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Journal Articles

Abstract 2584: In situ hybridization-based validation of transcriptionally-defined stromal clusters in the prostate cancer microenvironment

Free
Filippo Pederzoli, Hubert Pakula, Wikum Dinalankara, Jeanne Jiang, Mohamed Omar, Silvia Rodrigues, Pier Vitale Nuzzo, Fabio Socciarelli, Giuseppe Nicolò Fanelli, Luigi Marchionni, Massimo Loda
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2584.
https://doi.org/10.1158/1538-7445.AM2025-2584
Published: 21 April 2025
View articletitled, Abstract 2584: In situ hybridization-based validation of transcriptionally-defined stromal clusters in the prostate cancer microenvironment
Journal Articles

Abstract 3110: A clinically actionable lipid metabolic approach in potentiating the response to anti-androgen therapy in a castration resistant prostate cancer model

Free
Cynthia Sprenger, Silvia Rodrigues, Ali Talebi, Kathryn Soriano Epilepsia, Shihua Sun, Caroline Fidalgo Ribeiro, Fabio Socciarelli, Jonas Dehairs, Lisa Butler, Johannes V. Swinnen, Massimo Loda, Stephen Plymate
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3110.
https://doi.org/10.1158/1538-7445.AM2025-3110
Published: 21 April 2025
View articletitled, Abstract 3110: A clinically actionable lipid metabolic approach in potentiating the response to anti-androgen therapy in a castration resistant prostate cancer model
Journal Articles

Abstract 4152: Disrupting lipid elongation impairs prostate cancer progression in c-MYC driven mouse models

Free
Silvia D. Rodrigues, Isadora F. Teixeira, Giuseppe N. Fanelli, Caroline F. Ribeiro, Fabio Socciarelli, Jeanne Jiang, Debora C. Bastos, Hubert Pakula, Filippo Pederzoli, Pier V. Nuzzo, Alessandro Barberis, Lisa M. Butler, Johannes V. Swinnen, Massimo Loda
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4152.
https://doi.org/10.1158/1538-7445.AM2025-4152
Published: 21 April 2025
View articletitled, Abstract 4152: Disrupting lipid elongation impairs prostate cancer progression in c-MYC driven mouse models
Journal Articles

Editor’s Note: Androgen-Induced Differentiation and Tumorigenicity of Human Prostate Epithelial Cells

Free
Raanan Berger, Phillip G. Febbo, Pradip K. Majumder, Jean J. Zhao, Shayan Mukherjee, Sabina Signoretti, K. Thirza Campbell, William R. Sellers, Thomas M. Roberts, Massimo Loda, Todd R. Golub, William C. Hahn
Journal: Cancer Research
Cancer Res (2024) 84 (15): 2561.
https://doi.org/10.1158/0008-5472.CAN-24-1910
Published: 01 August 2024
View articletitled, Editor’s Note: Androgen-Induced Differentiation and Tumorigenicity of Human Prostate Epithelial Cells
Open the PDF for Editor’s Note: Androgen-Induced Differentiation and Tumorigenicity of Human Prostate Epithelial Cells in another window
Journal Articles

Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer

Open Access
Nadia Boufaied, Paolo Chetta, Tarek Hallal, Stefano Cacciatore, Daniela Lalli, Carole Luthold, Kevin Homsy, Eddie L. Imada, Sudeepa Syamala, Cornelia Photopoulos, Anna Di Matteo, Anna de Polo, Alessandra Maria Storaci, Ying Huang, Francesca Giunchi, Patricia A. Sheridan, Gregory Michelotti, Quang-De Nguyen, Xin Zhao, Yang Liu, Elai Davicioni, Daniel E. Spratt, Simone Sabbioneda, Giovanni Maga, Lorelei A. Mucci, Claudia Ghigna, Luigi Marchionni, Lisa M. Butler, Leigh Ellis, François Bordeleau, Massimo Loda, Valentina Vaira, David P. Labbé, Giorgia Zadra
Journal: Cancer Research
Cancer Res (2024) 84 (11): 1834–1855.
https://doi.org/10.1158/0008-5472.CAN-23-0519
Published: 04 June 2024
View articletitled, Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Open the PDF for Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 4987: TREM2 is a radiation-induced target for immunomodulation of tumor-associated macrophages in the prostate cancer tumor microenvironment

Free
Janny A. Villa-Pulgarin, Un In Chan, Francesca Khani, Fabio Socciarelli, Jiansheng Wu, Ryan Carelli, Jeffrey Kraynak, Silvia C. Formenti, Luigi Marchionni, Massimo Loda, Himanshu Nagar, Ariel E. Marciscano, Christopher E. Barbieri
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4987.
https://doi.org/10.1158/1538-7445.AM2024-4987
Published: 22 March 2024
View articletitled, Abstract 4987: TREM2 is a radiation-induced target for immunomodulation of tumor-associated macrophages in the prostate cancer tumor microenvironment
Journal Articles

Abstract 6849: Characterizing a discernible stromal fibroblastic gene signature in the shift from high-grade prostatic intraepithelial neoplasia to aggressive prostate cancer

Free
Mohammad K. Alexanderani, Lucio Queiroz, Mohamed Omar, Claudio Zanettini, Hubert Pakula, Luigi Marchionni, Massimo Loda
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6849.
https://doi.org/10.1158/1538-7445.AM2024-6849
Published: 22 March 2024
View articletitled, Abstract 6849: Characterizing a discernible stromal fibroblastic gene signature in the shift from high-grade prostatic intraepithelial neoplasia to aggressive prostate cancer
Journal Articles

Abstract 7286: Optimizing prediction of metastatic castration-resistant prostate cancer: Multimodal fusion of clinicopathological and genomic features with machine learning

Free
Mohammad K. Alexanderani, Francesca Khani, Matthew Greenblatt, Brian Robinson, Massimo Loda, Luigi Marchionni
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7286.
https://doi.org/10.1158/1538-7445.AM2024-7286
Published: 22 March 2024
View articletitled, Abstract 7286: Optimizing prediction of metastatic castration-resistant prostate cancer: Multimodal fusion of clinicopathological and genomic features with machine learning
Journal Articles

Abstract 7351: Delineating the prostate cancer tumor microenvironment through scRNA-seq profiling at different timepoints

Free
Itzel Valencia, Hubert Pakula, Mohamed Omar, Massimo Loda, Luigi Marchionni
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7351.
https://doi.org/10.1158/1538-7445.AM2024-7351
Published: 22 March 2024
View articletitled, Abstract 7351: Delineating the prostate cancer tumor microenvironment through scRNA-seq profiling at different timepoints
Journal Articles

Abstract 438: Inhibition of de novo lipogenesis with PUFA supplementation induces ferroptosis in advanced prostate cancer

Free
Silvia Daniele Rodrigues, Isadora Ferrari Teixeira, Pier Vitale Nuzzo, Hubert Pakula, David Nanus, Massimo Loda
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 438.
https://doi.org/10.1158/1538-7445.AM2024-438
Published: 22 March 2024
View articletitled, Abstract 438: Inhibition of de novo lipogenesis with PUFA supplementation induces ferroptosis in advanced prostate cancer
Journal Articles

Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity

Free
Dominik Awad, Pham Hong Anh Cao, Thomas L. Pulliam, Meredith Spradlin, Elavarasan Subramani, Tristen V. Tellman, Caroline F. Ribeiro, Riccardo Muzzioli, Brittany E. Jewell, Hubert Pakula, Jeffrey J. Ackroyd, Mollianne M. Murray, Jenny J. Han, Mei Leng, Antrix Jain, Badrajee Piyarathna, Jingjing Liu, Xingzhi Song, Jianhua Zhang, Albert R. Klekers, Justin M. Drake, Michael M. Ittmann, Cristian Coarfa, David Piwnica-Worms, Mary C. Farach-Carson, Massimo Loda, Livia S. Eberlin, Daniel E. Frigo
Journal: Cancer Research
Cancer Res (2024) 84 (5): 703–724.
https://doi.org/10.1158/0008-5472.CAN-23-0555
Published: 04 March 2024
View articletitled, Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity
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Includes: Supplementary data
Journal Articles

Abstract 737: Variation in prognostic value of Gleason score for lethal prostate cancer using time-varying area under the curve

Free
Zhike Lin, Konrad H. Stopsack, Michelangelo Fiorentino, Jane B. Vaselkiv, Travis Gerke, Andreas Pettersson, Sinead Flanagan, Kathryn L. Penney, Stephen P. Finn, Massimo Loda, Lorelei A. Mucci
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 737.
https://doi.org/10.1158/1538-7445.AM2023-737
Published: 04 April 2023
View articletitled, Abstract 737: Variation in prognostic value of Gleason score for lethal prostate cancer using time-varying area under the curve
Journal Articles

Abstract 3676: De novo lipogenesis and cholesterol synthesis pathways can be simultaneously targeted to induce metabolic synthetic lethality in prostate cancer

Free
Caroline Fidalgo Ribeiro, Silvia Daniele Rodrigues, Guilherme Tamarindo, Hubert Pakula, Massimo Loda
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3676.
https://doi.org/10.1158/1538-7445.AM2023-3676
Published: 04 April 2023
View articletitled, Abstract 3676: De novo lipogenesis and cholesterol synthesis pathways can be simultaneously targeted to induce metabolic synthetic lethality in prostate cancer
Journal Articles

Abstract 6039: ELOVL5 affects prostate cancer cell proliferation and modulates the AR pathway

Free
Silvia D. Rodrigues, Caroline Ribeiro, Isadora Teixeira, Hubert Pakula, Giuseppe N. Fanelli, Fabio Socciarelli, Lisa Butler, Johannes Swinnen, Massimo Loda
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6039.
https://doi.org/10.1158/1538-7445.AM2023-6039
Published: 04 April 2023
View articletitled, Abstract 6039: ELOVL5 affects prostate cancer cell proliferation and modulates the AR pathway
Journal Articles

Abstract 1343: Mesenchymal cell populations associated with different stages of prostate cancer progression in mice and human

Free
Mohamed Omar, Hubert Pakula, Filippo Pederzoli, Giuseppe N. Fanelli, Tania Panellinni, Ryan Carelli, Silvia Rodrigues, Caroline Fidalgo-Ribeiro, Pier V. Nuzzo, Lucie V. Emmenis, Mohammad Mohammad, Madhavi Jere, Caitlin Unkenholz, David Rickman, Christopher Barbieri, Brian Robinson, Luigi Marchionni, Massimo Loda
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1343.
https://doi.org/10.1158/1538-7445.AM2023-1343
Published: 04 April 2023
View articletitled, Abstract 1343: Mesenchymal cell populations associated with different stages of prostate cancer progression in mice and human
Journal Articles

Abstract 5369: Detection of ERG:TMPRSS2 gene fusion in prostate cancer from histopathology slides using attention-based deep learning

Free
Mohamed Omar, Zhuoran Xu, Sophie B. Rand, Daniela C. Salles, Edward M. Schaeffer, Tamara L. Lotan, Massimo Loda, Luigi Marchionni
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5369.
https://doi.org/10.1158/1538-7445.AM2023-5369
Published: 04 April 2023
View articletitled, Abstract 5369: Detection of ERG:TMPRSS2 gene fusion in prostate cancer from histopathology slides using attention-based deep learning
Journal Articles

The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission

Available to Purchase
Kenneth C. Anderson, Lewis C. Cantley, Riccardo Dalla-Favera, Chi Van Dang, Luis A. Diaz, Raymond N. DuBois, Keith T. Flaherty, Philip D. Greenberg, Massimo Loda, Elaine R. Mardis, Elizabeth A. Platz, Michael N. Pollak, Robert D. Schreiber, Lillian L. Siu, Beverly A. Teicher
Journal: Cancer Research
Cancer Res (2022) 82 (21): 3861–3867.
https://doi.org/10.1158/0008-5472.CAN-22-2453
Published: 02 November 2022
View articletitled, The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission
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Journal Articles

The Prostate Cancer Androgen Receptor Cistrome in African American Men Associates with Upregulation of Lipid Metabolism and Immune Response

Open Access
Jacob E. Berchuck, Elio Adib, Sarah Abou Alaiwi, Amit K. Dash, Jin Na Shin, Dallin Lowder, Collin McColl, Patricia Castro, Ryan Carelli, Elisa Benedetti, Jenny Deng, Matthew Robertson, Sylvan C. Baca, Connor Bell, Heather M. McClure, Talal El Zarif, Matthew P. Davidsohn, Gitanjali Lakshminarayanan, Kinza Rizwan, Darlene G. Skapura, Sandra L. Grimm, Christel M. Davis, Erik A. Ehli, Kaitlin M. Kelleher, Ji-Heui Seo, Nicholas Mitsiades, Cristian Coarfa, Mark M. Pomerantz, Massimo Loda, Michael Ittmann, Matthew L. Freedman, Salma Kaochar
Journal: Cancer Research
Cancer Res (2022) 82 (16): 2848–2859.
https://doi.org/10.1158/0008-5472.CAN-21-3552
Published: 16 August 2022
View articletitled, The Prostate Cancer Androgen Receptor Cistrome in African American Men Associates with Upregulation of Lipid Metabolism and Immune Response
Open the PDF for The Prostate Cancer Androgen Receptor Cistrome in African American Men Associates with Upregulation of Lipid Metabolism and Immune Response in another window
Includes: Supplementary data
Journal Articles

Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma

Open Access
Shawn M. Davidson, Daniel R. Schmidt, Julia E. Heyman, James P. O'Brien, Amy C. Liu, William J. Israelsen, Talya L. Dayton, Raghav Sehgal, Roderick T. Bronson, Elizaveta Freinkman, Howard H. Mak, Giuseppe Nicolò Fanelli, Scott Malstrom, Gary Bellinger, Arkaitz Carracedo, Pier Paolo Pandolfi, Kevin D. Courtney, Abhishek Jha, Ronald A. DePinho, James W. Horner, Craig J. Thomas, Lewis C. Cantley, Massimo Loda, Matthew G. Vander Heiden
Journal: Cancer Research
Cancer Res (2022) 82 (13): 2403–2416.
https://doi.org/10.1158/0008-5472.CAN-21-2352
Published: 05 July 2022
View articletitled, Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma
Open the PDF for Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 3018: Targeting lipid metabolism and diet in advanced prostate cancer

Free
Silvia D. Rodrigues, Caroline Fidalgo Ribeiro, Guilherme H. Tamarindo, Hubert Pakula, Massimo Loda
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3018.
https://doi.org/10.1158/1538-7445.AM2022-3018
Published: 15 June 2022
View articletitled, Abstract 3018: Targeting lipid metabolism and diet in advanced prostate cancer