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Journal Articles

Abstract LB181: First disclosure of XRD-0394, a novel dual ATM/DNA-PK inhibitor, that potently radiosensitizes and potentiates PARP and topoisomerase inhibitors

Tona M. Gilmer, Chun-Hsiang Lai, Kexiao Guo, Katherine Deland, Kathleen A. Ashcraft, Amy E. Stewart, Yaode Wang, Jianmin Fu, Kris C. Wood, Deborah A. Smith, Jonathan T. Yang, Christopher T. Chen, Michael F. Gensheimer, Paul B. Romesser, Steven H. Lin, David G. Kirsch, Michael B. Kastan

Cancer Res (2024) 84 (7_Supplement): LB181.

https://doi.org/10.1158/1538-7445.AM2024-LB181

Published: 05 April 2024

View article titled, Abstract LB181: First disclosure of XRD-0394, a novel dual ATM/DNA-PK inhibitor, that potently radiosensitizes and potentiates PARP and topoisomerase inhibitors

Journal Articles

Commentary on “Participation of p53 Protein in the Cellular Response to DNA Damage”

Michael B. Kastan

Cancer Res (2016) 76 (13): 3663–3665.

https://doi.org/10.1158/0008-5472.CAN-16-1560

Published: 30 June 2016

View article titled, Commentary on “Participation of p53 Protein in the Cellular Response to DNA Damage”

Journal Articles

Repair versus Checkpoint Functions of BRCA1 Are Differentially Regulated by Site of Chromatin Binding

Michael Goldstein, Michael B. Kastan

Cancer Res (2015) 75 (13): 2699–2707.

https://doi.org/10.1158/0008-5472.CAN-15-0400

Published: 30 June 2015

View article titled, Repair versus Checkpoint Functions of BRCA1 Are Differentially Regulated by Site of Chromatin Binding

Includes: Supplementary data

Journal Articles

Abstract IA11: New insights into DNA double-strand break responses

Michael B. Kastan

Cancer Res (2014) 74 (23_Supplement): IA11.

https://doi.org/10.1158/1538-7445.CANSUSC14-IA11

Published: 12 December 2014

View article titled, Abstract IA11: New insights into DNA double-strand break responses

Journal Articles

Abstract IA08: Ataxia-telangiectasia: Broad implications from the study of a rare disease

Michael B. Kastan

Cancer Res (2014) 74 (20_Supplement): IA08.

https://doi.org/10.1158/1538-7445.PEDCAN-IA08

Published: 09 October 2014

View article titled, Abstract IA08: Ataxia-telangiectasia: Broad implications from the study of a rare disease

Journal Articles

Abstract 3086: Interactions of nucleolin and ribosomal protein RPL26 in the translational control of human p53 mRNA

Jing Chen, Kexiao Guo, Michael B. Kastan

Cancer Res (2011) 71 (8_Supplement): 3086.

https://doi.org/10.1158/1538-7445.AM2011-3086

Published: 15 April 2011

View article titled, Abstract 3086: Interactions of nucleolin and ribosomal protein RPL26 in the translational control of human p53 mRNA

Journal Articles

Abstract 4831: ATM signals to TSC2 in the cytoplasm to regulate mTORC1 and autophagy in response to ROS

Angela Alexander, Sheng-Li Cai, Jinhee Kim, Adrian Nanez, Mustafa Sahin, Kristeen H. MacLean, Ken Inoki, Kun-Liang Guan, Jianjun Shen, Maria D. Person, Donna Kusewitt, Gordon B. Mills, Michael B. Kastan, Cheryl L. Walker

Cancer Res (2010) 70 (8_Supplement): 4831.

https://doi.org/10.1158/1538-7445.AM10-4831

Published: 15 April 2010

View article titled, Abstract 4831: ATM signals to TSC2 in the cytoplasm to regulate mTORC1 and autophagy in response to ROS

Journal Articles

Transient Inhibition of ATM Kinase Is Sufficient to Enhance Cellular Sensitivity to Ionizing Radiation

Michael D. Rainey, Maura E. Charlton, Robert V. Stanton, Michael B. Kastan

Cancer Res (2008) 68 (18): 7466–7474.

https://doi.org/10.1158/0008-5472.CAN-08-0763

Published: 14 September 2008

View article titled, Transient Inhibition of ATM Kinase Is Sufficient to Enhance Cellular Sensitivity to Ionizing Radiation

Includes: Supplementary data

Journal Articles

Ataxia Telangiectasia-Mutated and p53 Are Potential Mediators of Chloroquine-Induced Resistance to Mammary Carcinogenesis

Christian R. Loehberg, Tiia Thompson, Michael B. Kastan, Kirsteen H. Maclean, Dean G. Edwards, Frances S. Kittrell, Daniel Medina, Orla M. Conneely, Bert W. O'Malley

Cancer Res (2007) 67 (24): 12026–12033.

https://doi.org/10.1158/0008-5472.CAN-07-3058

Published: 18 December 2007

View article titled, Ataxia Telangiectasia-Mutated and p53 Are Potential Mediators of Chloroquine-Induced Resistance to Mammary Carcinogenesis

Journal Articles

Disappearance of the Telomere Dysfunction-Induced Stress Response in Fully Senescent Cells

Christopher J. Bakkenist, Rachid Drissi, Jing Wu, Michael B. Kastan, Jeffrey S. Dome

Cancer Res (2004) 64 (11): 3748–3752.

https://doi.org/10.1158/0008-5472.CAN-04-0453

Published: 01 June 2004

View article titled, Disappearance of the Telomere Dysfunction-Induced Stress Response in Fully Senescent Cells

Journal Articles

Signaling to and from ATM after DNA damage.

Michael B. Kastan, Risa Kitagawa, Christopher J. Bakkenist

Cancer Res (2004) 64 (7_Supplement): 1318.

Published: 01 April 2004

View article titled, Signaling to and from ATM after DNA damage.

Journal Articles

ATM activation is a marker of cellular aging and a precursor to replicative senescence.

Christopher J. Bakkenist, Rachid Drissi, Jing Wu, Michael B. Kastan, Jeffrey S. Dome

Cancer Res (2004) 64 (7_Supplement): 556–557.

Published: 01 April 2004

View article titled, ATM activation is a marker of cellular aging and a precursor to replicative senescence.

Journal Articles

Nicotinamide adenine dinucleotide modulates p53 DNA binding specificity and function

Kevin G. McLure, Masatoshi Takagi, Michael B. Kastan

Cancer Res (2004) 64 (7_Supplement): 1280.

Published: 01 April 2004

View article titled, Nicotinamide adenine dinucleotide modulates p53 DNA binding specificity and function

Journal Articles

The role of SMC1 in DNA damage induced signaling pathways

Risa Kitagawa, Christopher Bakkenist, Michael Absalon, Michael B. Kastan

Cancer Res (2004) 64 (7_Supplement): 1279.

Published: 01 April 2004

View article titled, The role of SMC1 in DNA damage induced signaling pathways

Journal Articles

Phosphorylation of Serine 1387 in Brca1 Is Specifically Required for the Atm-mediated S-Phase Checkpoint after Ionizing Irradiation

Bo Xu, Anne H. O’Donnell, Seong-Tae Kim, Michael B. Kastan

Cancer Res (2002) 62 (16): 4588–4591.

Published: 15 August 2002

View article titled, Phosphorylation of Serine 1387 in Brca1 Is Specifically Required for the Atm-mediated S-Phase Checkpoint after Ionizing Irradiation

Journal Articles

Loss of atm Radiosensitizes Multiple p53 Null Tissues

Christoph H. Westphal, Kathryn P. Hoyes, Christine E. Canman, Xin Huang, Michael B. Kastan, Jolyon H. Hendry, Philip Leder

Cancer Res (1998) 58 (24): 5637–5639.

Published: 01 December 1998

View article titled, Loss of atm Radiosensitizes Multiple p53 Null Tissues

Journal Articles

p53 Does Not Repress Hypoxia-induced Transcription of the Vascular Endothelial Growth Factor Gene

Faton Agani, David G. Kirsch, Scott L. Friedman, Michael B. Kastan, Gregg L. Semenza

Cancer Res (1997) 57 (20): 4474–4477.

Published: 01 October 1997

View article titled, p53 Does Not Repress Hypoxia-induced Transcription of the Vascular Endothelial Growth Factor Gene

Journal Articles

Dissociation of Radiation-induced Phosphorylation of Replication Protein A from the S-Phase Checkpoint

Susan E. Morgan, Michael B. Kastan

Cancer Res (1997) 57 (16): 3386–3389.

Published: 01 August 1997

View article titled, Dissociation of Radiation-induced Phosphorylation of Replication Protein A from the S-Phase Checkpoint

Journal Articles

Separate Pathways for p53 Induction by Ionizing Radiation and N-(Phosphonoacetyl)-l-aspartate¹

Chaw-Yuan M. Chen, Ingrid Hall, Timothy J. Lansing, Tona M. Gilmer, Thea D. Tlsty, Michael B. Kastan

Cancer Res (1996) 56 (16): 3659–3662.

Published: 01 August 1996

View article titled, Separate Pathways for p53 Induction by Ionizing Radiation and N-(Phosphonoacetyl)-<sc>l</sc>-aspartate1

Journal Articles

The p53-dependent G₁ Cell Cycle Checkpoint Pathway and Ataxia-Telangiectasia

Christine E. Canman, Antonio C. Wolff, Chaw-Yuan Chen, Albert J. Fornace, Jr, Michael B. Kastan

Cancer Res (1994) 54 (19): 5054–5058.

Published: 01 October 1994

View article titled, The p53-dependent G1 Cell Cycle Checkpoint Pathway and Ataxia-Telangiectasia

NARROW

Abstract LB181: First disclosure of XRD-0394, a novel dual ATM/DNA-PK inhibitor, that potently radiosensitizes and potentiates PARP and topoisomerase inhibitors

Commentary on “Participation of p53 Protein in the Cellular Response to DNA Damage”

Repair versus Checkpoint Functions of BRCA1 Are Differentially Regulated by Site of Chromatin Binding

Abstract IA11: New insights into DNA double-strand break responses

Abstract IA08: Ataxia-telangiectasia: Broad implications from the study of a rare disease

Abstract 3086: Interactions of nucleolin and ribosomal protein RPL26 in the translational control of human p53 mRNA

Abstract 4831: ATM signals to TSC2 in the cytoplasm to regulate mTORC1 and autophagy in response to ROS

Transient Inhibition of ATM Kinase Is Sufficient to Enhance Cellular Sensitivity to Ionizing Radiation

Ataxia Telangiectasia-Mutated and p53 Are Potential Mediators of Chloroquine-Induced Resistance to Mammary Carcinogenesis

Disappearance of the Telomere Dysfunction-Induced Stress Response in Fully Senescent Cells

Signaling to and from ATM after DNA damage.

ATM activation is a marker of cellular aging and a precursor to replicative senescence.

Nicotinamide adenine dinucleotide modulates p53 DNA binding specificity and function

The role of SMC1 in DNA damage induced signaling pathways

Phosphorylation of Serine 1387 in Brca1 Is Specifically Required for the Atm-mediated S-Phase Checkpoint after Ionizing Irradiation

Loss of atm Radiosensitizes Multiple p53 Null Tissues

p53 Does Not Repress Hypoxia-induced Transcription of the Vascular Endothelial Growth Factor Gene

Dissociation of Radiation-induced Phosphorylation of Replication Protein A from the S-Phase Checkpoint

Separate Pathways for p53 Induction by Ionizing Radiation and N-(Phosphonoacetyl)-l-aspartate¹

The p53-dependent G₁ Cell Cycle Checkpoint Pathway and Ataxia-Telangiectasia

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