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Abstract 6687: Micromanaging resistance: microRNA expression and chemoresistance in testicular germ cell tumors

Ratnakar Singh, Kelly Kries, Aayush Gupta, Amy Li, Zeeshan Fazal, Doha Shokry, Raya Boyd, Brayden Rennels, Sarah J. Freemantle, Michael J. Spinella

Cancer Res (2025) 85 (8_Supplement_1): 6687.

https://doi.org/10.1158/1538-7445.AM2025-6687

Published: 21 April 2025

View articletitled, Abstract 6687: Micromanaging resistance: microRNA expression and chemoresistance in testicular germ cell tumors

Journal Articles

Abstract 4561: Mechanism of histone H3K27me3 demethylase therapy for restoring cisplatin sensitivity in refractory testicular cancer

Doha Naguib Ahmed Mohamed Shokry, Ratnakar Singh, Mehwish Khan, Zeeshan Fazal, Raya Boyd, Christine Powell, Sarah J. Freemantle, Michael J. Spinella

Cancer Res (2024) 84 (6_Supplement): 4561.

https://doi.org/10.1158/1538-7445.AM2024-4561

Published: 22 March 2024

View articletitled, Abstract 4561: Mechanism of histone H3K27me3 demethylase therapy for restoring cisplatin sensitivity in refractory testicular cancer

Journal Articles

Abstract 7208: Targeting histone demethylase KDM6B to overcome cisplatin resistance in testicular germ cell tumors

Ratnakar Singh, Doha Shokry, Raya I. Boyd, Brayden C. Rennels, Christine Powell, Mehwish Kahn, Sarah J. Freemantle, Michael J. Spinella

Cancer Res (2024) 84 (6_Supplement): 7208.

https://doi.org/10.1158/1538-7445.AM2024-7208

Published: 22 March 2024

View articletitled, Abstract 7208: Targeting histone demethylase KDM6B to overcome cisplatin resistance in testicular germ cell tumors

Journal Articles

Abstract 820: Nuclear receptor TLX inhibits cancer cell intrinsic properties required for triple-negative breast cancer progression

Adam T. Nelczyk, Hashni E. Vidana Gamage, Liqian Ma, Michael T. McHenry, Madeline A. Henn, Mohammed Kadiri, Yu Wang, Anasuya Das Gupta, Natalia Krawczynska, Sisi He, Michael J. Spinella, Erik R. Nelson

Cancer Res (2022) 82 (12_Supplement): 820.

https://doi.org/10.1158/1538-7445.AM2022-820

Published: 15 June 2022

View articletitled, Abstract 820: Nuclear receptor TLX inhibits cancer cell intrinsic properties required for triple-negative breast cancer progression

Journal Articles

Abstract 2488: Elucidating the role of G0S2 in breast cancer

Andrea K. Corbet, Emmanuel Bikorimana, Ratnakar Singh, Zeeshan Fazal, Raya I. Boyd, Sarah Freemantle, Michael J. Spinella

Cancer Res (2021) 81 (13_Supplement): 2488.

https://doi.org/10.1158/1538-7445.AM2021-2488

Published: 01 July 2021

View articletitled, Abstract 2488: Elucidating the role of G0S2 in breast cancer

Journal Articles

Abstract 2127: Polycomb signaling reciprocally regulates sensitivity of testicular germ cell tumors cells to cisplatin and DNA hypomethylating agents

Ratnakar Singh, Emmanuel Bikorimana, Zeeshan Fazal, Cliff Yerby, Hannah Baldwin, Aleyah Destiny Hattab, Megan Tomlin, Andrea K. Corbet, Raya Iman Boyd, Khadeeja Shahid, Doha Naguib Ahmed Mohamed Shokry, Sarah Joy Spinella, Michael J. Spinella

Cancer Res (2021) 81 (13_Supplement): 2127.

https://doi.org/10.1158/1538-7445.AM2021-2127

Published: 01 July 2021

View articletitled, Abstract 2127: Polycomb signaling reciprocally regulates sensitivity of testicular germ cell tumors cells to cisplatin and DNA hypomethylating agents

Journal Articles

Abstract 5188: Epigenetic changes mediated by polycomb repressive complex 2 are associated with cisplatin acquired resistance in testicular germ cell tumor

Ratnakar Singh, Zeeshan Fazal, Emmanuel Bikorimana, Andrea Corbet, Jennifer Rodriguez, Alyssa Steege, Sarah J. Freemantle, Michael J. Spinella

Cancer Res (2019) 79 (13_Supplement): 5188.

https://doi.org/10.1158/1538-7445.AM2019-5188

Published: 01 July 2019

View articletitled, Abstract 5188: Epigenetic changes mediated by polycomb repressive complex 2 are associated with cisplatin acquired resistance in testicular germ cell tumor

Journal Articles

Abstract 2999: Low-dose demethylation therapy for the treatment of cisplatin-resistant testicular cancer

Andrea Corbet, Costantine Albany, Emmanuel Bikorimana, Ema Khan, Jennifer Rodriguez, Brock C. Christensen, George Sandusky, Lawrence H. Einhorn, Sarah J. Freemantle, Michael J. Spinella

Cancer Res (2018) 78 (13_Supplement): 2999.

https://doi.org/10.1158/1538-7445.AM2018-2999

Published: 01 July 2018

View articletitled, Abstract 2999: Low-dose demethylation therapy for the treatment of cisplatin-resistant testicular cancer

Journal Articles

G0S2 Suppresses Oncogenic Transformation by Repressing a MYC-Regulated Transcriptional Program

Christina Y. Yim, David J. Sekula, Mary P. Hever-Jardine, Xi Liu, Joshua M. Warzecha, Janice Tam, Sarah J. Freemantle, Ethan Dmitrovsky, Michael J. Spinella

Cancer Res (2016) 76 (5): 1204–1213.

https://doi.org/10.1158/0008-5472.CAN-15-2265

Published: 29 February 2016

View articletitled, G0S2 Suppresses Oncogenic Transformation by Repressing a MYC-Regulated Transcriptional Program

Includes: Supplementary data

Journal Articles

Abstract 2026: G0S2 functions as a tumor suppressor gene through inhibition of c-Myc

Christina Y. Yim, David J. Sekula, Sarah J. Freemantle, Ethan Dmitrovsky, Michael J. Spinella

Cancer Res (2015) 75 (15_Supplement): 2026.

https://doi.org/10.1158/1538-7445.AM2015-2026

Published: 01 August 2015

View articletitled, Abstract 2026: G0S2 functions as a tumor suppressor gene through inhibition of c-Myc

Journal Articles

Abstract 2958: The novel protein kinase STK17A is a direct p53 target gene that mediates response to genotoxic and nutritional stress in a cancer cell context-dependent manner

Pingping Mao, Mary Jardine, Lynn Niemaszyk, Jessica Haghkerdar, Eric Yang, Esty G. yanco, Damayanti Desai, Maroun Beyrouthy, Joanna S. Kerley-Hamilton, Sarah J. Freemantle, Michael J. Spinella

Cancer Res (2012) 72 (8_Supplement): 2958.

https://doi.org/10.1158/1538-7445.AM2012-2958

Published: 15 April 2012

View articletitled, Abstract 2958: The novel protein kinase STK17A is a direct p53 target gene that mediates response to genotoxic and nutritional stress in a cancer cell context-dependent manner

Journal Articles

Abstract 4273: DNA methyltransferase 3B mediates 5-aza-deoxycytidine hypersensitivity in cisplatin-sensitive and cisplatin-resistant pluripotent embryonal carcinoma cells

Maroun J. Beyrouthy, Kristen Garner, Mary P. Hever, Sarah J. Freemantle, Alan Eastman, Ethan Dmitrovsky, Michael J. Spinella

Cancer Res (2010) 70 (8_Supplement): 4273.

https://doi.org/10.1158/1538-7445.AM10-4273

Published: 15 April 2010

View articletitled, Abstract 4273: DNA methyltransferase 3B mediates 5-aza-deoxycytidine hypersensitivity in cisplatin-sensitive and cisplatin-resistant pluripotent embryonal carcinoma cells

Journal Articles

High DNA Methyltransferase 3B Expression Mediates 5-Aza-Deoxycytidine Hypersensitivity in Testicular Germ Cell Tumors

Maroun J. Beyrouthy, Kristen M. Garner, Mary P. Hever, Sarah J. Freemantle, Alan Eastman, Ethan Dmitrovsky, Michael J. Spinella

Cancer Res (2009) 69 (24): 9360–9366.

https://doi.org/10.1158/0008-5472.CAN-09-1490

Published: 14 December 2009

View articletitled, High DNA Methyltransferase 3B Expression Mediates 5-Aza-Deoxycytidine Hypersensitivity in Testicular Germ Cell Tumors

Includes: Supplementary data

Journal Articles

A p53-dominant transcriptional response to cisplatin in testicular germ cell tumor-derived human embyronal carcinoma

Joanna S. Kerley-Hamilton, Aimee M. Pike, Sarah J. Freemantle, Michael J. Spinella

Cancer Res (2005) 65 (9_Supplement): 770.

Published: 01 May 2005

View articletitled, A p53-dominant transcriptional response to cisplatin in testicular germ cell tumor-derived human embyronal carcinoma

Journal Articles

The role of the nuclear receptor coregulator RIP140 in the regulation of retinoic acid induced tumor cell differentiation

Kristina A. White, Mark M. Yore, Shannon L. Warburton, Erica Rieder, Sarah J. Freemantle, Angelina V. Vaseva, Michael J. Spinella

Cancer Res (2004) 64 (7_Supplement): 665.

Published: 01 April 2004

View articletitled, The role of the nuclear receptor coregulator RIP140 in the regulation of retinoic acid induced tumor cell differentiation

Journal Articles

A Novel Synthetic Oleanane Triterpenoid, 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid, with Potent Differentiating, Antiproliferative, and Anti-Inflammatory Activity

Cancer Res (1999) 59 (2): 336–341.

Published: 15 January 1999

View articletitled, A Novel Synthetic Oleanane Triterpenoid, 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid, with Potent Differentiating, Antiproliferative, and Anti-Inflammatory Activity

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Abstract 6687: Micromanaging resistance: microRNA expression and chemoresistance in testicular germ cell tumors

Abstract 4561: Mechanism of histone H3K27me3 demethylase therapy for restoring cisplatin sensitivity in refractory testicular cancer

Abstract 7208: Targeting histone demethylase KDM6B to overcome cisplatin resistance in testicular germ cell tumors

Abstract 820: Nuclear receptor TLX inhibits cancer cell intrinsic properties required for triple-negative breast cancer progression

Abstract 2488: Elucidating the role of G0S2 in breast cancer

Abstract 2127: Polycomb signaling reciprocally regulates sensitivity of testicular germ cell tumors cells to cisplatin and DNA hypomethylating agents

Abstract 5188: Epigenetic changes mediated by polycomb repressive complex 2 are associated with cisplatin acquired resistance in testicular germ cell tumor

Abstract 2999: Low-dose demethylation therapy for the treatment of cisplatin-resistant testicular cancer

G0S2 Suppresses Oncogenic Transformation by Repressing a MYC-Regulated Transcriptional Program

Abstract 2026: G0S2 functions as a tumor suppressor gene through inhibition of c-Myc

Abstract 2958: The novel protein kinase STK17A is a direct p53 target gene that mediates response to genotoxic and nutritional stress in a cancer cell context-dependent manner

Abstract 4273: DNA methyltransferase 3B mediates 5-aza-deoxycytidine hypersensitivity in cisplatin-sensitive and cisplatin-resistant pluripotent embryonal carcinoma cells

High DNA Methyltransferase 3B Expression Mediates 5-Aza-Deoxycytidine Hypersensitivity in Testicular Germ Cell Tumors

A p53-dominant transcriptional response to cisplatin in testicular germ cell tumor-derived human embyronal carcinoma

The role of the nuclear receptor coregulator RIP140 in the regulation of retinoic acid induced tumor cell differentiation

A Novel Synthetic Oleanane Triterpenoid, 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid, with Potent Differentiating, Antiproliferative, and Anti-Inflammatory Activity

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