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Mathew J. Garnett
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Journal Articles

Abstract 5321: Large scale pan cancer drug combination screening to identify effective and actionable combinations and biomarker hypothesis

Azadeh Bashi, Elizabeth A. Coker, Krishna Bulusu, Marta Milo, Claire Crafter, James Lynch, David Jenkins, Howard Lightfoot, Brandon Willis, Courtney Andersen, Omid Tavana, Kevin Mongeon, Jacob Gordon, Paul Smith, Simon Barry, Ultan McDermott, Lisa Drew, Susan Critchlow, Mathew J. Garnett, Jerome Mettetal
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5321.
https://doi.org/10.1158/1538-7445.AM2023-5321
Published: 04 April 2023
View article titled, Abstract 5321: Large scale pan cancer drug combination screening to identify effective and actionable combinations and biomarker hypothesis
Journal Articles

MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia

Kumar Sanjiv, José Manuel Calderón-Montaño, Therese M. Pham, Tom Erkers, Viktoriia Tsuber, Ingrid Almlöf, Andreas Höglund, Yaser Heshmati, Brinton Seashore-Ludlow, Akhilesh Nagesh Danda, Helge Gad, Elisee Wiita, Camilla Göktürk, Azita Rasti, Stefanie Friedrich, Anders Centio, Montserrat Estruch, Thea Kristin Våtsveen, Nona Struyf, Torkild Visnes, Martin Scobie, Tobias Koolmeister, Martin Henriksson, Olov Wallner, Teresa Sandvall, Sören Lehmann, Kim Theilgaard-Mönch, Mathew J. Garnett, Päivi Östling, Julian Walfridsson, Thomas Helleday, Ulrika Warpman Berglund
Journal: Cancer Research
Cancer Res (2021) 81 (22): 5733–5744.
https://doi.org/10.1158/0008-5472.CAN-21-0061
Published: 15 November 2021
View article titled, MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia
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Includes: Supplementary data
Journal Articles

Abstract 393: Predictive biomarker evaluation and molecular differentiation for imipridones ONC201 and ONC206

Sara Morrow, Kirti Nath, Yiqun Zhang, Mathew J. Garnett, Ultan McDermott, Cyril H. Benes, Joel Basken, Wafik S. El-Deiry, Joshua E. Allen, Varun V. Prabhu
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 393.
https://doi.org/10.1158/1538-7445.AM2021-393
Published: 01 July 2021
View article titled, Abstract 393: Predictive biomarker evaluation and molecular differentiation for imipridones ONC201 and ONC206
Journal Articles

Abstract 2749: Defining structure activity relationships for GPCR engagement and anti-cancer efficacy of imipridone small molecules

Varun V. Prabhu, Abed Rahman Kawakibi, Neel S. Madhukar, Lakshmi Anantharaman, Sean Deacon, Neil S. Charter, Mathew J. Garnett, Ultan McDermott, Cyril H. Benes, Wolfgang Oster, Olivier Elemento, Martin Stogniew, Joshua E. Allen
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2749.
https://doi.org/10.1158/1538-7445.AM2019-2749
Published: 01 July 2019
View article titled, Abstract 2749: Defining structure activity relationships for GPCR engagement and anti-cancer efficacy of imipridone small molecules
Journal Articles

Abstract 3877: IND-enabling characterization of DRD2/3 imipridone antagonist ONC206 for oncology

Varun V. Prabhu, Abed Rahman Kawakibi, Neel Madhukar, Mathew J. Garnett, Ultan McDermott, Cyril H. Benes, Lakshmi Anantharaman, Neil Charter, Sean Deacon, Alexander VanEngelenburg, Joseph B. Rucker, Benjamin J. Doranz, Jessica Rusert, Robert Wechsler-Reya, Olivier Elemento, Martin Stogniew, Wolfgang Oster, Sharon DeMorrow, R. Benjamin Free, David R. Sibley, Joshua E. Allen
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3877.
https://doi.org/10.1158/1538-7445.AM2019-3877
Published: 01 July 2019
View article titled, Abstract 3877: IND-enabling characterization of DRD2/3 imipridone antagonist ONC206 for oncology
Journal Articles

Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer

Mathieu Unbekandt, Simone Belshaw, Justin Bower, Maeve Clarke, Jacqueline Cordes, Diane Crighton, Daniel R. Croft, Martin J. Drysdale, Mathew J. Garnett, Kathryn Gill, Christopher Gray, David A. Greenhalgh, James A.M. Hall, Jennifer Konczal, Sergio Lilla, Duncan McArthur, Patricia McConnell, Laura McDonald, Lynn McGarry, Heather McKinnon, Carol McMenemy, Mokdad Mezna, Nicolas A. Morrice, June Munro, Gregory Naylor, Nicola Rath, Alexander W. Schüttelkopf, Mairi Sime, Michael F. Olson
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (8): 2096–2114.
https://doi.org/10.1158/0008-5472.CAN-17-2870
Published: 12 April 2018
View article titled, Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer
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Includes: Supplementary data
Journal Articles

Transcription Factor Activities Enhance Markers of Drug Sensitivity in Cancer

Luz Garcia-Alonso, Francesco Iorio, Angela Matchan, Nuno Fonseca, Patricia Jaaks, Gareth Peat, Miguel Pignatelli, Fiammetta Falcone, Cyril H. Benes, Ian Dunham, Graham Bignell, Simon S. McDade, Mathew J. Garnett, Julio Saez-Rodriguez
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (3): 769–780.
https://doi.org/10.1158/0008-5472.CAN-17-1679
Published: 31 January 2018
View article titled, Transcription Factor Activities Enhance Markers of Drug Sensitivity in Cancer
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Includes: Supplementary data
Journal Articles

Drug Resistance Mechanisms in Colorectal Cancer Dissected with Cell Type–Specific Dynamic Logic Models

Federica Eduati, Victoria Doldàn-Martelli, Bertram Klinger, Thomas Cokelaer, Anja Sieber, Fiona Kogera, Mathurin Dorel, Mathew J. Garnett, Nils Blüthgen, Julio Saez-Rodriguez
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (12): 3364–3375.
https://doi.org/10.1158/0008-5472.CAN-17-0078
Published: 14 June 2017
View article titled, Drug Resistance Mechanisms in Colorectal Cancer Dissected with Cell Type–Specific Dynamic Logic Models
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Includes: Supplementary data
Journal Articles

Abstract LB-209: D2-like dopamine receptor antagonism by ONC201 identified by confluence of computational, receptor binding, and clinical studies

Neel S. Madhukar, Olivier Elemento, Cyril H. Benes, Mathew J. Garnett, Mark Stein, Joseph R. Bertino, Howard L. Kaufman, Isabel Arrillaga-Romany, Tracy T. Batchelor, Lee Schalop, Wolfgang Oster, Martin Stogniew, Michael Andreeff, Wafik S. El-Deiry, Joshua E. Allen
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-209.
https://doi.org/10.1158/1538-7445.AM2016-LB-209
Published: 15 July 2016
View article titled, Abstract LB-209: D2-like dopamine receptor antagonism by ONC201 identified by confluence of computational, receptor binding, and clinical studies
Journal Articles

Abstract LB-212: Mcl-1 and FBW7 control a dominant survival pathway underlying HDAC and Bcl-2 inhibitor synergy in squamous cell carcinoma.

Lei He, Kristine Torres-Lockhart, Nicole Forster, Saranya Ramakrishnan, Patricia Greninger, Mathew J. Garnett, Ultan McDermott, S. Michael Rothenberg, Cyril Benes, Leif Ellisen
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): LB-212.
https://doi.org/10.1158/1538-7445.AM2013-LB-212
Published: 15 April 2013
View article titled, Abstract LB-212: Mcl-1 and FBW7 control a dominant survival pathway underlying HDAC and Bcl-2 inhibitor synergy in squamous cell carcinoma.
Journal Articles

ETV6-NTRK3 Gene Fusions and Trisomy 11 Establish a Histogenetic Link between Mesoblastic Nephroma and Congenital Fibrosarcoma

Stevan R. Knezevich, Mathew J. Garnett, Theodore J. Pysher, J. Bruce Beckwith, Paul E. Grundy, Poul H. B. Sorensen
Journal: Cancer Research
Cancer Res (1998) 58 (22): 5046–5048.
Published: 01 November 1998
View article titled, <em>ETV6-NTRK3</em> Gene Fusions and Trisomy 11 Establish a Histogenetic Link between Mesoblastic Nephroma and Congenital Fibrosarcoma
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