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Massimo Cristofanilli
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Journal Articles

Abstract LB117: Pilot study to identify live circulating tumor cells (CTCs) in metastatic breast cancer (MBC) by application of a novel microfluidic workflow system and flow cytometry

Qiang Zhang, Marwa Manai, Andrew Davis, Carolina Reduzzi, Paolo D’Amico, Saya Liz Jacob, Jianhua Jiao, Weijun Qin, Lisa Flaum, Amir Behdad, Massimo Cristofanilli, Ami Shad, Leonidas Platanias, William Gradishar
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB117.
DOI: https://doi.org/10.1158/1538-7445.AM2022-LB117
Published: 15 June 2022
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Journal Articles

Abstract 1950: A novel ESR1 mutation assay for single circulating tumor cell by application of DEPArray࣪ System and Digital Droplet PCR

Qiang Zhang, Paolo D'Amico, Marwa Manai, Carolina Reduzzi, Andrew A. Davis, Lorenzo Gerratana, Weijun Qin, Jianhua Jiao, Saya L. Jacob, Jeannine Donahue, Youbin Zhang, Lisa Flaum, Massimo Cristofanilli, Leonidas C. Platanias, Ami N. Shah, William Gradishar
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1950.
DOI: https://doi.org/10.1158/1538-7445.AM2022-1950
Published: 15 June 2022
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Journal Articles

Hotspot ESR1 Mutations Are Multimodal and Contextual Modulators of Breast Cancer Metastasis

Zheqi Li, Yang Wu, Megan E. Yates, Nilgun Tasdemir, Amir Bahreini, Jian Chen, Kevin M. Levine, Nolan M. Priedigkeit, Azadeh Nasrazadani, Simak Ali, Laki Buluwela, Spencer Arnesen, Jason Gertz, Jennifer K. Richer, Benjamin Troness, Dorraya El-Ashry, Qiang Zhang, Lorenzo Gerratana, Youbin Zhang, Massimo Cristofanilli, Maritza A. Montanez, Prithu Sundd, Callen T. Wallace, Simon C. Watkins, Caterina Fumagalli, Elena Guerini-Rocco, Li Zhu, George C. Tseng, Nikhil Wagle, Jason S. Carroll, Paul Jank, Carsten Denkert, Maria M. Karsten, Jens-Uwe Blohmer, Ben H. Park, Peter C. Lucas, Jennifer M. Atkinson, Adrian V. Lee, Steffi Oesterreich
Journal: Cancer Research
Cancer Res (2022) 82 (7): 1321–1339.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-2576
Published: 01 April 2022
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Includes: Supplementary data
Journal Articles

Abstract P5-13-29: Analytical and clinical validation of a ctDNA assay for detecting copy number loss and structural rearrangement variants contributing to homologous recombination and repair (HRR) deficiency

Jennifer Yen, Leylah Drusbosky, Caroline Weipert, Nicole Zhang, David Hanna, Catalin Barbacioru, Hao Wang, Alex Artyomenko, Arielle Yablonovitch, Yu Fu, Aaron Hardin, Nagesh Alla, Robert Foley, Max Maligska, Bhargavi Panchangam, Phil Yen, Jane Meisel, Neelima Vidula, Massimo Cristofanilli, Jeremy Force, Michael Dorschner, Martina Lefterova, Elena Helman, Becky Nagy, Darya Chudova, AmirAli Talasaz
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P5-13-29.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P5-13-29
Published: 15 February 2022
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Journal Articles

Abstract P5-13-04: NF1 mutations render HER2+ breast cancer highly sensitive to T-DM1 by altering microtubule dynamics

Bruno A Duso, Elena Gavilán Dorronzoro, Giulia Tini, Maria R de Filippo, Emanuele Bonetti, Maria R Ippolito, Chiara Soriani, Paolo D'Amico, Simona Rodighiero, Giuseppe Curigliano, Stefano Santaguida, Massimo Cristofanilli, Pier Giuseppe Pelicci, Luca Mazzarella
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P5-13-04.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P5-13-04
Published: 15 February 2022
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Journal Articles

Abstract P5-17-08: A phase Ib/II study of leronlimab combined with carboplatin in patients with CCR5+ metastatic triple-negative breast cancer (mTNBC)

Massimo Cristofanilli, Namita Chittoria, Sima Ehsani, Hallgeir Rui, Milana Dolezal, Lisette Stork-Sloots, Femke de Snoo, Christopher Recknor, Vandana Abramson
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P5-17-08.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P5-17-08
Published: 15 February 2022
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Journal Articles

Abstract PD14-04: Circulating tumor DNA characterization of invasive lobular carcinoma in patients with metastatic breast cancer

Andrew A Davis, Lorenzo Gerratana, Katherine Clifton, Marko Velimirovic, Whitney L Hensing, Ami N Shah, Paolo D’Amico, Carolina Reduzzi, Qiang Zhang, Charles S Dai, Elyssa N Denault, Nusayba A Bagegni, Mateusz Opyrchal, Foluso O Ademuyiwa, Ron Bose, William J Gradishar, Amir Behdad, Cynthia X Ma, Aditya Bardia, Massimo Cristofanilli
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD14-04.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-PD14-04
Published: 15 February 2022
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Journal Articles

Abstract OT2-11-05: SERENA-6: A Phase III study to assess the efficacy and safety of AZD9833 (camizestrant) compared with aromatase inhibitors when given in combination with palbociclib or abemaciclib in patients with HR+/HER2- metastatic breast cancer with detectable ESR1m who have not experienced disease progression on first-line therapy

François-Clément Bidard, Kevin Kalinsky, Massimo Cristofanilli, Giampaolo Bianchini, Stephen KL Chia, Wolfgang Janni, Cynthia X Ma, Erica L Mayer, Yeon Hee Park, Steven Fox, Xiaochun Liu, Andrew Walding, Cynthia Huang Bartlett, Nick C Turner
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): OT2-11-05.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-OT2-11-05
Published: 15 February 2022
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Journal Articles

Abstract P1-02-11: Somatic alterations and PD-L1 positivity in advanced breast cancer

Brian S Finkelman, Massimo Cristofanilli, Luis Z Blanco, Jr, Amir Behdad, Leonidas C Platanias, William J Gradishar, Kalliopi P Siziopikou
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P1-02-11.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P1-02-11
Published: 15 February 2022
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Journal Articles

Abstract P1-24-02: Genetic variants and tumor microenvironment in inflammatory breast cancer: Clues for targeted therapies

Maria F. Arisi, Yulan Gong, Rajeswari Nagarathinam, Lorenzo Gerratana, Jianming Pei, Kathy Q. Cai, Jennifer Winn, Zachary Hasse, Elias Obeid, Julio Noriega, Christopher Sebastiano, Eric Ross, R. Katherine Alpaugh, Massimo Cristofanilli, Sandra V Fernandez
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P1-24-02.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P1-24-02
Published: 15 February 2022
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Journal Articles

Abstract P2-01-01: Genetic alterations detected by circulating tumor DNA (ctDNA) in HER2-low metastatic breast cancer (MBC)

Whitney L Hensing, Lorenzo Gerratana, Katherine Clifton, Marko Velimirovic, Ami Shah, Paolo D'Amico, Carolina Reduzzi, Qiang Zhang, Charles S Dai, Nusayba A Bagegni, Mateusz Opyrchal, Foluso O Ademuyiwa, Bose Ron, Amir Behdad, Cynthia X Ma, Aditya Bardia, Massimo Cristofanilli, Andrew A Davis
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P2-01-01.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P2-01-01
Published: 15 February 2022
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Journal Articles

Abstract P2-08-04: Progressive metastatic breast cancer with no detectable circulating tumor DNA: Evaluating limitations of this highly sensitive tool

Ami N Shah, Lorenzo Gerratana, Shruti Chandra, Dhruvika Mukhija, Neelima Katam, Anthony K Kang, Andrew A Davis, Millen Srivastava, Saya Jacob, Paolo D'Amico, Qiang Zhang, Carolina Reduzzi, Michael Gurley, Firas Wehbe, William J Gradishar, Amir Behdad, Massimo Cristofanilli
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P2-08-04.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P2-08-04
Published: 15 February 2022
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Journal Articles

Abstract P2-02-06: Her2-low ctcs in breast cancer: Pipeline for phenotypic driven, single-cell collection and molecular analysis

Paolo D'Amico, Carolina Reduzzi, Wenan Qiang, Qiang Zhang, Lorenzo Gerratana, Ami N Shah, Andrew A Davis, Anthony Kang, Meilynn Shi, Youbin Zhang, Saya Jacob, Amir Behdad, Giuseppe Curigliano, Massimo Cristofanilli
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P2-02-06.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P2-02-06
Published: 15 February 2022
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Journal Articles

Abstract P2-02-05: Dynamic circulating tumor cell changes in enumeration and HER2 expression during systemic therapy for metastatic breast cancer

Qiang Zhang, Weijun Qin, Paolo D'Amico, Andrew A. Davis, Jianhua Jiao, Lorenzo Gerratana, Saya L. Jacob, Youbin Zhang, Jeannine Donahue, Wenan Qiang, Ami N Shah, Amir Behdad, Lisa Flaum, William Gradishar, Leonidas C Platanias, Massimo Cristofanilli
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P2-02-05.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P2-02-05
Published: 15 February 2022
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Journal Articles

Abstract P2-01-04: Esr1 hotspot mutations in circulating tumor DNA mutation are associated with endocrine therapy resistance in metastatic breast cancer

Qiang Zhang, Paolo D'Amico, Weijun Qin, Jianhua Jiao, Andrew A. Davis, Lorenzo Gerratana, Saya L. Jacob, Youbin Zhang, Jeannine Donahue, Wenan Qiang, Ami N. Shah, Amir Behdad, Lisa Flaum, William Gradishar, Leonidas C Platanias, Massimo Cristofanilli
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P2-01-04.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P2-01-04
Published: 15 February 2022
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Journal Articles

Abstract P2-07-02: Genomic predictors of rapid progression to first line endocrine and CDK4/6 inhibitor combination therapy in patients with estrogen receptor positive (ER+) HER-2 negative (HER2-) advanced breast cancer (ABC)

Marko Velimirovic, Lorenzo Gerratana, Andrew A Davis, Whitney L Hensing, Katherine Clifton, Ami N Shah, Paolo D'Amico, Charles S Dai, Elyssa N Denault, Cynthia X Ma, Seth A Wander, Dejan Juric, Massimo Cristofanilli, Bruce A Chabner, Aditya Bardia
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P2-07-02.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P2-07-02
Published: 15 February 2022
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Journal Articles

Abstract P2-02-01: Stage IV stratification using circulating tumor cells (CTCs) enumeration modeling: A retrospective analysis of the MONARCH 2 study

Lorenzo Gerratana, Masha Kocherginsky, Andrew A Davis, Paolo D’Amico, Carolina Reduzzi, Qiang Zhang, Fabio Puglisi, Massimo Cristofanilli
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P2-02-01.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P2-02-01
Published: 15 February 2022
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Journal Articles

Abstract P2-01-08: Esr1 Y537 mutations are associated with increased baseline circulating tumor cells enumeration for patients with estrogen receptor positive metastatic breast cancer

Qiang Zhang, Jianhua Jiao, Paolo D'Amico, Andrew A. Davis, Weijun Qin, Lorenzo Gerratana, Saya L. Jacob, Youbin Zhang, Jeannine Donahue, Wenan Qiang, Ami N. Shah, Lisa Flaum, William Gradishar, Leonidas C. Platanias, Massimo Cristofanilli
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P2-01-08.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P2-01-08
Published: 15 February 2022
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Journal Articles

Abstract P2-14-05: Emerging molecular variants by circulating tumor DNA after immunotherapy in metastatic breast cancer

Anthony K Kang, Ami N Shah, Neelima Katam, Andrew A Davis, Lorenzo Gerratana, Shruti Chandra, Saya Jacob, Meilynn Shi, Jeeven Srivastava, Paolo D’Amico, Carolina Reduzzi, Michael Gurley, Firas Wehbe, Qiang Zhang, Amir Behdad, Massimo Cristofanilli
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P2-14-05.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P2-14-05
Published: 15 February 2022
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Journal Articles

Abstract PD14-01: Comprehensive molecular characterization of patients with metastatic invasive lobular carcinoma (ILC): Using real-world data to describe this unique clinical entity

Andrew A Davis, Amir Behdad, Kayla Viets Layng, Firas Wehbe, Lorenzo Gerratana, Elizabeth Mauer, Alex Barrett, Ami N Shah, Paolo D’Amico, Lisa Flaum, William J Gradishar, Leonidas C Platanias, Massimo Cristofanilli
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD14-01.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-PD14-01
Published: 15 February 2022
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