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Michael B. Sporn
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Journal Articles

Abstract LB-186: The rexinoid LG100268 decreases immunosuppressive immune cells and activates T cells in two preclinical models of breast cancer

Ana Sofia Leal, Sarah Carapellucci, Kayla ZydecK, Michael B. Sporn, Karen T. Liby
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-186.
https://doi.org/10.1158/1538-7445.AM2019-LB-186
Published: 01 July 2019
View article titled, Abstract LB-186: The rexinoid LG100268 decreases immunosuppressive immune cells and activates T cells in two preclinical models of breast cancer
Journal Articles

Abstract LB-344: The rexinoid LG100268 modulates immune cell populations in mammary gland tumors of MMTV-neu mice

Ana Sofia Leal, Sarah Carapellucci, Kayla Zydeck, Nupur Raychaudhuri, Michael B. Sporn, Karen T. Liby
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-344.
https://doi.org/10.1158/1538-7445.AM2018-LB-344
Published: 01 July 2018
View article titled, Abstract LB-344: The rexinoid LG100268 modulates immune cell populations in mammary gland tumors of MMTV-neu mice
Journal Articles

Abstract 2245: Evaluation of new rexinoids for lung cancer

Di Zhang, Ana S. Leal, Sarah E. Carapellucci, Kayla Zydeck, Nicole Chaaban, Michael B. Sporn, Carl E. Wagner, Karen T. Liby
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2245.
https://doi.org/10.1158/1538-7445.AM2017-2245
Published: 01 July 2017
View article titled, Abstract 2245: Evaluation of new rexinoids for lung cancer
Journal Articles

Abstract A88: The synthetic triterpenoid CDDO-Imidazolide reduces immune cell infiltration and cytokine secretion in the KC mouse model of pancreatic cancer

Ana Sofia Leal, Michael B. Sporn, Patricia A. Pioli, Karen T. Liby
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): A88.
https://doi.org/10.1158/1538-7445.PANCA16-A88
Published: 14 December 2016
View article titled, Abstract A88: The synthetic triterpenoid CDDO-Imidazolide reduces immune cell infiltration and cytokine secretion in the KC mouse model of pancreatic cancer
Journal Articles

Commentary on Eagle and Foley: “Cytotoxicity in Human Cell Cultures”

Michael B. Sporn
Journal: Cancer Research
Cancer Res (2016) 76 (5): 989–990.
https://doi.org/10.1158/0008-5472.CAN-16-0152
Published: 29 February 2016
View article titled, Commentary on Eagle and Foley: “Cytotoxicity in Human Cell Cultures”
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Journal Articles

Abstract 293: Therapeutic effects of the bromodomain inhibitors JQ1 and I-BET 762 on pancreatic cancer

Ana S. Leal, Charlotte R. Williams, Michael B. Sporn, Karen T. Liby
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 293.
https://doi.org/10.1158/1538-7445.AM2015-293
Published: 01 August 2015
View article titled, Abstract 293: Therapeutic effects of the bromodomain inhibitors JQ1 and I-BET 762 on pancreatic cancer
Journal Articles

Abstract LB-265: Comparison of oleanane triterpenoids and dimethyl fumarate in lung cancer

Ciric To, Darlene B. Royce, Charlotte R. Williams, Renee Risingsong, Michael B. Sporn, Karen T. Liby
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): LB-265.
https://doi.org/10.1158/1538-7445.AM2015-LB-265
Published: 01 August 2015
View article titled, Abstract LB-265: Comparison of oleanane triterpenoids and dimethyl fumarate in lung cancer
Journal Articles

Abstract A113: Immunomodulatory properties of bromodomain inhibitors in pancreatic cancer cells

Ana S. Leal, Charlotte R. Williams, Michael B. Sporn, Karen T. Liby
Journal: Cancer Research
Cancer Res (2015) 75 (13_Supplement): A113.
https://doi.org/10.1158/1538-7445.PANCA2014-A113
Published: 30 June 2015
View article titled, Abstract A113: Immunomodulatory properties of bromodomain inhibitors in pancreatic cancer cells
Journal Articles

Abstract 2965: Olaparib and veliparib as effective PARP inhibitors for cancer prevention in a BRCA1-deficient mouse model

Ciric To, Charlotte R. Williams, Darlene B. Royce, Ryan M. Collins, Michael B. Sporn, Karen T. Liby
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2965.
https://doi.org/10.1158/1538-7445.AM2014-2965
Published: 01 October 2014
View article titled, Abstract 2965: Olaparib and veliparib as effective PARP inhibitors for cancer prevention in a BRCA1-deficient mouse model
Journal Articles

Abstract LB-245: The EGRF receptor inhibitor Erlotinib, alone or in combination with the rexinoid LG100268, is effective for prevention in mouse models of lung and pancreatic cancer with Kras mutations

Karen T. Liby, Charlotte R. Williams, Renee Risingsong, Michael B. Sporn, Ryan M. Collins, Darlene B. Royce
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): LB-245.
https://doi.org/10.1158/1538-7445.AM2014-LB-245
Published: 01 October 2014
View article titled, Abstract LB-245: The EGRF receptor inhibitor Erlotinib, alone or in combination with the rexinoid LG100268, is effective for prevention in mouse models of lung and pancreatic cancer with Kras mutations
Journal Articles

Abstract 180: Inhibition of tumorigenesis by a novel Gemini vitamin D analog BXL0124 and a synthetic triterpenoid CDDO-Im in MMTV-HER2/neu transgenic mice.

Jae Young So, Amanda K. Smolarek, Hubert Maehr, Milan Uskokovic, Karen Liby, Michael B. Sporn, Nanjoo Suh
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 180.
https://doi.org/10.1158/1538-7445.AM2013-180
Published: 15 April 2013
View article titled, Abstract 180: Inhibition of tumorigenesis by a novel Gemini vitamin D analog BXL0124 and a synthetic triterpenoid CDDO-Im in MMTV-HER2/neu transgenic mice.
Journal Articles

ΔNp63α-Mediated Activation of Bone Morphogenetic Protein Signaling Governs Stem Cell Activity and Plasticity in Normal and Malignant Mammary Epithelial Cells

Amanda L. Balboni, Justine A. Hutchinson, Andrew J. DeCastro, Pratima Cherukuri, Karen Liby, Michael B. Sporn, Gary N. Schwartz, Wendy A. Wells, Lorenzo F. Sempere, Paul B. Yu, James DiRenzo
Journal: Cancer Research
Cancer Res (2013) 73 (2): 1020–1030.
https://doi.org/10.1158/0008-5472.CAN-12-2862
Published: 16 January 2013
View article titled, ΔNp63α-Mediated Activation of Bone Morphogenetic Protein Signaling Governs Stem Cell Activity and Plasticity in Normal and Malignant Mammary Epithelial Cells
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Journal Articles

Abstract 820: The synthetic triterpenoids, CDDO-methyl ester and CDDO-ethyl amide, and the histone deacetylase inhibitor vorinostat delay carcinogenesis in a transgenic model of estrogen receptor-negative breast cancer

Kim M. Tran, Michael B. Sporn, Karen Liby
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 820.
https://doi.org/10.1158/1538-7445.AM2011-820
Published: 15 April 2011
View article titled, Abstract 820: The synthetic triterpenoids, CDDO-methyl ester and CDDO-ethyl amide, and the histone deacetylase inhibitor vorinostat delay carcinogenesis in a transgenic model of estrogen receptor-negative breast cancer
Journal Articles

Abstract 2523: Synthetic triterpenoids protect against toxicity and enhance the efficacy of treatment with carboplatin/paclitaxel in experimental lung cancer

Karen T. Liby, Darlene B. Royce, Renee Risingsong, Charlotte R. Williams, Michael B. Sporn
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2523.
https://doi.org/10.1158/1538-7445.AM2011-2523
Published: 15 April 2011
View article titled, Abstract 2523: Synthetic triterpenoids protect against toxicity and enhance the efficacy of treatment with carboplatin/paclitaxel in experimental lung cancer
Journal Articles

Abstract 2509: CDDO-Im induces DNA damage, G2/M arrest and apoptosis in BRCA1-mutated breast cancer cells

Eun-Hee Kim, Michael B. Sporn, Karen T. Liby
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2509.
https://doi.org/10.1158/1538-7445.AM10-2509
Published: 15 April 2010
View article titled, Abstract 2509: CDDO-Im induces DNA damage, G2/M arrest and apoptosis in BRCA1-mutated breast cancer cells
Journal Articles

Abstract 2926: The synthetic triterpenoid CDDO-methyl ester and the rexinoid LG100268 extend survival in the KPC transgenic mouse model of pancreatic cancer

Karen T. Liby, Darlene Royce, Renee Risingsong, Charlotte Williams, Anirban Maitra, Michael B. Sporn
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2926.
https://doi.org/10.1158/1538-7445.AM10-2926
Published: 15 April 2010
View article titled, Abstract 2926: The synthetic triterpenoid CDDO-methyl ester and the rexinoid LG100268 extend survival in the KPC transgenic mouse model of pancreatic cancer
Journal Articles

Glycogen Synthase Kinase 3β Regulates Cell Death Induced by Synthetic Triterpenoids

Roberta Venè, Patrizia Larghero, Giuseppe Arena, Michael B. Sporn, Adriana Albini, Francesca Tosetti
Journal: Cancer Research
Cancer Res (2008) 68 (17): 6987–6996.
https://doi.org/10.1158/0008-5472.CAN-07-6362
Published: 28 August 2008
View article titled, Glycogen Synthase Kinase 3β Regulates Cell Death Induced by Synthetic Triterpenoids
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Includes: Supplementary data
Journal Articles

A Novel Acetylenic Tricyclic bis-(Cyano Enone) Potently Induces Phase 2 Cytoprotective Pathways and Blocks Liver Carcinogenesis Induced by Aflatoxin

Karen Liby, Mark M. Yore, Bill D. Roebuck, Karen J. Baumgartner, Tadashi Honda, Chitra Sundararajan, Hidenori Yoshizawa, Gordon W. Gribble, Charlotte R. Williams, Renee Risingsong, Darlene B. Royce, Albena T. Dinkova-Kostova, Katherine K. Stephenson, Patricia A. Egner, Melinda S. Yates, John D. Groopman, Thomas W. Kensler, Michael B. Sporn
Journal: Cancer Research
Cancer Res (2008) 68 (16): 6727–6733.
https://doi.org/10.1158/0008-5472.CAN-08-1123
Published: 12 August 2008
View article titled, A Novel Acetylenic Tricyclic <em>bis</em>-(Cyano Enone) Potently Induces Phase 2 Cytoprotective Pathways and Blocks Liver Carcinogenesis Induced by Aflatoxin
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Journal Articles

c-Jun N-terminal kinase (JNK)-independent c-FLIP downregulation contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate     (CDDO-Me) in human lung cancer cells.

Wei Zou, Shuzhen Chen, Xiangguo Liu, Ping Yue, Michael B. Sporn, Fadlo R. Khur, Shi-Yong Sun
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 5139.
Published: 01 May 2007
View article titled, c-Jun N-terminal kinase (JNK)-independent c-FLIP downregulation contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate     (CDDO-Me) in human lung cancer cells.
Journal Articles

The Synthetic Triterpenoids CDDO-Methyl Ester and CDDO-Ethyl Amide Prevent Lung Cancer Induced by Vinyl Carbamate in A/J Mice

Karen Liby, Darlene B. Royce, Charlotte R. Williams, Renee Risingsong, Mark M. Yore, Tadashi Honda, Gordon W. Gribble, Ethan Dmitrovsky, Thomas A. Sporn, Michael B. Sporn
Journal: Cancer Research
Cancer Res (2007) 67 (6): 2414–2419.
https://doi.org/10.1158/0008-5472.CAN-06-4534
Published: 15 March 2007
View article titled, The Synthetic Triterpenoids CDDO-Methyl Ester and CDDO-Ethyl Amide Prevent Lung Cancer Induced by Vinyl Carbamate in A/J Mice
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