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Journal Articles

Abstract 4281: Pharmacological inhibition of thymine DNA glycosylase (TDG) triggers an anti-tumor immunity to suppress p53-deficient cancer

Free
Jiannan Guo, Meng Wang, Jiaxin Zhou, Yao Cao, Yiqin Wang, Yilin Liu, Youzhen Wang, Yuan Mi, Yarui Du, Guoliang Xu, Haiping Wu
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4281.
https://doi.org/10.1158/1538-7445.AM2025-4281
Published: 21 April 2025
View articletitled, Abstract 4281: Pharmacological inhibition of thymine DNA glycosylase (TDG) triggers an anti-tumor immunity to suppress p53-deficient cancer
Journal Articles

Abstract 2599: Biological consequences and mechanisms of neural signatures in fusion-positive rhabdomyosarcoma

Free
Jack Kucinski, Alexi Tallan, Matthew Kent, Cenny Taslim, Meng Wang, Matthew V. Cannon, Katherine M. Silvius, Benjamin Z. Stanton, Genevieve C. Kendall
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2599.
https://doi.org/10.1158/1538-7445.AM2025-2599
Published: 21 April 2025
View articletitled, Abstract 2599: Biological consequences and mechanisms of neural signatures in fusion-positive rhabdomyosarcoma
Journal Articles

Abstract 498: In melanoma, disruption of the NF1/SPRED1 RAS inactivating complex cooperates with mutant KIT necessitating combined KIT and MEK inhibition to suppress tumor growth

Free
Meng Kian Tee, Jia Yang, Jiafang Ma, Meng Wang, Dirk Schadendorf, Boris C. Bastian, Iwei Yeh
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 498.
https://doi.org/10.1158/1538-7445.AM2025-498
Published: 21 April 2025
View articletitled, Abstract 498: In melanoma, disruption of the NF1/SPRED1 RAS inactivating complex cooperates with mutant KIT necessitating combined KIT and MEK inhibition to suppress tumor growth
Journal Articles

Abstract 4596: Targeting arginine methylome in 9p21/MTAP-deleted malignant cancers with a next generation PRMT5-specific inhibitor CTS3497

Free
Yilin Liu, Long Wang, Hui Shi, Yuanyuan Liu, Qiugeng Ouyang, Xingnian Fu, Meng Wang, Jiannan Guo, Yiqin Wang, Youzhen Wang, Guoliang Xu, Yuan Mi, Haiping Wu
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4596.
https://doi.org/10.1158/1538-7445.AM2024-4596
Published: 22 March 2024
View articletitled, Abstract 4596: Targeting arginine methylome in 9p21/MTAP-deleted malignant cancers with a next generation PRMT5-specific inhibitor CTS3497
Journal Articles

Abstract 2126: Efficacy and underlying mechanisms of surufatinib in non-small cell lung cancer treatment

Free
Yanfang Zheng, Binjie Shan, Meng Wang, Xiaoran Wu, Rui Cai, Feiyu Niu, Yan Yuan, Lu Liu, Xiongjie Zhu
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2126.
https://doi.org/10.1158/1538-7445.AM2024-2126
Published: 22 March 2024
View articletitled, Abstract 2126: Efficacy and underlying mechanisms of surufatinib in non-small cell lung cancer treatment
Journal Articles

Abstract 3885: A secondary Gαq mutation confers resistance to Gαq inhibitors in uveal melanoma

Free
Jiafang Ma, Meng Wang, Aashish Manglik, Boris C. Bastian, Xu Chen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3885.
https://doi.org/10.1158/1538-7445.AM2023-3885
Published: 04 April 2023
View articletitled, Abstract 3885: A secondary Gαq mutation confers resistance to Gαq inhibitors in uveal melanoma
Journal Articles

Abstract 4441: Bifunctional immunotherapeutic HCW9218 facilitates recruitment of immune cells from tumor draining lymph nodes to promote antitumor activity and enhance checkpoint blockade efficacy in solid tumors

Free
Varghese George, Pallavi Chaturvedi, Niraj Shrestha, Leah Kanakraj, Crystal Gilkes, Nicole Encalada, Meng Wang, Xiaoyun Zhu, Bai Liu, Peter Rhode, Hing C. Wong
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4441.
https://doi.org/10.1158/1538-7445.AM2023-4441
Published: 04 April 2023
View articletitled, Abstract 4441: Bifunctional immunotherapeutic HCW9218 facilitates recruitment of immune cells from tumor draining lymph nodes to promote antitumor activity and enhance checkpoint blockade efficacy in solid tumors
Journal Articles

Abstract 4021: CTS2016, a novel AXL/FLT3 inhibitor for targeting AML/MDS and solid tumors

Free
Hui Shi, Meng Wang, Jiaxin Huang, Qiugeng Ouyang, Jiannan Guo, Youzhen Wang, Yuan Mi, Haiping Wu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4021.
https://doi.org/10.1158/1538-7445.AM2023-4021
Published: 04 April 2023
View articletitled, Abstract 4021: CTS2016, a novel AXL/FLT3 inhibitor for targeting AML/MDS and solid tumors
Journal Articles

Abstract 6278: Combination therapeutic strategy with type I PRMT inhibition in cancer treatment

Free
Hui Shi, Xingnian Fu, Yilin Liu, Qiugeng Ouyang, Meng Wang, Jiaxin Huang, Long Wang, Youzhen Wang, Yuan Mi, Haiping Wu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6278.
https://doi.org/10.1158/1538-7445.AM2023-6278
Published: 04 April 2023
View articletitled, Abstract 6278: Combination therapeutic strategy with type I PRMT inhibition in cancer treatment
Journal Articles

Abstract 1299: Immunotherapeutic hcw9218 enhances anti-tumor activity of chemotherapy by facilitating immune-mediated elimination of therapy induced senescent cells

Free
Pallavi Chaturvedi, Varghese George, Bai Liu, Niraj Shrestha, Meng Wang, Micheal Dee, Xiaoyun Zhu, Jack Egan, Jin-an Jiao, Catherine Spanoudis, Jilan Xing, Victor Gallo, Christian Echeverri, Lijing You, Lin Kong, Gabriela Muniz, Peter Rhode, Hing Wong
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1299.
https://doi.org/10.1158/1538-7445.AM2022-1299
Published: 15 June 2022
View articletitled, Abstract 1299: Immunotherapeutic hcw9218 enhances anti-tumor activity of chemotherapy by facilitating immune-mediated elimination of therapy induced senescent cells
Journal Articles

The Roles of RNA Helicases in DNA Damage Repair and Tumorigenesis Reveal Precision Therapeutic Strategies

Available to Purchase
Jinru Xie, Ming Wen, Jiao Zhang, Zheng Wang, Meng Wang, Yanfang Qiu, Wenchao Zhao, Fang Zhu, Mianfeng Yao, Zhuoxian Rong, Wenfeng Hu, Qian Pei, Xiaoxiang Sun, Jinchen Li, Zhiyong Mao, Lun-Quan Sun, Rong Tan
Journal: Cancer Research
Cancer Res (2022) 82 (5): 872–884.
https://doi.org/10.1158/0008-5472.CAN-21-2187
Published: 03 March 2022
View articletitled, The Roles of RNA Helicases in DNA Damage Repair and Tumorigenesis Reveal Precision Therapeutic Strategies
Open the PDF for The Roles of RNA Helicases in DNA Damage Repair and Tumorigenesis Reveal Precision Therapeutic Strategies in another window
Includes: Supplementary data
Journal Articles

Nicotine-Induced ILF2 Facilitates Nuclear mRNA Export of Pluripotency Factors to Promote Stemness and Chemoresistance in Human Esophageal Cancer

Available to Purchase
Yue Li, Meng Wang, Muwen Yang, Yunyun Xiao, Yunting Jian, Dongni Shi, Xiangfu Chen, Ying Ouyang, Lingzhi Kong, Xinjian Huang, Jiewen Bai, Yameng Hu, Chuyong Lin, Libing Song
Journal: Cancer Research
Cancer Res (2021) 81 (13): 3525–3538.
https://doi.org/10.1158/0008-5472.CAN-20-4160
Published: 01 July 2021
View articletitled, Nicotine-Induced ILF2 Facilitates Nuclear mRNA Export of Pluripotency Factors to Promote Stemness and Chemoresistance in Human Esophageal Cancer
Open the PDF for Nicotine-Induced ILF2 Facilitates Nuclear mRNA Export of Pluripotency Factors to Promote Stemness and Chemoresistance in Human Esophageal Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 3450: Ganglioneuromas are driven by activated AKT and can be therapeutically targeted with mTOR inhibitors

Free
Ting Tao, Hui Shi, Adam D. Durbin, Meng Wang, Antonio R. Perez-Atayde, Wendy B. London, Alejandro Gutierrez, Bernardo Lemos, A. Thomas Look
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3450.
https://doi.org/10.1158/1538-7445.AM2020-3450
Published: 15 August 2020
View articletitled, Abstract 3450: Ganglioneuromas are driven by activated AKT and can be therapeutically targeted with mTOR inhibitors
Journal Articles

Abstract 5446: Tumor-derived miR-200c and 141 contribute to high levels of plasma microRNA-200c and 141 through exosomes

Free
Lizhong Wang, Runhua Liu, Song Gao, Yicun Wang, Meng Wang, Zhi Li
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5446.
https://doi.org/10.1158/1538-7445.AM2017-5446
Published: 01 July 2017
View articletitled, Abstract 5446: Tumor-derived miR-200c and 141 contribute to high levels of plasma microRNA-200c and 141 through exosomes
Journal Articles

Abstract 4756: A SPP1-EGFR pathway links stem-like properties of KRAS-mutated lung cancer to radiation resistance

Free
Meng Wang, Jing Han, Lynnette Marcar, Josh Black, Qi Liu, Xiangyong Li, Kshithija Nagulapalli, Lecia V. Sequist, Raymond H. Mak, Cyril H. Benes, Theodore S. Hong, Kristin Gurtner, Mechthild Krause, Michael Baumann, Jing X. Kang, Johnathan R. Whetstine, Henning Willers
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4756.
https://doi.org/10.1158/1538-7445.AM2017-4756
Published: 01 July 2017
View articletitled, Abstract 4756: A SPP1-EGFR pathway links stem-like properties of KRAS-mutated lung cancer to radiation resistance
Journal Articles

Radiation Resistance in KRAS-Mutated Lung Cancer Is Enabled by Stem-like Properties Mediated by an Osteopontin–EGFR Pathway

Free
Meng Wang, Jing Han, Lynnette Marcar, Josh Black, Qi Liu, Xiangyong Li, Kshithija Nagulapalli, Lecia V. Sequist, Raymond H. Mak, Cyril H. Benes, Theodore S. Hong, Kristin Gurtner, Mechthild Krause, Michael Baumann, Jing X. Kang, Johnathan R. Whetstine, Henning Willers
Journal: Cancer Research
Cancer Res (2017) 77 (8): 2018–2028.
https://doi.org/10.1158/0008-5472.CAN-16-0808
Published: 13 April 2017
View articletitled, Radiation Resistance in KRAS-Mutated Lung Cancer Is Enabled by Stem-like Properties Mediated by an Osteopontin–EGFR Pathway
Open the PDF for Radiation Resistance in KRAS-Mutated Lung Cancer Is Enabled by Stem-like Properties Mediated by an Osteopontin–EGFR Pathway in another window
Includes: Supplementary data
Journal Articles

Abstract LB-209: Chromatin condensation in KRAS-mutant lung cancer as a therapeutic target: challenging the paradigm of associating KRAS mutation with EGFR inhibitor resistance

Free
Meng Wang, Ashley M. Kern, Marieke Hülskötter, Patricia Greninger, Anurag Singh, Yunfeng Pan, Dipanjan Chowdhury, Mechthild Krause, Michael Baumann, Cyril H. Benes, Jason A. Efstathiou, Jeff Settleman, Henning Willers
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): LB-209.
https://doi.org/10.1158/1538-7445.AM2014-LB-209
Published: 01 October 2014
View articletitled, Abstract LB-209: Chromatin condensation in KRAS-mutant lung cancer as a therapeutic target: challenging the paradigm of associating KRAS mutation with EGFR inhibitor resistance
Journal Articles

EGFR-Mediated Chromatin Condensation Protects KRAS-Mutant Cancer Cells against Ionizing Radiation

Free
Meng Wang, Ashley M. Kern, Marieke Hülskötter, Patricia Greninger, Anurag Singh, Yunfeng Pan, Dipanjan Chowdhury, Mechthild Krause, Michael Baumann, Cyril H. Benes, Jason A. Efstathiou, Jeff Settleman, Henning Willers
Journal: Cancer Research
Cancer Res (2014) 74 (10): 2825–2834.
https://doi.org/10.1158/0008-5472.CAN-13-3157
Published: 14 May 2014
View articletitled, EGFR-Mediated Chromatin Condensation Protects KRAS-Mutant Cancer Cells against Ionizing Radiation
Open the PDF for EGFR-Mediated Chromatin Condensation Protects KRAS-Mutant Cancer Cells against Ionizing Radiation in another window
Includes: Supplementary data
Journal Articles

EGFR-Activating Mutations Correlate with a Fanconi Anemia–like Cellular Phenotype That Includes PARP Inhibitor Sensitivity

Free
Heike N. Pfäffle, Meng Wang, Liliana Gheorghiu, Natalie Ferraiolo, Patricia Greninger, Kerstin Borgmann, Jeffrey Settleman, Cyril H. Benes, Lecia V. Sequist, Lee Zou, Henning Willers
Journal: Cancer Research
Cancer Res (2013) 73 (20): 6254–6263.
https://doi.org/10.1158/0008-5472.CAN-13-0044
Published: 14 October 2013
View articletitled, EGFR-Activating Mutations Correlate with a Fanconi Anemia–like Cellular Phenotype That Includes PARP Inhibitor Sensitivity
Open the PDF for EGFR-Activating Mutations Correlate with a Fanconi Anemia–like Cellular Phenotype That Includes PARP Inhibitor Sensitivity in another window
Includes: Supplementary data
Journal Articles

Abstract LB-256: Targeting MLL1 methyltransferase activity for treatment of acute leukemia with MLL1 rearrangement

Free
Elizabeth C. Townsend, Fang Cao, Hacer Karatas, Shao-Meng Wang, Yali Dou
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): LB-256.
https://doi.org/10.1158/1538-7445.AM2012-LB-256
Published: 15 April 2012
View articletitled, Abstract LB-256: Targeting MLL1 methyltransferase activity for treatment of acute leukemia with MLL1 rearrangement