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Michael Kragh
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Journal Articles

Abstract 357: Pan-HER, an antibody mixture simultaneously targeting EGFR, HER2, and HER3, is highly effective in triple negative breast cancer patient-derived xenografts

Free
Roberto R. Rosato, Don S. Choi, Wei Qian, Wen Chen, Johan Lantto, Ivan D. Horak, Michael Kragh, Jenny C. Chang
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 357.
https://doi.org/10.1158/1538-7445.AM2019-357
Published: 01 July 2019
View articletitled, Abstract 357: Pan-HER, an antibody mixture simultaneously targeting EGFR, HER2, and HER3, is highly effective in triple negative breast cancer patient-derived xenografts
Journal Articles

Abstract 5629: Preclinical characterization of Sym023 a human anti-TIM3 antibody with a novel mechanism of action

Free
Trine Lindsted, Monika Gad, Michael V. Grandal, Camilla Frölich, Vikram K. Bhatia, Torben Gjetting, Johan Lantto, Ivan D. Horak, Michael Kragh, Klaus Koefoed, Mikkel W. Pedersen
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5629.
https://doi.org/10.1158/1538-7445.AM2018-5629
Published: 01 July 2018
View articletitled, Abstract 5629: Preclinical characterization of Sym023 a human anti-TIM3 antibody with a novel mechanism of action
Journal Articles

Abstract 5626: Preclinical characterization of Sym022, a novel anti-LAG3 antibody

Free
Michael M. Grandal, Maria C. Melander, Vikram K. Bhatia, Torben Gjetting, Trine Lindsted, Camilla Fröhlich, Johan Lantto, Ivan D. Horak, Michael Kragh, Klaus Kofoed, Mikkel W. Pedersen
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5626.
https://doi.org/10.1158/1538-7445.AM2018-5626
Published: 01 July 2018
View articletitled, Abstract 5626: Preclinical characterization of Sym022, a novel anti-LAG3 antibody
Journal Articles

Abstract 3822: Characterization of the first chicken-derived anti-PD-1 clinical stage antibody with a unique epitope and promising anticancer activity

Free
Torben Gjetting, Monika Gad, Camilla Fröhlich, Maria C. Melander, Gunther Galler, Johan Lantto, Thomas Bouquin, Ivan D. Horak, Michael Kragh, Mikkel W. Pedersen, Klaus Koefoed
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3822.
https://doi.org/10.1158/1538-7445.AM2018-3822
Published: 01 July 2018
View articletitled, Abstract 3822: Characterization of the first chicken-derived anti-PD-1 clinical stage antibody with a unique epitope and promising anticancer activity
Journal Articles

Abstract LB-216: Protein pathway activation analysis of a panel of patient-derived epithelial tumor models identifies signatures of response to ErbB1-3 co-targeting

Free
Valerie S. Calvert, Camilla Fröhlich, Thomas T. Poulsen, Mikkel W. Pedersen, Michael Kragh, Ivan D. Horak, Emanuel F. Petricoin
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-216.
https://doi.org/10.1158/1538-7445.AM2018-LB-216
Published: 01 July 2018
View articletitled, Abstract LB-216: Protein pathway activation analysis of a panel of patient-derived epithelial tumor models identifies signatures of response to ErbB1-3 co-targeting
Journal Articles

Abstract 1723: CD4+ and CD8a+ PET imaging in syngeneic mouse models for prediction of immuno-therapeutic response

Free
Lotte K. Kristensen, Camilla Fröhlich, Camilla Christensen, Maria C. Melander, Thomas T. Poulsen, Gunther R. Galler, Johan Lantto, Ivan D. Horak, Michael Kragh, Carsten H. Nielsen, Andreas Kjaer
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1723.
https://doi.org/10.1158/1538-7445.AM2018-1723
Published: 01 July 2018
View articletitled, Abstract 1723: CD4+ and CD8a+ PET imaging in syngeneic mouse models for prediction of immuno-therapeutic response
Journal Articles

Abstract 810: Anti-tumor effects of Sym015 in HGF overexpressing gastric cancer cell lines

Free
Hyun Jeong Kim, Sun Kyoung Kang, Michael Kragh, Ivan D. Horak, Woo Sun Kwon, Tae Soo Kim, Inhye Jeong, Joong Bae Ahn, Hyun Cheol Chung, Sun Young Rha
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 810.
https://doi.org/10.1158/1538-7445.AM2018-810
Published: 01 July 2018
View articletitled, Abstract 810: Anti-tumor effects of Sym015 in HGF overexpressing gastric cancer cell lines
Journal Articles

Abstract 3158: In vivo acquired resistance to an emibetuzumab analogue in MET-amplified gastric xenografts can be overcome by a MET-targeting antibody mixture or PIK3CA/AKT/mTOR inhibition

Free
Sofie Ellebæk Pollmann, Emanuel Frank Petricoin, Valerie Calvert, Shruti Rao, Simina Boca, Subha Madhavan, Ivan David Horak, Andreas Kjær, Michael Kragh, Thomas Tuxen Poulsen
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3158.
https://doi.org/10.1158/1538-7445.AM2017-3158
Published: 01 July 2017
View articletitled, Abstract 3158: In vivo acquired resistance to an emibetuzumab analogue in MET-amplified gastric xenografts can be overcome by a MET-targeting antibody mixture or PIK3CA/AKT/mTOR inhibition
Journal Articles

Abstract 27: Combination of paclitaxel and Sym015, a mixture of two monoclonal antibodies directed at MET receptor, to increase anti-tumor effects in gastric cancer

Free
Hyun Jeong Kim, Sun Kyoung Kang, Ivan Horak, Michael Kragh, Woo Sun Kwon, Tae Soo Kim, Inhye Jeong, Sun Young Rha, Hyun Cheol Chung
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 27.
https://doi.org/10.1158/1538-7445.AM2017-27
Published: 01 July 2017
View articletitled, Abstract 27: Combination of paclitaxel and Sym015, a mixture of two monoclonal antibodies directed at MET receptor, to increase anti-tumor effects in gastric cancer
Journal Articles

Abstract 1219: Sym015, a novel antibody mixture targeting non-overlapping epitopes of MET, effectively inhibits growth of MET dependent tumors and overcomes resistance to a single monoclonal antibody

Free
Thomas T. Poulsen, Michael M. Grandal, Helle J. Jacobsen, Dorte S. Hansen, Trine Lindsted, Mikkel W. Pedersen, Ivan D. Horak, Michael Kragh, Johan Lantto
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1219.
https://doi.org/10.1158/1538-7445.AM2016-1219
Published: 15 July 2016
View articletitled, Abstract 1219: Sym015, a novel antibody mixture targeting non-overlapping epitopes of MET, effectively inhibits growth of MET dependent tumors and overcomes resistance to a single monoclonal antibody
Journal Articles

Abstract 1218: A novel synergistic antibody pair targeting non-overlapping epitopes of MET effectively inhibits MET-driven cancer models

Free
Michael M. Grandal, Thomas T. Poulsen, Klaus Koefoed, Karsten W. Eriksen, Anna Dahlman, Paolo Conrotto, Thomas Bouquin, Helle Jacobsen, Ivan D. Horak, Michael Kragh, Johan Lantto, Mikkel W. Pedersen
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1218.
https://doi.org/10.1158/1538-7445.AM2016-1218
Published: 15 July 2016
View articletitled, Abstract 1218: A novel synergistic antibody pair targeting non-overlapping epitopes of MET effectively inhibits MET-driven cancer models
Journal Articles

Abstract 2149: The anti-EGFR antibody mixture Sym004 overcomes acquired resistance to cetuximab in colorectal cancer

Free
Francisco J. Sanchez-Martin, Alba Dalmases, Beatriz Bellosillo, Guillem Argiles, Mariona Gelabert, Israel Cañadas, Joana Vidal, Giulia Siravegna, Sabrina Arena, Klaus Koefoed, Laura Visa, Oriol Arpí, Ivan D. Horak, Mar Iglesias, Christopher Stroh, Michael Kragh, Ana Rovira, Joan Albanell, Alberto Bardelli, Josep Tabernero, Clara Montagut
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2149.
https://doi.org/10.1158/1538-7445.AM2016-2149
Published: 15 July 2016
View articletitled, Abstract 2149: The anti-EGFR antibody mixture Sym004 overcomes acquired resistance to cetuximab in colorectal cancer
Journal Articles

Abstract 1668: Effective targeting of colorectal cancer with a recombinant antibody mixture against EGFR, HER3 and IGF1R

Free
Christina Egebjerg, Camilla Fröhlich, Karsten Wessel Eriksen, Thomas Tuxen Poulsen, Klaus Kofoed, Thomas Bouquin, Andrea Bretotti, Livio Trusolino, Ivan David Horak, Michael Kragh, Mikkel Wandahl Pedersen
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1668.
https://doi.org/10.1158/1538-7445.AM2015-1668
Published: 01 August 2015
View articletitled, Abstract 1668: Effective targeting of colorectal cancer with a recombinant antibody mixture against EGFR, HER3 and IGF1R
Journal Articles

Abstract 3585: HER3 and IGF1R are major mediators of both acquired and intrinsic cetuximab resistance in head and neck squamous cell carcinomas

Free
Ida Kjaer, Trine Lindsted, Camilla Fröhlich, Ivan D. Horak, Michael Kragh, Jesper V. Olsen, Mikkel W. Pedersen
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3585.
https://doi.org/10.1158/1538-7445.AM2015-3585
Published: 01 August 2015
View articletitled, Abstract 3585: HER3 and IGF1R are major mediators of both acquired and intrinsic cetuximab resistance in head and neck squamous cell carcinomas
Journal Articles

Abstract 5455: Surface accumulation of receptor tyrosine kinases upon treatment with tyrosine kinase inhibitors and resulting enhancement of activity upon treatment cessation

Free
Anne-Mette Bjerregaard, Michael V. Grandal, Camilla Frohlich, Trine Lindsted, Christina Egebjerg, Ivan D. Horac, Michael Kragh, Mikkel W. Pedersen
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5455.
https://doi.org/10.1158/1538-7445.AM2015-5455
Published: 01 August 2015
View articletitled, Abstract 5455: Surface accumulation of receptor tyrosine kinases upon treatment with tyrosine kinase inhibitors and resulting enhancement of activity upon treatment cessation
Journal Articles

Abstract 4495: Sym013, novel pan-HER monoclonal antibody mixture, augments radiation response in human lung and head and neck tumors

Free
David Francis, Shyhmin Huang, Lauryn Werner, Johan Lantto, Ivan D. Horak, Michael Kragh, Paul M. Harari
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4495.
https://doi.org/10.1158/1538-7445.AM2014-4495
Published: 01 October 2014
View articletitled, Abstract 4495: Sym013, novel pan-HER monoclonal antibody mixture, augments radiation response in human lung and head and neck tumors
Journal Articles

Abstract 2070: In vivo imaging of therapy response to novel antibody mixtures targeted at the human epidermal growth factor receptor family using FDG and FLT positron emission tomography

Free
Carsten H. Nielsen, Mette M. Jensen, Helle J. Jacobsen, Thomas T. Poulsen, Ivan D. Horak, Johan Lantto, Michael Kragh, Andreas Kjaer
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2070.
https://doi.org/10.1158/1538-7445.AM2014-2070
Published: 01 October 2014
View articletitled, Abstract 2070: In vivo imaging of therapy response to novel antibody mixtures targeted at the human epidermal growth factor receptor family using FDG and FLT positron emission tomography
Journal Articles

Abstract 655: Effect of antibody mixtures on HER-family heterodimerization

Free
Sofie Ellebæk, Thomas Bouquin, Michael V. Grandal, Michael Kragh, Thomas T. Poulsen
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 655.
https://doi.org/10.1158/1538-7445.AM2014-655
Published: 01 October 2014
View articletitled, Abstract 655: Effect of antibody mixtures on HER-family heterodimerization
Journal Articles

Abstract 657: Simultaneous inhibition of HER-family receptors by Pan-HER antibody mixture prevents compensatory HER-family receptor upregulation and induces cell death in a broad range of tumor models

Free
Anna Dahlman, Helle J. Jacobsen, Thomas T. Poulsen, Paolo Conrotto, Mikkel W. Pedersen, Ivan D. Horak, Michael Kragh, Johan Lantto
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 657.
https://doi.org/10.1158/1538-7445.AM2014-657
Published: 01 October 2014
View articletitled, Abstract 657: Simultaneous inhibition of HER-family receptors by Pan-HER antibody mixture prevents compensatory HER-family receptor upregulation and induces cell death in a broad range of tumor models
Journal Articles

Abstract 1027: EGFR targeting antibody SYM004 causes radiosensitization in tumor cells expressing wild-type K-Ras via modulation of MAPK signaling.

Free
Jarob Saker, Shyhmin Huang, Lindsey Park, Mikkel Pedersen, Michael Kragh, Paul Harari
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1027.
https://doi.org/10.1158/1538-7445.AM2013-1027
Published: 15 April 2013
View articletitled, Abstract 1027: EGFR targeting antibody SYM004 causes radiosensitization in tumor cells expressing wild-type K-Ras via modulation of MAPK signaling.