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Abstract 4408: Metabolic alterations induced by ibrutinib in CLL cells as a basis for drug combinations to enhance ibrutinib therapeutic activity

Helene Pelicano, Li Feng, William G. Wierda, Michael J. Keating, Peng Huang

Cancer Res (2017) 77 (13_Supplement): 4408.

https://doi.org/10.1158/1538-7445.AM2017-4408

Published: 01 July 2017

View articletitled, Abstract 4408: Metabolic alterations induced by ibrutinib in CLL cells as a basis for drug combinations to enhance ibrutinib therapeutic activity

Journal Articles

Abstract 3547: B cell receptor signaling regulates cellular metabolism in Chronic Lymphocytic Leukemia

Hima V. Vangapandu, Ondrej Havranek, William G. Wierda, Michael J. Keating, Richard Eric Davis, Christine M. Stellrecht, Varsha Gandhi

Cancer Res (2017) 77 (13_Supplement): 3547.

https://doi.org/10.1158/1538-7445.AM2017-3547

Published: 01 July 2017

View articletitled, Abstract 3547: B cell receptor signaling regulates cellular metabolism in Chronic Lymphocytic Leukemia

Journal Articles

Abstract 1248: Ibrutinib inhibits platelet aggregation through inhibition of mitochondrial respiratory chain function and suppression of Syk activation

Jie Huang, Helen Pelicano, Feng Li, Michael J. Keating, Peng Huang

Cancer Res (2016) 76 (14_Supplement): 1248.

https://doi.org/10.1158/1538-7445.AM2016-1248

Published: 15 July 2016

View articletitled, Abstract 1248: Ibrutinib inhibits platelet aggregation through inhibition of mitochondrial respiratory chain function and suppression of Syk activation

Journal Articles

Abstract 3073: Targeting chronic lymphocytic leukemia by interfering glutathione synthesis using a novel therapeutic enzyme cyst(e)inase (AEB3103)

Jinyun Liu, Li Feng, Everett M. Stone, Joseph Tyler, Scott W. Rowlinson, Michael J. Keating, Peng Huang

Cancer Res (2016) 76 (14_Supplement): 3073.

https://doi.org/10.1158/1538-7445.AM2016-3073

Published: 15 July 2016

View articletitled, Abstract 3073: Targeting chronic lymphocytic leukemia by interfering glutathione synthesis using a novel therapeutic enzyme cyst(e)inase (AEB3103)

Journal Articles

Abstract 1023: Duration of signaling through IgM and IgD receptors differentially influences cell survival and BCL6-regulated CCL3/4 chemokine production in Chronic Lymphocytic Leukemia (CLL)

Elisa ten Hacken, Cristina Scielzo, Susan O'Brien, William G. Wierda, Michael J. Keating, Paolo Ghia, Federico Caligaris-Cappio, Jan A. Burger

Cancer Res (2015) 75 (15_Supplement): 1023.

https://doi.org/10.1158/1538-7445.AM2015-1023

Published: 01 August 2015

View articletitled, Abstract 1023: Duration of signaling through IgM and IgD receptors differentially influences cell survival and BCL6-regulated CCL3/4 chemokine production in Chronic Lymphocytic Leukemia (CLL)

Journal Articles

Abstract 2658: Stromal microenvironment modulates mitochondrial metabolism in chronic lymphocytic leukemia cells and is abrogated by PI3K δ and γ inhibition

Hima V. Vangapandu, Kumudha Balakrishnan, Mary L. Ayres, William G. Wierda, Michael J. Keating, Christine M. Stellrecht, Varsha Gandhi

Cancer Res (2015) 75 (15_Supplement): 2658.

https://doi.org/10.1158/1538-7445.AM2015-2658

Published: 01 August 2015

View articletitled, Abstract 2658: Stromal microenvironment modulates mitochondrial metabolism in chronic lymphocytic leukemia cells and is abrogated by PI3K δ and γ inhibition

Journal Articles

Abstract 4328: Marrow stromal cells promote mitochondrial energy metabolism in primary CLL cells without impacting cellular proliferation

Hima Venkata Vangapandu, Kumudha Balakrishnan, William G. Wierda, Michael J. Keating, Christine M. Stellrecht, Varsha Gandhi

Cancer Res (2014) 74 (19_Supplement): 4328.

https://doi.org/10.1158/1538-7445.AM2014-4328

Published: 01 October 2014

View articletitled, Abstract 4328: Marrow stromal cells promote mitochondrial energy metabolism in primary CLL cells without impacting cellular proliferation

Journal Articles

Abstract 343: Targeting SF3B1 mediated splicing control of Mcl-1 in chronic lymphocytic leukemia

Rong Chen, Yuling Chen, Emanuela M. Ghia, Laura Rassenti, Thomas Kipps, Michael J. Keating, William G. Wierda, William Plunkett

Cancer Res (2014) 74 (19_Supplement): 343.

https://doi.org/10.1158/1538-7445.AM2014-343

Published: 01 October 2014

View articletitled, Abstract 343: Targeting SF3B1 mediated splicing control of Mcl-1 in chronic lymphocytic leukemia

Journal Articles

Abstract 2697: A novel therapeutic strategy to effectively kill CLL cells in stromal microenvironment by targeting lipid metabolism

Panpan Liu, Jinyun Liu, Marcia A. Ogasawara, Helene Pelicano, Ruihua Xu, Michael J. Keating, Peng Huang

Cancer Res (2014) 74 (19_Supplement): 2697.

https://doi.org/10.1158/1538-7445.AM2014-2697

Published: 01 October 2014

View articletitled, Abstract 2697: A novel therapeutic strategy to effectively kill CLL cells in stromal microenvironment by targeting lipid metabolism

Journal Articles

Abstract 4769: Ex-vivo and in-vitro combination strategies with ibrutinib in chronic lymphocytic leukemia

Fabiola Cervantes-Gomez, Kumudha Balakrishnan, William G. Wierda, Michael J. Keating, Varsha Gandhi

Cancer Res (2014) 74 (19_Supplement): 4769.

https://doi.org/10.1158/1538-7445.AM2014-4769

Published: 01 October 2014

View articletitled, Abstract 4769: Ex-vivo and in-vitro combination strategies with ibrutinib in chronic lymphocytic leukemia

Journal Articles

Abstract 3528: Quantitation of ATM function in primary CLL cells.

Yingjun Jiang, Xiaojun Liu, Sijin Wen, Kim-Anh Do, Xiaoping Su, Michael J. Keating, William Wierda, William Plunkett

Cancer Res (2013) 73 (8_Supplement): 3528.

https://doi.org/10.1158/1538-7445.AM2013-3528

Published: 15 April 2013

View articletitled, Abstract 3528: Quantitation of ATM function in primary CLL cells.

Journal Articles

Abstract 120: Epigenetic silencing of miR-17 and miR-20a in chronic lymphocytic leukemia

Melanie L. Sulda, Chaomei Liu, Michael J. Keating, William G. Wierda, William Plunkett, Deepa Sampath

Cancer Res (2012) 72 (8_Supplement): 120.

https://doi.org/10.1158/1538-7445.AM2012-120

Published: 15 April 2012

View articletitled, Abstract 120: Epigenetic silencing of miR-17 and miR-20a in chronic lymphocytic leukemia

Journal Articles

Abstract 1191: Role of histone deacetylases in silencing functionally relevant microRNAs in CLL

Deepa Sampath, Chaomei Liu, William Wierda, William Plunkett, Michael J. Keating

Cancer Res (2011) 71 (8_Supplement): 1191.

https://doi.org/10.1158/1538-7445.AM2011-1191

Published: 15 April 2011

View articletitled, Abstract 1191: Role of histone deacetylases in silencing functionally relevant microRNAs in CLL

Journal Articles

Abstract 1541: Role of GSH in mediating stromal-leukemia interaction and promoting cell survival and drug resistance in chronic lymphocytic leukemia

Wan Zhang, Dunyaporn Trachootham, Jinyun Liu, Michael J. Keating, Peng Huang

Cancer Res (2010) 70 (8_Supplement): 1541.

https://doi.org/10.1158/1538-7445.AM10-1541

Published: 15 April 2010

View articletitled, Abstract 1541: Role of GSH in mediating stromal-leukemia interaction and promoting cell survival and drug resistance in chronic lymphocytic leukemia

Journal Articles

Abstract 4091: Epigenetic silencing of microRNA in the pathobiology of CLL

Deepa Sampath, Chaomei Liu, William G. Wierda, Michael J. Keating

Cancer Res (2010) 70 (8_Supplement): 4091.

https://doi.org/10.1158/1538-7445.AM10-4091

Published: 15 April 2010

View articletitled, Abstract 4091: Epigenetic silencing of microRNA in the pathobiology of CLL

Journal Articles

Fludarabine resistance in CLL is associated with non-functional p53

Deepa Sampath, Min Du, Michael J. Keating, William Plunkett

Cancer Res (2006) 66 (8_Supplement): 884.

Published: 15 April 2006

View articletitled, Fludarabine resistance in CLL is associated with non-functional p53

Journal Articles

Preclinical and early clinical study of forodesine hydrochloride (FH) in chronic lymphocytic leukemia (CLL).

Kumudha Balakrishnan, Ramadevi Nimmanapalli, Michael J. Keating, Farhad Ravandi, Varsha Gandhi

Cancer Res (2006) 66 (8_Supplement): 1329–1330.

Published: 15 April 2006

View articletitled, Preclinical and early clinical study of forodesine hydrochloride (FH) in chronic lymphocytic leukemia (CLL).

Journal Articles

The RNA-directed analog, 8-amino-adenosine (8-NH₂-Ado) induces cytotoxicity in human chronic lymphocytic leukemia cells

Kumudha Balakrishnan, Michael J. Keating, Varsha Gandhi

Cancer Res (2005) 65 (9_Supplement): 146–147.

Published: 01 May 2005

View articletitled, The RNA-directed analog, 8-amino-adenosine (8-NH2-Ado) induces cytotoxicity in human chronic lymphocytic leukemia cells

Journal Articles

CLL response to DNA repair inhibition: Role for p53 and XIAP

Deepa Sampath, Min Du, Michael J. Keating, William Plunkett

Cancer Res (2005) 65 (9_Supplement): 780.

Published: 01 May 2005

View articletitled, CLL response to DNA repair inhibition: Role for p53 and XIAP

Journal Articles

Flavopiridol induces apoptosis in chronic lymphocytic leukemia (CLL) cells through the transcriptional down-regulation of anti-apoptotic proteins

Rong Chen, Michael J. Keating, Varsha Gandhi, William Plunkett

Cancer Res (2005) 65 (9_Supplement): 769.

Published: 01 May 2005

View articletitled, Flavopiridol induces apoptosis in chronic lymphocytic leukemia (CLL) cells through the transcriptional down-regulation of anti-apoptotic proteins

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Abstract 4408: Metabolic alterations induced by ibrutinib in CLL cells as a basis for drug combinations to enhance ibrutinib therapeutic activity

Abstract 3547: B cell receptor signaling regulates cellular metabolism in Chronic Lymphocytic Leukemia

Abstract 1248: Ibrutinib inhibits platelet aggregation through inhibition of mitochondrial respiratory chain function and suppression of Syk activation

Abstract 3073: Targeting chronic lymphocytic leukemia by interfering glutathione synthesis using a novel therapeutic enzyme cyst(e)inase (AEB3103)

Abstract 1023: Duration of signaling through IgM and IgD receptors differentially influences cell survival and BCL6-regulated CCL3/4 chemokine production in Chronic Lymphocytic Leukemia (CLL)

Abstract 2658: Stromal microenvironment modulates mitochondrial metabolism in chronic lymphocytic leukemia cells and is abrogated by PI3K δ and γ inhibition

Abstract 4328: Marrow stromal cells promote mitochondrial energy metabolism in primary CLL cells without impacting cellular proliferation

Abstract 343: Targeting SF3B1 mediated splicing control of Mcl-1 in chronic lymphocytic leukemia

Abstract 2697: A novel therapeutic strategy to effectively kill CLL cells in stromal microenvironment by targeting lipid metabolism

Abstract 4769: Ex-vivo and in-vitro combination strategies with ibrutinib in chronic lymphocytic leukemia

Abstract 3528: Quantitation of ATM function in primary CLL cells.

Abstract 120: Epigenetic silencing of miR-17 and miR-20a in chronic lymphocytic leukemia

Abstract 1191: Role of histone deacetylases in silencing functionally relevant microRNAs in CLL

Abstract 1541: Role of GSH in mediating stromal-leukemia interaction and promoting cell survival and drug resistance in chronic lymphocytic leukemia

Abstract 4091: Epigenetic silencing of microRNA in the pathobiology of CLL

Fludarabine resistance in CLL is associated with non-functional p53

Preclinical and early clinical study of forodesine hydrochloride (FH) in chronic lymphocytic leukemia (CLL).

The RNA-directed analog, 8-amino-adenosine (8-NH₂-Ado) induces cytotoxicity in human chronic lymphocytic leukemia cells

CLL response to DNA repair inhibition: Role for p53 and XIAP

Flavopiridol induces apoptosis in chronic lymphocytic leukemia (CLL) cells through the transcriptional down-regulation of anti-apoptotic proteins

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