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Michael J. Weber
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Journal Articles

Abstract 937: The PP2A activation using a small molecule agonist triggers apoptosis by releasing mitochondrial permeability transition pores in multi-drug resistant leukemic B cells

Kallesh D. Jayappa, Caroline Farrington, Vicki L. Gordon, Shekhar Saha, Christopher Morris, Krista M. Isaac, Timothy P. Bender, Michael E. Williams, Craig A. Portell, Goutham Narla, Michael J. Weber
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 937.
https://doi.org/10.1158/1538-7445.AM2021-937
Published: 01 July 2021
View article titled, Abstract 937: The PP2A activation using a small molecule agonist triggers apoptosis by releasing mitochondrial permeability transition pores in multi-drug resistant leukemic B cells
Journal Articles

Abstract 3031: Diverse microenvironmental agonists promote a multi drug tolerant persister phenotype CLL and MCL

Kallesh D. Jayappa, Vicki L. Gordon, Konrad J. Cios, Christopher G. Morris, Puja C. Arora, Timothy P. Bender, Michael E. Williams, Craig A. Portell, Michael J. Weber
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3031.
https://doi.org/10.1158/1538-7445.AM2019-3031
Published: 01 July 2019
View article titled, Abstract 3031: Diverse microenvironmental agonists promote a multi drug tolerant persister phenotype CLL and MCL
Journal Articles

Abstract 2381: Loss of S6K2 perturbs redox balance and fatty acid metabolism, leading to oxidative cell death

Hsin-Yi Chen, Minu Samanta, Patricia Reyes-Uribe, Andrew V. Kossenkov, Xiangfan Yin, Yiling Lu, Mark Axelrod, Michael J. Weber, Qin Liu, Gordon B. Mills, Jessie Villanueva
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2381.
https://doi.org/10.1158/1538-7445.AM2018-2381
Published: 01 July 2018
View article titled, Abstract 2381: Loss of S6K2 perturbs redox balance and fatty acid metabolism, leading to oxidative cell death
Journal Articles

Abstract 4885: Diverse microenvironmental agonists induce de novo resistance to Bcl-2 and BTK targeted combination therapy and cancer cell proliferation in B cell malignancies

Kallesh D. Jayappa, Craig A. Portell, Vicki L. Gordon, Timothy P. Bender, Michael E. Williams, Michael J. Weber
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4885.
https://doi.org/10.1158/1538-7445.AM2018-4885
Published: 01 July 2018
View article titled, Abstract 4885: Diverse microenvironmental agonists induce <em>de novo</em> resistance to Bcl-2 and BTK targeted combination therapy and cancer cell proliferation in B cell malignancies
Journal Articles

Abstract 695: p70S6 kinase is a critical node that integrates HER-family and PI3 kinase signaling

Mark J. Axelrod, Rolando E. Mendez, Daniel G. Gioeli, Mark J. Jameson, Michael J. Weber
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 695.
https://doi.org/10.1158/1538-7445.AM2014-695
Published: 01 October 2014
View article titled, Abstract 695: p70S6 kinase is a critical node that integrates HER-family and PI3 kinase signaling
Journal Articles

Abstract 4166: Integrated molecular profiling of melanoma cell lines reveals genotype-drug phenotype associations giving insight on development of combination therapies

Brian J. Capaldo, Devin G. Roller, Mark Axelrod, Alex Koeppel, Michael J. Weber, Aaron Mackey, Dan Gioeli, Stefan Bekiranov
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4166.
https://doi.org/10.1158/1538-7445.AM2014-4166
Published: 01 October 2014
View article titled, Abstract 4166: Integrated molecular profiling of melanoma cell lines reveals genotype-drug phenotype associations giving insight on development of combination therapies
Journal Articles

Abstract 5633: Co-targeting the IGF1R pathway and compensatory signaling enhances cytotoxicity in head and neck cancer.

Mark J. Axelrod, Daniel Gioeli, Elizabeth R. Sharlow, Mark C. Conaway, Rolando E. Mendez, Ashraf Khalil, Linnea Taniguchi, Emmanual F. Petricoin, Stephanie Leimgruber, Michael J. Weber, Mark J. Jameson
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5633.
https://doi.org/10.1158/1538-7445.AM2013-5633
Published: 15 April 2013
View article titled, Abstract 5633: Co-targeting the IGF1R pathway and compensatory signaling enhances cytotoxicity in head and neck cancer.
Journal Articles

Abstract 3400: Small molecule biological screens and global analytical approaches reveal the complexity of cancer cell signaling networks and the challenge of personalized medicine.

Devin Roller, Brian Capaldo, Aaron J. Mackey, Mark Conaway, Michael J. Weber, Daniel G. Gioeli
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3400.
https://doi.org/10.1158/1538-7445.AM2013-3400
Published: 15 April 2013
View article titled, Abstract 3400: Small molecule biological screens and global analytical approaches reveal the complexity of cancer cell signaling networks and the challenge of personalized medicine.
Journal Articles

Abstract 2933: Synthetic lethal screening: A pathway for rational combinatorial therapies for cancer

Mark J. Axelrod, Daniel G. Gioeli, Michael J. Weber
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2933.
https://doi.org/10.1158/1538-7445.AM2012-2933
Published: 15 April 2012
View article titled, Abstract 2933: Synthetic lethal screening: A pathway for rational combinatorial therapies for cancer
Journal Articles

Abstract 1650: Targeting of compensatory signaling pathways identified in a synthetic lethal screen leads to synergistic growth inhibition in bladder cancer cells

Mark J. Axelrod, Daniel Gioeli, Michael J. Weber
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1650.
https://doi.org/10.1158/1538-7445.AM10-1650
Published: 15 April 2010
View article titled, Abstract 1650: Targeting of compensatory signaling pathways identified in a synthetic lethal screen leads to synergistic growth inhibition in bladder cancer cells
Journal Articles

Abstract 3843: Rational selection of combinatorial therapeutic targets for melanoma identified by synthetic lethal screening with small molecule inhibitors

Devin G. Roller, Kerrington R. Molhoek, Craig L. Slingluff, Michael J. Weber, Daniel Gioeli
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3843.
https://doi.org/10.1158/1538-7445.AM10-3843
Published: 15 April 2010
View article titled, Abstract 3843: Rational selection of combinatorial therapeutic targets for melanoma identified by synthetic lethal screening with small molecule inhibitors
Journal Articles

The Neuroendocrine-Derived Peptide Parathyroid Hormone–Related Protein Promotes Prostate Cancer Cell Growth by Stabilizing the Androgen Receptor

John DaSilva, Daniel Gioeli, Michael J. Weber, Sarah J. Parsons
Journal: Cancer Research
Cancer Res (2009) 69 (18): 7402–7411.
https://doi.org/10.1158/0008-5472.CAN-08-4687
Published: 14 September 2009
View article titled, The Neuroendocrine-Derived Peptide Parathyroid Hormone–Related Protein Promotes Prostate Cancer Cell Growth by Stabilizing the Androgen Receptor
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Journal Articles

Receptor for Activated C Kinase 1 (RACK1) and Src Regulate the Tyrosine Phosphorylation and Function of the Androgen Receptor

Sarah Kraus, Daniel Gioeli, Tomas Vomastek, Vicki Gordon, Michael J. Weber
Journal: Cancer Research
Cancer Res (2006) 66 (22): 11047–11054.
https://doi.org/10.1158/0008-5472.CAN-06-0596
Published: 15 November 2006
View article titled, Receptor for Activated C Kinase 1 (RACK1) and Src Regulate the Tyrosine Phosphorylation and Function of the Androgen Receptor
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Journal Articles

Constitutive Activation of the Ras/Mitogen-activated Protein Kinase Signaling Pathway Promotes Androgen Hypersensitivity in LNCaP Prostate Cancer Cells

Robert E. Bakin, Daniel Gioeli, Robert A. Sikes, Eric A. Bissonette, Michael J. Weber
Journal: Cancer Research
Cancer Res (2003) 63 (8): 1981–1989.
Published: 15 April 2003
View article titled, Constitutive Activation of the Ras/Mitogen-activated Protein Kinase Signaling Pathway Promotes Androgen Hypersensitivity in LNCaP Prostate Cancer Cells
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Journal Articles

Attenuation of Ras Signaling Restores Androgen Sensitivity to Hormone-refractory C4-2 Prostate Cancer Cells

Robert E. Bakin, Daniel Gioeli, Eric A. Bissonette, Michael J. Weber
Journal: Cancer Research
Cancer Res (2003) 63 (8): 1975–1980.
Published: 15 April 2003
View article titled, Attenuation of Ras Signaling Restores Androgen Sensitivity to Hormone-refractory C4-2 Prostate Cancer Cells
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Journal Articles

Smac Is Required for Cytochrome c -induced Apoptosis in Prostate Cancer LNCaP Cells

Jonathan P. Carson, Marcelina Behnam, Jennifer N. Sutton, Chunying Du, Xiaodong Wang, Donald F. Hunt, Michael J. Weber, George Kulik
Journal: Cancer Research
Cancer Res (2002) 62 (1): 18–23.
Published: 01 January 2002
View article titled, Smac Is Required for Cytochrome <em>c</em> -induced Apoptosis in Prostate Cancer LNCaP Cells
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Journal Articles

Tumor Necrosis Factor α Induces BID Cleavage and Bypasses Antiapoptotic Signals in Prostate Cancer LNCaP Cells

George Kulik, Jonathan P. Carson, Tomas Vomastek, Kevin Overman, Barry D. Gooch, Srinivasa Srinivasula, Emad Alnemri, Gabriel Nunez, Michael J. Weber
Journal: Cancer Research
Cancer Res (2001) 61 (6): 2713–2719.
Published: 03 March 2001
View article titled, Tumor Necrosis Factor α Induces BID Cleavage and Bypasses Antiapoptotic Signals in Prostate Cancer LNCaP Cells
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Journal Articles

Antiapoptotic Signaling in LNCaP Prostate Cancer Cells: A Survival Signaling Pathway Independent of Phosphatidylinositol 3′-Kinase and Akt/Protein Kinase B

Jonathan P. Carson, George Kulik, Michael J. Weber
Journal: Cancer Research
Cancer Res (1999) 59 (7): 1449–1453.
Published: 01 April 1999
View article titled, Antiapoptotic Signaling in LNCaP Prostate Cancer Cells: <subtitle>A Survival Signaling Pathway Independent of Phosphatidylinositol 3′-Kinase and Akt/Protein Kinase B</subtitle>
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Journal Articles

Activation of Mitogen-Activated Protein Kinase Associated with Prostate Cancer Progression

Daniel Gioeli, James W. Mandell, Gina R. Petroni, Henry F. Frierson, Jr., Michael J. Weber
Journal: Cancer Research
Cancer Res (1999) 59 (2): 279–284.
Published: 15 January 1999
View article titled, Activation of Mitogen-Activated Protein Kinase Associated with Prostate Cancer Progression
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Journal Articles

Elevation of Cyclic Adenosine 3′,5′-Monophosphate Potentiates Activation of Mitogen-activated Protein Kinase by Growth Factors in LNCaP Prostate Cancer Cells

Taosheng Chen, Richard W. Cho, Philip J. S. Stork, Michael J. Weber
Journal: Cancer Research
Cancer Res (1999) 59 (1): 213–218.
Published: 01 January 1999
View article titled, Elevation of Cyclic Adenosine 3′,5′-Monophosphate Potentiates Activation of Mitogen-activated Protein Kinase by Growth Factors in LNCaP Prostate Cancer Cells
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