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Mary Helen Barcellos-Hoff
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Journal Articles

Abstract 2040: βAlt score provides independent and significant clinical value in multiple tumor types

Mary Helen Barcellos-Hoff, Hang Chang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2040.
https://doi.org/10.1158/1538-7445.AM2025-2040
Published: 21 April 2025
View articletitled, Abstract 2040: βAlt score provides independent and significant clinical value in multiple tumor types
Journal Articles

Abstract 6651: Compromised TGFβ signaling and DNA repair primes immune poor tumors response to immune checkpoint blockade by activating NK cells

Jade T. Moore, Jim Gkantalis, Ines Guix, Mary Helen Barcellos-Hoff
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6651.
https://doi.org/10.1158/1538-7445.AM2024-6651
Published: 22 March 2024
View articletitled, Abstract 6651: Compromised TGFβ signaling and DNA repair primes immune poor tumors response to immune checkpoint blockade by activating NK cells
Journal Articles

Abstract B032: Compromised TGFβ signaling and DNA repair primes response to immune checkpoint inhibition by activating NK cells in immunologically cold breast cancers

Jade Moore, Jim Gkantalis, Ines Guix, Colin Foster, Mary Helen Barcellos-Hoff
Journal: Cancer Research
Cancer Res (2024) 84 (3_Supplement_1): B032.
https://doi.org/10.1158/1538-7445.ADVBC23-B032
Published: 01 February 2024
View articletitled, Abstract B032: Compromised TGFβ signaling and DNA repair primes response to immune checkpoint inhibition by activating NK cells in immunologically cold breast cancers
Journal Articles

Mammary Tumor–Derived Transplants as Breast Cancer Models to Evaluate Tumor–Immune Interactions and Therapeutic Responses

Jade Moore, Lin Ma, Ann A. Lazar, Mary Helen Barcellos-Hoff
Journal: Cancer Research
Cancer Res (2022) 82 (3): 365–376.
https://doi.org/10.1158/0008-5472.CAN-21-0253
Published: 02 February 2022
View articletitled, Mammary Tumor–Derived Transplants as Breast Cancer Models to Evaluate Tumor–Immune Interactions and Therapeutic Responses
Open the PDF for Mammary Tumor–Derived Transplants as Breast Cancer Models to Evaluate Tumor–Immune Interactions and Therapeutic Responses in another window
Journal Articles

Abstract 1388: Loss of TGFβ signaling increases alternative end-joining and could sensitize high-grade serous ovarian cancer to PARP inhibitors

Ines Guix, Qi Liu, Luis Palomero, Jade Moore, Miquel Angel Pujana, Mary Helen Barcellos-Hoff
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1388.
https://doi.org/10.1158/1538-7445.AM2020-1388
Published: 15 August 2020
View articletitled, Abstract 1388: Loss of TGFβ signaling increases alternative end-joining and could sensitize high-grade serous ovarian cancer to PARP inhibitors
Journal Articles

Abstract 1569: TGFβ signaling suppresses alternative end joining associated with genomic mutations and PARP Inhibition sensitivity

Qi Liu, Luis Palomero, Jade Moore, Ines Guix, Miquel Angel Pujana, Mary Helen Barcellos-Hoff
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1569.
https://doi.org/10.1158/1538-7445.AM2020-1569
Published: 15 August 2020
View articletitled, Abstract 1569: TGFβ signaling suppresses alternative end joining associated with genomic mutations and PARP Inhibition sensitivity
Journal Articles

Abstract 2812: Status of TGFbeta signaling determines PARP inhibitor sensitivity in head and neck cancer

Qi Liu, Lin Ma, Luis Palomero, Miquel Àngel Pujana, Trevor Jones, Patrick Ha, John Murnane, Mary Helen Barcellos-Hoff
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2812.
https://doi.org/10.1158/1538-7445.AM2018-2812
Published: 01 July 2018
View articletitled, Abstract 2812: Status of TGFbeta signaling determines PARP inhibitor sensitivity in head and neck cancer
Journal Articles

Abstract 831: TGFβ controls the DNA damage response via miR-182 regulation of BRCA1 and ATM

Qi Liu, Haydeliz Martinez-Ruiz, John Murnane, Simon N. Powell, Mary Helen Barcellos-Hoff
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 831.
https://doi.org/10.1158/1538-7445.AM2017-831
Published: 01 July 2017
View articletitled, Abstract 831: TGFβ controls the DNA damage response via miR-182 regulation of BRCA1 and ATM
Journal Articles

Abstract 4987: Role of the PD-1/PDL-1 pathway in resistance of patients with metastatic breast cancer to treatment with radiotherapy and TGFβ neutralization

Sandra Demaria, Claire Vanpouille-Box, Rachael E. Hawtin, Christie Fanton, Andy Conroy, Erik Evensen, Neha Dixit, Alan Barber, Dorthe Schaue, William H. McBride, Mary Helen Barcellos-Hoff, Silvia C. Formenti
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4987.
https://doi.org/10.1158/1538-7445.AM2016-4987
Published: 15 July 2016
View articletitled, Abstract 4987: Role of the PD-1/PDL-1 pathway in resistance of patients with metastatic breast cancer to treatment with radiotherapy and TGFβ neutralization
Journal Articles

Abstract 5247: Caffeic acid phenethyl ester (CAPE) reverses aggressive breast cancer in the radiation chimera model

Coral O. Omene, Manan Patel, Irineu IllaBochaca, Mary Helen Barcellos-Hoff
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 5247.
https://doi.org/10.1158/1538-7445.AM2016-5247
Published: 15 July 2016
View articletitled, Abstract 5247: Caffeic acid phenethyl ester (CAPE) reverses aggressive breast cancer in the radiation chimera model
Journal Articles

Abstract 4232: CAPE (caffeic acid phenethyl ester) induces a mammary stem cell lineage restriction to a luminal phenotype via chromatin remodeling

Coral O. Omene, Manan Patel, Kasthuri Kannan, Adriana Heguy, Mary Helen Barcellos-Hoff
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4232.
https://doi.org/10.1158/1538-7445.AM2015-4232
Published: 01 August 2015
View articletitled, Abstract 4232: CAPE (caffeic acid phenethyl ester) induces a mammary stem cell lineage restriction to a luminal phenotype via chromatin remodeling
Journal Articles

TGFβ Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity

Claire Vanpouille-Box, Julie M. Diamond, Karsten A. Pilones, Jiri Zavadil, James S. Babb, Silvia C. Formenti, Mary Helen Barcellos-Hoff, Sandra Demaria
Journal: Cancer Research
Cancer Res (2015) 75 (11): 2232–2242.
https://doi.org/10.1158/0008-5472.CAN-14-3511
Published: 31 May 2015
View articletitled, TGFβ Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity
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Includes: Supplementary data
Journal Articles

Abstract IA19: Multiplexing TGFβ in the tumor microenvironment

Mary Helen Barcellos-Hoff
Journal: Cancer Research
Cancer Res (2015) 75 (1_Supplement): IA19.
https://doi.org/10.1158/1538-7445.CHTME14-IA19
Published: 12 January 2015
View articletitled, Abstract IA19: Multiplexing TGFβ in the tumor microenvironment
Journal Articles

Distinct Luminal-Type Mammary Carcinomas Arise from Orthotopic Trp53-Null Mammary Transplantation of Juvenile versus Adult Mice

David H. Nguyen, Haoxu Ouyang, Jian-Hua Mao, Lynn Hlatky, Mary Helen Barcellos-Hoff
Journal: Cancer Research
Cancer Res (2014) 74 (23): 7149–7158.
https://doi.org/10.1158/0008-5472.CAN-14-1440
Published: 30 November 2014
View articletitled, Distinct Luminal-Type Mammary Carcinomas Arise from Orthotopic Trp53-Null Mammary Transplantation of Juvenile versus Adult Mice
Open the PDF for Distinct Luminal-Type Mammary Carcinomas Arise from Orthotopic Trp53-Null Mammary Transplantation of Juvenile versus Adult Mice in another window
Includes: Supplementary data
Journal Articles

Densely Ionizing Radiation Acts via the Microenvironment to Promote Aggressive Trp53-Null Mammary Carcinomas

Irineu Illa-Bochaca, Haoxu Ouyang, Jonathan Tang, Christopher Sebastiano, Jian-Hua Mao, Sylvain V. Costes, Sandra Demaria, Mary Helen Barcellos-Hoff
Journal: Cancer Research
Cancer Res (2014) 74 (23): 7137–7148.
https://doi.org/10.1158/0008-5472.CAN-14-1212
Published: 30 November 2014
View articletitled, Densely Ionizing Radiation Acts via the Microenvironment to Promote Aggressive Trp53-Null Mammary Carcinomas
Open the PDF for Densely Ionizing Radiation Acts via the Microenvironment to Promote Aggressive Trp53-Null Mammary Carcinomas in another window
Includes: Supplementary data
Journal Articles

Abstract 633: Inhibition of TGFβ as a strategy to convert the irradiated tumor into in situ individualized vaccine

Claire I. Vanpouille-Box, Julie M. Diamond, Jiri Zavadil, James Babb, Dörthe Schaue, Mary Helen Barcellos-Hoff, William H. McBride, Silvia C. Formenti, Sandra Demaria
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 633.
https://doi.org/10.1158/1538-7445.AM2014-633
Published: 01 October 2014
View articletitled, Abstract 633: Inhibition of TGFβ as a strategy to convert the irradiated tumor into in situ individualized vaccine
Journal Articles

Abstract LB-175: Concomitant radiotherapy (RT) and TGFβ neutralizing antibodies alters tumor microenvironment and promotes tumor regression

Ilenia Pellicciotta, Shisuo Du, Silvia Formenti, Mary Helen Barcellos-Hoff
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): LB-175.
https://doi.org/10.1158/1538-7445.AM2014-LB-175
Published: 01 October 2014
View articletitled, Abstract LB-175: Concomitant radiotherapy (RT) and TGFβ neutralizing antibodies alters tumor microenvironment and promotes tumor regression
Journal Articles

Abstract 2304: Biologically distinct mammary tumors develop from Trp53 null tissue transplanted to juvenile versus adult gland.

David H. Nguyen, Jian-Hua Mao, Mary Helen Barcellos-Hoff
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2304.
https://doi.org/10.1158/1538-7445.AM2013-2304
Published: 15 April 2013
View articletitled, Abstract 2304: Biologically distinct mammary tumors develop from Trp53 null tissue transplanted to juvenile versus adult gland.
Journal Articles

Resistance of Glioblastoma-Initiating Cells to Radiation Mediated by the Tumor Microenvironment Can Be Abolished by Inhibiting Transforming Growth Factor-β

Matthew E. Hardee, Ariel E. Marciscano, Christina M. Medina-Ramirez, David Zagzag, Ashwatha Narayana, Scott M. Lonning, Mary Helen Barcellos-Hoff
Journal: Cancer Research
Cancer Res (2012) 72 (16): 4119–4129.
https://doi.org/10.1158/0008-5472.CAN-12-0546
Published: 14 August 2012
View articletitled, Resistance of Glioblastoma-Initiating Cells to Radiation Mediated by the Tumor Microenvironment Can Be Abolished by Inhibiting Transforming Growth Factor-β
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Journal Articles

Abstract 4268: Gene signature of host irradiation from Trp53 null mammary tumors detects radiation-preceded human cancers and has prognostic value for sporadic human breast cancer

David H. Nguyen, Erik Fredlund, Wei Zhao, Charles M. Perou, Allan Balmain, Jian-Hua Mao, Mary Helen Barcellos-Hoff
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4268.
https://doi.org/10.1158/1538-7445.AM2012-4268
Published: 15 April 2012
View articletitled, Abstract 4268: Gene signature of host irradiation from Trp53 null mammary tumors detects radiation-preceded human cancers and has prognostic value for sporadic human breast cancer