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Abstract 6950: VRK1 as a novel therapeutic target in small cell neuroendocrine carcinoma of the uterine cervix via mitochondrial dysfunction

Mariya Kobayashi, Satoshi Nakagawa, Yusuke Ishii, Yuji Kamei, Mizuki Kanda, Tatsuo Masuda, Mamoru Kakuda, Kosuke Hiramatsu, Tadashi Iwamiya, Shinya Matsuzaki, Masahiro Inoue, Yutaka Ueda

Cancer Res (2025) 85 (8_Supplement_1): 6950.

https://doi.org/10.1158/1538-7445.AM2025-6950

Published: 21 April 2025

View articletitled, Abstract 6950: VRK1 as a novel therapeutic target in small cell neuroendocrine carcinoma of the uterine cervix via mitochondrial dysfunction

Journal Articles

Abstract 5969: VRK1 can be a therapeutic target in small cell neuroendocrine carcinoma of the uterine cervix

Mariya Kobayashi, Satoshi Nakagawa, Mizuki Kanda, Yuji Kamei, Masuda Tatsuo, Mamoru Kakuda, Kosuke Hiramatsu, Toshihiro Kimura, Yutaka Ueda, Takayuki Enomoto, Masahiro Inoue, Tadashi Kimura

Cancer Res (2024) 84 (6_Supplement): 5969.

https://doi.org/10.1158/1538-7445.AM2024-5969

Published: 22 March 2024

View articletitled, Abstract 5969: VRK1 can be a therapeutic target in small cell neuroendocrine carcinoma of the uterine cervix

Journal Articles

Abstract 33: Ex vivo drug sensitivity assay with a panel of cancer patient-derived spheroids of small cell neuroendocrine carcinoma of uterine cervix

Mie Tanaka, Satoshi Kubota, Yu Ito, Yumiko Kiyohara, Hiroko Endo, Jumpei Kondo, Satoshi Nakagawa, Akiko Okazawa, Shinya Matsuzaki, Toshihiro Kimura, Eiji Kobayashi, Yutaka Ueda, Kiyoshi Yoshino, Shoji Kamiura, Tadashi Kimura, Masahiro Inoue

Cancer Res (2019) 79 (13_Supplement): 33.

https://doi.org/10.1158/1538-7445.AM2019-33

Published: 01 July 2019

View articletitled, Abstract 33: Ex vivo drug sensitivity assay with a panel of cancer patient-derived spheroids of small cell neuroendocrine carcinoma of uterine cervix

Journal Articles

Abstract 3229: Distinct types of cetuximab resistant KRAS mutant of colorectal cancer revealed by an integrated sensitivity assay

Takahiro Tashiro, Hiroaki Okuyama, Hiroko Endo, Kenji Kawada, Masayuki Ohue, Yoshiharu Sakai, Masahiro Inoue

Cancer Res (2015) 75 (15_Supplement): 3229.

https://doi.org/10.1158/1538-7445.AM2015-3229

Published: 01 August 2015

View articletitled, Abstract 3229: Distinct types of cetuximab resistant KRAS mutant of colorectal cancer revealed by an integrated sensitivity assay

Journal Articles

Abstract 1341: Rapid decrease of ATP followed by necrosis-like cell death in bladder cancer cells after exposure to high-dose chemotherapeutics used in intravesical therapy

Takahiro Yoshida, Hiroaki Okuyama, Masashi Nakayama, Kazuo Nishimura, Norio Nonomura, Masahiro Inoue

Cancer Res (2014) 74 (19_Supplement): 1341.

https://doi.org/10.1158/1538-7445.AM2014-1341

Published: 01 October 2014

View articletitled, Abstract 1341: Rapid decrease of ATP followed by necrosis-like cell death in bladder cancer cells after exposure to high-dose chemotherapeutics used in intravesical therapy

Journal Articles

Abstract 14: Drug sensitivity of vascularized tumor tissue in vitro

Seema M. Ehsan, Masahiro Inoue, Marian L. Waterman, Christopher C. Hughes, Steven C. George

Cancer Res (2014) 74 (19_Supplement): 14.

https://doi.org/10.1158/1538-7445.AM2014-14

Published: 01 October 2014

View articletitled, Abstract 14: Drug sensitivity of vascularized tumor tissue in vitro

Journal Articles

Abstract 495: Inactive status of cancer cells with suppression of AKT activity contributes to survival in chronic hypoxia

Masahiro Inoue, Hiroaki Okuyama, Hiroko Endo, Masayuki Ohue

Cancer Res (2014) 74 (19_Supplement): 495.

https://doi.org/10.1158/1538-7445.AM2014-495

Published: 01 October 2014

View articletitled, Abstract 495: Inactive status of cancer cells with suppression of AKT activity contributes to survival in chronic hypoxia

Journal Articles

Abstract 3832: Cancer tissue-derived spheroid, CTOS, for evaluation of drug response from individual patient tumor samples.

Masahiro Inoue, Hiroko Endo, Masayuki Ohue, Kazuo Nishimura, Fumio Imamura, Jiro Okami, Hiroaki Okuyama

Cancer Res (2013) 73 (8_Supplement): 3832.

https://doi.org/10.1158/1538-7445.AM2013-3832

Published: 15 April 2013

View articletitled, Abstract 3832: Cancer tissue-derived spheroid, CTOS, for evaluation of drug response from individual patient tumor samples.

Journal Articles

Abstract 4257: Establishment of cancer-tissue originated spheroids (CTOSs) and chemo-sensitivity test for endometrial cancer

Toshihiro Kimura, Kiyoshi Yoshino, Kosuke Hiramatsu, Yumiko Kiyohara, Akiko Morimoto, Takuhei Yokoyama, Eiji Kobayashi, Yutaka Ueda, Masami Fujita, Masahiro Inoue, Takayuki Enomoto, Tadashi Kimura

Cancer Res (2012) 72 (8_Supplement): 4257.

https://doi.org/10.1158/1538-7445.AM2012-4257

Published: 15 April 2012

View articletitled, Abstract 4257: Establishment of cancer-tissue originated spheroids (CTOSs) and chemo-sensitivity test for endometrial cancer

Journal Articles

Abstract 774: Preliminary experiment of α-gal epitopes immune-based therapy against pancreatic cancer using tumor cell lysates

Tsukasa Tanida, Masahiro Tanemura, Eiji Miyoshi, Masahiro Inoue, Hiroaki Nagano, Yoshiaki Ohmura, Tomohiko Machida, Hiroshi Wada, Syogo Kobayashi, Shigeru Marubashi, Hidetoshi Eguchi, Toshinori Ito, Masaki Mori, Yuichiro Doki

Cancer Res (2011) 71 (8_Supplement): 774.

https://doi.org/10.1158/1538-7445.AM2011-774

Published: 15 April 2011

View articletitled, Abstract 774: Preliminary experiment of α-gal epitopes immune-based therapy against pancreatic cancer using tumor cell lysates

Journal Articles

Downregulation of c-MYC Protein Levels Contributes to Cancer Cell Survival under Dual Deficiency of Oxygen and Glucose

Hiroaki Okuyama, Hiroko Endo, Tamaki Akashika, Kikuya Kato, Masahiro Inoue

Cancer Res (2010) 70 (24): 10213–10223.

https://doi.org/10.1158/0008-5472.CAN-10-2720

Published: 14 December 2010

View articletitled, Downregulation of c-MYC Protein Levels Contributes to Cancer Cell Survival under Dual Deficiency of Oxygen and Glucose

Includes: Supplementary data

Journal Articles

Mutant p53 Disrupts the Stress MAPK Activation Circuit Induced by ASK1-Dependent Stabilization of Daxx

Tetsuya Kitamura, Yayoi Fukuyo, Masahiro Inoue, Nobuko T. Horikoshi, Masanobu Shindoh, Buck E. Rogers, Anny Usheva, Nobuo Horikoshi

Cancer Res (2009) 69 (19): 7681–7688.

https://doi.org/10.1158/0008-5472.CAN-09-2133

Published: 01 October 2009

View articletitled, Mutant p53 Disrupts the Stress MAPK Activation Circuit Induced by ASK1-Dependent Stabilization of Daxx

Includes: Supplementary data

Journal Articles

Phosphorylation-Dependent Lys⁶³-Linked Polyubiquitination of Daxx Is Essential for Sustained TNF-α–Induced ASK1 Activation

Yayoi Fukuyo, Tetsuya Kitamura, Masahiro Inoue, Nobuko T. Horikoshi, Ryuji Higashikubo, Clayton R. Hunt, Anny Usheva, Nobuo Horikoshi

Cancer Res (2009) 69 (19): 7512–7517.

https://doi.org/10.1158/0008-5472.CAN-09-2148

Published: 01 October 2009

View articletitled, Phosphorylation-Dependent Lys63-Linked Polyubiquitination of Daxx Is Essential for Sustained TNF-α–Induced ASK1 Activation

Journal Articles

Oxidative Stress Plays a Critical Role in Inactivating Mutant BRAF by Geldanamycin Derivatives

Yayoi Fukuyo, Masahiro Inoue, Takuma Nakajima, Ryuji Higashikubo, Nobuko T. Horikoshi, Clayton Hunt, Anny Usheva, Michael L. Freeman, Nobuo Horikoshi

Cancer Res (2008) 68 (15): 6324–6330.

https://doi.org/10.1158/0008-5472.CAN-07-6602

Published: 01 August 2008

View articletitled, Oxidative Stress Plays a Critical Role in Inactivating Mutant BRAF by Geldanamycin Derivatives

Includes: Supplementary data

Journal Articles

Activation of Insulin-like Growth Factor Signaling Induces Apoptotic Cell Death Under Prolonged Hypoxia by Enhancing Endoplasmic Reticulum Stress Response

Hiroko Endo, Kohei Murata, Mutsuko Mukai, Osamu Ishikawa, Masahiro Inoue

Cancer Res (2007) 67 (17): 8095–8103.

https://doi.org/10.1158/0008-5472.CAN-06-3389

Published: 05 September 2007

View articletitled, Activation of Insulin-like Growth Factor Signaling Induces Apoptotic Cell Death Under Prolonged Hypoxia by Enhancing Endoplasmic Reticulum Stress Response

Includes: Supplementary data

Journal Articles

Cross Talk between Apoptosis and Invasion Signaling in Cancer Cells through Caspase-3 Activation

Mutsuko Mukai, Toshiyuki Kusama, Yukou Hamanaka, Takumi Koga, Hiroko Endo, Masaharu Tatsuta, Masahiro Inoue

Cancer Res (2005) 65 (20): 9121–9125.

https://doi.org/10.1158/0008-5472.CAN-04-4344

Published: 17 October 2005

View articletitled, Cross Talk between Apoptosis and Invasion Signaling in Cancer Cells through Caspase-3 Activation

Journal Articles

CD4⁺ T Cell-Mediated Antigen-Specific Immunotherapy in a Mouse Model of Cervical Cancer

Dylan Daniel, Christopher Chiu, Enrico Giraudo, Masahiro Inoue, Lee A. Mizzen, N. Randall Chu, Douglas Hanahan

Cancer Res (2005) 65 (5): 2018–2025.

https://doi.org/10.1158/0008-5472.CAN-04-3444

Published: 07 March 2005

View articletitled, CD4+ T Cell-Mediated Antigen-Specific Immunotherapy in a Mouse Model of Cervical Cancer

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Abstract 6950: VRK1 as a novel therapeutic target in small cell neuroendocrine carcinoma of the uterine cervix via mitochondrial dysfunction

Abstract 5969: VRK1 can be a therapeutic target in small cell neuroendocrine carcinoma of the uterine cervix

Abstract 33: Ex vivo drug sensitivity assay with a panel of cancer patient-derived spheroids of small cell neuroendocrine carcinoma of uterine cervix

Abstract 3229: Distinct types of cetuximab resistant KRAS mutant of colorectal cancer revealed by an integrated sensitivity assay

Abstract 1341: Rapid decrease of ATP followed by necrosis-like cell death in bladder cancer cells after exposure to high-dose chemotherapeutics used in intravesical therapy

Abstract 14: Drug sensitivity of vascularized tumor tissue in vitro

Abstract 495: Inactive status of cancer cells with suppression of AKT activity contributes to survival in chronic hypoxia

Abstract 3832: Cancer tissue-derived spheroid, CTOS, for evaluation of drug response from individual patient tumor samples.

Abstract 4257: Establishment of cancer-tissue originated spheroids (CTOSs) and chemo-sensitivity test for endometrial cancer

Abstract 774: Preliminary experiment of α-gal epitopes immune-based therapy against pancreatic cancer using tumor cell lysates

Downregulation of c-MYC Protein Levels Contributes to Cancer Cell Survival under Dual Deficiency of Oxygen and Glucose

Mutant p53 Disrupts the Stress MAPK Activation Circuit Induced by ASK1-Dependent Stabilization of Daxx

Phosphorylation-Dependent Lys⁶³-Linked Polyubiquitination of Daxx Is Essential for Sustained TNF-α–Induced ASK1 Activation

Oxidative Stress Plays a Critical Role in Inactivating Mutant BRAF by Geldanamycin Derivatives

Activation of Insulin-like Growth Factor Signaling Induces Apoptotic Cell Death Under Prolonged Hypoxia by Enhancing Endoplasmic Reticulum Stress Response

Cross Talk between Apoptosis and Invasion Signaling in Cancer Cells through Caspase-3 Activation

CD4⁺ T Cell-Mediated Antigen-Specific Immunotherapy in a Mouse Model of Cervical Cancer

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