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Maurizio Pellecchia
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Journal Articles

Abstract 3911: Targeting the EphA2-ligand binding domain for the design of innovative cancer therapeutics

Free
Parima Udompholkul, Luca Gambini, Ahmed F. Salem, Carlo Baggio, Maurizio Pellecchia
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3911.
https://doi.org/10.1158/1538-7445.AM2018-3911
Published: 01 July 2018
View articletitled, Abstract 3911: Targeting the EphA2-ligand binding domain for the design of innovative cancer therapeutics
Journal Articles

Abstract 3913: Selective targeting of circulating tumor cells with agonistic EphA2 ligand

Free
Ahmed F. Salem, Si Wang, Sandrine Billet, Jie-Fu Chen, Parima Udompholkul, Luca Gambini, Carlo Baggio, Edwin M. Posadas, Neil A. Bhowmick, Maurizio Pellecchia
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3913.
https://doi.org/10.1158/1538-7445.AM2018-3913
Published: 01 July 2018
View articletitled, Abstract 3913: Selective targeting of circulating tumor cells with agonistic EphA2 ligand
Journal Articles

SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex

Free
Yongmei Feng, Anthony B. Pinkerton, Laura Hulea, Tongwu Zhang, Michael A. Davies, Stefan Grotegut, Yann Cheli, Hongwei Yin, Eric Lau, Hyungsoo Kim, Surya K. De, Elisa Barile, Maurizio Pellecchia, Marcus Bosenberg, Jian-Liang Li, Brian James, Christian A. Hassig, Kevin M. Brown, Ivan Topisirovic, Ze'ev A. Ronai
Journal: Cancer Research
Cancer Res (2015) 75 (24): 5211–5218.
https://doi.org/10.1158/0008-5472.CAN-15-0885
Published: 14 December 2015
View articletitled, SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex
Open the PDF for SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex in another window
Includes: Supplementary data
Journal Articles

Pancreatic Cancer Combination Therapy Using a BH3 Mimetic and a Synthetic Tetracycline

Free
Bridget A. Quinn, Rupesh Dash, Siddik Sarkar, Belal Azab, Praveen Bhoopathi, Swadesh K. Das, Luni Emdad, Jun Wei, Maurizio Pellecchia, Devanand Sarkar, Paul B. Fisher
Journal: Cancer Research
Cancer Res (2015) 75 (11): 2305–2315.
https://doi.org/10.1158/0008-5472.CAN-14-3013
Published: 31 May 2015
View articletitled, Pancreatic Cancer Combination Therapy Using a BH3 Mimetic and a Synthetic Tetracycline
Open the PDF for Pancreatic Cancer Combination Therapy Using a BH3 Mimetic and a Synthetic Tetracycline in another window
Includes: Supplementary data
Journal Articles

PDK1 and SGK3 Contribute to the Growth of BRAF-Mutant Melanomas and Are Potential Therapeutic Targets

Free
Marzia Scortegagna, Eric Lau, Tongwu Zhang, Yongmei Feng, Chris Sereduk, Hongwei Yin, Surya K. De, Katrina Meeth, James T. Platt, Casey G. Langdon, Ruth Halaban, Maurizio Pellecchia, Michael A. Davies, Kevin Brown, David F. Stern, Marcus Bosenberg, Ze'ev A. Ronai
Journal: Cancer Research
Cancer Res (2015) 75 (7): 1399–1412.
https://doi.org/10.1158/0008-5472.CAN-14-2785
Published: 31 March 2015
View articletitled, PDK1 and SGK3 Contribute to the Growth of BRAF-Mutant Melanomas and Are Potential Therapeutic Targets
Open the PDF for PDK1 and SGK3 Contribute to the Growth of BRAF-Mutant Melanomas and Are Potential Therapeutic Targets in another window
Includes: Supplementary data
Journal Articles

Abstract 59: PDK1 in melanoma development and metastasis

Free
Marzia Scortegagna, Chelsea Ruller, Yongmei Feng, Rossitza Lazova, Harriet Kluger, Jian-Liang Li, Surya K. De, Robert Rickert, Maurizio Pellecchia, Marcus Bosenberg, Ze'ev Ronai
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 59.
https://doi.org/10.1158/1538-7445.AM2014-59
Published: 01 October 2014
View articletitled, Abstract 59: PDK1 in melanoma development and metastasis
Journal Articles

Abstract 4520: Inhibition of melanoma growth by small molecules that attenuate PI3K/PDK1 signaling and promote ATF2 mitochondrial localization

Free
Tal Varsano, Yongmei Feng, Giuseppina Claps, Marzia Scortegagna, Eric Lau, Marilyn Leonard, Anthony Pinkerton, Maurizio Pellecchia, Michael Davies, Marcus Bosenberg, Ze'ev Ronai
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4520.
https://doi.org/10.1158/1538-7445.AM2014-4520
Published: 01 October 2014
View articletitled, Abstract 4520: Inhibition of melanoma growth by small molecules that attenuate PI3K/PDK1 signaling and promote ATF2 mitochondrial localization
Journal Articles

Abstract B85: MDA-9/syntenin is a key regulator of glioma pathogenesis

Free
Timothy P. Kegelman, Swadesh K. Das, Bin Hu, Mitchell Menezes, Luni Emdad, Santanu Dasgupta, Albert S. Baldwin, Jr., Jeffery N. Bruce, Paul Dent, Maurizio Pellecchia, Devanand Sarkar, Paul B. Fisher
Journal: Cancer Research
Cancer Res (2013) 73 (3_Supplement): B85.
https://doi.org/10.1158/1538-7445.TIM2013-B85
Published: 01 May 2014
View articletitled, Abstract B85: MDA-9/syntenin is a key regulator of glioma pathogenesis
Journal Articles

Abstract 605: Apogossypolone derivative -BI97D6 effectively targets MCL1 overexpressing Acute Myeloid Leukemia cells.

Free
Rongqing Pan, Vivian Ruvolo, Maurizio Pellecchia, Jun Wei, Marina Konopleva, John C. Reed, Peter Ruvolo, Michael Andreeff
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 605.
https://doi.org/10.1158/1538-7445.AM2013-605
Published: 15 April 2013
View articletitled, Abstract 605: Apogossypolone derivative -BI97D6 effectively targets MCL1 overexpressing Acute Myeloid Leukemia cells.
Journal Articles

Abstract 217: BCR-ABL tyrosine kinase inhibition combined with a novel pan BCL2 family inhibitor abrogates leukemia stem cell survival in a niche-dependent manner.

Free
Wenxue Ma, Janine Low-Marchelli, Heather S. Leu, Angela Court Recart, Jun Wei, Xianshu Huang, Maryla Krajewska, Maurizio Pellecchia, John C. Reed, Catriona H.M. Jamieson
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 217.
https://doi.org/10.1158/1538-7445.AM2013-217
Published: 15 April 2013
View articletitled, Abstract 217: BCR-ABL tyrosine kinase inhibition combined with a novel pan BCL2 family inhibitor abrogates leukemia stem cell survival in a niche-dependent manner.
Journal Articles

Abstract 2618: MDA-9/syntenin is a key regulator of glioma pathogenesis.

Free
Timothy P. Kegelman, Swadesh K. Das, Bin Hu, Mitchell Menezes, Luni Emdad, Santanu Dasgupta, Albert S. Baldwin, Jeffrey N. Bruce, Paul Dent, Maurizio Pellecchia, Devanand Sarkar, Paul B. Fisher
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2618.
https://doi.org/10.1158/1538-7445.AM2013-2618
Published: 15 April 2013
View articletitled, Abstract 2618: MDA-9/syntenin is a key regulator of glioma pathogenesis.
Journal Articles

Abstract 3902: MDA-9/syntenin and IGFBP-2 promote angiogenesis in human melanoma.

Free
Swadesh K. Das, Timothy P. Kegelman, Prasanna K. Santhekadur, Santanu Dasgupta, Paul Dent, Steven Grant, Luni Emdad, Devanand Sarkar, Paul B. Fisher, Maurizio Pellecchia
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3902.
https://doi.org/10.1158/1538-7445.AM2013-3902
Published: 15 April 2013
View articletitled, Abstract 3902: MDA-9/syntenin and IGFBP-2 promote angiogenesis in human melanoma.
Journal Articles

MDA-9/Syntenin and IGFBP-2 Promote Angiogenesis in Human Melanoma

Free
Swadesh K. Das, Sujit K. Bhutia, Belal Azab, Timothy P. Kegelman, Leyla Peachy, Prasanna K. Santhekadur, Santanu Dasgupta, Rupesh Dash, Paul Dent, Steven Grant, Luni Emdad, Maurizio Pellecchia, Devanand Sarkar, Paul B. Fisher
Journal: Cancer Research
Cancer Res (2013) 73 (2): 844–854.
https://doi.org/10.1158/0008-5472.CAN-12-1681
Published: 16 January 2013
View articletitled, MDA-9/Syntenin and IGFBP-2 Promote Angiogenesis in Human Melanoma
Open the PDF for MDA-9/Syntenin and IGFBP-2 Promote Angiogenesis in Human Melanoma in another window
Includes: Supplementary data
Journal Articles

Raf Kinase Inhibitor RKIP Inhibits MDA-9/Syntenin-Mediated Metastasis in Melanoma

Free
Swadesh K. Das, Sujit K. Bhutia, Upneet K. Sokhi, Belal Azab, Zhao-zhong Su, Habib Boukerche, Talha Anwar, Erika L. Moen, Devasis Chatterjee, Maurizio Pellecchia, Devanand Sarkar, Paul B. Fisher
Journal: Cancer Research
Cancer Res (2012) 72 (23): 6217–6226.
https://doi.org/10.1158/0008-5472.CAN-12-0402
Published: 29 November 2012
View articletitled, Raf Kinase Inhibitor RKIP Inhibits MDA-9/Syntenin-Mediated Metastasis in Melanoma
Open the PDF for Raf Kinase Inhibitor RKIP Inhibits MDA-9/Syntenin-Mediated Metastasis in Melanoma in another window
Includes: Supplementary data
Journal Articles

Novel MT1-MMP Small-Molecule Inhibitors Based on Insights into Hemopexin Domain Function in Tumor Growth

Free
Albert G. Remacle, Vladislav S. Golubkov, Sergey A. Shiryaev, Russell Dahl, John L. Stebbins, Andrei V. Chernov, Anton V. Cheltsov, Maurizio Pellecchia, Alex Y. Strongin
Journal: Cancer Research
Cancer Res (2012) 72 (9): 2339–2349.
https://doi.org/10.1158/0008-5472.CAN-11-4149
Published: 30 April 2012
View articletitled, Novel MT1-MMP Small-Molecule Inhibitors Based on Insights into Hemopexin Domain Function in Tumor Growth
Open the PDF for Novel MT1-MMP Small-Molecule Inhibitors Based on Insights into Hemopexin Domain Function in Tumor Growth in another window
Includes: Supplementary data
Journal Articles

Abstract 2008: Broad spectrum BH3 mimetic BI-97D6 induces apoptosis of acute myeloid leukemia cells even when co-cultured with supporting stromal cells

Free
Rongqing Pan, Peter P. Ruvolo, Maurizio Pellecchia, Jun Wei, Yuexi Shi, Marina Konopleva, John C. Reed, Michael Andreeff
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2008.
https://doi.org/10.1158/1538-7445.AM2012-2008
Published: 15 April 2012
View articletitled, Abstract 2008: Broad spectrum BH3 mimetic BI-97D6 induces apoptosis of acute myeloid leukemia cells even when co-cultured with supporting stromal cells
Journal Articles

Abstract 61: A new serotype chimera Cancer Terminator Virus (Ad.5/3-CTV) expands the efficiency and specificity of prostate cancer gene transfer and therapy

Free
Belal Azab, Rupesh Dash, Swadesh Das, Sujit Bhutia, Xue-Ning Shen, Bridget Quinn, Santanu Dasgupta, Paul Dent, Igor Dmitriev, Xiang-Yang Wang, David Curiel, Steven Grant, Maurizio Pellecchia, John Reed, Devanand Sarkar, Paul Fisher
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 61.
https://doi.org/10.1158/1538-7445.AM2012-61
Published: 15 April 2012
View articletitled, Abstract 61: A new serotype chimera Cancer Terminator Virus (Ad.5/3-CTV) expands the efficiency and specificity of prostate cancer gene transfer and therapy
Journal Articles

Abstract 8: Identification of a non-canonical BH3 peptide that binds the BH3 pocket of Mcl-1

Free
William J. Placzek, Mattia Sturlese, Jun Wei, Bainan Wu, Jason Cellitti, Maurizio Pellecchia
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 8.
https://doi.org/10.1158/1538-7445.AM2011-8
Published: 15 April 2011
View articletitled, Abstract 8: Identification of a non-canonical BH3 peptide that binds the BH3 pocket of Mcl-1
Journal Articles

Abstract 3834: 3-ethynyl-1H-indazoles as inhibitors of PI3k signaling pathway

Free
Elisa Barile, Surya De, Coby B. Carlson, Vida Chen, Christine Knutzen, Megan Riel-Mehan, Russell Dahl, Gary Chiang, Maurizio Pellecchia
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3834.
https://doi.org/10.1158/1538-7445.AM2011-3834
Published: 15 April 2011
View articletitled, Abstract 3834: 3-ethynyl-1H-indazoles as inhibitors of PI3k signaling pathway
Journal Articles

Abstract 5: Synthesis and biological evaluation of 5, 5’ substituted apogossypol and apogossypolone derivatives as pan-active inhibitors of anti-apoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins

Free
Jun Wei, William J. Placzek, John L. Stebbins, John C. Reed, Maurizio Pellecchia, Paul B. Fisher, Rupesh Dash, Catriona Jamieson, Shinichi Kitada
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5.
https://doi.org/10.1158/1538-7445.AM2011-5
Published: 15 April 2011
View articletitled, Abstract 5: Synthesis and biological evaluation of 5, 5’ substituted apogossypol and apogossypolone derivatives as pan-active inhibitors of anti-apoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins