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Journal Articles

Tumor-Derived Small Extracellular Vesicles Inhibit the Efficacy of CAR T Cells against Solid Tumors

Wenqun Zhong, Zebin Xiao, Zhiyuan Qin, Jingbo Yang, Yi Wen, Ziyan Yu, Yumei Li, Neil C. Sheppard, Serge Y. Fuchs, Xiaowei Xu, Meenhard Herlyn, Carl H. June, Ellen Puré, Wei Guo
Journal: Cancer Research
Cancer Res (2023) 83 (16): 2790–2806.
https://doi.org/10.1158/0008-5472.CAN-22-2220
Published: 15 August 2023
View article titled, Tumor-Derived Small Extracellular Vesicles Inhibit the Efficacy of CAR T Cells against Solid Tumors
Open the PDF for Tumor-Derived Small Extracellular Vesicles Inhibit the Efficacy of CAR T Cells against Solid Tumors in another window
Includes: Supplementary data
Journal Articles

Abstract 1164: Spatiotemporal profiling defines persister and resistance signatures in targeted treatment of melanoma

Jill Carol Rubinstein, Sergii Domanskyi, Todd B. Sheridan, Brian J. Sanderson, SungHee Park, Jessica Kaster, Haiyin Li, Olga Anczukow, Meenhard Herlyn, Jeffrey H. Chuang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1164.
https://doi.org/10.1158/1538-7445.AM2023-1164
Published: 04 April 2023
View article titled, Abstract 1164: Spatiotemporal profiling defines persister and resistance signatures in targeted treatment of melanoma
Journal Articles

Abstract 2276: Spatiotemporal analysis of metastatic melanoma reveals mechanisms of resistance to immune checkpoint blockade

Shiyou Wei, Jinho Lee, Marilyne Labrie, Courtney Betts, Lunxu Liu, Lisa Coussens, Meenhard Herlyn, Genevieve Boland, Gordon Mills, Gao Zhang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2276.
https://doi.org/10.1158/1538-7445.AM2023-2276
Published: 04 April 2023
View article titled, Abstract 2276: Spatiotemporal analysis of metastatic melanoma reveals mechanisms of resistance to immune checkpoint blockade
Journal Articles

Abstract 5407: A pan-cancer PDX histology image repository with genomic and pathological annotations for deep learning analysis

Brian S. White, Xing Yi Woo, Soner Koc, Todd Sheridan, Steven B. Neuhauser, Shidan Wang, Yvonne A. Evrard, John David Landua, R Jay Mashl, Sherri R. Davies, Bingliang Fang, Maria Gabriela Raso, Kurt W. Evans, Matthew H. Bailey, Yeqing Chen, Min Xiao, Jill Rubinstein, Ali Foroughi pour, Lacey Elizabeth Dobrolecki, Maihi Fujita, Junya Fujimoto, Guanghua Xiao, Ryan C. Fields, Jacqueline L. Mudd, Xiaowei Xu, Melinda G. Hollingshead, Shahanawaz Jiwani, PDXNet consortium, Tiffany A. Wallace, Jeffrey A. Moscow, James H. Doroshow, Nicholas Mitsiades, Salma Kaochar, Chong-xian Pan, Moon S. Chen, Luis G. Carvajal-Carmona, Alana L. Welm, Bryan E. Welm, Ramaswamy Govindan, Shunqiang Li, Michael A. Davies, Jack A. Roth, Funda Meric-Bernstam, Yang Xie, Meenhard Herlyn, Li Ding, Michael T. Lewis, Carol J. Bolt, Dennis A. Dean, Jeffrey H. Chuang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5407.
https://doi.org/10.1158/1538-7445.AM2023-5407
Published: 04 April 2023
View article titled, Abstract 5407: A pan-cancer PDX histology image repository with genomic and pathological annotations for deep learning analysis
Journal Articles

Abstract LB083: BRAF dimer-selective inhibitors synergize with BRAF monomer-selective inhibitors to overcome adaptive resistance and retain therapeutic index

Christos Adamopoulos, Tamer Ahmed, Peter M. Ung, Min Xiao, Stuart Aaronson, Celina Ang, Vito Rebecca, Avner Schlessinger, Meenhard Herlyn, Poulikos I. Poulikakos
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB083.
https://doi.org/10.1158/1538-7445.AM2022-LB083
Published: 15 June 2022
View article titled, Abstract LB083: BRAF dimer-selective inhibitors synergize with BRAF monomer-selective inhibitors to overcome adaptive resistance and retain therapeutic index
Journal Articles

Abstract 966: All stressed out: Phenoytpe plasticity and therapy resistance in melanoma

Jasmin Giles, Maria Biancaniello, Mitchell Fane, Gretchen Alicea, Andrew Kossenkov, Amanpreet Kaur, Vito Rebecca, Xiaowei Xu, Meenhard Herlyn, Maureen Murphy, Ashani Weeraratna, Marie R. Webster
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 966.
https://doi.org/10.1158/1538-7445.AM2022-966
Published: 15 June 2022
View article titled, Abstract 966: All stressed out: Phenoytpe plasticity and therapy resistance in melanoma
Journal Articles

Abstract 1202: A repository of PDX histology images for exploring spatial heterogeneity and cancer dynamics

Brian S. White, Xingyi Woo, Soner Koc, Todd Sheridan, Steven B. Neuhauser, Akshat M. Savaliya, Lacey E. Dobrolecki, John D. Landua, Matthew H. Bailey, Maihi Fujita, Kurt W. Evans, Bingliang Fang, Junya Fujimoto, Maria Gabriela Raso, Shidan Wang, Guanghua Xiao, Yang Xie, Sherri R. Davies, Ryan C. Fields, R Jay Mashl, Jacqueline L. Mudd, Yeqing Chen, Min Xiao, Xiaowei Xu, Melinda G. Hollingshead, Shahanawaz Jiwani, PDXNet Consortium, Yvonne A. Evrard, Tiffany A. Wallace, Jeffrey A. Moscow, James H. Doroshow, Nicholas Mitsiades, Salma Kaochar, Chong-xian Pan, Moon S. Chen, Luis G. Carvajal-Carmona, Alana L. Welm, Bryan E. Welm, Michael T. Lewis, Ramaswamy Govindan, Li Ding, Shunqiang Li, Meenhard Herlyn, Michael A. Davies, Jack A. Roth, Funda Meric-Bernstam, Carol J. Bult, Brandi Davis-Dusenbery, Dennis A. Dean, Jeffrey H. Chuang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1202.
https://doi.org/10.1158/1538-7445.AM2022-1202
Published: 15 June 2022
View article titled, Abstract 1202: A repository of PDX histology images for exploring spatial heterogeneity and cancer dynamics
Journal Articles

Protein Signatures of NK Cell–Mediated Melanoma Killing Predict Response to Immunotherapies

Sabrina Cappello, Hsu-Min Sung, Christian Ickes, Christine S. Gibhardt, Adina Vultur, Hilal Bhat, Zhongwen Hu, Patricia Brafford, Andreas Denger, Ioana Stejerean-Todoran, Rixa-Mareike Köhn, Verena Lorenz, Nicolas Künzel, Gabriela Salinas, Hedwig Stanisz, Tobias Legler, Peter Rehling, Michael P. Schön, Karl S. Lang, Volkhard Helms, Meenhard Herlyn, Markus Hoth, Carsten Kummerow, Ivan Bogeski
Journal: Cancer Research
Cancer Res (2021) 81 (21): 5540–5554.
https://doi.org/10.1158/0008-5472.CAN-21-0164
Published: 01 November 2021
View article titled, Protein Signatures of NK Cell–Mediated Melanoma Killing Predict Response to Immunotherapies
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Includes: Supplementary data
Journal Articles

Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance

Jianglan Liu, Vito W. Rebecca, Andrew V. Kossenkov, Thomas Connelly, Qin Liu, Alexis Gutierrez, Min Xiao, Ling Li, Gao Zhang, Anastasia Samarkina, Delaine Zayasbazan, Jie Zhang, Chaoran Cheng, Zhi Wei, Gretchen M. Alicea, Mizuho Fukunaga-Kalabis, Clemens Krepler, Pedro Aza-Blanc, Chih-Cheng Yang, Bela Delvadia, Cynthia Tong, Ye Huang, Maya Delvadia, Alice S. Morias, Katrin Sproesser, Patricia Brafford, Joshua X. Wang, Marilda Beqiri, Rajasekharan Somasundaram, Adina Vultur, Denitsa M. Hristova, Lawrence W. Wu, Yiling Lu, Gordon B. Mills, Wei Xu, Giorgos C. Karakousis, Xiaowei Xu, Lynn M. Schuchter, Tara C. Mitchell, Ravi K. Amaravadi, Lawrence N. Kwong, Dennie T. Frederick, Genevieve M. Boland, Joseph M. Salvino, David W. Speicher, Keith T. Flaherty, Ze'ev A. Ronai, Meenhard Herlyn
Journal: Cancer Research
Cancer Res (2021) 81 (20): 5230–5241.
https://doi.org/10.1158/0008-5472.CAN-20-1496
Published: 15 October 2021
View article titled, Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance
Open the PDF for Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance in another window
Includes: Supplementary data
Journal Articles

Abstract 78: A strategy for effective targeting of oncogenic BRAF signaling with increased therapeutic index using conformation-selective RAF and MEK inhibitors

Christos Adamopoulos, Tamer A. Ahmed, Maxwell R. Tucker, Peter M. Ung, Min Xiao, Zoi Karoulia, Xuewei Wu, Stuart A. Aaronson, Celina Ang, Vito Rebecca, Avner Schlessinger, Meenhard Herlyn, Qi Wang, David E. Shaw, Poulikos I. Poulikakos
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 78.
https://doi.org/10.1158/1538-7445.AM2021-78
Published: 01 July 2021
View article titled, Abstract 78: A strategy for effective targeting of oncogenic BRAF signaling with increased therapeutic index using conformation-selective RAF and MEK inhibitors
Journal Articles

Abstract 40: Targeting SOX10-deficient cells to reduce resistance to targeted therapy in melanoma

Claudia Capparelli, Timothy J. Purwin, Manoela Tiago, Nicole Wilski, Danielle Pomante, McKenna Glasheen, Sheera Rosenbaum, Mai Q. Nguyen, Weijia Cai, Richard Zheng, Gaurav Kumar, Inna Chervoneva, Ayako Shimada, Adam E. Snook, Paolo Fortina, Xiaowei Xu, Kim Hookim, Edna Cukierman, Michael A. Davies, Meenhard Herlyn, Andrew E. Aplin
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 40.
https://doi.org/10.1158/1538-7445.AM2021-40
Published: 01 July 2021
View article titled, Abstract 40: Targeting SOX10-deficient cells to reduce resistance to targeted therapy in melanoma
Journal Articles

Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines

Manuel Valiente, Amanda E.D. Van Swearingen, Carey K. Anders, Amos Bairoch, Adrienne Boire, Paula D. Bos, Diana M. Cittelly, Neta Erez, Gino B. Ferraro, Dai Fukumura, Brunilde Gril, Meenhard Herlyn, Sheri L. Holmen, Rakesh K. Jain, Johanna A. Joyce, Mihaela Lorger, Joan Massague, Josh Neman, Nicola R. Sibson, Patricia S. Steeg, Frits Thorsen, Leonie S. Young, Damir Varešlija, Adina Vultur, Frances Weis-Garcia, Frank Winkler
Journal: Cancer Research
Cancer Res (2020) 80 (20): 4314–4323.
https://doi.org/10.1158/0008-5472.CAN-20-0291
Published: 15 October 2020
View article titled, Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines
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Includes: Supplementary data
Journal Articles

Abstract PR18: Comparative screening of skin-derived NCSCs, melanocytes, and melanoma developmental programs reveals LPAR1 in MAPKi resistance

Vito W. Rebecca, Jianglan Liu, Thomas Connelly, Keith Flaherty, Ze’ev Ronai, Meenhard Herlyn
Journal: Cancer Research
Cancer Res (2020) 80 (19_Supplement): PR18.
https://doi.org/10.1158/1538-7445.MEL2019-PR18
Published: 02 October 2020
View article titled, Abstract PR18: Comparative screening of skin-derived NCSCs, melanocytes, and melanoma developmental programs reveals LPAR1 in MAPKi resistance
Journal Articles

Abstract IA01: Strategies for targeted and immune therapy in melanoma

Meenhard Herlyn
Journal: Cancer Research
Cancer Res (2020) 80 (19_Supplement): IA01.
https://doi.org/10.1158/1538-7445.MEL2019-IA01
Published: 02 October 2020
View article titled, Abstract IA01: Strategies for targeted and immune therapy in melanoma
Journal Articles

Abstract A26: Humanized mouse model: A model to understand mechanisms of immune non-responsiveness to immune checkpoint inhibitors in melanoma

Rajasekharan Somasundaram, Anastasia Samarkina, Thomas Connelly, Robin Choi, Hedy Choi, Kar Muthumani, Xiaowei Xu, Klaus Kaestner, Meenhard Herlyn
Journal: Cancer Research
Cancer Res (2020) 80 (19_Supplement): A26.
https://doi.org/10.1158/1538-7445.MEL2019-A26
Published: 02 October 2020
View article titled, Abstract A26: Humanized mouse model: A model to understand mechanisms of immune non-responsiveness to immune checkpoint inhibitors in melanoma
Journal Articles

Abstract 1118: Absence of mouse-specific tumor evolution in patient-derived cancer xenografts

Jessica Giordano, Xing Yi Woo, Anuj Srivastava, Zi-Ming Zhao, Michael W. Lloyd, Roebi de Bruijn, Yun-Suhk Suh, Francesco Galimi, Andrea Bertotti, Adam Lafferty, Alice C. O'Farrell, Elodie Modave, Diether Lambrechts, Petra ter Brugge, Violeta Serra, Elisabetta Marangoni, Rania El Botty, Jong-Il Kim, Han-Kwang Yang, Charles Lee, Dennis A. Dean, Brandi Davis-Dusenbery, Yvonne A. Evrard, James H. Doroshow, Alana L. Welm, Bryan E. Welm, Michael T. Lewis, Bingliang Fang, Jack Roth, Funda Meric-Bernstam, Meenhard Herlyn, Michael Davies, Li Ding, Shunqiang Li, Ramaswamy Govindan, Jeffrey A. Moscow, Carol J. Bult, Claudio Isella, Livio Trusolino, Annette T. Byrne, Jos Jonkers, Jeffrey H. Chuang, Enzo Medico, EurOPDX consortium & PDXNET consortium
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1118.
https://doi.org/10.1158/1538-7445.AM2020-1118
Published: 15 August 2020
View article titled, Abstract 1118: Absence of mouse-specific tumor evolution in patient-derived cancer xenografts
Journal Articles

Abstract 1673: Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

Xing Yi Woo, Jessica Giordano, Anuj Srivastava, Zi-Ming Zhao, Michael W. Lloyd, Roebi de Bruijn, Yun-Suhk Suh, Jong-Il Kim, Han-Kwang Yang, Charles Lee, Dennis A. Dean, Brandi Davis-Dusenbery, Yvonne A. Evrard, James H. Doroshow, Alana L. Welm, Bryan Welm, Michael T. Lewis, Bingliang Fang, Jack A. Roth, Funda Meric-Bernstam, Meenhard Herlyn, Michael Davies, Li Ding, Shunqiang Li, Ramaswamy Govindan, Claudio Isella, Jeffrey A. Moscow, Livio Trusolino, Annette Byrne, Jos Jonkers, Carol J. Bult, Enzo Medico, Jeffrey H. Chuang, PDXNET consortium & EurOPDX consortium
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1673.
https://doi.org/10.1158/1538-7445.AM2020-1673
Published: 15 August 2020
View article titled, Abstract 1673: Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts
Journal Articles

MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer

Jae Ho Seo, Young Chan Chae, Andrew V. Kossenkov, Yu Geon Lee, Hsin-Yao Tang, Ekta Agarwal, Dmitry I. Gabrilovich, Lucia R. Languino, David W. Speicher, Prashanth K. Shastrula, Alessandra Maria Storaci, Stefano Ferrero, Gabriella Gaudioso, Manuela Caroli, Davide Tosi, Massimo Giroda, Valentina Vaira, Vito W. Rebecca, Meenhard Herlyn, Min Xiao, Dylan Fingerman, Alessandra Martorella, Emmanuel Skordalakes, Dario C. Altieri
Journal: Cancer Research
Cancer Res (2019) 79 (24): 6215–6226.
https://doi.org/10.1158/0008-5472.CAN-19-1982
Published: 13 December 2019
View article titled, MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer
Open the PDF for MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract LB-149: Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy

Avinash Das, Joo Sang Lee, Gao Zhang, Zhiyong Wang, Arnaud Amzallag, Genevieve Boland, Sridhar Hannenhalli, Meenhard Herlyn, Cyril Benes, J. Silvio Gutkind, Keity Flaherty, Eytan Ruppin
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-149.
https://doi.org/10.1158/1538-7445.AM2019-LB-149
Published: 01 July 2019
View article titled, Abstract LB-149: Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy
Journal Articles

Abstract 1682: Non-V600 BRAF mutants in melanoma: Multiple MAPK mutations and distinctive RNA expression

Elizabeth Kiernan, Paul Bastian, Liza Dorfman, Ioannis N. Anastopoulos, Brad Wubbenhorst, Clemens Krepler, Vito Rebecca, Meenhard Herlyn, Katherine Nathanson
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1682.
https://doi.org/10.1158/1538-7445.AM2019-1682
Published: 01 July 2019
View article titled, Abstract 1682: Non-V600 BRAF mutants in melanoma: Multiple MAPK mutations and distinctive RNA expression