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Michael F. Olson
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Journal Articles

A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma

Joanna L. Birch, Karen Strathdee, Lesley Gilmour, Antoine Vallatos, Laura McDonald, Ariadni Kouzeli, Richa Vasan, Abdulrahman Hussain Qaisi, Daniel R. Croft, Diane Crighton, Kathryn Gill, Christopher H. Gray, Jennifer Konczal, Mokdad Mezna, Duncan McArthur, Alexander W. Schüttelkopf, Patricia McConnell, Mairi Sime, William M. Holmes, Justin Bower, Heather J. McKinnon, Martin Drysdale, Michael F. Olson, Anthony J. Chalmers
Journal: Cancer Research
Cancer Res (2018) 78 (22): 6509–6522.
https://doi.org/10.1158/0008-5472.CAN-18-1697
Published: 15 November 2018
View article titled, A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma
Open the PDF for A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract 1933: A novel small molecule inhibitor of MRCK shows utility in blocking radiation induced invasion of glioblastoma cells in vitro and in vivo

Heather J. McKinnon, Joanna Birch, Laura McDonald, Mairi Sime, Daniel Croft, Diane Crighton, Martin Drysdale, Lesley Gilmore, Christopher Gray, Jennifer Konczal, Duncan McArthur, Patricia McConnell, Mokdad Mezna, Alexander Schuettelkopf, Karen Strathdee, Justin Bower, Michael F. Olson, Anthony J. Chalmers
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1933.
https://doi.org/10.1158/1538-7445.AM2018-1933
Published: 01 July 2018
View article titled, Abstract 1933: A novel small molecule inhibitor of MRCK shows utility in blocking radiation induced invasion of glioblastoma cells <em>in vitro</em> and <em>in vivo</em>
Journal Articles

Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth

Nicola Rath, June Munro, Marie Francene Cutiongco, Alicja Jagiełło, Nikolaj Gadegaard, Lynn McGarry, Mathieu Unbekandt, Evdokia Michalopoulou, Jurre J. Kamphorst, David Sumpton, Gillian Mackay, Claire Vennin, Marina Pajic, Paul Timpson, Michael F. Olson
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (12): 3321–3336.
https://doi.org/10.1158/0008-5472.CAN-17-1339
Published: 14 June 2018
View article titled, Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth
Open the PDF for Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth in another window
Includes: Supplementary data
Journal Articles

Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer

Mathieu Unbekandt, Simone Belshaw, Justin Bower, Maeve Clarke, Jacqueline Cordes, Diane Crighton, Daniel R. Croft, Martin J. Drysdale, Mathew J. Garnett, Kathryn Gill, Christopher Gray, David A. Greenhalgh, James A.M. Hall, Jennifer Konczal, Sergio Lilla, Duncan McArthur, Patricia McConnell, Laura McDonald, Lynn McGarry, Heather McKinnon, Carol McMenemy, Mokdad Mezna, Nicolas A. Morrice, June Munro, Gregory Naylor, Nicola Rath, Alexander W. Schüttelkopf, Mairi Sime, Michael F. Olson
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (8): 2096–2114.
https://doi.org/10.1158/0008-5472.CAN-17-2870
Published: 12 April 2018
View article titled, Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer
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Includes: Supplementary data
Journal Articles

Abstract C22: ROCK kinases drive invasive pancreatic tumor growth

Nicola Rath, Shereen Kadir, Jennifer P. Morton, Andreia V. Pinho, Lena Helbig, Linda Julian, Ewan J. McGhee, Gabriela Kalna, Alexei Vazquez, Kurt I. Anderson, Ilse Rooman, Michael S. Samuel, Michael F. Olson
Journal: Cancer Research
Cancer Res (2016) 76 (15_Supplement): C22.
https://doi.org/10.1158/1538-7445.TME16-C22
Published: 28 July 2016
View article titled, Abstract C22: ROCK kinases drive invasive pancreatic tumor growth
Journal Articles

Abstract 2956: The role of apoptotic blebbing in tissue homeostasis and cancer

Linda Julian, Michael F. Olson
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2956.
https://doi.org/10.1158/1538-7445.AM2014-2956
Published: 01 October 2014
View article titled, Abstract 2956: The role of apoptotic blebbing in tissue homeostasis and cancer
Journal Articles

Abstract 930: Inducible ROCK 2/rasHa cooperation requires wound promotion to achieve malignancy in transgenic mouse skin carcinogenesis, whereas inducible ROCK 2/PTEN loss fails to achieve benign papilloma

Siti F. Masre, Michael S. Samuel, Michael F. Olson, David A. Greenhalgh
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 930.
https://doi.org/10.1158/1538-7445.AM2014-930
Published: 01 October 2014
View article titled, Abstract 930: Inducible <em>ROCK 2/ras<sup>Ha</sup></em> cooperation requires wound promotion to achieve malignancy in transgenic mouse skin carcinogenesis, whereas inducible <em>ROCK 2/PTEN</em> loss fails to achieve benign papilloma
Journal Articles

Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53

Paul Timpson, Ewan J. McGhee, Jennifer P. Morton, Alex von Kriegsheim, Juliane P. Schwarz, Saadia A. Karim, Brendan Doyle, Jean A. Quinn, Neil O. Carragher, Mike Edward, Michael F. Olson, Margaret C. Frame, Valerie G. Brunton, Owen J. Sansom, Kurt I. Anderson
Journal: Cancer Research
Cancer Res (2011) 71 (3): 747–757.
https://doi.org/10.1158/0008-5472.CAN-10-2267
Published: 01 February 2011
View article titled, Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53
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Includes: Multimedia, Supplementary data
Journal Articles

Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation

Suzanne C. Brady, Mathew L. Coleman, June Munro, Stephan M. Feller, Nicolas A. Morrice, Michael F. Olson
Journal: Cancer Research
Cancer Res (2009) 69 (17): 6773–6781.
https://doi.org/10.1158/0008-5472.CAN-08-4447
Published: 31 August 2009
View article titled, Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
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Includes: Supplementary data
Journal Articles

Modeling Human Cancer: Report on the Eighth Beatson International Cancer Conference

Michael F. Olson
Journal: Cancer Research
Cancer Res (2005) 65 (24): 11247–11250.
https://doi.org/10.1158/0008-5472.CAN-05-2713
Published: 15 December 2005
View article titled, Modeling Human Cancer: Report on the Eighth Beatson International Cancer Conference
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Includes: Supplementary data
Journal Articles

Conditional ROCK Activation In vivo Induces Tumor Cell Dissemination and Angiogenesis

Daniel R. Croft, Erik Sahai, Georgia Mavria, Shuixing Li, Jeff Tsai, William M. F. Lee, Christopher J. Marshall, Michael F. Olson
Journal: Cancer Research
Cancer Res (2004) 64 (24): 8994–9001.
https://doi.org/10.1158/0008-5472.CAN-04-2052
Published: 16 December 2004
View article titled, Conditional ROCK Activation <em>In vivo</em> Induces Tumor Cell Dissemination and Angiogenesis
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Journal Articles

SPRY2 Is an Inhibitor of the Ras/Extracellular Signal-Regulated Kinase Pathway in Melanocytes and Melanoma Cells with Wild-Type BRAF but Not with the V599E Mutant

Dimitra Tsavachidou, Mathew L. Coleman, Galene Athanasiadis, Shuixing Li, Jonathan D. Licht, Michael F. Olson, Barbara L. Weber
Journal: Cancer Research
Cancer Res (2004) 64 (16): 5556–5559.
https://doi.org/10.1158/0008-5472.CAN-04-1669
Published: 16 August 2004
View article titled, SPRY2 Is an Inhibitor of the Ras/Extracellular Signal-Regulated Kinase Pathway in Melanocytes and Melanoma Cells with Wild-Type <em>BRAF</em> but Not with the V599E Mutant
Open the PDF for SPRY2 Is an Inhibitor of the Ras/Extracellular Signal-Regulated Kinase Pathway in Melanocytes and Melanoma Cells with Wild-Type <em>BRAF</em> but Not with the V599E Mutant in another window
Journal Articles

Role of the BRAF mutation in melanoma. A global gene expression profiling approach

Dimitra Tsavachidou, Mathew L. Coleman, Michael F. Olson, Barbara L. Weber
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 375.
Published: 01 April 2004
View article titled, Role of the BRAF mutation in melanoma. A global gene expression profiling approach