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Michael G. Roth
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Journal Articles

Abstract B037: Characterizing and targeting polyaneuploid/polyploid giant cancer cells (PACCs/PGCCs)

Vural Tagal, Uttam K. Tambar, Michael G. Roth, John D. Minna
Journal: Cancer Research
Cancer Res (2022) 82 (10_Supplement): B037.
https://doi.org/10.1158/1538-7445.EVODYN22-B037
Published: 15 May 2022
View article titled, Abstract B037: Characterizing and targeting polyaneuploid/polyploid giant cancer cells (PACCs/PGCCs)
Journal Articles

Loss of Aurora Kinase Signaling Allows Lung Cancer Cells to Adopt Endoreplication and Form Polyploid Giant Cancer Cells That Resist Antimitotic Drugs

Vural Tagal, Michael G. Roth
Journal: Cancer Research
Cancer Res (2021) 81 (2): 400–413.
https://doi.org/10.1158/0008-5472.CAN-20-1693
Published: 15 January 2021
View article titled, Loss of Aurora Kinase Signaling Allows Lung Cancer Cells to Adopt Endoreplication and Form Polyploid Giant Cancer Cells That Resist Antimitotic Drugs
Open the PDF for Loss of Aurora Kinase Signaling Allows Lung Cancer Cells to Adopt Endoreplication and Form Polyploid Giant Cancer Cells That Resist Antimitotic Drugs in another window
Includes: Supplementary data
Journal Articles

Abstract PO-128: Lack of Aurora kinase signaling leads cancer cells to adopt an endocycle and form polyploid multinucleated giant cells that resist antimitotic drugs

Vural Tagal, Michael G. Roth
Journal: Cancer Research
Cancer Res (2020) 80 (21_Supplement): PO-128.
https://doi.org/10.1158/1538-7445.TUMHET2020-PO-128
Published: 03 November 2020
View article titled, Abstract PO-128: Lack of Aurora kinase signaling leads cancer cells to adopt an endocycle and form polyploid multinucleated giant cells that resist antimitotic drugs
Journal Articles

Abstract LB-318: SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A-targeted therapies in non-small cell lung cancers (NSCLCs)

Vural Tagal, Shuguang Wei, Wei Zhang, Rolf A. Brekken, Bruce A. Posner, Adi F. Gazdar, Michael G. Roth
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-318.
https://doi.org/10.1158/1538-7445.AM2016-LB-318
Published: 15 July 2016
View article titled, Abstract LB-318: SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A-targeted therapies in non-small cell lung cancers (NSCLCs)
Journal Articles

Abstract 573: BRG1-inactivating mutations as potential predictive markers for Aurora kinase A-targeted therapies in non-small cell lung cancers (NSCLCs)

Vural Tagal, Shuguang Wei, Wei Zhang, Bruce A. Posner, John D. Minna, Adi F. Gazdar, Michael G. Roth
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 573.
https://doi.org/10.1158/1538-7445.AM2014-573
Published: 01 October 2014
View article titled, Abstract 573: BRG1-inactivating mutations as potential predictive markers for Aurora kinase A-targeted therapies in non-small cell lung cancers (NSCLCs)
Journal Articles

Abstract C16: Mapping synthetic vulnerabilities in non-small cell lung cancer

Hyun Seok Kim, Saurabh Mendiratta, Jiyeon Kim, Chad Victor Pecot, Jill E. Larsen, Iryna Zubovych, Bo Yeun Seo, Jimi Kim, Banu Eskiocak, Hannah Chung, Elizabeth McMillan, Sherry Wu, Jef De Brabander, Kakajan Komurov, Bruce A. Posner, Rolf Brekken, Anil K. Sood, Ralph J. Deberardinis, Michael G. Roth, John D. Minna, Michael A. White
Journal: Cancer Research
Cancer Res (2013) 73 (19_Supplement): C16.
https://doi.org/10.1158/1538-7445.FBCR13-C16
Published: 15 May 2014
View article titled, Abstract C16: Mapping synthetic vulnerabilities in non-small cell lung cancer
Journal Articles

Epidermal Growth Factor Receptors with Tyrosine Kinase Domain Mutations Exhibit Reduced Cbl Association, Poor Ubiquitylation, and Down-regulation but Are Efficiently Internalized

David Padrón, Mitsuo Sato, Jerry W. Shay, Adi F. Gazdar, John D. Minna, Michael G. Roth
Journal: Cancer Research
Cancer Res (2007) 67 (16): 7695–7702.
https://doi.org/10.1158/0008-5472.CAN-07-0484
Published: 15 August 2007
View article titled, Epidermal Growth Factor Receptors with Tyrosine Kinase Domain Mutations Exhibit Reduced Cbl Association, Poor Ubiquitylation, and Down-regulation but Are Efficiently Internalized
Open the PDF for Epidermal Growth Factor Receptors with Tyrosine Kinase Domain Mutations Exhibit Reduced Cbl Association, Poor Ubiquitylation, and Down-regulation but Are Efficiently Internalized in another window
Includes: Supplementary data