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Michael Andreeff
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Journal Articles

Abstract PO2-24-08: GD3 Synthase is a Master Regulator of Wild-Type p53–Mediated Apoptosis and Mutant p53–Mediated Tumorigenesis

Vivek Anand, FOUAD EL-DANA, JENNY BORGMAN, MICHAEL ANDREEFF, Venkata Lokesh Battula
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO2-24-08.
https://doi.org/10.1158/1538-7445.SABCS23-PO2-24-08
Published: 02 May 2024
View article titled, Abstract PO2-24-08: GD3 Synthase is a Master Regulator of Wild-Type p53–Mediated Apoptosis and Mutant p53–Mediated Tumorigenesis
Journal Articles

Abstract 3860: ERK1/2 inhibition overcomes resistance to venetoclax in AML by altering mitochondrial metabolism

Priyanka Sharma, Lauren Ostermann, Sujan Piya, Natalia Baran, Anudishi Tyagi, Christopher Hindley, Kim-Hien Dao, Martin Sims, V. Lokesh Battula, Michael Andreeff, Gautam Borthakur
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3860.
https://doi.org/10.1158/1538-7445.AM2023-3860
Published: 04 April 2023
View article titled, Abstract 3860: ERK1/2 inhibition overcomes resistance to venetoclax in AML by altering mitochondrial metabolism
Journal Articles

Abstract 5479: Discovery and evaluation of GT19630, a c-Myc/GSPT1 cereblon E3 ligase modulator (CELMoD), for targeting Myc-driven blood cancers and small cell lung cancers (SCLC)

Liandong Ma, Youzhi Tong, Zhaohui Yang, Qianxiang Zhou, Hongha Yan, Ru Xu, Jie Chen, Jie Pan, Huiyuan Wang, Jiangwei Li, Dong Chen, Xiang Cai, Jie Qu, Yini Wang, Jun Qin, Yuki Nishida, Michael Andreeff, Qilnli Guo, Yuki Nishida, Michael Andreeff
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5479.
https://doi.org/10.1158/1538-7445.AM2022-5479
Published: 15 June 2022
View article titled, Abstract 5479: Discovery and evaluation of GT19630, a c-Myc/GSPT1 cereblon E3 ligase modulator (CELMoD), for targeting Myc-driven blood cancers and small cell lung cancers (SCLC)
Journal Articles

Abstract 5337: Tolinapant (ASTX660) enhances the anti-leukemic activity of Venetoclax and Dexamethasone in T cell acute lymphoblastic leukemia (T-ALL)

Priyanka Sharma, Sujan Piya, Huaxian Ma, Natalia Baran, Muharrem Muftuoglu, Mahesh Basyal, Vivian Ruvolo, George Ward, Tomoko Smyth, Martin J. Sims, Michael Andreeff, Gautam Borthakur
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5337.
https://doi.org/10.1158/1538-7445.AM2022-5337
Published: 15 June 2022
View article titled, Abstract 5337: Tolinapant (ASTX660) enhances the anti-leukemic activity of Venetoclax and Dexamethasone in T cell acute lymphoblastic leukemia (T-ALL)
Journal Articles

Abstract P5-06-10: Tumor microenvironment modulates ganglioside expression leading to immunosuppression in triple negative breast cancer

Vivek Anand, Fouad El-Dana, Stanley Ly, Michael Andreeff, Venkata Lokesh Battula
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P5-06-10.
https://doi.org/10.1158/1538-7445.SABCS21-P5-06-10
Published: 15 February 2022
View article titled, Abstract P5-06-10: Tumor microenvironment modulates ganglioside expression leading to immunosuppression in triple negative breast cancer
Journal Articles

Abstract 2017: Dual targeting of glutathione-GPX4 nexus and mitochondrial protease CLPP causes synergistic anti-leukemia effects in acute myeloid leukemia (AML)

Hiroki Akiyama, Ran Zhao, Lauren B. Ostermann, Jo Ishizawa, Michael Andreeff
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2017.
https://doi.org/10.1158/1538-7445.AM2021-2017
Published: 01 July 2021
View article titled, Abstract 2017: Dual targeting of glutathione-GPX4 nexus and mitochondrial protease CLPP causes synergistic anti-leukemia effects in acute myeloid leukemia (AML)
Journal Articles

Abstract 2322: Targeting glutamine transporter (ASCT2) inhibits metabolic stress-induced GD2+ cancer stem cell-like phenotype in triple-negative breast cancer

Appalaraju Jaggupilli, Stanley Ly, Khoa Nguyen, Roshan Borkar, Bin Yuan, Danthasinghe Waduge Piyarathna, Yuanqing Yan, Helen Piwnica-Worms, Henry Charles Manning, Michael Andreeff, Nagireddy Putluri, Lokesh Battula
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2322.
https://doi.org/10.1158/1538-7445.AM2021-2322
Published: 01 July 2021
View article titled, Abstract 2322: Targeting glutamine transporter (ASCT2) inhibits metabolic stress-induced GD2+ cancer stem cell-like phenotype in triple-negative breast cancer
Journal Articles

Abstract 3801: Oxidative stress induces glutamine-dependent GD2+ triple negative breast cancer stem cells

Appalaraju Jaggupilli, Stanely J. Ly, Roshan Borkar, Khoa Nguyen, Bin Yuan, Nagireddy Putluri, Michael Andreeff, V. Lokesh Battula
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3801.
https://doi.org/10.1158/1538-7445.AM2020-3801
Published: 15 August 2020
View article titled, Abstract 3801: Oxidative stress induces glutamine-dependent GD2<sup>+</sup> triple negative breast cancer stem cells
Journal Articles

Abstract 6038: Combined targeting of E-selectin/CXCR4 and FLT3 by GMI-1359 and sorafenib effectively reduces leukemia cell burden and protects normal hematopoiesis in a patient-derived AML xenograft model

Weiguo Zhang, Kyung Hee Chang, Mahesh Basyal, Yannan Jia, Lauren Ostermann, William E. Fogler, John L. Magnani, Michael Andreeff
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6038.
https://doi.org/10.1158/1538-7445.AM2020-6038
Published: 15 August 2020
View article titled, Abstract 6038: Combined targeting of E-selectin/CXCR4 and FLT3 by GMI-1359 and sorafenib effectively reduces leukemia cell burden and protects normal hematopoiesis in a patient-derived AML xenograft model
Journal Articles

Abstract P3-02-05: Targeting glutamine metabolism inhibits GD2+ breast cancer stem cell function in triple negative breast cancer

Stanley Ly, Khoa Nguyen, Michael Andreeff, Venkata Lokesh Battula
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P3-02-05.
https://doi.org/10.1158/1538-7445.SABCS19-P3-02-05
Published: 15 February 2020
View article titled, Abstract P3-02-05: Targeting glutamine metabolism inhibits GD2<sup>+</sup> breast cancer stem cell function in triple negative breast cancer
Journal Articles

Abstract 1169: Characterization of a small molecule inhibitor for GD3 synthase (ST8SIA1), a novel target in breast cancer stem-like cells

Appalaraju Jappupilli, Khoa Nguyen, Stanley Ly, Michael Andreeff, Prashen Chelikani, Venkata Lokesh Battula
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1169.
https://doi.org/10.1158/1538-7445.AM2019-1169
Published: 01 July 2019
View article titled, Abstract 1169: Characterization of a small molecule inhibitor for GD3 synthase (ST8SIA1), a novel target in breast cancer stem-like cells
Journal Articles

Abstract LB-222: Polyfunctionality determined by single-cell proteomics of bone marrow-derived CD4 T cells from patients with acute myeloid leukemia identifies patients responding to anti-PD-1-based therapy and discovers profound T cell defect in mutant TP53 disease

Naval Daver, Hagop Kantarjian, Sean Mackay, Brianna Flynn, Sreyashi Basu, Guillermo Garcia-Manero, Mansour Alfayez, Marina Konopleva, Jairo Matthews, Steven Kornblau, Ellias Jabbour, Jing Zhou, Michael Andreeff
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-222.
https://doi.org/10.1158/1538-7445.AM2019-LB-222
Published: 01 July 2019
View article titled, Abstract LB-222: Polyfunctionality determined by single-cell proteomics of bone marrow-derived CD4 T cells from patients with acute myeloid leukemia identifies patients responding to anti-PD-1-based therapy and discovers profound T cell defect in mutant TP53 disease
Journal Articles

Abstract 3248: B7-H3, an immune checkpoint protein is overexpressed in AML and the blocking monoclonal antibodies enhance NK cell-mediated apoptosis in AML cells

Stanley Ly, Bin Yuan, Sabrina Grimm, Michael Andreeff, Hans-Jörg Bühring, Venkata Lokesh Battula
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3248.
https://doi.org/10.1158/1538-7445.AM2019-3248
Published: 01 July 2019
View article titled, Abstract 3248: B7-H3, an immune checkpoint protein is overexpressed in AML and the blocking monoclonal antibodies enhance NK cell-mediated apoptosis in AML cells
Journal Articles

Abstract 2720: Mitochondrial ClpP-mediated proteolysis induces selective cancer cell lethality

Jo Ishizawa, Sarah F. Zarabi, R Eric Davis, Ondrej Halgas, Takenobu Nii, Yulia Jitkova, Ran Zhao, Jonathan St-Germain, Lauren E. Heese, Grace Egan, Vivian R. Ruvolo, Samir H. Barghout, Yuki Nishida, Rose Hurren, Wencai Ma, Marcela Gronda, Todd Link, Keith Wong, Mark Mabanglo, Kensuke Kojima, Gautam Borthakur, Neil MacLean, John Man Chun Ma, Andrew B. Leber, Mark D. Minden, Walid Houry, Hagop Kantarjian, Martin Stogniew, Brian Raught, Emil F. Pai, Aaron D. Schimmer, Michael Andreeff
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2720.
https://doi.org/10.1158/1538-7445.AM2019-2720
Published: 01 July 2019
View article titled, Abstract 2720: Mitochondrial ClpP-mediated proteolysis induces selective cancer cell lethality
Journal Articles

Abstract 2040: Acute myeloid leukemia cells induce new bone formation by expanding osteoprogenitor niche in the bone marrow

Bin Yuan, Stanley Ly, Ivo Veletic, Kiersten Maldonado, Xin Zhou, Benoit deCrombrugghe, Michael Andreeff, Venkata Lokesh Battula
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2040.
https://doi.org/10.1158/1538-7445.AM2019-2040
Published: 01 July 2019
View article titled, Abstract 2040: Acute myeloid leukemia cells induce new bone formation by expanding osteoprogenitor niche in the bone marrow
Journal Articles

Abstract 2725: The single-cell atlas of driver mutations in acute myeloid leukemia

Kiyomi Morita, Feng Wang, Katharina Jahn, Yuanqing Yan, Robert Durruthy-Durruthy, Anup Parikh, Jairo Matthews, Latasha Little, Curtis Gumbs, Jianhua Zhang, Xingzhi Song, Erika Thompson, Keyur Patel, Carlos Bueso-Ramos, Courtney DiNardo, Farhad Ravandi, Elias Jabbour, Michael Andreeff, Jorge Cortes, Marina Konopleva, Guillermo Garcia-Manero, Hagop Kantarjian, Dennis J. Eastburn, P Andrew Futreal, Niko Beerenwinkel, Koichi Takahashi
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2725.
https://doi.org/10.1158/1538-7445.AM2019-2725
Published: 01 July 2019
View article titled, Abstract 2725: The single-cell atlas of driver mutations in acute myeloid leukemia
Journal Articles

An ARC-Regulated IL1β/Cox-2/PGE2/β-Catenin/ARC Circuit Controls Leukemia–Microenvironment Interactions and Confers Drug Resistance in AML

Bing Z. Carter, Po Yee Mak, Xiangmeng Wang, Wenjing Tao, Vivian Ruvolo, Duncan Mak, Hong Mu, Jared K. Burks, Michael Andreeff
Journal: Cancer Research
Cancer Res (2019) 79 (6): 1165–1177.
https://doi.org/10.1158/0008-5472.CAN-18-0921
Published: 15 March 2019
View article titled, An ARC-Regulated IL1β/Cox-2/PGE2/β-Catenin/ARC Circuit Controls Leukemia–Microenvironment Interactions and Confers Drug Resistance in AML
Open the PDF for An ARC-Regulated IL1β/Cox-2/PGE2/β-Catenin/ARC Circuit Controls Leukemia–Microenvironment Interactions and Confers Drug Resistance in AML in another window
Includes: Supplementary data
Journal Articles

Abstract 1766: Dinutuximab targets GD2+ breast cancer stem cells and inhibits TNBC tumor growth

Venkata Lokesh Battula, Khoa Nguyen, Anitha Somanchi, Hong Mu, Naoto T. Ueno, Dean Lee, Michael Andreeff
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1766.
https://doi.org/10.1158/1538-7445.AM2018-1766
Published: 01 July 2018
View article titled, Abstract 1766: Dinutuximab targets GD2<sup>+</sup> breast cancer stem cells and inhibits TNBC tumor growth
Journal Articles

Abstract 1929: ST8SIA1 is a novel therapeutic target in TNBC: Regulates FAK-PI3K-AKT-mTOR signaling to promote tumor growth and metastasis

Khoa Nguyen, Bin Yuan, Yuanqing Yan, Kim-Anh Do, Naoto T. Ueno, Michael Andreeff, Venkata Lokesh Battula
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1929.
https://doi.org/10.1158/1538-7445.AM2018-1929
Published: 01 July 2018
View article titled, Abstract 1929: ST8SIA1 is a novel therapeutic target in TNBC: Regulates FAK-PI3K-AKT-mTOR signaling to promote tumor growth and metastasis
Journal Articles

Abstract 75: A phase I trial of mesenchymal stem cells transfected with a plasmid secreting interferon beta in advanced ovarian cancer

Michael Andreeff, Frank C. Marini, Shannon N. Westin, Robert L. Coleman, Peter F. Thall, Vivian Aljahdami, Muzaffar H. Qazilbash, Katy Rezvani, Melissa Timmons, Lauren Heese, Rui-Yu Wang, Richard E. Champlin, Elizabeth J. Shpall, Amanda Olson
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 75.
https://doi.org/10.1158/1538-7445.AM2018-75
Published: 01 July 2018
View article titled, Abstract 75: A phase I trial of mesenchymal stem cells transfected with a plasmid secreting interferon beta in advanced ovarian cancer