha R. Summar, Soumya Sasi, Michael L. Freeman
Journal: Cancer Research
Cancer Res (2003) 63 (17): 5636–5645.
Published: 18 September 2003
View articletitled, NADPH Oxidase Activity Is Essential for Keap1/Nrf2-mediated Induction of GCLC in Response to 2-Indol-3-yl-methylenequinuclidin-3-ols
Open the PDF for NADPH Oxidase Activity Is Essential for Keap1/Nrf2-mediated Induction of GCLC in Response to 2-Indol-3-yl-methylenequinuclidin-3-ols in another window
Journal Articles

Failure of Chronic Glutathione Elevation to Reduce Cytotoxicity Produced by Exposure to cis-Diamminedichloroplatinum(II), Ionizing Radiation, or Hyperthermia

Free
Michael L. Freeman, Michael J. Meredith, Donald R. Eisert
Journal: Cancer Research
Cancer Res (1990) 50 (17): 5296–5300.
Published: 01 September 1990
View articletitled, Failure of Chronic Glutathione Elevation to Reduce Cytotoxicity Produced by Exposure to cis-Diamminedichloroplatinum(II), Ionizing Radiation, or Hyperthermia
Open the PDF for Failure of Chronic Glutathione Elevation to Reduce Cytotoxicity Produced by Exposure to cis-Diamminedichloroplatinum(II), Ionizing Radiation, or Hyperthermia in another window
Journal Articles

Conjugation of 9-Deoxy-Δ9,Δ12(E)-prostaglandin D2 with Intracellular Glutathione and Enhancement of Its Antiproliferative Activity by Glutathione Depletion

Free
Jacob Atsmon, Michael L. Freeman, Michael J. Meredith, Brian J. Sweetman, L. Jackson Roberts, II
Journal: Cancer Research
Cancer Res (1990) 50 (6): 1879–1885.
Published: 01 March 1990
View articletitled, Conjugation of 9-Deoxy-Δ9,Δ12(E)-prostaglandin D2 with Intracellular Glutathione and Enhancement of Its Antiproliferative Activity by Glutathione Depletion
Open the PDF for Conjugation of 9-Deoxy-Δ9,Δ12(E)-prostaglandin D2 with Intracellular Glutathione and Enhancement of Its Antiproliferative Activity by Glutathione Depletion in another window
Journal Articles

Modulation of Diamide Toxicity in Thermotolerant Cells by Inhibition of Protein Synthesis

Free
Michael L. Freeman, Michael J. Meredith
Journal: Cancer Research
Cancer Res (1989) 49 (16): 4493–4498.
Published: 01 August 1989
View articletitled, Modulation of Diamide Toxicity in Thermotolerant Cells by Inhibition of Protein Synthesis
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Journal Articles

Depletion of Glutathione, Heat Shock Protein Synthesis, and the Development of Thermotolerance in Chinese Hamster Ovary Cells

Free
Michael L. Freeman, Michael J. Meredith, Andrei Laszlo
Journal: Cancer Research
Cancer Res (1988) 48 (24_Part_1): 7033–7037.
Published: 15 December 1988
View articletitled, Depletion of Glutathione, Heat Shock Protein Synthesis, and the Development of Thermotolerance in Chinese Hamster Ovary Cells
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Journal Articles

Role of Glutathione in Cell Survival after Hyperthermic Treatment of Chinese Hamster Ovary Cells

Free
Michael L. Freeman, Arnold W. Malcolm, Michael J. Meredith
Journal: Cancer Research
Cancer Res (1985) 45 (12_Part_1): 6308–6313.
Published: 01 December 1985
View articletitled, Role of Glutathione in Cell Survival after Hyperthermic Treatment of Chinese Hamster Ovary Cells
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