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Massimo Broggini
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Journal Articles

Abstract 2380: The effect of metabolic alterations on chemo-immunotherapy response in non-small-cell lung cancer model

Gloriana Ndembe, Mirko Marabese, Ilenia Intini, Alessandra Fabbri, Massimo Moro, Mario Occhipinti, Elisa Sottotetti, Giuseppe Lo Russo, Monica Ganzinelli, Massimo Broggini
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2380.
https://doi.org/10.1158/1538-7445.AM2022-2380
Published: 15 June 2022
View article titled, Abstract 2380: The effect of metabolic alterations on chemo-immunotherapy response in non-small-cell lung cancer model
Journal Articles

Abstract 6346: Identification of ERK inhibitor-based combinations targeting LKB1-mutated NSCLC

Marika Colombo, Matteo Demetrio Tripodi, Gabriel Caso, Elisa Perin, Mirko Marabese, Massimo Broggini, Elisa Caiola
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6346.
https://doi.org/10.1158/1538-7445.AM2022-6346
Published: 15 June 2022
View article titled, Abstract 6346: Identification of ERK inhibitor-based combinations targeting LKB1-mutated NSCLC
Journal Articles

Abstract 1539: LKB1 down-modulation by miR-17 biologically and clinically mirrors LKB1-mutated NSCLC

Cristina Borzi, Monica Ganzinelli, Elisa Caiola, Marika Colombo, Giovanni Centonze, Mattia Boeri, Laura Caleca, Ugo Pastorino, Mirko Marabese, Massimo Milione, Massimo Broggini, Marina C. Garassino, Gabriella Sozzi, Massimo Moro
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1539.
https://doi.org/10.1158/1538-7445.AM2022-1539
Published: 15 June 2022
View article titled, Abstract 1539: LKB1 down-modulation by miR-17 biologically and clinically mirrors LKB1-mutated NSCLC
Journal Articles

Abstract LB-245: Multiple DNA-damage response pathways are modulated by RANBP9 protein in NSCLC

Anna Tessari, Kareesma Parbhoo, Meghan Pawlikowski, Matteo Fassan, Eliana Rulli, Claudia Foray, Alessandra Fabbri, Valerio Embrione, Monica Ganzinelli, Marina Capece, Massimo Broggini, Gabriella Farina, Mirko Marabese, Marina C. Garassino, Carlo Croce, Dario Palmieri, Vincenzo Coppola
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-245.
https://doi.org/10.1158/1538-7445.AM2018-LB-245
Published: 01 July 2018
View article titled, Abstract LB-245: Multiple DNA-damage response pathways are modulated by RANBP9 protein in NSCLC
Journal Articles

Abstract 3739: Comparison of technologies for EGFR analysis within a subset of a randomized clinical trial

Mirko Marabese, Massimo Broggini, Martin Reijans, Cedric Gouedard, Geert Maertens, Erwin Sablon, Monica Ganzinelli, Marina C. Garassino, Samuel Murray
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3739.
https://doi.org/10.1158/1538-7445.AM2017-3739
Published: 01 July 2017
View article titled, Abstract 3739: Comparison of technologies for <em>EGFR</em> analysis within a subset of a randomized clinical trial
Journal Articles

Abstract 2352: Effect of inhibition of cell cycle versus transcription cyclin-dependent kinases (CDKs) in ovarian cancer cells

Rosaria Chilà, Nicolò Panini, Eugenio Erba, Giovanna Damia, Massimo Broggini
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2352.
https://doi.org/10.1158/1538-7445.AM2017-2352
Published: 01 July 2017
View article titled, Abstract 2352: Effect of inhibition of cell cycle versus transcription cyclin-dependent kinases (CDKs) in ovarian cancer cells
Journal Articles

Abstract 174: Preclinical activity of new liposomal formulation of doxorubicin (TLD-1)

Massimo Broggini, Federica Guffanti, Roberta Affatato, Lavinia Morosi, Patrick Buschor, Christoph Matthieu, Florian Weiss, Andreas Konig, Peter Halbherr, Stefan Halbherr
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 174.
https://doi.org/10.1158/1538-7445.AM2017-174
Published: 01 July 2017
View article titled, Abstract 174: Preclinical activity of new liposomal formulation of doxorubicin (TLD-1)
Journal Articles

Abstract 760: Detection of EGFR T790M mutation by ddPCR in untreated NSCLC patients: Correlation with clinical outcome

Monica Ganzinelli, Eliana Rulli, Elena Tamborini, Adele Busico, Giuseppe Lo Russo, Giulia Corrao, Milena Vitali, Marina Chiara Garassino, Massimo Broggini, Mirko Marabese
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 760.
https://doi.org/10.1158/1538-7445.AM2017-760
Published: 01 July 2017
View article titled, Abstract 760: Detection of EGFR T790M mutation by ddPCR in untreated NSCLC patients: Correlation with clinical outcome
Journal Articles

Abstract 508: DNA repair status in a patient derived ovarian cancer xenobank

Federica Guffanti, Maddalena Fratelli, Monica Ganzinelli, Francesca Ricci, Roberta Affatato, Maria Rosa Cappelletti, Daniele Generali, Francesca Bizzaro, Massimo Broggini, Raffaella Giavazzi, Giovanna Damia
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 508.
https://doi.org/10.1158/1538-7445.AM2017-508
Published: 01 July 2017
View article titled, Abstract 508: DNA repair status in a patient derived ovarian cancer xenobank
Journal Articles

Abstract 380: The dual PI3K/MTOR inhibitor PQR309 is active in mature B cell lymphoma cell lines bearing resistance to the PI3K-delta inhibitor idelalisib and specific gene expression features

Tarantelli Chiara, Eugenio Gaudio, Ivo Kwee, Alberto Arribas, Andrea Rinaldi, Elena Bernasconi, Luciano Cascione, Petra Hillmann, Anastasios Stathis, Laura Carrassa, Massimo Broggini, Georg Stussi, Doriano Fabbro, Emanuele Zucca, Vladimir Cmiljanovic, Francesco Bertoni
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 380.
https://doi.org/10.1158/1538-7445.AM2016-380
Published: 15 July 2016
View article titled, Abstract 380: The dual PI3K/MTOR inhibitor PQR309 is active in mature B cell lymphoma cell lines bearing resistance to the PI3K-delta inhibitor idelalisib and specific gene expression features
Journal Articles

Abstract 226: PI3K pathway inhibition induces a different metabolic response in NSCLC cells harboring WT and G12C mutant KRAS

Elisa Caiola, Laura Brunelli, Mirko Marabese, Roberta Pastorelli, Monica Lupi, Massimo Broggini
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 226.
https://doi.org/10.1158/1538-7445.AM2016-226
Published: 15 July 2016
View article titled, Abstract 226: PI3K pathway inhibition induces a different metabolic response in NSCLC cells harboring WT and G12C mutant KRAS
Journal Articles

Abstract 1654: The small molecule YK-4-279 shows anti-lymphoma activity in pre-clinical models

Elain YL Chung, Valdemar Priebe, Eugenio Gaudio, Ivo Kwee, Chiara Tarantelli, Andrea Rinaldi, Laura Carrassa, Monica Testoni, Luciano Cascione, Massimo Broggini, Jeffrey A. Toretsky, Emanuele Zucca, Francesco Bertoni
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1654.
https://doi.org/10.1158/1538-7445.AM2015-1654
Published: 01 August 2015
View article titled, Abstract 1654: The small molecule YK-4-279 shows anti-lymphoma activity in pre-clinical models
Journal Articles

Abstract 2652: Pre-clinical activity and mechanism of action of the novel dual PI3K/mTOR inhibitor PQR309 in B-cell lymphomas

Chiara Tarantelli, Eugenio Gaudio, Ivo Kwee, Andrea Rinaldi, Elena Bernasconi, Luciano Cascione, Petra Hillmann, Anastasios Stathis, Laura Carrassa, Massimo Broggini, Georg Stussi, Doriano Fabbro, Florent Beaufils, Anna Melone, Thomas Bohnacker, Matthias P. Wymann, Andreas Wicki, Emanuele Zucca, Vladimir Cmiljanovic, Francesco Bertoni
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2652.
https://doi.org/10.1158/1538-7445.AM2015-2652
Published: 01 August 2015
View article titled, Abstract 2652: Pre-clinical activity and mechanism of action of the novel dual PI3K/mTOR inhibitor PQR309 in B-cell lymphomas
Journal Articles

Abstract 3500: Combinations of ARQ087 with chemotherapeutic agents are safe and show a striking antitumor activity in different xenograft models

Rosaria Chilà, Federica Guffanti, Terence Hall, Francesca Ricci, Massimo Broggini, Giovanna Damia
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3500.
https://doi.org/10.1158/1538-7445.AM2015-3500
Published: 01 August 2015
View article titled, Abstract 3500: Combinations of ARQ087 with chemotherapeutic agents are safe and show a striking antitumor activity in different xenograft models
Journal Articles

Abstract 3760: Role of epithelial to mesenchymal transition in response to cisplatin in patient-derived ovarian carcinomas

Francesca Ricci, Federica Guffanti, Fratelli Maddalena, Patrizia Perego, Robert Fruscio, Romina Baldo, Sonia Magni, Massimo Broggini, Giovanna Damia
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3760.
https://doi.org/10.1158/1538-7445.AM2014-3760
Published: 01 October 2014
View article titled, Abstract 3760: Role of epithelial to mesenchymal transition in response to cisplatin in patient-derived ovarian carcinomas
Journal Articles

Abstract 4406: Role of KRAS in modulating the metabolomic profile and the response of NSCLC cells to PI3K/mTOR and AMPK interfering agents

Elisa Caiola, Laura Brunelli, Mirko Marabese, Marina Chiara Garassino, Gabriella Farina, Massimo Broggini, Roberta Pastorelli
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4406.
https://doi.org/10.1158/1538-7445.AM2014-4406
Published: 01 October 2014
View article titled, Abstract 4406: Role of KRAS in modulating the metabolomic profile and the response of NSCLC cells to PI3K/mTOR and AMPK interfering agents
Journal Articles

Abstract 803: A vertical combination strategy hitting multiple steps along the MAPK cascade: Molecular mechanisms of action and putative genetic determinants of synergism

Anais Del Curatolo, Ursula Cesta Incani, Ludovica Ciuffreda, Italia Falcone, Senji Shirasawa, Massimo Broggini, Isabella Sperduti, Adriana Eramo, Ruggero D. Maria, Francesco Cognetti, Michele Milella
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 803.
https://doi.org/10.1158/1538-7445.AM2014-803
Published: 01 October 2014
View article titled, Abstract 803: A vertical combination strategy hitting multiple steps along the MAPK cascade: Molecular mechanisms of action and putative genetic determinants of synergism
Journal Articles

Abstract 2766: Inhibition of Chk1 and Wee1 as a new therapeutic approach in Mantle Cell Lymphoma

Laura Carrassa, Rosaria Chilà, Alessandra Basana, Francesca Ricci, Federica Guffanti, Monica Lupi, Andrea Rinaldi, Luciano Cascione, Francesco Bertoni, Massimo Broggini, Giovanna Damia
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2766.
https://doi.org/10.1158/1538-7445.AM2014-2766
Published: 01 October 2014
View article titled, Abstract 2766: Inhibition of Chk1 and Wee1 as a new therapeutic approach in Mantle Cell Lymphoma
Journal Articles

Abstract 792: DRAGO (KIAA0247), a new p53-regulated antioncogene.

Paolo Rusconi, Federica Polato, Alberto Musi, Massimo Broggini
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 792.
https://doi.org/10.1158/1538-7445.AM2013-792
Published: 15 April 2013
View article titled, Abstract 792: DRAGO (KIAA0247), a new p53-regulated antioncogene.
Journal Articles

Abstract 846: Targeted inhibition of c-Met receptor by a selective c-Met inhibitor, Tivantinib, and a specific shRNA reduces breast cancer-derived bone metastases

Sara Previdi, Giovanni Abbadessa, Francesca Dalò, Dennis S. France, Massimo Broggini
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 846.
https://doi.org/10.1158/1538-7445.AM2012-846
Published: 15 April 2012
View article titled, Abstract 846: Targeted inhibition of c-Met receptor by a selective c-Met inhibitor, Tivantinib, and a specific shRNA reduces breast cancer-derived bone metastases