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Michael J. Gough
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Journal Articles

Abstract 6647: Established 3D tumor-spheroid co-culture models demonstrate macrophage plasticity and unveil potential supportive roles of macrophages in the T cell-tumor-macrophage crosstalk post radiation therapy

Aanchal Preet Kaur, Alejandro F. Alice, Megan R. Potuznik, Gwen Kramer, Jason Baird, David J. Friedman, Marka R. Crittenden, Michael J. Gough
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6647.
https://doi.org/10.1158/1538-7445.AM2024-6647
Published: 22 March 2024
View article titled, Abstract 6647: Established 3D tumor-spheroid co-culture models demonstrate macrophage plasticity and unveil potential supportive roles of macrophages in the T cell-tumor-macrophage crosstalk post radiation therapy
Journal Articles

Abstract 2582: Intra- and peri-tumoral radiomic features are predictive of pathologic response to multiple neoadjuvant therapy regimen in rectal cancers via pre-treatment MRI

Leo Bao, Thomas DeSilvio, Benjamin N. Parker, Mohsen Hariri, Prathyush Chirra, Murad Labbad, Stephen Tang, Gregory M. O'Connor, Emily Steinhagen, Jennifer L. Miller-Ocuin, Amit Gupta, Eric L. Marderstein, Aaron Carroll, Marka Crittenden, Michael J. Gough, Smitha Krishnamurthi, Kristina H. Young, Satish E. Viswanath
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2582.
https://doi.org/10.1158/1538-7445.AM2024-2582
Published: 22 March 2024
View article titled, Abstract 2582: Intra- and peri-tumoral radiomic features are predictive of pathologic response to multiple neoadjuvant therapy regimen in rectal cancers via pre-treatment MRI
Journal Articles

Abstract 2880: Radiation induces myofibroblast differentiation of pericytes

Tomoko Yamazaki, Kelley R. Jordan, Marka R. Crittenden, Michael J. Gough, Kristina H. Young
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2880.
https://doi.org/10.1158/1538-7445.AM2024-2880
Published: 22 March 2024
View article titled, Abstract 2880: Radiation induces myofibroblast differentiation of pericytes
Journal Articles

Abstract 6860: Fluorescent tracking reveals that radiation therapy influences the migration and plasticity of Tregs within the tumor microenvironment

David J. Friedman, Tiffany Blair, Gwen Kramer, Aanchal Preet Kaur, Jason Baird, Alejandro Alice, Megan Potuznik, Marka R. Crittenden, Michael J. Gough
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6860.
https://doi.org/10.1158/1538-7445.AM2024-6860
Published: 22 March 2024
View article titled, Abstract 6860: Fluorescent tracking reveals that radiation therapy influences the migration and plasticity of Tregs within the tumor microenvironment
Journal Articles

Abstract 6410: Deciphering the role of MyD88 signaling pathway in regulating type I IFN-mediated responses to radiation therapy in solid tumors

Aanchal Preet Kaur, Terry R. Medler, Tiffany C. Blair, Alejandro F. Alice, Megan R. Ball, Alexa K. Dowdell, Brian D. Piening, Marka R. Crittenden, Michael J. Gough
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6410.
https://doi.org/10.1158/1538-7445.AM2023-6410
Published: 04 April 2023
View article titled, Abstract 6410: Deciphering the role of MyD88 signaling pathway in regulating type I IFN-mediated responses to radiation therapy in solid tumors
Journal Articles

Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer

Adam C. Mueller, Miles Piper, Andrew Goodspeed, Shiv Bhuvane, Jason S. Williams, Shilpa Bhatia, Andy V. Phan, Benjamin Van Court, Kathryn L. Zolman, Brisa Peña, Ayman J. Oweida, Sara Zakem, Cheryl Meguid, Michael W. Knitz, Laurel Darragh, Thomas E. Bickett, Jacob Gadwa, Luisa Mestroni, Matthew R.G. Taylor, Kimberly R. Jordan, Peter Dempsey, M. Scott Lucia, Martin D. McCarter, Marco Del Chiaro, Wells A. Messersmith, Richard D. Schulick, Karyn A. Goodman, Michael J. Gough, Casey S. Greene, James C. Costello, Antonio Galveo Neto, David Lagares, Kirk C. Hansen, Adrie Van Bokhoven, Sana D. Karam
Journal: Cancer Research
Cancer Res (2021) 81 (12): 3255–3269.
https://doi.org/10.1158/0008-5472.CAN-20-3892
Published: 15 June 2021
View article titled, Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer
Open the PDF for Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Evaluation of Explant Responses to STING Ligands: Personalized Immunosurgical Therapy for Head and Neck Squamous Cell Carcinoma

Jason R. Baird, R. Bryan Bell, Victoria Troesch, David Friedman, Shelly Bambina, Gwen Kramer, Tiffany C. Blair, Terry Medler, Yaping Wu, Zhaoyu Sun, Tanja D. de Gruijl, Rieneke van de Ven, Rom S. Leidner, Marka R. Crittenden, Michael J. Gough
Journal: Cancer Research
Cancer Res (2018) 78 (21): 6308–6319.
https://doi.org/10.1158/0008-5472.CAN-18-1652
Published: 01 November 2018
View article titled, Evaluation of Explant Responses to STING Ligands: Personalized Immunosurgical Therapy for Head and Neck Squamous Cell Carcinoma
Open the PDF for Evaluation of Explant Responses to STING Ligands: Personalized Immunosurgical Therapy for Head and Neck Squamous Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

Radiotherapy Combined with Novel STING-Targeting Oligonucleotides Results in Regression of Established Tumors

Jason R. Baird, David Friedman, Benjamin Cottam, Thomas W. Dubensky, Jr., David B. Kanne, Shelly Bambina, Keith Bahjat, Marka R. Crittenden, Michael J. Gough
Journal: Cancer Research
Cancer Res (2016) 76 (1): 50–61.
https://doi.org/10.1158/0008-5472.CAN-14-3619
Published: 03 January 2016
View article titled, Radiotherapy Combined with Novel STING-Targeting Oligonucleotides Results in Regression of Established Tumors
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Includes: Supplementary data
Journal Articles

Abstract 1788: Converting radiation-mediated tumor control to tumor cure by manipulating the macrophage response to dying cells

Marka R. Crittenden, Jason R. Baird, Talicia Savage, Benjamin Cottam, David Friedman, Kristina Young, Pippa Newell, Cynthia Nguyen, Andrew M. Jackson, Michael J. Gough
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1788.
https://doi.org/10.1158/1538-7445.AM2015-1788
Published: 01 August 2015
View article titled, Abstract 1788: Converting radiation-mediated tumor control to tumor cure by manipulating the macrophage response to dying cells
Journal Articles

OX40 Agonist Therapy Enhances CD8 Infiltration and Decreases Immune Suppression in the Tumor

Michael J. Gough, Carl E. Ruby, William L. Redmond, Birat Dhungel, Alexis Brown, Andrew D. Weinberg
Journal: Cancer Research
Cancer Res (2008) 68 (13): 5206–5215.
https://doi.org/10.1158/0008-5472.CAN-07-6484
Published: 01 July 2008
View article titled, OX40 Agonist Therapy Enhances CD8 Infiltration and Decreases Immune Suppression in the Tumor
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Includes: Supplementary data
Journal Articles

Viral Fusogenic Membrane Glycoproteins Kill Solid Tumor Cells by Nonapoptotic Mechanisms That Promote Cross Presentation of Tumor Antigens by Dendritic Cells

Andrew R. Bateman, Kevin J. Harrington, Tim Kottke, Atique Ahmed, Alan A. Melcher, Michael J. Gough, Emmanouela Linardakis, David Riddle, Allan Dietz, Christine M. Lohse, Scott Strome, Tim Peterson, Robert Simari, Richard G. Vile
Journal: Cancer Research
Cancer Res (2002) 62 (22): 6566–6578.
Published: 15 November 2002
View article titled, Viral Fusogenic Membrane Glycoproteins Kill Solid Tumor Cells by Nonapoptotic Mechanisms That Promote Cross Presentation of Tumor Antigens by Dendritic Cells
Open the PDF for Viral Fusogenic Membrane Glycoproteins Kill Solid Tumor Cells by Nonapoptotic Mechanisms That Promote Cross Presentation of Tumor Antigens by Dendritic Cells in another window
Journal Articles

Macrophages Orchestrate the Immune Response to Tumor Cell Death

Michael J. Gough, Alan A. Melcher, Atique Ahmed, Marka R. Crittenden, David S. Riddle, Emmanouela Linardakis, Anja N. Ruchatz, Lisa M. Emiliusen, Richard G. Vile
Journal: Cancer Research
Cancer Res (2001) 61 (19): 7240–7247.
Published: 01 October 2001
View article titled, Macrophages Orchestrate the Immune Response to Tumor Cell Death
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