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Melinda Hollingshead
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Journal Articles

Abstract LB192: Demethylation, DNA damage and antitumor activity of DNA methyltransferase inhibitors in models with intact and disrupted DNMT1 gene

Angelo B. Laranjeira, Melinda Hollingshead, Dat Nguyen, Robert Kinders, Michael Difilippantonio, James H. Doroshow, Sherry X. Yang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB192.
DOI: https://doi.org/10.1158/1538-7445.AM2022-LB192
Published: 15 June 2022
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Journal Articles

Abstract 973: Comparative single cell transcriptome profiling of primary tumors, CTCs and metastatic sites from a bladder cancer PDX model

Tomas Vilimas, Brandie Fullmer, Alyssa Chapman, Rini Pauly, Ting-Chia Chang, Li Chen, Biswajit Das, Chris Karlovich, Yvonne Evrard, Melinda Hollingshead, Howard Stotler, Michelle Ahalt-Gottholm, Tara Grinnage-Pulley, Mickey Williams, James H. Doroshow
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 973.
DOI: https://doi.org/10.1158/1538-7445.AM2022-973
Published: 15 June 2022
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Journal Articles

Abstract 3091: Patient-derived organoid drug responses corroborate known target-drug interactions for selected anticancer agents

Curtis Hose, Erik Harris, John Connelly, Petreena S. Campbell, Mariaestela Ortiz, Eric Jones, Dianne Newton, Yvonne A. Evrard, Melinda Hollingshead, Ralph Parchment, Beverly A. Teicher, Nathan P. Coussens, James H. Doroshow, Annamaria Rapisarda
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3091.
DOI: https://doi.org/10.1158/1538-7445.AM2022-3091
Published: 15 June 2022
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Journal Articles

Abstract 3120: Method development for generation of PDX models from rapid autopsy samples for the NCI patient-derived models repository

Yvonne A. Evrard, Michelle Eugeni, Michelle Ahalt-Gottholm, Carrie Bonomi, Suzanne Borgel, Thomas C. Caffrey, John Carter, Ting-Chia Chang, Li Chen, Kevin Cooper, Biswajit Das, Emily Delaney, Kelly Dougherty, Eleonora Duregon, Stephanie Ecker, Joe Geraghty, Marion Gibson, Lauren Hicks, Jenna Hull, Sharon Int Veldt, Shahanawaz Jiwani, Chris A. Karlovich, Jade Loewenstein, Candace Mallow, Chelsea McGlynn, Justine Mills, Tiffanie Miner, Jowaly Schneider, Tia Shearer, Savanna Styers, Shannon Uzelac, Paul Grandgenett, Michael Hollingsworth, Jody E. Hooper, P. Mickey Williams, Melinda Hollingshead, James H. Doroshow
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3120.
DOI: https://doi.org/10.1158/1538-7445.AM2022-3120
Published: 15 June 2022
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Journal Articles

Abstract 2644: Comparison of PDMR cell line complex spheroid response and PDX response to trametinib

Beverly A. Teicher, Nathan P. Coussens, Melinda Hollingshead, John Wright, Thomas Silvers, Rene Delosh, Julie Laudeman, Russell Reinhart, Chad Ogle, James Doroshow
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2644.
DOI: https://doi.org/10.1158/1538-7445.AM2021-2644
Published: 01 July 2021
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Journal Articles

Abstract 3015: Applications of immunohistochemistry in characterization of patient derived xenograft models

Lindsay Dutko, Gloryvee Rivera, Erin Cantu, Vishnuprabha Rahulkannan, Kelly Benauer, Tiffanie Chase, Emily Delaney, Jesse Stottlemyer, Chelsea McGlynn, Howard Stotler, John Carter, Suzanne Borgel, Michelle M. Gottholm Ahalt, Michelle Eugeni, Melinda Hollingshead, Yvonne Evrard, Chris Karlovich, Biswajit Das, Mickey Williams, James H. Doroshow, Shahanawaz Jiwani
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3015.
DOI: https://doi.org/10.1158/1538-7445.AM2021-3015
Published: 01 July 2021
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Journal Articles

Abstract 3007: Imaging characterization of NCI patient derived model repository (PDMR) xenografts

Paula M. Jacobs, James L. Tatum, Joseph D. Kalen, Lilia V. Ileva, Lisa A. Riffle, Keita Saito, Nimit L. Patel, Jessica Phillips, Melinda Hollingshead, Yvonne A. Evrard, Michelle Gottholm-Ahalt, Chelsea Sanders, Amy James, Simone Difilippantonio, Elijah F. Edmondson, James H. Doroshow
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3007.
DOI: https://doi.org/10.1158/1538-7445.AM2021-3007
Published: 01 July 2021
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Journal Articles

Abstract 1961: Preclinical development of NSC-801845, a new cytidine analog, in comparative cell culture and xenograft studies with the clinical candidates T-dCyd and aza-T-dCyd

Joel Morris, Donn Wishka, Omar Lopez, Beverly A. Teicher, Raymond Divelbiss, Suzanne Borgel, Kyle Georgius, John Carter, Howard Stotler, Jerry Collins, Melinda Hollingshead
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1961.
DOI: https://doi.org/10.1158/1538-7445.AM2020-1961
Published: 15 August 2020
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Journal Articles

Abstract 6495: Development of robust and reproducible controls to support clinical implementation of quantitative immunofluorescence assays for pharmacodynamic biomarkers

Gabriel J. Benton, Katherine V. Ferry-Galow, Victor E. Lonsberry, Manisha Mohandoss, Howard Stotler, Debbie Trail, Kyle Georgius, Melinda Hollingshead, Deborah Wilsker, Robert Kinders, James H. Doroshow, Ralph E. Parchment
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6495.
DOI: https://doi.org/10.1158/1538-7445.AM2020-6495
Published: 15 August 2020
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Journal Articles

Abstract 5056: Quality control efforts in a large-scale, preclinical trial of rare cancer PDXs by the National Cancer Institute's patient-derived models repository (NCI PDMR)

Yvonne A. Evrard, Biswajit Das, Sergio Y. Alcoser, Suzanne Borgel, Devynn Breen, John Carter, Tiffanie Chase, Alice Chen, Lily Chen, Kristen Cooley, Emily Delaney, Raymond Divelbiss, Lyndsay Dutko, Thomas Forbes, Kyle Georgius, Michelle Gottholm-Ahalt, Tara Grinnage-Pulley, Sierra Hoffman, Chris Karlovich, Shahanawaz Jiwani, Justine Mills, Malorie Morris, Michael Mullendore, Dianne Newton, Rajesh Patidar, Gloryvee Rivera, Howard Stotler, Jesse Stottlemyer, Savanna Styers, Debbie Trail, Shannon Uzelac, Thomas Vilimas, Abigail Walke, Thomas Walsh, Nicole Walters, Peng Wang, P. Mickey Williams, Melinda Hollingshead, James H. Doroshow
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5056.
DOI: https://doi.org/10.1158/1538-7445.AM2020-5056
Published: 15 August 2020
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Journal Articles

Abstract 3913: Evaluation of patient-derived cell lines and cancer organoids for the prediction of drug responses in patient-derived xenograft models

Petreena Campbell, Curtis Hose, Lara El Touny, Erik Harris, John Connelly, Carrie Bonomi, Kelly Dougherty, Savanna Styers, Abigail Walke, Jenna Moyer, Mariah Baldwin, Anna Wade, Michael Mullendore, Kaitlyn Arthur, Matthew Murphy, Kevin Plater, Marion Gibson, Joseph Geraghty, Michelle Gottholm-Ahalt, Tara Grinnage-Pulley, Tiffanie Chase, John Carter, Howard Stotler, Debbie Trail, Luke Stockwin, Dianne Newton, Yvonne Evrard, Melinda Hollingshead, Ralph E. Parchment, Nathan P. Coussens, Beverly A. Teicher, James H. Doroshow, Annamaria Rapisarda
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3913.
DOI: https://doi.org/10.1158/1538-7445.AM2020-3913
Published: 15 August 2020
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Journal Articles

The National Cancer Institute ALMANAC: A Comprehensive Screening Resource for the Detection of Anticancer Drug Pairs with Enhanced Therapeutic Activity

Susan L. Holbeck, Richard Camalier, James A. Crowell, Jeevan Prasaad Govindharajulu, Melinda Hollingshead, Lawrence W. Anderson, Eric Polley, Larry Rubinstein, Apurva Srivastava, Deborah Wilsker, Jerry M. Collins, James H. Doroshow
Journal: Cancer Research
Cancer Res (2017) 77 (13): 3564–3576.
DOI: https://doi.org/10.1158/0008-5472.CAN-17-0489
Published: 02 July 2017
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Includes: Supplementary data
Journal Articles

Abstract 4722: Selective inhibition of DNA methyltransferases and efficacy of novel DNMT inhibitors in leukemia xenografts

Dat Nguyen, Melinda Hollingshead, Larry Rubinstein, James Doroshow, Sherry X. Yang
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4722.
DOI: https://doi.org/10.1158/1538-7445.AM2016-4722
Published: 15 July 2016
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Journal Articles

Abstract 5178: Determinants of response to temozolomide in an exceptionally sensitive patient derived model

Lara H. el Touny, John Connelly, Curtis Hose, Anne Monks, Mark W. Burkett, Erik Harris, Rene’ M. Delosh, Julie Laudeman, Chad Ogle, Russell Reinhart, Michael Selby, Thomas Silvers, David Evans, Dianne Newton, Luke Stockwin, Melinda Hollingshead, Ralph Parchment, James H. Doroshow, Beverly Teicher, Annamaria Rapisarda
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 5178.
DOI: https://doi.org/10.1158/1538-7445.AM2016-5178
Published: 15 July 2016
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Journal Articles

Abstract 3236: Clonal heterogeneity in patient-derived xenografts: The SCLC model LG0904F1496M23 contains stable clones with epithelial or mesenchymal characteristics and differential drug sensitivities

Michael Mullendore, Luke H. Stockwin, Carrie Bonomi, Kelly Dougherty, Howard Stotler, Adrienne Kimmel, Biswajit Das, Vivekananda Datta, Jason Lih, Mickie Williams, James Doroshow, Melinda Hollingshead, Dianne Lynn Newton
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3236.
DOI: https://doi.org/10.1158/1538-7445.AM2015-3236
Published: 01 August 2015
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Journal Articles

Abstract 2306: Pre-clinical development of 4′-thio-2′-deoxycytidine (TdCyd) as a DNA-demethylating agent for use in treating solid tissue tumors

Robert J. Kinders, Melinda Hollingshead, Jaideep Thottassery, William B. Parker, Thomas D. Pfister, Lawrence W. Anderson, Joseph E. Tomaszewski, Jerry M. Collins, James H. Doroshow
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2306.
DOI: https://doi.org/10.1158/1538-7445.AM2014-2306
Published: 01 October 2014
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Journal Articles

Abstract 3062: Isolation and characterization of circulating tumor cells (CTCs) from peripheral blood specimens of patients with advanced solid tumor malignancies (using ApoStream™ instrumentation)

Priya Balasubramanian, Lihua Wang, Scott M. Lawrence, Tony Navas, Shivaani Kummar, Melinda Hollingshead, Francis Owusu, Ralph E. Parchment, Joseph E. Tomaszewski, James H. Doroshow, Robert J. Kinders
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3062.
DOI: https://doi.org/10.1158/1538-7445.AM2014-3062
Published: 01 October 2014
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Journal Articles

Abstract 4689: Pre-clinical investigation of the wee1 inhibitor MK-1775 using pharmacodynamic and mechanistic markers in diverse cancer models in vivo

Deborah F. Wilsker, Allison M. Marrero, Melinda Hollingshead, Scott M. Lawrence, Alice Chen, Shivaani Kummar, Joseph M. Covey, Ralph E. Parchment, Robert J. Kinders, Joseph E. Tomaszewski, James H. Doroshow
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4689.
DOI: https://doi.org/10.1158/1538-7445.AM2014-4689
Published: 01 October 2014
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Journal Articles

Abstract 1173: Development of calibrators and controls as quality control tools for clinical implementation of quantitative immunofluorescence assays for pharmacodynamic biomarkers of molecular targeted agents in tumor biopsies.

Katherine V. Ferry-Galow, Tony Navas, Scott M. Lawrence, Karun Mutreja, Donna Butcher, Melinda Hollingshead, Ralph Parchment, Joseph E. Tomaszewski, James H. Doroshow, Robert J. Kinders
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1173.
DOI: https://doi.org/10.1158/1538-7445.AM2013-1173
Published: 15 April 2013
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Journal Articles

Abstract 1500: Development of a Quantitative Immunofluorescence imaging assay to assess β-catenin translocation and multiplex biomarkers for Epithelial-Mesenchymal Transition (EMT) in tumor tissues.

Tony Navas, Robert J. Kinders, Karun Mutreja, Scott M. Lawrence, Donna Butcher, Melinda Hollingshead, Ralph E. Parchment, Joseph E. Tomaszewski, James H. Doroshow
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1500.
DOI: https://doi.org/10.1158/1538-7445.AM2013-1500
Published: 15 April 2013
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