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Matthew M. Ames
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Journal Articles

Abstract PD7-06: A randomized phase II trial of tamoxifen versus Z-endoxifen HCL in postmenopausal women with metastatic estrogen receptor positive, HER2 negative breast cancer

Matthew P. Goetz, Vera J Suman, Joel M Reid, Mary Kuffel, Sarah A Buhrow, Renee M McGovern, John Black, Travis Dockter, William F Symmans, Minetta C Liu, John R Hawse, James Doroshow, Anna M Storniolo, Jerry M Collins, Howard Streicher, Matthew M Ames, James N Ingle, Ann Partridge, Lisa Carey
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): PD7-06.
https://doi.org/10.1158/1538-7445.SABCS19-PD7-06
Published: 15 February 2020
View article titled, Abstract PD7-06: A randomized phase II trial of tamoxifen versus Z-endoxifen HCL in postmenopausal women with metastatic estrogen receptor positive, HER2 negative breast cancer
Journal Articles

Abstract 4631: Pharmacokinetics and in vivo metabolism of Z-endoxifen: Results from two phase I studies in women with ER+ breast cancer, gynecologic malignancies and desmoids

Joel M. Reid, Matthew P. Goetz, Shivaani Kumar, Renee M. McGovern, Sarah A. Buhrow, Stephanie L. Safgren, Vera J. Suman, Travis J. Docktor, Charles Erlichman, Howard Streicher, James H. Doroshow, Jerry Collins, Matthew M. Ames
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4631.
https://doi.org/10.1158/1538-7445.AM2014-4631
Published: 01 October 2014
View article titled, Abstract 4631: Pharmacokinetics and in vivo metabolism of Z-endoxifen: Results from two phase I studies in women with ER+ breast cancer, gynecologic malignancies and desmoids
Journal Articles

Abstract 4557: LC/MS/MS assay and mouse pharmacokinetics of the phenylurea thiocarbamate NSC 161128.

Chad A. Walden, Joel M. Reid, Renee M. McGovern, Joseh M. Covey, Matthew M. Ames
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4557.
https://doi.org/10.1158/1538-7445.AM2013-4557
Published: 15 April 2013
View article titled, Abstract 4557: LC/MS/MS assay and mouse pharmacokinetics of the phenylurea thiocarbamate NSC 161128.
Journal Articles

Abstract 2462: Pharmacokinetics and in vivo metabolism of the naphthofuran NSC373981 in male nu/nu mice.

Joel M. Reid, Sarah A. Buhrow, Renee M. McGovern, Joseph M. Covey, Matthew M. Ames
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2462.
https://doi.org/10.1158/1538-7445.AM2013-2462
Published: 15 April 2013
View article titled, Abstract 2462: Pharmacokinetics and <em>in vivo</em> metabolism of the naphthofuran NSC373981 in male nu/nu mice.
Journal Articles

Abstract 3781: Pharmacokinetics of endoxifen and tamoxifen in female mice: Implications for comparative in vivo activity studies

Stephanie L. Safgren, Sarah A. Buhrow, Chad Walden, Mary J. Kuffel, Kathryn E. Reinicke, Joel M. Reid, Matthew P. Goetz, Matthew M. Ames
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3781.
https://doi.org/10.1158/1538-7445.AM2012-3781
Published: 15 April 2012
View article titled, Abstract 3781: Pharmacokinetics of endoxifen and tamoxifen in female mice: Implications for comparative <em>in vivo</em> activity studies
Journal Articles

Abstract 3769: Metabolic activation of batracylin and N-acetylbatracylin to reactive metabolites that bind protein and DNA: Possible role in toxicity

Sarah A. Buhrow, Mary Kuffel, Chad Walden, Joel M. Reid, Joseph Covey, Matthew M. Ames
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3769.
https://doi.org/10.1158/1538-7445.AM2012-3769
Published: 15 April 2012
View article titled, Abstract 3769: Metabolic activation of batracylin and N-acetylbatracylin to reactive metabolites that bind protein and DNA: Possible role in toxicity
Journal Articles

Abstract 4727: Breast cancer prevention and selective estrogen response modulators (SERMs): Pharmacogenomics and differential estrogen and SERM regulation of BRCA1 and BRCA2 expression

Mohan Liu, Liewei Wang, Daniel Schaid, D. Lawrence Wickerham, Joseph P. Costantino, Matthew P. Goetz, Matthew M. Ames, Victor G. Vogel, Soonmyung Paik, Anthony Batzler, Norman Wolmark, Yusuke Nakamura, Michiaki Kubo, Naoyuki Kamatani, James N. Ingle, Richard M. Weinshilboum
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4727.
https://doi.org/10.1158/1538-7445.AM2011-4727
Published: 15 April 2011
View article titled, Abstract 4727: Breast cancer prevention and selective estrogen response modulators (SERMs): Pharmacogenomics and differential estrogen and SERM regulation of BRCA1 and BRCA2 expression
Journal Articles

Abstract 1301: Investigation of a potential pharmacokinetic interaction between ABT-888 and topotecan in a phase I trial

Olumide Kayode, Joel M. Reid, Danel V. Satele, Hui Tang, Paul Haluska, Prema P. Peethambaram, Matthew M. Ames, Alice Chen, Scott H. Kaufmann, Donald W. Northfelt, Charles Erlichman, Michael E. Menefee
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1301.
https://doi.org/10.1158/1538-7445.AM2011-1301
Published: 15 April 2011
View article titled, Abstract 1301: Investigation of a potential pharmacokinetic interaction between ABT-888 and topotecan in a phase I trial
Journal Articles

Abstract 1303: Characterization of the metabolite profile for batracylin and N-acetylbatracylin in rat and human models of invitro and in vivo metabolism: Elucidation of pathways that might contribute to batracylin toxicity

Matthew M. Ames, Joel M. Reid, Sarah A. Buhrow, Mary J. Kuffel, Chad A. Walden, Joseph M. Covey, Holger P. Behrsing, Myrtle Davis Millin
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1303.
https://doi.org/10.1158/1538-7445.AM2011-1303
Published: 15 April 2011
View article titled, Abstract 1303: Characterization of the metabolite profile for batracylin and N-acetylbatracylin in rat and human models of invitro and in vivo metabolism: Elucidation of pathways that might contribute to batracylin toxicity
Journal Articles

Abstract 2283: Endoxifen exhibits potent in vitro and in vivo antitumor activity in ER+/HER2+ breast cancer and tamoxifen refractory tumors

Kathryn E. Reinicke, Xiaonan Hou, Matthew P. Goetz, Vera J. Suman, Mary J. Kuffel, Paul Haluska, Joel M. Reid, Matthew M. Ames
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2283.
https://doi.org/10.1158/1538-7445.AM2011-2283
Published: 15 April 2011
View article titled, Abstract 2283: Endoxifen exhibits potent <em>in vitro</em> and <em>in vivo</em> antitumor activity in ER+/HER2+ breast cancer and tamoxifen refractory tumors
Journal Articles

Abstract 2607: Endoxifen pharmacokinetics and bioavailability of in female rats and dogs

Joel M. Reid, Sarah A. Buhrow, Stephanie L. Safgren, Lee Jia, Karen Schweikart, Patricia E. Noker, Myrtle Davis, Jerry M. Collins, Matthew P. Goetz, Matthew M. Ames
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2607.
https://doi.org/10.1158/1538-7445.AM10-2607
Published: 15 April 2010
View article titled, Abstract 2607: Endoxifen pharmacokinetics and bioavailability of in female rats and dogs
Journal Articles

Abstract 2662: Pharmacokinetics, metabolism and tissue distribution of the nitric oxide-donating prodrug JS-K following administration in liposomes

Sarah A. Buhrow, Joel M. Reid, Chad A. Walden, Lee Jia, Myrtle Davis, Larry K. Keefer, Heba Barazi, Matthew M. Ames
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2662.
https://doi.org/10.1158/1538-7445.AM10-2662
Published: 15 April 2010
View article titled, Abstract 2662: Pharmacokinetics, metabolism and tissue distribution of the nitric oxide-donating prodrug JS-K following administration in liposomes
Journal Articles

Abstract 4549: Plasma pharmacokinetics and oral bioavailability of the 3,4,5,6-tetrahydrouridine (THU) prodrug, triacetyl-THU (taTHU), in mice

Jan H. Beumer, Julie L. Eiseman, Judith A. Gilbert, Julianne L. Holleran, Archibong E. Yellow-Duke, Dana M. Clausen, David Z. D'Argenio, Matthew M. Ames, Pamela A. Hershberger, Robert A. Parise, Lihua Bai, Joseph M. Covey, Merrill J. Egorin
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4549.
https://doi.org/10.1158/1538-7445.AM10-4549
Published: 15 April 2010
View article titled, Abstract 4549: Plasma pharmacokinetics and oral bioavailability of the 3,4,5,6-tetrahydrouridine (THU) prodrug, triacetyl-THU (taTHU), in mice
Journal Articles

Abstract 3603: Endoxifen pharmacokinetics and bioavailability in female mice

Matthew M. Ames, Joel M. Reid, Sarah A. Buhrow, Chad A. Walden, Stephanie L. Safgren, Matthew P. Goetz
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3603.
https://doi.org/10.1158/1538-7445.AM10-3603
Published: 15 April 2010
View article titled, Abstract 3603: Endoxifen pharmacokinetics and bioavailability in female mice
Journal Articles

Targeted Delivery of Gemcitabine to Pancreatic Adenocarcinoma Using Cetuximab as a Targeting Agent

Chitta Ranjan Patra, Resham Bhattacharya, Enfeng Wang, Aaron Katarya, Julie S. Lau, Shamit Dutta, Michael Muders, Shanfeng Wang, Sarah A. Buhrow, Stephanie L. Safgren, Michael J. Yaszemski, Joel M. Reid, Matthew M. Ames, Priyabrata Mukherjee, Debabrata Mukhopadhyay
Journal: Cancer Research
Cancer Res (2008) 68 (6): 1970–1978.
https://doi.org/10.1158/0008-5472.CAN-07-6102
Published: 13 March 2008
View article titled, Targeted Delivery of Gemcitabine to Pancreatic Adenocarcinoma Using Cetuximab as a Targeting Agent
Open the PDF for Targeted Delivery of Gemcitabine to Pancreatic Adenocarcinoma Using Cetuximab as a Targeting Agent in another window
Includes: Supplementary data
Journal Articles

Identification and Characterization of Genetic Variation in the Folylpolyglutamate Synthase Gene

Tarek A. Leil, Chiaki Endo, Araba A. Adjei, Grace K. Dy, Oreste E. Salavaggione, Joel R. Reid, Matthew M. Ames, Alex A. Adjei
Journal: Cancer Research
Cancer Res (2007) 67 (18): 8772–8782.
https://doi.org/10.1158/0008-5472.CAN-07-0156
Published: 17 September 2007
View article titled, Identification and Characterization of Genetic Variation in the Folylpolyglutamate Synthase Gene
Open the PDF for Identification and Characterization of Genetic Variation in the Folylpolyglutamate Synthase Gene in another window
Includes: Supplementary data
Journal Articles

A limited sample model for 17-(Allylamino)-17-demethoxygeldanamycin and its active metabolite 17-(amino)-17-demethoxygeldanomycin

Alfred F. Furth, Sumithra J. Mandrekar, Andrea Rau, Joel M. Reid, Angelina Tan, Sara J. Felten, Charles Erlichman, Matthew M. Ames, Alex A. Adjei
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 737.
Published: 15 April 2006
View article titled, A limited sample model for 17-(Allylamino)-17-demethoxygeldanamycin and its active metabolite 17-(amino)-17-demethoxygeldanomycin
Journal Articles

Tissue distribution of viral gene expression after intravenous administration of an oncolytic measles virus encoding the sodium-iodide symporter (MV-NIS) in transgenic IfnarKO x CD46 Ge mice

Mary J. Kuffel, Sarah A. Buhrow, Rae M. Myers, Susan M. Greiner, Mary E. Harvey, Joel M. Reid, Kah-Whye Peng, Mark J. Federspiel, Lee Jia, Stephen J. Russell, Matthew M. Ames
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 494.
Published: 15 April 2006
View article titled, Tissue distribution of viral gene expression after intravenous administration of an oncolytic measles virus encoding the sodium-iodide symporter (MV-NIS) in transgenic Ifnar<sup>KO</sup> x CD46 Ge mice
Journal Articles

Gastrointestinal neuroendocrine tumors lack epidermal growth factor receptor mutations predictive of gefitinib response

Judith A. Gilbert, Stephanie L. Safgren, Ricardo V. Lloyd, Matthew M. Ames
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 974.
Published: 01 May 2005
View article titled, Gastrointestinal neuroendocrine tumors lack epidermal growth factor receptor mutations predictive of gefitinib response
Journal Articles

Relationships between irinotecan pharmacokinetics and UGT1A1 and MDR1 polymorphisms in a Phase I trial of irinotecan and erlotinib

Joel M. Reid, Matthew P. Goetz, Ravi D. Rao, Stephanie L. Safgren, Renee M. McGovern, Alfred F. Furth, Sara J. Felten, Sumithra J. Mandrekar, Alex A. Adjei, Charles Erlichman, Henry C. Pitot, Matthew M. Ames
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 975.
Published: 01 May 2005
View article titled, Relationships between irinotecan pharmacokinetics and UGT1A1 and MDR1 polymorphisms in a Phase I trial of irinotecan and erlotinib