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Melissa L. Fishel
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Journal Articles

Abstract B072: Pharmacological depletion of fibrinogen suppresses the growth of primary tumors and liver metastasis of pancreatic cancer

Nayela N Chowdhury, Dana K Mitchell, Kadri Kangro, Kierra Eldridge, Sara Abrahams, Francesca Ferraresso, Lih J Juang, Silpa Gampala, Kylee Brewster, Alexey Revenko, Christian Kastrup, Paul R Territo, D Wade Clapp, Jorge A Belgodere, Bumsoo Han, Alisa S Wolberg, Chi Zhang, Matthew J Flick, Melissa L Fishel
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): B072.
https://doi.org/10.1158/1538-7445.PANCREATIC24-B072
Published: 15 September 2024
View article titled, Abstract B072: Pharmacological depletion of fibrinogen suppresses the growth of primary tumors and liver metastasis of pancreatic cancer
Journal Articles

Abstract C028: Challenging PDAC adaptability: Uncovering therapeutic vulnerabilities in APE1 DNA repair mechanisms

Eyram K Kpenu, Randall Wireman, Mahmut Mijiti, Silpa Gampala, Melissa L Fishel, Mark R Kelley
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): C028.
https://doi.org/10.1158/1538-7445.PANCREATIC24-C028
Published: 15 September 2024
View article titled, Abstract C028: Challenging PDAC adaptability: Uncovering therapeutic vulnerabilities in APE1 DNA repair mechanisms
Journal Articles

Abstract 2009: Elucidating the mechanistic effect of targeting Ref-1 redox function on MPNST survival signaling using patient-derived xenolines

Silpa Gampala, Olivia Babb, Nikkitha Umesh Ganesh, Steven D. Rhodes, Reza M. Saadatzadeh, Kai Pollard, Christine Pratilas, Jing-Ruey Joanna Yeh, Karen E. Pollok, Wade D. Clapp, Mark R. Kelley, Chi Zhang, Melissa L. Fishel
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2009.
https://doi.org/10.1158/1538-7445.AM2022-2009
Published: 15 June 2022
View article titled, Abstract 2009: Elucidating the mechanistic effect of targeting Ref-1 redox function on MPNST survival signaling using patient-derived xenolines
Journal Articles

Abstract 2366: Inhibition of Ref-1/APE1 redox activity with APX3330 enhances Ref-1/APE1 protein unfolded conformation in human PDAC cells

Mahmut Mijit, Olivia Babb, Silpa Gampala, Randall Wireman, Millie M. Georgiadis, Melissa L. Fishel, Mark R. Kelley
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2366.
https://doi.org/10.1158/1538-7445.AM2022-2366
Published: 15 June 2022
View article titled, Abstract 2366: Inhibition of Ref-1/APE1 redox activity with APX3330 enhances Ref-1/APE1 protein unfolded conformation in human PDAC cells
Journal Articles

Abstract 2447: Unraveling the role of the fibrinolytic system in pancreatic cancer progression

Nayela N. Chowdhury, Yi Yang, Yingnan Shen, Silpa Gampala, Olivia Babb, Bumsoo Han, Alisa S. Wolberg, Matthew J. Flick, Melissa L. Fishel
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2447.
https://doi.org/10.1158/1538-7445.AM2022-2447
Published: 15 June 2022
View article titled, Abstract 2447: Unraveling the role of the fibrinolytic system in pancreatic cancer progression
Journal Articles

Abstract 2475: Differential sensitivity of mouse PDAC KrasG12D cells to Ref-1/APE1 redox signalling inhibitors: Role of NFkB as a primary target of Ref-1/APE1 in Kras driven pancreatic ductal adenocarcinoma

Rachel A. Caston, Randy Wireman, Lee Armstrong, Silpa Gampala, Olivia Babb, Nayela Chowdhury, Zonera Hassan, Christian Schneeweis, Gunter Schneider, Melissa L. Fishel, Mark R. Kelley
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2475.
https://doi.org/10.1158/1538-7445.AM2021-2475
Published: 01 July 2021
View article titled, Abstract 2475: Differential sensitivity of mouse PDAC Kras<sup>G12D</sup> cells to Ref-1/APE1 redox signalling inhibitors: Role of NFkB as a primary target of Ref-1/APE1 in <em>Kras</em> driven pancreatic ductal adenocarcinoma
Journal Articles

Abstract 1452: Deciphering mechanisms of Ref-1 signaling and its inhibition in aggressive tumor-stroma PDAC models

Silpa Gampala, Nayela Chowdhury, Olivia Babb, Rachel A. Caston, Randall S. Wireman, Hye-ran Moon, George Sandusky, Emily Hulsey, Bumsoo Han, Millie M. Georgiadis, Sara K. Quinney, Andi R. Masters, James H. Wikel, Mark R. Kelley, Melissa L. Fishel
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1452.
https://doi.org/10.1158/1538-7445.AM2021-1452
Published: 01 July 2021
View article titled, Abstract 1452: Deciphering mechanisms of Ref-1 signaling and its inhibition in aggressive tumor-stroma PDAC models
Journal Articles

Abstract PO025: Ref-1 redox function identified as mitochondrial metabolic regulator in pancreatic cancer cells but not in CAFs

Silpa Gampala, Fenil Shah, Xiaoyu Lu, Hye-ran Moon, George E. Sandusky, Emily Hulsey, Amber L. Mosley, Bamsoo Han, Chi Zhang, Mark R. Kelley, Melissa L. Fishel
Journal: Cancer Research
Cancer Res (2021) 81 (5_Supplement): PO025.
https://doi.org/10.1158/1538-7445.TME21-PO025
Published: 01 March 2021
View article titled, Abstract PO025: Ref-1 redox function identified as mitochondrial metabolic regulator in pancreatic cancer cells but not in CAFs
Journal Articles

Abstract 2644: Oncostatin M in pancreatic cancer tumor microenvironment

Daenique H. Jengelley, Melissa L. Fishel, Michael Ostrowski, Teresa A. Zimmers
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2644.
https://doi.org/10.1158/1538-7445.AM2020-2644
Published: 15 August 2020
View article titled, Abstract 2644: Oncostatin M in pancreatic cancer tumor microenvironment
Journal Articles

Abstract 955: Long-term gemcitabine treatment reshapes the pancreatic tumor microenvironment and sensitizes murine carcinoma to combination immunotherapy

Daniel R. Principe, Matthew Narbutis, Sandeep Kumar, Alex Park, Navin Viswakarma, Matthew J. Dorman, Suneel D. Kamath, Paul Grippo, Melissa L. Fishel, Rosa F. Hwang, Dinesh Thummuri, Patrick W. Underwood, Hidayatullah G. Munshi, Jose G. Trevino, Ajay Rana
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 955.
https://doi.org/10.1158/1538-7445.AM2020-955
Published: 15 August 2020
View article titled, Abstract 955: Long-term gemcitabine treatment reshapes the pancreatic tumor microenvironment and sensitizes murine carcinoma to combination immunotherapy
Journal Articles

Long-Term Gemcitabine Treatment Reshapes the Pancreatic Tumor Microenvironment and Sensitizes Murine Carcinoma to Combination Immunotherapy

Daniel R. Principe, Matthew Narbutis, Sandeep Kumar, Alex Park, Navin Viswakarma, Matthew J. Dorman, Suneel D. Kamath, Paul J. Grippo, Melissa L. Fishel, Rosa F. Hwang, Dinesh Thummuri, Patrick W. Underwood, Hidayatullah G. Munshi, Jose G. Trevino, Ajay Rana
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (15): 3101–3115.
https://doi.org/10.1158/0008-5472.CAN-19-2959
Published: 04 August 2020
View article titled, Long-Term Gemcitabine Treatment Reshapes the Pancreatic Tumor Microenvironment and Sensitizes Murine Carcinoma to Combination Immunotherapy
Open the PDF for Long-Term Gemcitabine Treatment Reshapes the Pancreatic Tumor Microenvironment and Sensitizes Murine Carcinoma to Combination Immunotherapy in another window
Includes: Supplementary data
Journal Articles

Abstract B51: Regulation of HIF1α under hypoxia by APE1/Ref-1 impacts CA9 expression: Dual-targeting in patient-derived 3D pancreatic cancer models

Derek P. Logsdon, Michelle Grimard, Safi Shahda, Nicholas Zyromski, Ernestina Schipani, Fabrizio Carta, Claudiu T. Supuran, Murray Korc, Mircea Ivan, Mark R. Kelley, Melissa L. Fishel
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): B51.
https://doi.org/10.1158/1538-7445.PANCA16-B51
Published: 14 December 2016
View article titled, Abstract B51: Regulation of HIF1α under hypoxia by APE1/Ref-1 impacts CA9 expression: Dual-targeting in patient-derived 3D pancreatic cancer models
Journal Articles

Abstract 1246: Development of STAT3 dual-targeting strategies for the treatment of pancreatic cancer

Melissa L. Fishel, Michelle L. Grimard, Mark R. Kelley, David A. Rosa, Andrew Shouksmith, Gary Tin, Ji Park, Patrick T. Gunning
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1246.
https://doi.org/10.1158/1538-7445.AM2016-1246
Published: 15 July 2016
View article titled, Abstract 1246: Development of STAT3 dual-targeting strategies for the treatment of pancreatic cancer
Journal Articles

Abstract 4740: Targeting Ref-1/APE1 pathway inhibition in pancreatic cancer using APX3330 for clinical trials

Melissa L. Fishel, Derek P. Logsdon, Michelle L. Grimard, Claudiu T. Supuran, Nicholas Zyromski, Mircea Ivan, Mark R. Kelley, Fenil Shah
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4740.
https://doi.org/10.1158/1538-7445.AM2016-4740
Published: 15 July 2016
View article titled, Abstract 4740: Targeting Ref-1/APE1 pathway inhibition in pancreatic cancer using APX3330 for clinical trials
Journal Articles

Abstract 5183: Efficacy study of APX3330, a Ref-1 redox inhibitor, and Gemcitabine in a mouse pancreatic ductal adenocarcinoma model

Kyle C. McElyea, Max H. Jacobsen, Max Schmidt, Huiwen Cheng, Mark R. Kelley, George E. Sandusky, Melissa L. Fishel
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 5183.
https://doi.org/10.1158/1538-7445.AM2016-5183
Published: 15 July 2016
View article titled, Abstract 5183: Efficacy study of APX3330, a Ref-1 redox inhibitor, and Gemcitabine in a mouse pancreatic ductal adenocarcinoma model
Journal Articles

Abstract B19: Redox factor 1 (Ref-1) signaling in the interaction between pancreatic tumor cells and cancer-associated fibroblasts

Melissa L. Fishel, Huiwen Cheng, Murray Korc, Mark R. Kelley
Journal: Cancer Research
Cancer Res (2015) 75 (13_Supplement): B19.
https://doi.org/10.1158/1538-7445.PANCA2014-B19
Published: 30 June 2015
View article titled, Abstract B19: Redox factor 1 (Ref-1) signaling in the interaction between pancreatic tumor cells and cancer-associated fibroblasts
Journal Articles

Abstract 4961: Longitudinal bioluminescence imaging of primary versus abdominal metastatic tumor growth in orthotopic pancreatic tumor models in NOD/SCIDγ(-/-) mice

Harlan E. Shannon, Melissa L. Fishel, Jingwu Xie, Dongsheng Gu, Brian P. McCarthy, Amanda A. Riley, Anthony L. Sinn, Jayne M. Silver, Mark R. Kelley, Helmut Hanenberg, Murray Korc, Karen E. Pollok, Paul R. Territo
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4961.
https://doi.org/10.1158/1538-7445.AM2014-4961
Published: 01 October 2014
View article titled, Abstract 4961: Longitudinal bioluminescence imaging of primary versus abdominal metastatic tumor growth in orthotopic pancreatic tumor models in NOD/SCIDγ(-/-) mice
Journal Articles

Abstract 1963: Novel small molecule inhibitor of the endonuclease function of the APE1 DNA repair and redox signaling enzyme blocks proliferation and reduces viability of glioblastoma cells

Aditi Bapat, LaTeca S. Glass, Meihua Luo, Melissa L. Fishel, April Reed, Eric C. Long, Millie M. Georgiadis, Mark R. Kelley
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1963.
https://doi.org/10.1158/1538-7445.AM10-1963
Published: 15 April 2010
View article titled, Abstract 1963: Novel small molecule inhibitor of the endonuclease function of the APE1 DNA repair and redox signaling enzyme blocks proliferation and reduces viability of glioblastoma cells
Journal Articles

O6-Benzylguanine enhances DNA damage caused by cisplatin in head and neck cancer cell lines

Cara A. Rabik, Shannon M. Delaney, Melissa L. Fishel, Christopher J. Ottley, D. Graham Pearson, Michael J. Tilby, M. Eileen Dolan
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 254–255.
Published: 15 April 2006
View article titled, <em>O</em><sup>6</sup>-Benzylguanine enhances DNA damage caused by cisplatin in head and neck cancer cell lines
Journal Articles

Enhancement of ovarian cancer treatment via manipulation of the base excision repair pathway after temozolomide treatment

Melissa L. Fishel, Ying He, Shanbao Chai, Karen Pollok, Mark R. Kelley
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 124–125.
Published: 15 April 2006
View article titled, Enhancement of ovarian cancer treatment via manipulation of the base excision repair pathway after temozolomide treatment