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Journal Articles

Abstract 2807: HER3 is an actionable target in advanced prostate cancer

Susana Miranda, Veronica Gil, Ruth Riisnaes, Bora Gurel, Mariantonietta D’Ambrosio, Alessandro Vasciaveo, Mateus Crespo, Ana Ferreira, Daniela Brina, Martina Troiani, Adam Sharp, Beshara Sheehan, Rossitza Christova, George Seed, Ines Figueiredo, Maryou Lambros, David Dolling, Jan Rekowski, Abdullah Alajati, Matthew Clarke, Rita Pereira, Penny Flohr, Gemma Fowler, Gunther Boysen, Semini Sumanasuriya, Diletta Bianchini, Pasquale Rescigno, Caterina Aversa, Nina Tunariu, Christina Guo, Alec Paschalis, Claudia Bertan, Lorenzo Buroni, Jian Ning, Suzanne Carreira, Paul Workman, Amanda Swain, Andrea Califano, Michael M. Shen, Andrea Alimonti, Antje Neeb, SU2C/PCF International Prostate Cancer Dream Team, Jonathan Welti, Wei Yuan, Johann de Bono
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2807.
https://doi.org/10.1158/1538-7445.AM2022-2807
Published: 15 June 2022
View article titled, Abstract 2807: HER3 is an actionable target in advanced prostate cancer
Journal Articles

HER3 Is an Actionable Target in Advanced Prostate Cancer

Veronica Gil, Susana Miranda, Ruth Riisnaes, Bora Gurel, Mariantonietta D’Ambrosio, Alessandro Vasciaveo, Mateus Crespo, Ana Ferreira, Daniela Brina, Martina Troiani, Adam Sharp, Beshara Sheehan, Rossitza Christova, George Seed, Ines Figueiredo, Maryou Lambros, David Dolling, Jan Rekowski, Abdullah Alajati, Matthew Clarke, Rita Pereira, Penny Flohr, Gemma Fowler, Gunther Boysen, Semini Sumanasuriya, Diletta Bianchini, Pasquale Rescigno, Caterina Aversa, Nina Tunariu, Christina Guo, Alec Paschalis, Claudia Bertan, Lorenzo Buroni, Jian Ning, Suzanne Carreira, Paul Workman, Amanda Swain, Andrea Califano, Michael M. Shen, Andrea Alimonti, Antje Neeb, PCF/SU2C International Prostate Cancer Dream Team, Jonathan Welti, Wei Yuan, Johann de Bono
Journal: Cancer Research
Cancer Res (2021) 81 (24): 6207–6218.
https://doi.org/10.1158/0008-5472.CAN-21-3360
Published: 15 December 2021
View article titled, HER3 Is an Actionable Target in Advanced Prostate Cancer
Open the PDF for HER3 Is an Actionable Target in Advanced Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract LB-270: Discovery of genomic correlates and tumor purity as an independent clinical factor of poor outcome in advanced prostate cancer lpWGS CNA data

George Seed, Semini Sumanasuriya, Claudia Bertan, Harry Parr, Gemma Fowler, Rossitza Christova, Lorna Pope, Jane Goodall, Maryou Lambros, Pasquale Rescigno, Penelope Flohr, Suzanne Carreira, Wei Yuan, Mustapha Chadjaa, Sandrine Mace, Johann De Bono
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-270.
https://doi.org/10.1158/1538-7445.AM2020-LB-270
Published: 15 August 2020
View article titled, Abstract LB-270: Discovery of genomic correlates and tumor purity as an independent clinical factor of poor outcome in advanced prostate cancer lpWGS CNA data
Journal Articles

Abstract A067: Targeting the bromodomain and extra-terminal (BET) family proteins and beyond in metastatic castration-resistant prostate cancer (mCRPC): Overcoming aberrant androgen receptor (AR) signaling

Adam Sharp, Jon Welti, Wei Yuan, Ines Figueiredo, Veronica Gil, Daniel Nava Rodrigues, Maryou Lambros, Eleanor Knight, Jian Ning, Jeff Francis, David Dolling, Lorna Pope, Antje Neeb, Gunther Boysen, Yezi Zhu, Mateus Crespo, Alec Paschalis, Jun Luo, Stephen Plymate, Bissan Al-Lazikani, Amanda Swain, Johann de Bono
Journal: Cancer Research
Cancer Res (2018) 78 (16_Supplement): A067.
https://doi.org/10.1158/1538-7445.PRCA2017-A067
Published: 14 August 2018
View article titled, Abstract A067: Targeting the bromodomain and extra-terminal (BET) family proteins and beyond in metastatic castration-resistant prostate cancer (mCRPC): Overcoming aberrant androgen receptor (AR) signaling
Journal Articles

Abstract 4579: The genetic heterogeneity and the molecular evolution of systemic metastatic castration resistant prostate cancer during therapy

Rui PL Neves, Streit LRF Anna, Katharina Raba, Elina-Katharina Bongers, Bianca Behrens, Guus van Dalum, Penny Flohr, Joaquin Mateo, Semini Sumanasuriya, Mateus Crespo, Berni Ebbs, Gemma Fowler, Pasquale Rescigno, Suzanne Carreira, Maryou Lambros, Edoardo Petrini, Marianna Garonzi, Nicolò Manaresi, Johann de Bono, Nikolas H. Stoecklein
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4579.
https://doi.org/10.1158/1538-7445.AM2018-4579
Published: 01 July 2018
View article titled, Abstract 4579: The genetic heterogeneity and the molecular evolution of systemic metastatic castration resistant prostate cancer during therapy
Journal Articles

Abstract 1723: Diagnostic leukapheresis results in a significant increase in CTC yield in metastatic breast and prostate cancer

Kiki C. Andree, Anouk Mentink, Joost F. Swennenhuis, Leon W. Terstappen, Nikolas H. Stoecklein, Rui P. Neves, Rita Lampignano, Hans Neubauer, Tanja Fehm, Johannes C. Fischer, Elisabetta Rossi, Mariangela Manicone, Umberto Basso, Piero Marson, Rita Zamarchi, Yohann Loriot, Valérie Lapierre, Vincent Faugeroux, Marianne Oulhen, Francoise Farace, Gemma Fowler, Mariane Sousa Fontes, Berni Ebbs, Maryou Lambros, Mateus Crespo, Penelope Flohr, Johann S. de Bono
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1723.
https://doi.org/10.1158/1538-7445.AM2017-1723
Published: 01 July 2017
View article titled, Abstract 1723: Diagnostic leukapheresis results in a significant increase in CTC yield in metastatic breast and prostate cancer
Journal Articles

Abstract 4679: Mismatch repair defects in lethal prostate cancer

Pasquale Rescigno, Daniel Nava Rodrigues, Wei Yuan, Suzanne Carreira, Maryou Lambros, George Seed, Ruth Riisnaes, Susana Miranda, David Dolling, Matthew Clarke, Mateus Crespo, Claudia Bertan, Gunther Boysen, Joaquin Mateo, Ana Ferreira, Adam Sharp, Ines Figueiredo, Semini Sumanasuriya, Mariane Sousa Fontes, Diletta Bianchini, Zafeiris Zafeiriou, Johann Sebastian de Bono
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4679.
https://doi.org/10.1158/1538-7445.AM2017-4679
Published: 01 July 2017
View article titled, Abstract 4679: Mismatch repair defects in lethal prostate cancer
Journal Articles

Abstract LB-044: Copy number estimation from targeted amplicon-based next-generation sequencing of castration-resistant prostate cancer biopsies: analytic validation and clinical qualification for a iPARP clinical trial

George Seed, Wei Yuan, Joaquin Mateo, Suzanne Carreira, Maryou Lambros, Gunther Boysen, Roberta Ferraldeschi, Susana Miranda, Ines Figueiredo, Ruth Riisnaes, Mateus Crespo, Daniel Nava Rodrigues, Eric Talevich, Dan Robinson, Priya Kunju, Yi-mi Wu, Robert Lonigro, Shahneen Sandhu, Arul Chinnayan, Johann De Bono
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-044.
https://doi.org/10.1158/1538-7445.AM2017-LB-044
Published: 01 July 2017
View article titled, Abstract LB-044: Copy number estimation from targeted amplicon-based next-generation sequencing of castration-resistant prostate cancer biopsies: analytic validation and clinical qualification for a iPARP clinical trial
Journal Articles

Abstract 1470: Ovarian cancer PDXs preserve preexisting genetic oligoclonality

Pierre-Emmanuel Colombo, Stanislas du Manoir, Beatrice Orsetti, Rui Bras-Goncalves, Alan MacKay, Maryou Lambros, Tuan T. Nguyen, Florence Boissiere, Didier Pourquier, Jorge Reis-Filho, Charles G. Theillet
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1470.
https://doi.org/10.1158/1538-7445.AM2015-1470
Published: 01 August 2015
View article titled, Abstract 1470: Ovarian cancer PDXs preserve preexisting genetic oligoclonality
Journal Articles

Abstract 8: Genomic analyses of heterogeneous HER2 3+ invasive ductal carcinomas of the breast

Arnaud Gauthier, Maryou Lambros, Daniel N. Rodrigues, Laurent Arnould, Magali Lacroix-Tikri, Frédérique Penault-Llorca, Marie-Christine Baranzelli, Xavier Sastre, Rachael Natrajan, Olivier Delattre, Paul Cottu, Jorge Sergio Reis-Filho, Anne Vincent-Salomon
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 8.
https://doi.org/10.1158/1538-7445.AM2012-8
Published: 15 April 2012
View article titled, Abstract 8: Genomic analyses of heterogeneous HER2 3+ invasive ductal carcinomas of the breast
Journal Articles

Abstract 4835: Genetic determinants of mTOR inhibitor response in breast and endometrial cancer

Britta Weigelt, Patricia H. Warne, Maryou Lambros, Jorge S. Reis-Filho, Julian Downward
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4835.
https://doi.org/10.1158/1538-7445.AM2012-4835
Published: 15 April 2012
View article titled, Abstract 4835: Genetic determinants of mTOR inhibitor response in breast and endometrial cancer
Journal Articles

Abstract 5076: Integrative genomic and transcriptomic analysis of metaplastic carcinomas of the breast

Alan G. Mackay, Rachael Natrajan, Christopher Maher, Maryou Lambros, Britta Weigelt, Daniel Nava-Rodrigues, Paul Wilkerson, Adriana CampionFlora, Iwanka Kozarewa, Kerry Fenwick, James Campbell, Lina Chen, Christopher J. Lord, Arnaud Gauthier, Vidya Pawar, Odette Mariani, Anne Vincent-Salomon, Jorge Reis-Filho
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5076.
https://doi.org/10.1158/1538-7445.AM2012-5076
Published: 15 April 2012
View article titled, Abstract 5076: Integrative genomic and transcriptomic analysis of metaplastic carcinomas of the breast
Journal Articles

A Novel, Selective, and Efficacious Nanomolar Pyridopyrazinone Inhibitor of V600EBRAF

Steven Whittaker, Delphine Ménard, Ruth Kirk, Lesley Ogilvie, Douglas Hedley, Alfonso Zambon, Filipa Lopes, Natasha Preece, Helen Manne, Sareena Rana, Maryou Lambros, Jorge S. Reis-Filho, Richard Marais, Caroline J. Springer
Journal: Cancer Research
Cancer Res (2010) 70 (20): 8036–8044.
https://doi.org/10.1158/0008-5472.CAN-10-1366
Published: 13 October 2010
View article titled, A Novel, Selective, and Efficacious Nanomolar Pyridopyrazinone Inhibitor of <sup>V600E</sup>BRAF
Open the PDF for A Novel, Selective, and Efficacious Nanomolar Pyridopyrazinone Inhibitor of <sup>V600E</sup>BRAF in another window
Includes: Supplementary data
Journal Articles

A Mouse Model of Melanoma Driven by Oncogenic KRAS

Carla Milagre, Nathalie Dhomen, Felipe C. Geyer, Robert Hayward, Maryou Lambros, Jorge S. Reis-Filho, Richard Marais
Journal: Cancer Research
Cancer Res (2010) 70 (13): 5549–5557.
https://doi.org/10.1158/0008-5472.CAN-09-4254
Published: 30 June 2010
View article titled, A Mouse Model of Melanoma Driven by Oncogenic KRAS
Open the PDF for A Mouse Model of Melanoma Driven by Oncogenic KRAS in another window
Includes: Supplementary data
Journal Articles

FGFR1 Amplification Drives Endocrine Therapy Resistance and Is a Therapeutic Target in Breast Cancer

Nicholas Turner, Alex Pearson, Rachel Sharpe, Maryou Lambros, Felipe Geyer, Maria A. Lopez-Garcia, Rachael Natrajan, Caterina Marchio, Elizabeth Iorns, Alan Mackay, Cheryl Gillett, Anita Grigoriadis, Andrew Tutt, Jorge S. Reis-Filho, Alan Ashworth
Journal: Cancer Research
Cancer Res (2010) 70 (5): 2085–2094.
https://doi.org/10.1158/0008-5472.CAN-09-3746
Published: 28 February 2010
View article titled, <em>FGFR1</em> Amplification Drives Endocrine Therapy Resistance and Is a Therapeutic Target in Breast Cancer
Open the PDF for <em>FGFR1</em> Amplification Drives Endocrine Therapy Resistance and Is a Therapeutic Target in Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Molecular alterations of c-KIT oncogene in gliomas

Ana Gomes, Jorge Reis-Filho, Jose Lopes, Maryou Lambros, Albino Martins, Fernando Schmitt, Fernando Pardal, Rui Reis
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 150.
Published: 01 May 2007
View article titled, Molecular alterations of c-<em>KIT</em> oncogene in gliomas