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Mechthild Krause
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Journal Articles

Abstract 4756: A SPP1-EGFR pathway links stem-like properties of KRAS-mutated lung cancer to radiation resistance

Meng Wang, Jing Han, Lynnette Marcar, Josh Black, Qi Liu, Xiangyong Li, Kshithija Nagulapalli, Lecia V. Sequist, Raymond H. Mak, Cyril H. Benes, Theodore S. Hong, Kristin Gurtner, Mechthild Krause, Michael Baumann, Jing X. Kang, Johnathan R. Whetstine, Henning Willers
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4756.
https://doi.org/10.1158/1538-7445.AM2017-4756
Published: 01 July 2017
View article titled, Abstract 4756: A SPP1-EGFR pathway links stem-like properties of KRAS-mutated lung cancer to radiation resistance
Journal Articles

Radiation Resistance in KRAS-Mutated Lung Cancer Is Enabled by Stem-like Properties Mediated by an Osteopontin–EGFR Pathway

Meng Wang, Jing Han, Lynnette Marcar, Josh Black, Qi Liu, Xiangyong Li, Kshithija Nagulapalli, Lecia V. Sequist, Raymond H. Mak, Cyril H. Benes, Theodore S. Hong, Kristin Gurtner, Mechthild Krause, Michael Baumann, Jing X. Kang, Johnathan R. Whetstine, Henning Willers
Journal: Cancer Research
Cancer Res (2017) 77 (8): 2018–2028.
https://doi.org/10.1158/0008-5472.CAN-16-0808
Published: 13 April 2017
View article titled, Radiation Resistance in KRAS-Mutated Lung Cancer Is Enabled by Stem-like Properties Mediated by an Osteopontin–EGFR Pathway
Open the PDF for Radiation Resistance in KRAS-Mutated Lung Cancer Is Enabled by Stem-like Properties Mediated by an Osteopontin–EGFR Pathway in another window
Includes: Supplementary data
Journal Articles

An Epigenetic Reprogramming Strategy to Resensitize Radioresistant Prostate Cancer Cells

Claudia Peitzsch, Monica Cojoc, Linda Hein, Ina Kurth, Katrin Mäbert, Franziska Trautmann, Barbara Klink, Evelin Schröck, Manfred P. Wirth, Mechthild Krause, Eduard A. Stakhovsky, Gennady D. Telegeev, Vladimir Novotny, Marieta Toma, Michael Muders, Gustavo B. Baretton, Fiona M. Frame, Norman J. Maitland, Michael Baumann, Anna Dubrovska
Journal: Cancer Research
Cancer Res (2016) 76 (9): 2637–2651.
https://doi.org/10.1158/0008-5472.CAN-15-2116
Published: 01 May 2016
View article titled, An Epigenetic Reprogramming Strategy to Resensitize Radioresistant Prostate Cancer Cells
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Includes: Supplementary data
Journal Articles

Abstract 3304: Role of Vascular Endothelial Growth Factor C in promoting radioresistance of prostate cancer

Steffi Haberlau, Pia Hönscheid, Rafael E. Jimenez, Gustavo B. Baretton, Donald J. Tindall, Mechthild Krause, Kaustubh Datta, Michael H. Muders
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3304.
https://doi.org/10.1158/1538-7445.AM2015-3304
Published: 01 August 2015
View article titled, Abstract 3304: Role of Vascular Endothelial Growth Factor C in promoting radioresistance of prostate cancer
Journal Articles

Aldehyde Dehydrogenase Is Regulated by β-Catenin/TCF and Promotes Radioresistance in Prostate Cancer Progenitor Cells

Monica Cojoc, Claudia Peitzsch, Ina Kurth, Franziska Trautmann, Leoni A. Kunz-Schughart, Gennady D. Telegeev, Eduard A. Stakhovsky, John R. Walker, Karl Simin, Stephen Lyle, Susanne Fuessel, Kati Erdmann, Manfred P. Wirth, Mechthild Krause, Michael Baumann, Anna Dubrovska
Journal: Cancer Research
Cancer Res (2015) 75 (7): 1482–1494.
https://doi.org/10.1158/0008-5472.CAN-14-1924
Published: 31 March 2015
View article titled, Aldehyde Dehydrogenase Is Regulated by β-Catenin/TCF and Promotes Radioresistance in Prostate Cancer Progenitor Cells
Open the PDF for Aldehyde Dehydrogenase Is Regulated by β-Catenin/TCF and Promotes Radioresistance in Prostate Cancer Progenitor Cells in another window
Includes: Supplementary data
Journal Articles

Abstract LB-209: Chromatin condensation in KRAS-mutant lung cancer as a therapeutic target: challenging the paradigm of associating KRAS mutation with EGFR inhibitor resistance

Meng Wang, Ashley M. Kern, Marieke Hülskötter, Patricia Greninger, Anurag Singh, Yunfeng Pan, Dipanjan Chowdhury, Mechthild Krause, Michael Baumann, Cyril H. Benes, Jason A. Efstathiou, Jeff Settleman, Henning Willers
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): LB-209.
https://doi.org/10.1158/1538-7445.AM2014-LB-209
Published: 01 October 2014
View article titled, Abstract LB-209: Chromatin condensation in KRAS-mutant lung cancer as a therapeutic target: challenging the paradigm of associating KRAS mutation with EGFR inhibitor resistance
Journal Articles

EGFR-Mediated Chromatin Condensation Protects KRAS-Mutant Cancer Cells against Ionizing Radiation

Meng Wang, Ashley M. Kern, Marieke Hülskötter, Patricia Greninger, Anurag Singh, Yunfeng Pan, Dipanjan Chowdhury, Mechthild Krause, Michael Baumann, Cyril H. Benes, Jason A. Efstathiou, Jeff Settleman, Henning Willers
Journal: Cancer Research
Cancer Res (2014) 74 (10): 2825–2834.
https://doi.org/10.1158/0008-5472.CAN-13-3157
Published: 14 May 2014
View article titled, EGFR-Mediated Chromatin Condensation Protects KRAS-Mutant Cancer Cells against Ionizing Radiation
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Includes: Supplementary data
Journal Articles

Cetuximab Attenuates Its Cytotoxic and Radiosensitizing Potential by Inducing Fibronectin Biosynthesis

Iris Eke, Katja Storch, Mechthild Krause, Nils Cordes
Journal: Cancer Research
Cancer Res (2013) 73 (19): 5869–5879.
https://doi.org/10.1158/0008-5472.CAN-13-0344
Published: 01 October 2013
View article titled, Cetuximab Attenuates Its Cytotoxic and Radiosensitizing Potential by Inducing Fibronectin Biosynthesis
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Includes: Supplementary data
Journal Articles

Abstract LB-211: beta1 integrin targeting results in radiosensitization by controlling DNA repair mechanisms and chromatin organization

Ellen Dickreuter, Katja Storch, Iris Eke, Mechthild Krause, Michael Baumann, Nils Cordes
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): LB-211.
https://doi.org/10.1158/1538-7445.AM2012-LB-211
Published: 15 April 2012
View article titled, Abstract LB-211: beta1 integrin targeting results in radiosensitization by controlling DNA repair mechanisms and chromatin organization
Journal Articles

EGF Receptor Inhibition Radiosensitizes NSCLC Cells by Inducing Senescence in Cells Sustaining DNA Double-Strand Breaks

Meng Wang, Fabian Morsbach, David Sander, Liliana Gheorghiu, Akash Nanda, Cyril Benes, Malte Kriegs, Mechthild Krause, Ekkehard Dikomey, Michael Baumann, Jochen Dahm-Daphi, Jeffrey Settleman, Henning Willers
Journal: Cancer Research
Cancer Res (2011) 71 (19): 6261–6269.
https://doi.org/10.1158/0008-5472.CAN-11-0213
Published: 29 September 2011
View article titled, EGF Receptor Inhibition Radiosensitizes NSCLC Cells by Inducing Senescence in Cells Sustaining DNA Double-Strand Breaks
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Includes: Supplementary data
Journal Articles

Three-Dimensional Cell Growth Confers Radioresistance by Chromatin Density Modification

Katja Storch, Iris Eke, Kerstin Borgmann, Mechthild Krause, Christian Richter, Kerstin Becker, Evelin Schröck, Nils Cordes
Journal: Cancer Research
Cancer Res (2010) 70 (10): 3925–3934.
https://doi.org/10.1158/0008-5472.CAN-09-3848
Published: 12 May 2010
View article titled, Three-Dimensional Cell Growth Confers Radioresistance by Chromatin Density Modification
Open the PDF for Three-Dimensional Cell Growth Confers Radioresistance by Chromatin Density Modification in another window
Includes: Supplementary data