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Michael A. Morse
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Journal Articles

Abstract 3531: Sensitizing immune unresponsive colorectal cancers to immune checkpoint inhibitors through MAVS overexpression

Bin-Jin Hwang, Li-Chung Tsao, Chaitanya Acharya, Timothy Trotter, Pankaj Agarwal, Tao Wang, Junping Wei, Xiao-Yi Yang, Gang-jun Lei, Takuya Osada, Herbert Kim Lyerly, Michael A. Morse, Zachary Hartman
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3531.
https://doi.org/10.1158/1538-7445.AM2022-3531
Published: 15 June 2022
View article titled, Abstract 3531: Sensitizing immune unresponsive colorectal cancers to immune checkpoint inhibitors through MAVS overexpression
Journal Articles

Abstract 904: Stimulation and expansion of oncogene-reactive tumor infiltrating T cells through combined Ad-HER2Δ16 vaccination and anti-PD1 enable anti-tumor responses against established HER2 BC

Erika J. Crosby, Chaitanya Acharya, Christopher Rabiola, William J. Muller, Lewis A. Chodosh, Gloria Broadwater, Jonathan Shepherd, Daniel Hollern, Xiaping He, Charles M. Perou, Benjamin K. Ashby, Benjamin G. Vincent, Michael A. Morse, Herbert K. Lyerly, Zachary C. Hartman
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 904.
https://doi.org/10.1158/1538-7445.AM2020-904
Published: 15 August 2020
View article titled, Abstract 904: Stimulation and expansion of oncogene-reactive tumor infiltrating T cells through combined Ad-HER2Δ16 vaccination and anti-PD1 enable anti-tumor responses against established HER2 BC
Journal Articles

Abstract 3731: A novel heat shock protein 90-targeted photosensitizer (HS-201) enables enhanced tumor-specific photodynamic therapy of inflammatory breast cancers

Kensuke Kaneko, Takuya Osada, Philip F. Hughes, Timothy A. Haystead, Michael A. Morse, Herbert K. Lyerly
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3731.
https://doi.org/10.1158/1538-7445.AM2019-3731
Published: 01 July 2019
View article titled, Abstract 3731: A novel heat shock protein 90-targeted photosensitizer (HS-201) enables enhanced tumor-specific photodynamic therapy of inflammatory breast cancers
Journal Articles

XIAP Regulation by MNK Links MAPK and NFκB Signaling to Determine an Aggressive Breast Cancer Phenotype

Myron K. Evans, Michael C. Brown, Joseph Geradts, Xuhui Bao, Timothy J. Robinson, Mohit Kumar Jolly, Peter B. Vermeulen, Gregory M. Palmer, Matthias Gromeier, Herbert Levine, Michael A. Morse, Steven J. Van Laere, Gayathri R. Devi
Journal: Cancer Research
Cancer Res (2018) 78 (7): 1726–1738.
https://doi.org/10.1158/0008-5472.CAN-17-1667
Published: 01 April 2018
View article titled, XIAP Regulation by MNK Links MAPK and NFκB Signaling to Determine an Aggressive Breast Cancer Phenotype
Open the PDF for XIAP Regulation by MNK Links MAPK and NFκB Signaling to Determine an Aggressive Breast Cancer Phenotype in another window
Includes: Supplementary data
Journal Articles

Abstract 4709: Induction of enhanced tumor-specific immunity by Hsp90 targeted photodynamic therapy (Hsp90-PDT) combined with immune checkpoint inhibition

Kensuke Kaneko, Takuya Osada, Timothy A. Haystead, Michael A. Morse, Herbert K. Lyerly
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4709.
https://doi.org/10.1158/1538-7445.AM2017-4709
Published: 01 July 2017
View article titled, Abstract 4709: Induction of enhanced tumor-specific immunity by Hsp90 targeted photodynamic therapy (Hsp90-PDT) combined with immune checkpoint inhibition
Journal Articles

Abstract A29: An Ad5 [E1-, E2b-] platform carrying the TAA CEA(6D) induces CEA directed CMI responses in patients with advanced CEA-expressing colorectal cancer in a phase I/II clinical trial..

Michael A. Morse, Elizabeth S. Gabitzsch, Younong Xu, Dua Rajesh, Susan Nguyen, Stephanie Balcaitis, Joseph P. Balint, Jr., Frank Jones
Journal: Cancer Research
Cancer Res (2013) 73 (1_Supplement): A29.
https://doi.org/10.1158/1538-7445.TUMIMM2012-A29
Published: 02 April 2014
View article titled, Abstract A29: An Ad5 [E1-, E2b-] platform carrying the TAA CEA(6D) induces CEA directed CMI responses in patients with advanced CEA-expressing colorectal cancer in a phase I/II clinical trial..
Journal Articles

Abstract LB-164: Treatment of advanced stage colorectal cancer with ETBX-011 immunotherapeutic.

Elizabeth S. Gabitzsch, Michael A. Morse, H. Kim Lyerly, Frank Jones
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): LB-164.
https://doi.org/10.1158/1538-7445.AM2013-LB-164
Published: 15 April 2013
View article titled, Abstract LB-164: Treatment of advanced stage colorectal cancer with ETBX-011 immunotherapeutic.
Journal Articles

Abstract LB-161: A phase I safety study of NPC-1C, a novel, therapeutic antibody to treat pancreas and colorectal cancers.

Sandip P. Patel, Michael A. Morse, Luiz A. Diaz, Nilofer S. Azad, Sherri Haley, Phil M. Arlen
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): LB-161.
https://doi.org/10.1158/1538-7445.AM2013-LB-161
Published: 15 April 2013
View article titled, Abstract LB-161: A phase I safety study of NPC-1C, a novel, therapeutic antibody to treat pancreas and colorectal cancers.
Journal Articles

Abstract 3548: Loss of the type III TGF-β receptor during cancer progression generates an immunotolerant tumor microenvironment: Translational implications for TGF-β inhibition and immunotherapy biomarker development

Brent A. Hanks, Alisha Holtzhausen, Petra Gimpel, Olivia Campbell, Rebekah Jamieson, Leona E. Ling, Michael A. Morse, H. K. Lyerly, Gerard Blobe
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3548.
https://doi.org/10.1158/1538-7445.AM2012-3548
Published: 15 April 2012
View article titled, Abstract 3548: Loss of the type III TGF-β receptor during cancer progression generates an immunotolerant tumor microenvironment: Translational implications for TGF-β inhibition and immunotherapy biomarker development
Journal Articles

HER2 Overexpression Elicits a Proinflammatory IL-6 Autocrine Signaling Loop That Is Critical for Tumorigenesis

Zachary C. Hartman, Xiao-Yi Yang, Oliver Glass, Gangjun Lei, Takuya Osada, Sandeep S. Dave, Michael A. Morse, Timothy M. Clay, Herbert K. Lyerly
Journal: Cancer Research
Cancer Res (2011) 71 (13): 4380–4391.
https://doi.org/10.1158/0008-5472.CAN-11-0308
Published: 30 June 2011
View article titled, HER2 Overexpression Elicits a Proinflammatory IL-6 Autocrine Signaling Loop That Is Critical for Tumorigenesis
Open the PDF for HER2 Overexpression Elicits a Proinflammatory IL-6 Autocrine Signaling Loop That Is Critical for Tumorigenesis in another window
Includes: Supplementary data
Journal Articles

Antihelminth Compound Niclosamide Downregulates Wnt Signaling and Elicits Antitumor Responses in Tumors with Activating APC Mutations

Takuya Osada, Minyong Chen, Xiao Yi Yang, Ivan Spasojevic, Jeffrey B. Vandeusen, David Hsu, Bryan M. Clary, Timothy M. Clay, Wei Chen, Michael A. Morse, H. Kim Lyerly
Journal: Cancer Research
Cancer Res (2011) 71 (12): 4172–4182.
https://doi.org/10.1158/0008-5472.CAN-10-3978
Published: 14 June 2011
View article titled, Antihelminth Compound Niclosamide Downregulates Wnt Signaling and Elicits Antitumor Responses in Tumors with Activating APC Mutations
Open the PDF for Antihelminth Compound Niclosamide Downregulates Wnt Signaling and Elicits Antitumor Responses in Tumors with Activating APC Mutations in another window
Includes: Supplementary data
Journal Articles

Abstract 5338: Metastatic colorectal cancer cells from patients previously treated with chemotherapy are sensitive to T cell killing mediated by CEA/CD3-bispecific T cell-engaging BiTE antibody

Takuya Osada, David Hsu, Scott Hammond, Amy Hobeika, Gayathri Devi, Timothy M. Clay, H. Kim Lyerly, Michael A. Morse
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5338.
https://doi.org/10.1158/1538-7445.AM10-5338
Published: 15 April 2010
View article titled, Abstract 5338: Metastatic colorectal cancer cells from patients previously treated with chemotherapy are sensitive to T cell killing mediated by CEA/CD3-bispecific T cell-engaging BiTE antibody
Journal Articles

Induction of Wilms’ tumor protein (WT1)-specific immunity using a WT1-expressing adenovirus vaccine

Christopher Y. Woo, Takuya Osada, Xiao Yi Yang, Gangjun Lei, Matthew McKinney, Heather Labreche, Zachary C. Hartman, Andrea Amalfitano, Michael A. Morse, H. Kim Lyerly, Timothy M. Clay
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 332.
Published: 15 April 2006
View article titled, Induction of Wilms’ tumor protein (WT1)-specific immunity using a WT1-expressing adenovirus vaccine
Journal Articles

Replication-competent packaging-deficient [E1+,100k-] adenoviral vector-transduced dendritic cells can efficiently induce antigen-specific immune responses

Takuya Osada, Heather Labreche, Zachery C. Hartman, Delila Serra, Michael A. Morse, H Kim Lyerly, Andrea Amalfitano, Timothy M. Clay
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 706.
Published: 15 April 2006
View article titled, Replication-competent packaging-deficient [E1+,100k-] adenoviral vector-transduced dendritic cells can efficiently induce antigen-specific immune responses
Journal Articles

Does adenoviral vector replicative capacity influence the efficiency of antigen-specific immune response induction by Ad-transduced dendritic cells?

Takuya Osada, Xiao Yi Yang, Christina Bourgeois Venturi, Zachery Hartman, Delila Serra, Donna Niedzwiecki, Michael A. Morse, H. Kim Lyerly, Andrea Amalfitano, Timothy M. Clay
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1217.
Published: 01 May 2005
View article titled, Does adenoviral vector replicative capacity influence the efficiency of antigen-specific immune response induction by Ad-transduced dendritic cells?
Journal Articles

Correlation of relative FoxP3 mRNA levels in human CD4+CD25+ subsets to cell surface markers and suppressive activity

Matthew S. McKinney, Amy C. Hobeika, Michael A. Morse, H. Kim Lyerly, Timothy M. Clay
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 568.
Published: 01 May 2005
View article titled, Correlation of relative <em>FoxP3</em> mRNA levels in human CD4+CD25+ subsets to cell surface markers and suppressive activity
Journal Articles

Depletion of human tregs enhances antigen specific CTL expansion

Amy C. Hobeika, Teresa Doldo, Timothy M. Clay, H. Kim Lyerly, Michael A. Morse
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 568.
Published: 01 May 2005
View article titled, Depletion of human tregs enhances antigen specific CTL expansion
Journal Articles

Development of HER2 expressing adenoviral vectors for cancer immunotherapy

Gabriel T. Chong, Xiao Y. Yang, Takuya Osada, Matthew McKinney, Zachary Hartman, Delila Serra, H. Kim Lyerly, Michael A. Morse, Andrea Amalfitano, Timothy M. Clay
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1420.
Published: 01 May 2005
View article titled, Development of HER2 expressing adenoviral vectors for cancer immunotherapy
Journal Articles

A novel non-replicating adenoviral vector expressing carcinoembryonic antigen (CEA) breaks tolerance to CEA in CEA-transgenic mice

Takuya Osada, Xiao Yi Yang, Christina Bourgeois Venturi, Zachary Hartman, Delila Serra, Donna Niedzwiecki, Michael A. Morse, H. Kim Lyerly, Andrea Amalfitano, Timothy M. Clay
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1266.
Published: 01 April 2004
View article titled, A novel non-replicating adenoviral vector expressing carcinoembryonic antigen (CEA) breaks tolerance to CEA in CEA-transgenic mice
Journal Articles

Regulatory and effector T cell subsets in colon cancer

Amy C. Hobeika, Teresa Doldo, Tim M. Clay, H. K. Lyerly, Michael A. Morse
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1090.
Published: 01 April 2004
View article titled, Regulatory and effector T cell subsets in colon cancer