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Journal Articles

Tumor-Targeted Enzyme/Prodrug Therapy Mediates Long-term Disease-Free Survival of Mice Bearing Disseminated Neuroblastoma

Free
Mary K. Danks, K. Jin Yoon, Rebecca A. Bush, Joanna S. Remack, Monika Wierdl, Lyudmila Tsurkan, Seung U. Kim, Elizabeth Garcia, Marianne Z. Metz, Joseph Najbauer, Philip M. Potter, Karen S. Aboody
Journal: Cancer Research
Cancer Res (2007) 67 (1): 22–25.
https://doi.org/10.1158/0008-5472.CAN-06-3607
Published: 08 January 2007
View articletitled, Tumor-Targeted Enzyme/Prodrug Therapy Mediates Long-term Disease-Free Survival of Mice Bearing Disseminated Neuroblastoma
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Journal Articles

The glycosylation status of ICAM-2 alters its ability to suppress the metastatic potential of neuroblastoma cells

Free
K. Jin Yoon, Joanna S. Remack, Rebecca B. Bush, Mary K. Danks
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 654.
Published: 15 April 2006
View articletitled, The glycosylation status of ICAM-2 alters its ability to suppress the metastatic potential of neuroblastoma cells
Journal Articles

Brain Tumor Oncolysis with Replication-Conditional Herpes Simplex Virus Type 1 Expressing the Prodrug-Activating Genes, CYP2B1 and Secreted Human Intestinal Carboxylesterase, in Combination with Cyclophosphamide and Irinotecan

Free
Edyta Tyminski, Stanley LeRoy, Kinya Terada, Dianne M. Finkelstein, Janice L. Hyatt, Mary K. Danks, Philip M. Potter, Yoshinaga Saeki, E. Antonio Chiocca
Journal: Cancer Research
Cancer Res (2005) 65 (15): 6850–6857.
https://doi.org/10.1158/0008-5472.CAN-05-0154
Published: 01 August 2005
View articletitled, Brain Tumor Oncolysis with Replication-Conditional Herpes Simplex Virus Type 1 Expressing the Prodrug-Activating Genes, CYP2B1 and Secreted Human Intestinal Carboxylesterase, in Combination with Cyclophosphamide and Irinotecan
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Journal Articles

Human neural progenitor cells (NPCs) as delivery vectors for therapeutic transgenes: NPC-directed enzyme prodrug therapy (NDEPT)

Free
Karen S. Aboody, Rebecca A. Bush, Elizabeth Garcia, Marianne Metz, Doris A. Phelps, Joanna Remack, Monika Wierdl, K. Jin Yoon, Philip M. Potter, Mary K. Danks
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 796.
Published: 01 May 2005
View articletitled, Human neural progenitor cells (NPCs) as delivery vectors for therapeutic transgenes: NPC-directed enzyme prodrug therapy (NDEPT)
Journal Articles

Development of an etoposide prodrug that is selectively activated by rabbit carboxylesterase, for combination with irinotecan, in enzyme-prodrug activation approaches to therapy

Free
K. Jin Yoon, Joanna S. Remack, Jianjun Qi, Richard E. Lee, Philip M. Potter, Mary K. Danks
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 330.
Published: 01 May 2005
View articletitled, Development of an etoposide prodrug that is selectively activated by rabbit carboxylesterase, for combination with irinotecan, in enzyme-prodrug activation approaches to therapy
Journal Articles

Identification of novel selective inhibitors of human intestinal carboxylesterase: Synthesis, QSAR analysis, mechanism of action and biological activity.

Free
Randy M. Wadkins, Janice L. Hyatt, Kyoung Jin P. Yoon, Christopher L. Morton, Richard E. Lee, Komath Damodaran, Paul Beroza, Mary K. Danks, Philip M. Potter
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 462.
Published: 01 April 2004
View articletitled, Identification of novel selective inhibitors of human intestinal carboxylesterase: Synthesis, QSAR analysis, mechanism of action and biological activity.
Journal Articles

Development of a viral-directed, combination prodrug-enzyme therapy (VDEPT) for the treatment of solid tumors

Free
Kyoung J. Yoon, Joanna S. Remack, Kristopher G. Virga, Richard E. Lee, Philip M. Potter, Mary K. Danks
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 151.
Published: 01 April 2004
View articletitled, Development of a viral-directed, combination prodrug-enzyme therapy (VDEPT) for the treatment of solid tumors
Journal Articles

VDEPT using a rabbit liver carboxylesterase and CPT-11.

Free
Christopher L. Morton, Monika Wierdl, Peter J. Houghton, Mary K. Danks, Philip M. Potter
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 871.
Published: 01 April 2004
View articletitled, VDEPT using a rabbit liver carboxylesterase and CPT-11.
Journal Articles

Gains of chromosome 17q common in high-risk neuroblastomas do not involve the topoisomerase IIα gene: FISH and quantitative-PCR (Q-PCR) studies of six neuroblastoma cell lines

Free
Kyoung Jin P. Yoon, Marcus B. Valentine, Virginia A. Valentine, Susan T. Ragsdale, Mary K. Danks
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 629.
Published: 01 April 2004
View articletitled, Gains of chromosome 17q common in high-risk neuroblastomas do not involve the topoisomerase IIα gene: FISH and quantitative-PCR (Q-PCR) studies of six neuroblastoma cell lines
Journal Articles

A Prodrug Strategy Using ONYX-015-Based Replicating Adenoviruses to Deliver Rabbit Carboxylesterase to Tumor Cells for Conversion of CPT-11 to SN-38

Free
Hilde Stubdal, Noah Perin, Marilyn Lemmon, Patricia Holman, Maxine Bauzon, Philip M. Potter, Mary K. Danks, Ali Fattaey, Thomas Dubensky, Leisa Johnson
Journal: Cancer Research
Cancer Res (2003) 63 (20): 6900–6908.
Published: 28 October 2003
View articletitled, A Prodrug Strategy Using ONYX-015-Based Replicating Adenoviruses to Deliver Rabbit Carboxylesterase to Tumor Cells for Conversion of CPT-11 to SN-38
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Journal Articles

p21Waf1/Cip1 Dysfunction in Neuroblastoma: A Novel Mechanism of Attenuating G0-G1 Cell Cycle Arrest

Free
Pamela P. McKenzie, Mary K. Danks, Richard W. Kriwacki, Linda C. Harris
Journal: Cancer Research
Cancer Res (2003) 63 (13): 3840–3844.
Published: 01 July 2003
View articletitled, p21Waf1/Cip1 Dysfunction in Neuroblastoma: A Novel Mechanism of Attenuating G0-G1 Cell Cycle Arrest
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Journal Articles

Efficacy and Toxicity of a Virus-directed Enzyme Prodrug Therapy Purging Method: Preclinical Assessment and Application to Bone Marrow Samples from Neuroblastoma Patients

Free
Lars M. Wagner, Sylvie M. Guichard, Rebecca A. Burger, Christopher L. Morton, Charles M. Straign, Richard A. Ashmun, Linda C. Harris, Peter J. Houghton, Philip M. Potter, Mary K. Danks
Journal: Cancer Research
Cancer Res (2002) 62 (17): 5001–5007.
Published: 01 September 2002
View articletitled, Efficacy and Toxicity of a Virus-directed Enzyme Prodrug Therapy Purging Method: Preclinical Assessment and Application to Bone Marrow Samples from Neuroblastoma Patients
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Journal Articles

Sensitization of Human Tumor Cells to CPT-11 via Adenoviral-mediated Delivery of a Rabbit Liver Carboxylesterase

Free
Monika Wierdl, Christopher L. Morton, James K. Weeks, Mary K. Danks, Linda C. Harris, Philip M. Potter
Journal: Cancer Research
Cancer Res (2001) 61 (13): 5078–5082.
Published: 01 July 2001
View articletitled, Sensitization of Human Tumor Cells to CPT-11 via Adenoviral-mediated Delivery of a Rabbit Liver Carboxylesterase
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Journal Articles

A Virus-directed Enzyme Prodrug Therapy Approach to Purging Neuroblastoma Cells from Hematopoietic Cells Using Adenovirus Encoding Rabbit Carboxylesterase and CPT-11

Free
Mandy M. Meck, Monika Wierdl, Lars M. Wagner, Rebecca A. Burger, Sylvie M. Guichard, Erik. J. Krull, Linda C. Harris, Philip M. Potter, Mary K. Danks
Journal: Cancer Research
Cancer Res (2001) 61 (13): 5083–5089.
Published: 01 July 2001
View articletitled, A Virus-directed Enzyme Prodrug Therapy Approach to Purging Neuroblastoma Cells from Hematopoietic Cells Using Adenovirus Encoding Rabbit Carboxylesterase and CPT-11
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Journal Articles

Use of a Modified Ornithine Decarboxylase Promoter to Achieve Efficient c-MYC- or N-MYC-regulated Protein Expression

Free
Rekha V. Iyengar, Cynthia A. Pawlik, Erik J. Krull, Doris A. Phelps, Rebecca A. Burger, Linda C. Harris, Philip M. Potter, Mary K. Danks
Journal: Cancer Research
Cancer Res (2001) 61 (7): 3045–3052.
Published: 01 April 2001
View articletitled, Use of a Modified Ornithine Decarboxylase Promoter to Achieve Efficient c-MYC- or N-MYC-regulated Protein Expression
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Journal Articles

Proficient Metabolism of Irinotecan by a Human Intestinal Carboxylesterase

Free
Ruchi Khanna, Christopher L. Morton, Mary K. Danks, Philip M. Potter
Journal: Cancer Research
Cancer Res (2000) 60 (17): 4725–4728.
Published: 01 September 2000
View articletitled, Proficient Metabolism of Irinotecan by a Human Intestinal Carboxylesterase
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Journal Articles

Activation of CPT-11 in Mice: Identification and Analysis of a Highly Effective Plasma Esterase

Free
Christopher L. Morton, Monika Wierdl, LaGora Oliver, Margaret K. Ma, Mary K. Danks, Clinton F. Stewart, Julie L. Eiseman, Philip M. Potter
Journal: Cancer Research
Cancer Res (2000) 60 (15): 4206–4210.
Published: 01 August 2000
View articletitled, Activation of CPT-11 in Mice: Identification and Analysis of a Highly Effective Plasma Esterase
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Journal Articles

The Anticancer Prodrug CPT-11 Is a Potent Inhibitor of Acetylcholinesterase but Is Rapidly Catalyzed to SN-38 by Butyrylcholinesterase

Free
Christopher L. Morton, Randy M. Wadkins, Mary K. Danks, Philip M. Potter
Journal: Cancer Research
Cancer Res (1999) 59 (7): 1458–1463.
Published: 01 April 1999
View articletitled, The Anticancer Prodrug CPT-11 Is a Potent Inhibitor of Acetylcholinesterase but Is Rapidly Catalyzed to SN-38 by Butyrylcholinesterase
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Journal Articles

Cellular Localization Domains of a Rabbit and a Human Carboxylesterase: Influence on Irinotecan (CPT-11) Metabolism by the Rabbit Enzyme

Free
Philip M. Potter, Judith S. Wolverton, Christopher L. Morton, Monika Wierdl, Mary K. Danks
Journal: Cancer Research
Cancer Res (1998) 58 (16): 3627–3632.
Published: 01 August 1998
View articletitled, Cellular Localization Domains of a Rabbit and a Human Carboxylesterase: Influence on Irinotecan (CPT-11) Metabolism by the Rabbit Enzyme
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Journal Articles

Isolation and Partial Characterization of a cDNA Encoding a Rabbit Liver Carboxylesterase That Activates the Prodrug Irinotecan (CPT-11)

Free
Philip M. Potter, Cynthia A. Pawlik, Christopher L. Morton, Clayton W. Naeve, Mary K. Danks
Journal: Cancer Research
Cancer Res (1998) 58 (12): 2646–2651.
Published: 01 June 1998
View articletitled, Isolation and Partial Characterization of a cDNA Encoding a Rabbit Liver Carboxylesterase That Activates the Prodrug Irinotecan (CPT-11)
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