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Merrill J. Egorin
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Journal Articles

Abstract 5499: Temozolomide (TMZ) cytotoxicity in human melanoma cell lines is enhanced by concomitant treatment with the histone deacetylase (HDAC) inhibitor vorinostat (SAHA) and PARP inhibitor MK-4827

Hussein Tawbi, John M. Kirkwood, Ying-Chih Lin, Shama C. Buch, Yan Lin, Lyubov Kublo, Jan H. Beumer, Merrill J. Egorin, Edward Chu, Pamela Hershberger
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5499.
https://doi.org/10.1158/1538-7445.AM2011-5499
Published: 15 April 2011
View articletitled, Abstract 5499: Temozolomide (TMZ) cytotoxicity in human melanoma cell lines is enhanced by concomitant treatment with the histone deacetylase (HDAC) inhibitor vorinostat (SAHA) and PARP inhibitor MK-4827
Journal Articles

Abstract 3524: Plasma pharmacokinetics and metabolism of benzaldehyde dimethane sulfonate (NSC281612, DMS612, BEN) in mice

Robert A. Parise, Julie L. Eiseman, Merrill J. Egorin, Dana M. Clausen, Joseph M. Covey, Jan H. Beumer
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3524.
https://doi.org/10.1158/1538-7445.AM10-3524
Published: 15 April 2010
View articletitled, Abstract 3524: Plasma pharmacokinetics and metabolism of benzaldehyde dimethane sulfonate (NSC281612, DMS612, BEN) in mice
Journal Articles

Abstract 2540: Cytotoxicity, pharmacokinetics and metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc

Dana Clausen, Jianxia Guo, Jan H. Beumer, Robert A. Parise, Lihua Bai, Merrill J. Egorin, John S. Lazo, Edward V. Prochownik, Julie L. Eiseman
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2540.
https://doi.org/10.1158/1538-7445.AM10-2540
Published: 15 April 2010
View articletitled, Abstract 2540: Cytotoxicity, pharmacokinetics and metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc
Journal Articles

Abstract 4549: Plasma pharmacokinetics and oral bioavailability of the 3,4,5,6-tetrahydrouridine (THU) prodrug, triacetyl-THU (taTHU), in mice

Jan H. Beumer, Julie L. Eiseman, Judith A. Gilbert, Julianne L. Holleran, Archibong E. Yellow-Duke, Dana M. Clausen, David Z. D'Argenio, Matthew M. Ames, Pamela A. Hershberger, Robert A. Parise, Lihua Bai, Joseph M. Covey, Merrill J. Egorin
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4549.
https://doi.org/10.1158/1538-7445.AM10-4549
Published: 15 April 2010
View articletitled, Abstract 4549: Plasma pharmacokinetics and oral bioavailability of the 3,4,5,6-tetrahydrouridine (THU) prodrug, triacetyl-THU (taTHU), in mice
Journal Articles

Abstract 5450: Enhanced cytotoxicity of carboplatin and paclitaxel (CP) by vorinostat (SAHA), a histone deacetylase (HDAC) inhibitor, in melanoma cell lines

Hussein Tawbi, Ying-Chih Lin, Liza Villaruz, Merrill J. Egorin, Jan H. Beumer, John M. Kirkwood, Robert W. Sobol
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5450.
https://doi.org/10.1158/1538-7445.AM10-5450
Published: 15 April 2010
View articletitled, Abstract 5450: Enhanced cytotoxicity of carboplatin and paclitaxel (CP) by vorinostat (SAHA), a histone deacetylase (HDAC) inhibitor, in melanoma cell lines
Journal Articles

Abstract 2532: In vitro cytotoxicity, and pharmacokinetics, tissue distribution, and metabolism of the protein kinase D inhibitors, kb-NB142-70 and kb-NB184-43, in mice bearing human cancer xenografts

Guo Jianxia, Robert A. Parise, Jan H. Beumer, Dana M. Clausen, Merrill J. Egorin, John S. Lazo, Peter Wipf, Q. Jane Wang, Julie L. Eiseman
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2532.
https://doi.org/10.1158/1538-7445.AM10-2532
Published: 15 April 2010
View articletitled, Abstract 2532: In vitro cytotoxicity, and pharmacokinetics, tissue distribution, and metabolism of the protein kinase D inhibitors, kb-NB142-70 and kb-NB184-43, in mice bearing human cancer xenografts
Journal Articles

Dominant-Negative Histone H3 Lysine 27 Mutant Derepresses Silenced Tumor Suppressor Genes and Reverses the Drug-Resistant Phenotype in Cancer Cells

Phillip H. Abbosh, John S. Montgomery, Jason A. Starkey, Milos Novotny, Eleanor G. Zuhowski, Merrill J. Egorin, Annie P. Moseman, Adam Golas, Kate M. Brannon, Curtis Balch, Tim H.M. Huang, Kenneth P. Nephew
Journal: Cancer Research
Cancer Res (2006) 66 (11): 5582–5591.
https://doi.org/10.1158/0008-5472.CAN-05-3575
Published: 01 June 2006
View articletitled, Dominant-Negative Histone H3 Lysine 27 Mutant Derepresses Silenced Tumor Suppressor Genes and Reverses the Drug-Resistant Phenotype in Cancer Cells
Open the PDF for Dominant-Negative Histone H3 Lysine 27 Mutant Derepresses Silenced Tumor Suppressor Genes and Reverses the Drug-Resistant Phenotype in Cancer Cells in another window
Includes: Supplementary data
Journal Articles

Modulation by tetrahydrouridine (THU) of fluorodeoxycytidine (FdC) metabolism and pharmacokinetics (PK) in mice

Jan H. Beumer, Julie L. Eiseman, Robert Parise, Erin Joseph, Joseph Covey, Julianne Holleran, Merrill J. Egorin
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 508.
Published: 15 April 2006
View articletitled, Modulation by tetrahydrouridine (THU) of fluorodeoxycytidine (FdC) metabolism and pharmacokinetics (PK) in mice
Journal Articles

Dominant-negative histone H3 lysine 27 mutant derepresses silenced tumor suppressor genes and reverses the drug-resistant phenotype in cancer cells

Phillip H. Abbosh, John S. Montgomery, Jason A. Starkey, Milos V. Novotny, Kate Brannon, Merrill J. Egorin, Curt R. Balch, Tim H-M. Huang, Kenneth P. Nephew
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 539.
Published: 15 April 2006
View articletitled, Dominant-negative histone H3 lysine 27 mutant derepresses silenced tumor suppressor genes and reverses the drug-resistant phenotype in cancer cells
Journal Articles

Mass balance and pharmacokinetic (PK) study of zebularine (NSC 309132), a DNA-methyltransferase inhibitor, and three metabolites in mice

Jan H. Beumer, Erin Joseph, Merrill J. Egorin, Joseph M. Covey, Julie L. Eiseman
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 729.
Published: 15 April 2006
View articletitled, Mass balance and pharmacokinetic (PK) study of zebularine (NSC 309132), a DNA-methyltransferase inhibitor, and three metabolites in mice
Journal Articles

A physiologically-based pharmacokinetic (PBPK) model of docetaxel in SCID mice bearing SKOV3 human ovarian cancer xenografts

Jeffry A. Florian, Jr., William C. Zamboni, Julie L. Eiseman, Mihaela C. Krasteva, Sandra Strychor, Erin Joseph, Robert A. Parise, Merrill J. Egorin, Robert S. Parker
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 730.
Published: 15 April 2006
View articletitled, A physiologically-based pharmacokinetic (PBPK) model of docetaxel in SCID mice bearing SKOV3 human ovarian cancer xenografts
Journal Articles

In vitro metabolism & decomposition of benzaldehyde dimethane sulfonate (NSC 281612) (BEN)

Kimberly P. Kicielinski, Robert A. Parise, Julianne L. Holleran, Julie L. Eiseman, Joseph M. Covey, Merrill J. Egorin
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 129.
Published: 15 April 2006
View articletitled, In vitro metabolism & decomposition of benzaldehyde dimethane sulfonate (NSC 281612) (BEN)
Journal Articles

Plasma pharmacokinetics and tissue distribution of the photodynamic therapy (PDT) agent, Pc4, in mice: measurement comparison of Optical Pharmacokinetic System (OPS) with high performance liquid chromatography (HPLC).

Stephen C. Kanick, Jianxia Guo, Erin Joseph, Merrill J. Egorin, Robert S. Parker, Julie L. Eiseman
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1218.
Published: 15 April 2006
View articletitled, Plasma pharmacokinetics and tissue distribution of the photodynamic therapy (PDT) agent, Pc4, in mice: measurement comparison of Optical Pharmacokinetic System (OPS) with high performance liquid chromatography (HPLC).
Journal Articles

Non-invasive optical pharmacokinetic system (OPS) measurement of motexafin gadolinium (GdTex) concentrations in tumors of SCID mice bearing MDA-MB-231 breast cancer xenografts

Julie L. Eiseman, Erin Joseph, Robert S. Parker, Jianxia Guo, S. Chad Kanick, Merrill J. Egorin
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 344.
Published: 01 May 2005
View articletitled, Non-invasive optical pharmacokinetic system (OPS) measurement of motexafin gadolinium (GdTex) concentrations in tumors of SCID mice bearing MDA-MB-231 breast cancer xenografts
Journal Articles

Effect of the St. John’s wort constituent hyperforin on docetaxel metabolism by human hepatocyte cultures

Merrill J. Egorin, Bernard J. Komoroski, Robert A. Parise, Stephen C. Strom, Raman Venkataramanan
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 980–981.
Published: 01 May 2005
View articletitled, Effect of the St. John’s wort constituent hyperforin on docetaxel metabolism by human hepatocyte cultures
Journal Articles

Pre-clinical studies assessing the therapeutic potential of 1,25-dihydroxyvitamin D3 (1,25D3) as a treatment for non-small cell lung cancer (NSCLC)

Robert A. Parise, Merrill J. Egorin, Candace S. Johnson, Donald L. Trump, Mark Nichols, Pamela A. Hershberger
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 951.
Published: 01 May 2005
View articletitled, Pre-clinical studies assessing the therapeutic potential of 1,25-dihydroxyvitamin D3 (1,25D3) as a treatment for non-small cell lung cancer (NSCLC)
Journal Articles

Plasma pharmacokinetics, oral bioavailability, and interspecies scaling of the DNA methyl transferase inhibitor, zebularine (NSC 309132), in mice, rats, and Rhesus monkeys

Julianne L. Holleran, Robert A. Parise, Erin Joseph, Julie L. Eiseman, Joseph M. Covey, Elizabeth R. Glaze, Alexander V. Lyubimov, Ya-Fei Chen, David Z. D’Argenio, Merrill J. Egorin
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 983–984.
Published: 01 May 2005
View articletitled, Plasma pharmacokinetics, oral bioavailability, and interspecies scaling of the DNA methyl transferase inhibitor, zebularine (NSC 309132), in mice, rats, and Rhesus monkeys
Journal Articles

Plasma, tumor, and tissue disposition of docetaxel in SCID mice bearing SKOV-3 human ovarian xenografts

Sandra Strychor, Julie L. Eiseman, Robert A. Parise, Merrill J. Egorin, Erin Joseph, William C. Zamboni
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 983.
Published: 01 May 2005
View articletitled, Plasma, tumor, and tissue disposition of docetaxel in SCID mice bearing SKOV-3 human ovarian xenografts
Journal Articles

Preclinical pharmacokinetics and metabolism of benzaldehyde dimethane sulfonate (BEN) (NSC 281612)

Joseph M. Covey, Merrill J. Egorin, Julianne L. Holleran, Robert A. Parise, Erin Joseph, Julie L. Eiseman, Stephen M. Musser
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 321–322.
Published: 01 May 2005
View articletitled, Preclinical pharmacokinetics and metabolism of benzaldehyde dimethane sulfonate (BEN) (NSC 281612)
Journal Articles

Pharmacokinetics of 9-nitrocamptothecin (9NC) and 9- aminocamptothecin (9AC) in SCID mice bearing human colon xenografts, HT29

Julie L. Eiseman, Robert A. Parise, Erin Joseph, Sandra Strychor, Robert S. Parker, Merrill J. Egorin, William C. Zamboni
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1246.
Published: 01 April 2004
View articletitled, Pharmacokinetics of 9-nitrocamptothecin (9NC) and 9- aminocamptothecin (9AC) in SCID mice bearing human colon xenografts, HT29