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Tumor-Targeted Enzyme/Prodrug Therapy Mediates Long-term Disease-Free Survival of Mice Bearing Disseminated Neuroblastoma

Mary K. Danks, K. Jin Yoon, Rebecca A. Bush, Joanna S. Remack, Monika Wierdl, Lyudmila Tsurkan, Seung U. Kim, Elizabeth Garcia, Marianne Z. Metz, Joseph Najbauer, Philip M. Potter, Karen S. Aboody

Cancer Res (2007) 67 (1): 22–25.

DOI: https://doi.org/10.1158/0008-5472.CAN-06-3607

Published: 08 January 2007

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The glycosylation status of ICAM-2 alters its ability to suppress the metastatic potential of neuroblastoma cells

K. Jin Yoon, Joanna S. Remack, Rebecca B. Bush, Mary K. Danks

Cancer Res (2006) 66 (8_Supplement): 654.

Published: 15 April 2006

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Brain Tumor Oncolysis with Replication-Conditional Herpes Simplex Virus Type 1 Expressing the Prodrug-Activating Genes, CYP2B1 and Secreted Human Intestinal Carboxylesterase, in Combination with Cyclophosphamide and Irinotecan

Edyta Tyminski, Stanley LeRoy, Kinya Terada, Dianne M. Finkelstein, Janice L. Hyatt, Mary K. Danks, Philip M. Potter, Yoshinaga Saeki, E. Antonio Chiocca

Cancer Res (2005) 65 (15): 6850–6857.

DOI: https://doi.org/10.1158/0008-5472.CAN-05-0154

Published: 01 August 2005

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Journal Articles

Development of an etoposide prodrug that is selectively activated by rabbit carboxylesterase, for combination with irinotecan, in enzyme-prodrug activation approaches to therapy

K. Jin Yoon, Joanna S. Remack, Jianjun Qi, Richard E. Lee, Philip M. Potter, Mary K. Danks

Cancer Res (2005) 65 (9_Supplement): 330.

Published: 01 May 2005

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Human neural progenitor cells (NPCs) as delivery vectors for therapeutic transgenes: NPC-directed enzyme prodrug therapy (NDEPT)

Karen S. Aboody, Rebecca A. Bush, Elizabeth Garcia, Marianne Metz, Doris A. Phelps, Joanna Remack, Monika Wierdl, K. Jin Yoon, Philip M. Potter, Mary K. Danks

Cancer Res (2005) 65 (9_Supplement): 796.

Published: 01 May 2005

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VDEPT using a rabbit liver carboxylesterase and CPT-11.

Christopher L. Morton, Monika Wierdl, Peter J. Houghton, Mary K. Danks, Philip M. Potter

Cancer Res (2004) 64 (7_Supplement): 871.

Published: 01 April 2004

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Journal Articles

Identification of novel selective inhibitors of human intestinal carboxylesterase: Synthesis, QSAR analysis, mechanism of action and biological activity.

Randy M. Wadkins, Janice L. Hyatt, Kyoung Jin P. Yoon, Christopher L. Morton, Richard E. Lee, Komath Damodaran, Paul Beroza, Mary K. Danks, Philip M. Potter

Cancer Res (2004) 64 (7_Supplement): 462.

Published: 01 April 2004

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Journal Articles

Development of a viral-directed, combination prodrug-enzyme therapy (VDEPT) for the treatment of solid tumors

Kyoung J. Yoon, Joanna S. Remack, Kristopher G. Virga, Richard E. Lee, Philip M. Potter, Mary K. Danks

Cancer Res (2004) 64 (7_Supplement): 151.

Published: 01 April 2004

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Journal Articles

Gains of chromosome 17q common in high-risk neuroblastomas do not involve the topoisomerase IIα gene: FISH and quantitative-PCR (Q-PCR) studies of six neuroblastoma cell lines

Kyoung Jin P. Yoon, Marcus B. Valentine, Virginia A. Valentine, Susan T. Ragsdale, Mary K. Danks

Cancer Res (2004) 64 (7_Supplement): 629.

Published: 01 April 2004

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Journal Articles

A Prodrug Strategy Using ONYX-015-Based Replicating Adenoviruses to Deliver Rabbit Carboxylesterase to Tumor Cells for Conversion of CPT-11 to SN-38

Hilde Stubdal, Noah Perin, Marilyn Lemmon, Patricia Holman, Maxine Bauzon, Philip M. Potter, Mary K. Danks, Ali Fattaey, Thomas Dubensky, Leisa Johnson

Cancer Res (2003) 63 (20): 6900–6908.

Published: 28 October 2003

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Journal Articles

p21^Waf1/Cip1 Dysfunction in Neuroblastoma: A Novel Mechanism of Attenuating G₀-G₁ Cell Cycle Arrest

Pamela P. McKenzie, Mary K. Danks, Richard W. Kriwacki, Linda C. Harris

Cancer Res (2003) 63 (13): 3840–3844.

Published: 01 July 2003

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Journal Articles

Efficacy and Toxicity of a Virus-directed Enzyme Prodrug Therapy Purging Method: Preclinical Assessment and Application to Bone Marrow Samples from Neuroblastoma Patients

Lars M. Wagner, Sylvie M. Guichard, Rebecca A. Burger, Christopher L. Morton, Charles M. Straign, Richard A. Ashmun, Linda C. Harris, Peter J. Houghton, Philip M. Potter, Mary K. Danks

Cancer Res (2002) 62 (17): 5001–5007.

Published: 01 September 2002

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Journal Articles

Sensitization of Human Tumor Cells to CPT-11 via Adenoviral-mediated Delivery of a Rabbit Liver Carboxylesterase

Monika Wierdl, Christopher L. Morton, James K. Weeks, Mary K. Danks, Linda C. Harris, Philip M. Potter

Cancer Res (2001) 61 (13): 5078–5082.

Published: 01 July 2001

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A Virus-directed Enzyme Prodrug Therapy Approach to Purging Neuroblastoma Cells from Hematopoietic Cells Using Adenovirus Encoding Rabbit Carboxylesterase and CPT-11

Mandy M. Meck, Monika Wierdl, Lars M. Wagner, Rebecca A. Burger, Sylvie M. Guichard, Erik. J. Krull, Linda C. Harris, Philip M. Potter, Mary K. Danks

Cancer Res (2001) 61 (13): 5083–5089.

Published: 01 July 2001

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Journal Articles

Use of a Modified Ornithine Decarboxylase Promoter to Achieve Efficient c-MYC- or N-MYC-regulated Protein Expression

Rekha V. Iyengar, Cynthia A. Pawlik, Erik J. Krull, Doris A. Phelps, Rebecca A. Burger, Linda C. Harris, Philip M. Potter, Mary K. Danks

Cancer Res (2001) 61 (7): 3045–3052.

Published: 01 April 2001

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Journal Articles

Proficient Metabolism of Irinotecan by a Human Intestinal Carboxylesterase

Ruchi Khanna, Christopher L. Morton, Mary K. Danks, Philip M. Potter

Cancer Res (2000) 60 (17): 4725–4728.

Published: 01 September 2000

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Journal Articles

Activation of CPT-11 in Mice: Identification and Analysis of a Highly Effective Plasma Esterase

Christopher L. Morton, Monika Wierdl, LaGora Oliver, Margaret K. Ma, Mary K. Danks, Clinton F. Stewart, Julie L. Eiseman, Philip M. Potter

Cancer Res (2000) 60 (15): 4206–4210.

Published: 01 August 2000

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Journal Articles

The Anticancer Prodrug CPT-11 Is a Potent Inhibitor of Acetylcholinesterase but Is Rapidly Catalyzed to SN-38 by Butyrylcholinesterase

Christopher L. Morton, Randy M. Wadkins, Mary K. Danks, Philip M. Potter

Cancer Res (1999) 59 (7): 1458–1463.

Published: 01 April 1999

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Journal Articles

Cellular Localization Domains of a Rabbit and a Human Carboxylesterase: Influence on Irinotecan (CPT-11) Metabolism by the Rabbit Enzyme

Philip M. Potter, Judith S. Wolverton, Christopher L. Morton, Monika Wierdl, Mary K. Danks

Cancer Res (1998) 58 (16): 3627–3632.

Published: 01 August 1998

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Journal Articles

Isolation and Partial Characterization of a cDNA Encoding a Rabbit Liver Carboxylesterase That Activates the Prodrug Irinotecan (CPT-11)

Philip M. Potter, Cynthia A. Pawlik, Christopher L. Morton, Clayton W. Naeve, Mary K. Danks

Cancer Res (1998) 58 (12): 2646–2651.

Published: 01 June 1998

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NARROW

Tumor-Targeted Enzyme/Prodrug Therapy Mediates Long-term Disease-Free Survival of Mice Bearing Disseminated Neuroblastoma

The glycosylation status of ICAM-2 alters its ability to suppress the metastatic potential of neuroblastoma cells

Brain Tumor Oncolysis with Replication-Conditional Herpes Simplex Virus Type 1 Expressing the Prodrug-Activating Genes, CYP2B1 and Secreted Human Intestinal Carboxylesterase, in Combination with Cyclophosphamide and Irinotecan

Development of an etoposide prodrug that is selectively activated by rabbit carboxylesterase, for combination with irinotecan, in enzyme-prodrug activation approaches to therapy

Human neural progenitor cells (NPCs) as delivery vectors for therapeutic transgenes: NPC-directed enzyme prodrug therapy (NDEPT)

VDEPT using a rabbit liver carboxylesterase and CPT-11.

Identification of novel selective inhibitors of human intestinal carboxylesterase: Synthesis, QSAR analysis, mechanism of action and biological activity.

Development of a viral-directed, combination prodrug-enzyme therapy (VDEPT) for the treatment of solid tumors

Gains of chromosome 17q common in high-risk neuroblastomas do not involve the topoisomerase IIα gene: FISH and quantitative-PCR (Q-PCR) studies of six neuroblastoma cell lines

A Prodrug Strategy Using ONYX-015-Based Replicating Adenoviruses to Deliver Rabbit Carboxylesterase to Tumor Cells for Conversion of CPT-11 to SN-38

p21^Waf1/Cip1 Dysfunction in Neuroblastoma: A Novel Mechanism of Attenuating G₀-G₁ Cell Cycle Arrest

Efficacy and Toxicity of a Virus-directed Enzyme Prodrug Therapy Purging Method: Preclinical Assessment and Application to Bone Marrow Samples from Neuroblastoma Patients

Sensitization of Human Tumor Cells to CPT-11 via Adenoviral-mediated Delivery of a Rabbit Liver Carboxylesterase

A Virus-directed Enzyme Prodrug Therapy Approach to Purging Neuroblastoma Cells from Hematopoietic Cells Using Adenovirus Encoding Rabbit Carboxylesterase and CPT-11

Use of a Modified Ornithine Decarboxylase Promoter to Achieve Efficient c-MYC- or N-MYC-regulated Protein Expression

Proficient Metabolism of Irinotecan by a Human Intestinal Carboxylesterase

Activation of CPT-11 in Mice: Identification and Analysis of a Highly Effective Plasma Esterase

The Anticancer Prodrug CPT-11 Is a Potent Inhibitor of Acetylcholinesterase but Is Rapidly Catalyzed to SN-38 by Butyrylcholinesterase

Cellular Localization Domains of a Rabbit and a Human Carboxylesterase: Influence on Irinotecan (CPT-11) Metabolism by the Rabbit Enzyme

Isolation and Partial Characterization of a cDNA Encoding a Rabbit Liver Carboxylesterase That Activates the Prodrug Irinotecan (CPT-11)

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