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Martin Schuler
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Journal Articles

Abstract 5019: Comprehensive pan-cancer analysis of cfDNA methylation marks in tumors reveals complex epigenetic regulatory circuits and diagnostic biomarkers

Free
Smiths Sengkwawoh Lueong, Martin Metzenmacher, Gregor Zaun, Gina Lauren Mayer, Erik Jan Hemmer, Katharina Lückerath, Kelsey Pomykala, Balazs Hegedüs, Peter A. Horn, Marija Trajkovic-Arsic, Tibor Szarvas, Renáta Váraljai, Corinna Keup, Ingeborg Tinhofer, Stephen George, Sabine Kasimir-Bauer, Samuel Peña-Llopis, Alexander Roesch, Cornelius Kürten, Lukas Boosfeld, Kirsten Bruderek, Christopher Darr, Thomas Hilser, Viktor Grünwald, Sven Brandau, Boris Hadaschik, Hans Neubauer, Irene Irene Esposito Irene Esposito, Tanja Fehm, Csilla Oláh, Anita Csizmarik, Fabinshy Thangarajah, Laura Reetz, Ghanam Jamal, Basant Kumar Thakur, Halime Kalkavan, Alexander Schramm, Martin Schuler, Jens T. Siveke
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5019.
https://doi.org/10.1158/1538-7445.AM2024-5019
Published: 22 March 2024
View articletitled, Abstract 5019: Comprehensive pan-cancer analysis of cfDNA methylation marks in tumors reveals complex epigenetic regulatory circuits and diagnostic biomarkers
Journal Articles

Abstract CT033: KontRASt-01: A phase Ib/II, dose-escalation study of JDQ443 in patients (pts) with advanced, KRAS G12C-mutated solid tumors

Free
Daniel S. Tan, Toshio Shimizu, Benjamin Solomon, Rebecca S. Heist, Martin Schuler, Maria J. De Miguel Luken, Anas Gazzah, Martin Wermke, Christophe Dooms, Herbert H. Loong, Neeltje Steeghs, Enriqueta Felip, Conor E. Steuer, Eric van Cutsem, Ross A. Soo, Ashley C. Jaeger, Jaeyeon Kim, Kun Xu, Xueying Chen, Xiaoming Cui, Heather Burks, Anna Farago, Philippe A. Cassier
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT033.
https://doi.org/10.1158/1538-7445.AM2022-CT033
Published: 15 June 2022
View articletitled, Abstract CT033: KontRASt-01: A phase Ib/II, dose-escalation study of JDQ443 in patients (pts) with advanced, KRAS G12C-mutated solid tumors
Journal Articles

Abstract CT008: Long-term outcomes with sotorasib in pretreated KRASp.G12C-mutated NSCLC: 2-year analysis of CodeBreaK100

Free
Grace K. Dy, Ramaswamy Govindan, Vamsidhar Velcheti, Gerald S. Falchook, Antoine Italiano, Juergen Wolf, Adrian G. Sacher, Toshiaki Takahashi, Suresh S. Ramalingam, Christophe Dooms, Dong-Wan Kim, Alfredo Addeo, Jayesh Desai, Martin Schuler, Pascale Tomasini, Qui Tran, Simon Jones, Agnes Ang, Abraham Anderson, Antreas A. Hindoyan, David S. Hong, Bob T. Li
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT008.
https://doi.org/10.1158/1538-7445.AM2022-CT008
Published: 15 June 2022
View articletitled, Abstract CT008: Long-term outcomes with sotorasib in pretreated KRASp.G12C-mutated NSCLC: 2-year analysis of CodeBreaK100
Journal Articles

GPR15 Facilitates Recruitment of Regulatory T Cells to Promote Colorectal Cancer

Available to Purchase
Alexandra Adamczyk, Eva Pastille, Jan Kehrmann, Vivian P. Vu, Robert Geffers, Marie-Hélène Wasmer, Stefan Kasper, Martin Schuler, Christian M. Lange, Beat Muggli, Tilman T. Rau, Diana Klein, Wiebke Hansen, Philippe Krebs, Jan Buer, Astrid M. Westendorf
Journal: Cancer Research
Cancer Res (2021) 81 (11): 2970–2982.
https://doi.org/10.1158/0008-5472.CAN-20-2133
Published: 01 June 2021
View articletitled, GPR15 Facilitates Recruitment of Regulatory T Cells to Promote Colorectal Cancer
Open the PDF for GPR15 Facilitates Recruitment of Regulatory T Cells to Promote Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract PS10-31: Ribecca - a phase 3b, multi-center, open label study for women with estrogen receptor positive, locally advanced or metastatic breast cancer treated with ribociclib (lee011) in combination with letrozole: Final results

Free
Mattea Reinisch, Arndt Nusch, Thomas Decker, Andreas Hartkopf, Bernhard J Heinrich, Christian M Kurbacher, Roswitha Fuchs, Hans Tesch, Petra Krabisch, Sara Y Brucker, Tanja Fehm, Wolfgang Janni, Sherko Kuemmel, Diana Lüftner, Andreas Schneeweiss, Martin Schuler, Claudia Voges, Joerg Schubert, Peter A Fasching
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS10-31.
https://doi.org/10.1158/1538-7445.SABCS20-PS10-31
Published: 15 February 2021
View articletitled, Abstract PS10-31: Ribecca - a phase 3b, multi-center, open label study for women with estrogen receptor positive, locally advanced or metastatic breast cancer treated with ribociclib (lee011) in combination with letrozole: Final results
Journal Articles

Abstract CT255: EATON: A phase I dose-escalation trial of nazartinib (EGF816) and trametinib in EGFR-mutant NSCLC

Free
Sebastian Michels, Lucia Nogova, Matthias Scheffler, Barbara Deschler-Baier, Martin Sebastian, Martin Schuler, Martin Wermke, Enriqueta Felip, Rafael Rosell, Delvys Rodriguez Abreu, Diana S.Y. Abdulla, Rieke N. Fischer, Sophia Koleczko, Anna Kron, Richard Riedel, Jan-Philipp Weber, Jana Fassunke, Sabine Merkelbach-Bruse, Heinz Haverkammp, Martin Hellmich, Reinhard Büttner, Jürgen Wolf, Lung Cancer Group Cologne (LCGC) and Network Genomic Medicine (NGM)
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT255.
https://doi.org/10.1158/1538-7445.AM2020-CT255
Published: 15 August 2020
View articletitled, Abstract CT255: EATON: A phase I dose-escalation trial of nazartinib (EGF816) and trametinib in EGFR-mutant NSCLC
Journal Articles

Abstract CT301: A phase Ib study to evaluate RO7198457, an individualized Neoantigen Specific immunoTherapy (iNeST), in combination with atezolizumab in patients with locally advanced or metastatic solid tumors

Free
Juanita S. Lopez, Ross Camidge, Marco Iafolla, Sylvie Rottey, Martin Schuler, Matthew Hellmann, Ani Balmanoukian, Luc Dirix, Michael Gordon, Ryan Sullivan, Brian S. Henick, Charles Drake, Kit Wong, Patricia LoRusso, Patrick Ott, Lawrence Fong, Aglaia Schiza, Jeffery Yachnin, Christian Ottensmeier, Fadi Braiteh, Johanna Bendell, Rom Leidner, George Fisher, Guy Jerusalem, Laura Molenaar-Kuijsten, Marcus Schmidt, Scott A. Laurie, Raid Aljumaily, Achim Rittmeyer, Eelke Gort, Ignacio Melero, Lars Mueller, Rachel Sabado, Patrick Twomey, Jack Huang, Manesh Yadav, Jingbin Zhang, Felicitas Mueller, Evelyna Derhovanessian, Ugur Sahin, Özlem Türeci, Thomas Powles
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT301.
https://doi.org/10.1158/1538-7445.AM2020-CT301
Published: 15 August 2020
View articletitled, Abstract CT301: A phase Ib study to evaluate RO7198457, an individualized Neoantigen Specific immunoTherapy (iNeST), in combination with atezolizumab in patients with locally advanced or metastatic solid tumors
Journal Articles

Abstract CT106: Ph I/II study of FGF401 in adult pts with HCC or solid tumors characterized by FGFR4/KLB expression

Free
Stephen L. Chan, Chia-Jui Yen, Martin Schuler, Chia-Chi Lin, Su Pin Choo, Karl-Heinz Weiss, Andreas Geier, Takuji Okusaka, Ho Yeong Lim, Teresa Macarulla, Andrew X. Zhu, Tomoyuki Kakizume, Yi (Gary) Gu, Diana Graus Porta, Andrea P. Myers, Jean-Pierre Delord
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): CT106.
https://doi.org/10.1158/1538-7445.AM2017-CT106
Published: 01 July 2017
View articletitled, Abstract CT106: Ph I/II study of FGF401 in adult pts with HCC or solid tumors characterized by FGFR4/KLB expression
Journal Articles

Abstract 3738: Use of tumor mRNA expression for patient selection in a phase I study of the pan-fibroblast growth factor receptor inhibitor BAY 1163877

Free
Peter Ellinghaus, Matthias Ocker, Sebastian Bender, Christoph Kneip, Stuart Ince, Markus Joerger, Martin Schuler
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3738.
https://doi.org/10.1158/1538-7445.AM2017-3738
Published: 01 July 2017
View articletitled, Abstract 3738: Use of tumor mRNA expression for patient selection in a phase I study of the pan-fibroblast growth factor receptor inhibitor BAY 1163877
Journal Articles

Abstract 1033: Alternative tumor suppressor mechanisms in lung carcinomas - modulation of senescence by growth factor-induced signaling

Free
Boyka Markova, Frank Breitenbuecher, Martin Schuler
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1033.
https://doi.org/10.1158/1538-7445.AM2015-1033
Published: 01 August 2015
View articletitled, Abstract 1033: Alternative tumor suppressor mechanisms in lung carcinomas - modulation of senescence by growth factor-induced signaling
Journal Articles

Abstract CT136: Final biomarker analysis of the phase I study of the selective BRAF V600 inhibitor encorafenib (LGX818) combined with cetuximab with or without the α-specific PI3K inhibitor alpelisib (BYL719) in patients with advanced BRAF-mutant colorectal cancer

Free
Jan H. M. Schellens, Robin van Geel, Johanna C. Bendell, Anna Spreafico, Martin Schuler, Takayuki Yoshino, Jean-Pierre Delord, Yasuhide Yamada, Martijn P. Lolkema, Jason E. Faris, Ferry A. L. M. Eskens, Sunil Sharma, Rona Yaeger, Heinz-Josef Lenz, Zev A. Wainberg, Emin Avsar, Arkendu Chatterjee, Savina Jaeger, Tim Demuth, Josep Tabernero
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): CT136.
https://doi.org/10.1158/1538-7445.AM2015-CT136
Published: 01 August 2015
View articletitled, Abstract CT136: Final biomarker analysis of the phase I study of the selective BRAF V600 inhibitor encorafenib (LGX818) combined with cetuximab with or without the α-specific PI3K inhibitor alpelisib (BYL719) in patients with advanced BRAF-mutant colorectal cancer
Journal Articles

Abstract PD5-5: Phase I study of the PI3Kα inhibitor BYL719 plus fulvestrant in patients with PIK3CA-altered and wild type ER+/HER2- locally advanced or metastatic breast cancer

Free
Filip Janku, Dejan Juric, Javier Cortes, Hope Rugo, Howard A Burris, Martin Schuler, Barbara Deschler-Baier, Mark R Middleton, Marta Gil-Martin, Jordan Berlin, Eric Winer, Douglas Bootle, Lars Blumenstein, David Demanse, Christina Coughlin, Cornelia Quadt, José Baselga
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): PD5-5.
https://doi.org/10.1158/1538-7445.SABCS14-PD5-5
Published: 01 May 2015
View articletitled, Abstract PD5-5: Phase I study of the PI3Kα inhibitor BYL719 plus fulvestrant in patients with PIK3CA-altered and wild type ER+/HER2- locally advanced or metastatic breast cancer
Journal Articles

Abstract 3375: Targeting glucose metabolism by 2-deoxyglucose in gastrointestinal stromal tumors

Free
Thomas Mühlenberg, Susanne Grunewald, Martin Schuler, Sebastian Bauer
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3375.
https://doi.org/10.1158/1538-7445.AM2014-3375
Published: 01 October 2014
View articletitled, Abstract 3375: Targeting glucose metabolism by 2-deoxyglucose in gastrointestinal stromal tumors
Journal Articles

Abstract CT326: Phase I study of BGJ398, a selective pan-FGFR inhibitor in genetically preselected advanced solid tumors

Free
Lecia V. Sequist, Phillippe Cassier, Andrea Varga, Josep Tabernero, Jan H. Schellens, Jean-Pierre Delord, Patricia LoRusso, D. Ross Camidge, Manuel Hidalgo Medina, Martin Schuler, Mario Campone, G. Gary Tian, Steven Wong, Jesus Corral, Randi Isaacs, Suman K. Sen, Diana Graus Porta, Swarupa G. Kulkarni, Caroline Lefebvre, Jürgen Wolf
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): CT326.
https://doi.org/10.1158/1538-7445.AM2014-CT326
Published: 01 October 2014
View articletitled, Abstract CT326: Phase I study of BGJ398, a selective pan-FGFR inhibitor in genetically preselected advanced solid tumors
Journal Articles

Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer

Free
Eva Pastille, Katrin Bardini, Diana Fleissner, Alexandra Adamczyk, Annika Frede, Munisch Wadwa, Dorthe von Smolinski, Stefan Kasper, Tim Sparwasser, Achim D. Gruber, Martin Schuler, Shimon Sakaguchi, Axel Roers, Werner Müller, Wiebke Hansen, Jan Buer, Astrid M. Westendorf
Journal: Cancer Research
Cancer Res (2014) 74 (16): 4258–4269.
https://doi.org/10.1158/0008-5472.CAN-13-3065
Published: 13 August 2014
View articletitled, Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer
Open the PDF for Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer in another window
Includes: Supplementary data
Journal Articles

DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal Tumors

Free
Susanne Simon, Florian Grabellus, Loretta Ferrera, Luis Galietta, Benjamin Schwindenhammer, Thomas Mühlenberg, Georg Taeger, Grant Eilers, Juergen Treckmann, Frank Breitenbuecher, Martin Schuler, Takahiro Taguchi, Jonathan A. Fletcher, Sebastian Bauer
Journal: Cancer Research
Cancer Res (2013) 73 (12): 3661–3670.
https://doi.org/10.1158/0008-5472.CAN-12-3839
Published: 13 June 2013
View articletitled, DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal Tumors
Open the PDF for DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal Tumors in another window
Includes: Supplementary data
Journal Articles

Abstract 3855: Inhibitors of apoptosis (IAPs) in gastrointestinal stromal tumors

Free
Johanna Falkenhorst, Thomas Mühlenberg, Susanne Simon, Sonja Ecken, Joern Henze, Florian Grabellus, Frank Breitenbücher, Martin Schuler, Jonathan A. Fletcher, Sebastian Bauer
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3855.
https://doi.org/10.1158/1538-7445.AM2012-3855
Published: 15 April 2012
View articletitled, Abstract 3855: Inhibitors of apoptosis (IAPs) in gastrointestinal stromal tumors
Journal Articles

Abstract LB-122: A phase I dose escalation study of NVP-BGJ398, a selective pan FGFR inhibitor in genetically preselected advanced solid tumors

Free
Jurgen Wolf, Patricia M. LoRusso, Ross D. Camidge, Jose Manuel Perez, Josep Tabernero, Manuel Hidalgo, Martin Schuler, Gary G. Tian, Jean Charles Soria, Jean Pierre Delord, Mario Campone, Thomas Bachelot, Ruud van der Noll, Francois P. Ringeisen, Lucia Nogova, Lecia V. Sequist, Jan HM Schellens
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): LB-122.
https://doi.org/10.1158/1538-7445.AM2012-LB-122
Published: 15 April 2012
View articletitled, Abstract LB-122: A phase I dose escalation study of NVP-BGJ398, a selective pan FGFR inhibitor in genetically preselected advanced solid tumors
Journal Articles

Abstract 1713: Folylpoly-α-glutamate synthetase and thymidylate synthase are associated with clinical outcome from pemetrexed-based therapy in advanced non-small cell lung cancer (NSCLC)

Free
Daniel C. Christoph, Bernadette Reyna Asuncion, Murry Wynes, Thomas C. Gauler, Jeremias Wohlschlaeger, Dirk Theegarten, Stefan Welter, Cindy Tran, Biftu Hassan, Heike Loewendick, Anja Peglow, Martin Schuler, Wilfried Eberhardt, Fred R. Hirsch
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1713.
https://doi.org/10.1158/1538-7445.AM2012-1713
Published: 15 April 2012
View articletitled, Abstract 1713: Folylpoly-α-glutamate synthetase and thymidylate synthase are associated with clinical outcome from pemetrexed-based therapy in advanced non-small cell lung cancer (NSCLC)
Journal Articles

Abstract 1824: Functional characterization of DOG1 in Gastrointestinal Stromal Tumors (GIST)

Free
Susanne Simon, Loretta Fererra, Luis Galietta, Florian Grabellus, Frank Breitenbücher, Martin Schuler, Jonathan Fletcher, Sebastian Bauer
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1824.
https://doi.org/10.1158/1538-7445.AM2012-1824
Published: 15 April 2012
View articletitled, Abstract 1824: Functional characterization of DOG1 in Gastrointestinal Stromal Tumors (GIST)