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Matthew G. Vander Heiden
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Journal Articles

Abstract 4154: Cancer cells exhibit novel metabolic vulnerabilities when exposed to low lipid environments

Free
Diya L. Ramesh, Keene L. Abbott, Raphael Ferreira, Matthew G. Vander Heiden
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4154.
https://doi.org/10.1158/1538-7445.AM2025-4154
Published: 21 April 2025
View articletitled, Abstract 4154: Cancer cells exhibit novel metabolic vulnerabilities when exposed to low lipid environments
Journal Articles

Abstract 4174: Regulation of metabolic programming in esophageal cancer by transcription factor p63

Free
Niamh McNamee, Keene Abbott, Aya Tal-Mason, Matthew G. Vander Heiden, Uma M. Sachdeva
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4174.
https://doi.org/10.1158/1538-7445.AM2025-4174
Published: 21 April 2025
View articletitled, Abstract 4174: Regulation of metabolic programming in esophageal cancer by transcription factor p63
Journal Articles

Abstract 4136: The causes and consequences of off-target activation of the GCN2-eIF2a-ATF4 axis in cancer therapy

Free
C. Ryland, Ill, Nasreen Marikar, Vu Nguyen, Varuna Nangia, Alicia Darnell, Stacey Bagby, Kasey Couts, Matthew G. Vander Heiden, Philip Reigan, Sabrina L. Spencer
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4136.
https://doi.org/10.1158/1538-7445.AM2025-4136
Published: 21 April 2025
View articletitled, Abstract 4136: The causes and consequences of off-target activation of the GCN2-eIF2a-ATF4 axis in cancer therapy
Journal Articles

Abstract 3800: Physiological nutrient levels reveal nucleotide salvage as a dependency in B-cell acute lymphoblastic leukemia

Free
Ryan Elbashir, Keene L. Abbott, Ahmed Ali, Diya L. Ramesh, Michelle Wu, Brian T. Do, Anya Shevzov-Zebrun, Tenzin Kunchok, Millenia Waite, Wontaek Chung, Chelsea Zhang, Sharanya Sivanand, Azucena Ramos, Jacob A. Hansen, Raphael Ferreira, Alexander Muir, Michael H. Hemann, Matthew G. Vander Heiden
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3800.
https://doi.org/10.1158/1538-7445.AM2025-3800
Published: 21 April 2025
View articletitled, Abstract 3800: Physiological nutrient levels reveal nucleotide salvage as a dependency in B-cell acute lymphoblastic leukemia
Journal Articles

Abstract LB405: CTP synthase 1 is a synthetic vulnerability in prostate cancer treated with supraphysiological androgen

Free
Sheila Jonnatan, Rajendra Kumar, Varsha Vakkala, Karthik Vasan, Zachary R. Chalmers, Daniel R. Schmidt, Philip A. Beer, Matthew G. Vander Heiden, Samuel R. Denmeade, Navdeep S. Chandel, Laura A. Sena
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB405.
https://doi.org/10.1158/1538-7445.AM2024-LB405
Published: 05 April 2024
View articletitled, Abstract LB405: CTP synthase 1 is a synthetic vulnerability in prostate cancer treated with supraphysiological androgen
Journal Articles

Abstract 734: Inhibition of equilibrative nucleoside transporter 1 relieves intracellular adenosine-mediated immune suppression

Free
Theodore J. Sanders, Christopher S. Nabel, Margreet Brouwer, Annelise L. Hermant, Lucas Chaible, Jean-Philippe Deglasse, Angelique Pabois, Wilfried Cathou, Aurore Smets, Michael Deligny, Joao Marchante, Quentin Dubray, Marie-Claire Lettelier, Chiara Martinoli, Reece Marillier, Olivier De Henau, Yvonne McGrath, Matthew G. Vander Heiden, Erica Houthuys
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 734.
https://doi.org/10.1158/1538-7445.AM2024-734
Published: 22 March 2024
View articletitled, Abstract 734: Inhibition of equilibrative nucleoside transporter 1 relieves intracellular adenosine-mediated immune suppression
Journal Articles

Abstract 402: Aneuploidy-associated SQLE gain promotes prostate cancer aggressiveness by altering lipid metabolism

Free
Thomas Walter Janas, Xiaofeng A. Su, Konrad H. Stopsack, Daniel R. Schmidt, Duanduan Ma, Zhe Li, Kathryn L. Penny, Tamara L. Lotan, Lorelei A. Mucci, Matthew G. Vander Heiden, Elise DeArment, Angelika Amon, Paul A. Scheet
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 402.
https://doi.org/10.1158/1538-7445.AM2024-402
Published: 22 March 2024
View articletitled, Abstract 402: Aneuploidy-associated SQLE gain promotes prostate cancer aggressiveness by altering lipid metabolism
Journal Articles

Abstract A018: Increased RAD21 promotes prostate cancer development

Free
Xiaofeng A. Su, Konrad H. Stopsack, Daniel R. Schmidt, Duanduan Ma, Zhe Li, Matthew G. Vander Heiden, Angelika Amon, Lorelei A. Mucci
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): A018.
https://doi.org/10.1158/1538-7445.PRCA2023-A018
Published: 02 June 2023
View articletitled, Abstract A018: Increased RAD21 promotes prostate cancer development
Journal Articles

Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma

Open Access
Shawn M. Davidson, Daniel R. Schmidt, Julia E. Heyman, James P. O'Brien, Amy C. Liu, William J. Israelsen, Talya L. Dayton, Raghav Sehgal, Roderick T. Bronson, Elizaveta Freinkman, Howard H. Mak, Giuseppe Nicolò Fanelli, Scott Malstrom, Gary Bellinger, Arkaitz Carracedo, Pier Paolo Pandolfi, Kevin D. Courtney, Abhishek Jha, Ronald A. DePinho, James W. Horner, Craig J. Thomas, Lewis C. Cantley, Massimo Loda, Matthew G. Vander Heiden
Journal: Cancer Research
Cancer Res (2022) 82 (13): 2403–2416.
https://doi.org/10.1158/0008-5472.CAN-21-2352
Published: 05 July 2022
View articletitled, Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma
Open the PDF for Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Patient-Derived Xenografts to Study Cancer Metabolism: When Does X Mark the Spot?

Available to Purchase
Christopher S. Nabel, Matthew G. Vander Heiden
Journal: Cancer Research
Cancer Res (2021) 81 (17): 4399–4401.
https://doi.org/10.1158/0008-5472.CAN-21-0770
Published: 01 September 2021
View articletitled, Patient-Derived Xenografts to Study Cancer Metabolism: When Does X Mark the Spot?
Open the PDF for Patient-Derived Xenografts to Study Cancer Metabolism: When Does X Mark the Spot? in another window
Journal Articles

Abstract NG10: A metastasis map of human cancer cell lines

Free
Xin Jin, Zelalem Demere, Karthik Nair, Ahmed Ali, Gino B. Ferraro, Ted Natoli, Amy Deik, Lia Petronio, Andrew A. Tang, Cong Zhu, Li Wang, Danny Rosenberg, Vamsi Mangena, Jennifer Roth, Kwanghun Chung, Rakesh K. Jain, Clary B. Clish, Matthew G. Vander Heiden, Todd R. Golub
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): NG10.
https://doi.org/10.1158/1538-7445.AM2021-NG10
Published: 01 July 2021
View articletitled, Abstract NG10: A metastasis map of human cancer cell lines
Journal Articles

Abstract 90: Fatty acid synthesis is required for breast cancer brain metastasis

Free
Gino B. Ferraro, Ahmed Ali, Alba Luengo, David P. Kodack, Amy Deik, Keene L. Abbott, Divya Bezwada, Landry Blanc, Brendan Prideaux, Xin Jin, Jessica M. Possada, Jiang Chen, Christopher R. Chin, Zohreh Amoozgar, Raphael Ferreira, Ivy Chen, Kamila Naxerova, Christopher Ng, Anna M. Westermark, Mark Duquette, Sylvie Roberge, Costas A. Lyssiotis, Dan G. Duda, Todd R. Golub, Shawn M. Davidson, Dai Fukumura, Véronique A. Dartois, Clary B. Clish, Matthew G. Vander Heiden, Rakesh K. Jain
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 90.
https://doi.org/10.1158/1538-7445.AM2021-90
Published: 01 July 2021
View articletitled, Abstract 90: Fatty acid synthesis is required for breast cancer brain metastasis
Journal Articles

Abstract PO-031: MetMap: A map of metastatic potential of human cancer cell lines

Free
Xin Jin, Zelalem Demere, Karthik Nair, Ahmed Ali, Gino B. Ferraro, Ted Natoli, Amy Deik, Lia Petronio, Andrew A. Tang, Cong Zhu, Li Wang, Danny Rosenberg, Vamsi Mangena, Jennifer Roth, Kwanghun Chung, Rakesh K. Jain, Clary B. Clish, Matthew G. Vander Heiden, Todd R. Golub
Journal: Cancer Research
Cancer Res (2020) 80 (23_Supplement): PO-031.
https://doi.org/10.1158/1538-7445.EPIMETAB20-PO-031
Published: 02 December 2020
View articletitled, Abstract PO-031: MetMap: A map of metastatic potential of human cancer cell lines
Journal Articles

Abstract 5712: Nutrient scarcity confers breast cancer brain metastasis sensitivity to serine synthesis pathway inhibition

Free
Bryan Ngo, Eugenie Kim, Sophia Doll, Sophia Bustraan, Alba Luengo, Shawn M. Davidson, Ahmed Ali, Gino Ferraro, Diane Kang, Jing Ni, Roger Liang, Ariana Plasger, Edward R. Kastenhuber, Roozbeh Eskandari, Sarah Bacha, Roshan Sriram, Benjamin D. Stein, Samuel F. Bakhoum, Edouard Mullarky, Matija Snuderl, Nello Mainolfi, Vipin Suri, Adam Friedman, Mark Manfredi, David M. Sabatini, Drew Jones, Min Yu, Jean J. Zhao, Rakesh K. Jain, Matthew G. Vander Heiden, Matthias Mann, Lewis C. Cantley, Michael E. Pacold
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5712.
https://doi.org/10.1158/1538-7445.AM2020-5712
Published: 15 August 2020
View articletitled, Abstract 5712: Nutrient scarcity confers breast cancer brain metastasis sensitivity to serine synthesis pathway inhibition
Journal Articles

Abstract 5989: Metabolic heterogeneity of the tumor microenvironment

Free
Bradley I. Reinfeld, Matthew Z. Madden, Ahmed Ali, Melissa M. Wolf, Kirsten L. Young, Racheal Hongo, Kathryn E. Beckermann, Matthew G. Vander Heiden, Alex Muir, Jeffrey C. Rathmell, W. Kimryn Rathmell
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5989.
https://doi.org/10.1158/1538-7445.AM2020-5989
Published: 15 August 2020
View articletitled, Abstract 5989: Metabolic heterogeneity of the tumor microenvironment
Journal Articles

Abstract B06: The angiotensin receptor blocker and partial PPARγ agonist telmisartan inhibits the growth of pancreatic ductal adenocarcinoma

Free
Jelena Grahovac, Shiwei Han, Hao Liu, Mark Duquette, Alba Luengo, Daniel Schanne, Andrew S. Liss, Matthew G. Vander Heiden, Rakesh K. Jain, Yves Boucher
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): B06.
https://doi.org/10.1158/1538-7445.PANCA19-B06
Published: 13 December 2019
View articletitled, Abstract B06: The angiotensin receptor blocker and partial PPARγ agonist telmisartan inhibits the growth of pancreatic ductal adenocarcinoma
Journal Articles

Abstract I21: Understanding metabolic limitations in pancreatic cancer

Free
Matthew G. Vander Heiden
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): I21.
https://doi.org/10.1158/1538-7445.PANCA19-I21
Published: 13 December 2019
View articletitled, Abstract I21: Understanding metabolic limitations in pancreatic cancer
Journal Articles

Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance

Free
Simona Dalin, Mark R. Sullivan, Allison N. Lau, Beatrice Grauman-Boss, Helen S. Mueller, Emanuel Kreidl, Silvia Fenoglio, Alba Luengo, Jacqueline A. Lees, Matthew G. Vander Heiden, Douglas A. Lauffenburger, Michael T. Hemann
Journal: Cancer Research
Cancer Res (2019) 79 (22): 5723–5733.
https://doi.org/10.1158/0008-5472.CAN-19-0960
Published: 15 November 2019
View articletitled, Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance
Open the PDF for Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance in another window
Includes: Supplementary data
Journal Articles

Abstract A43: Loss of Keap1 promotes KRAS-driven lung cancer and results in genotype-specific vulnerabilities

Free
Rodrigo Romero, Volkan I. Sayin, Davidson M. Shawn, Matthew Bauer, Simranjit X. Singh, Sarah LeBoeuf, Triantafyllia R. Karakousi, Donald C. Ellis, Arjun Bhutkar, Francisco Sanchez-Rivera, Lakshmipriya Subbaraj, Britney Martinez, Roderick T. Bronson, Justin R. Prigge, Edward E. Schmidt, Craig J. Thomas, Angela Davies, Igor Dolgalev, Adriana Heguy, Viola Allaj, John T. Piorier, Andre L. Moreira, Charles M. Rudin, Harvey I. Pass, Matthew G. Vander Heiden, Tyler Jacks, Thales Papagiannakopoulos
Journal: Cancer Research
Cancer Res (2018) 78 (10_Supplement): A43.
https://doi.org/10.1158/1538-7445.MOUSEMODELS17-A43
Published: 14 May 2018
View articletitled, Abstract A43: Loss of Keap1 promotes KRAS-driven lung cancer and results in genotype-specific vulnerabilities
Journal Articles

Pyruvate Kinase Inhibits Proliferation during Postnatal Cerebellar Neurogenesis and Suppresses Medulloblastoma Formation

Free
Katherine Tech, Andrey P. Tikunov, Hamza Farooq, A. Sorana Morrissy, Jessica Meidinger, Taylor Fish, Sarah C. Green, Hedi Liu, Yisu Li, Andrew J. Mungall, Richard A. Moore, Yussanne Ma, Steven J.M. Jones, Marco A. Marra, Matthew G. Vander Heiden, Michael D. Taylor, Jeffrey M. Macdonald, Timothy R. Gershon
Journal: Cancer Research
Cancer Res (2017) 77 (12): 3217–3230.
https://doi.org/10.1158/0008-5472.CAN-16-3304
Published: 14 June 2017
View articletitled, Pyruvate Kinase Inhibits Proliferation during Postnatal Cerebellar Neurogenesis and Suppresses Medulloblastoma Formation
Open the PDF for Pyruvate Kinase Inhibits Proliferation during Postnatal Cerebellar Neurogenesis and Suppresses Medulloblastoma Formation in another window
Includes: Supplementary data