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Journal Articles

Abstract 6168: Characterization of ATM inhibitor (AZD1390) distribution and pharmacodynamic changes in brain and glioblastoma in preclinical models to inform on mechanism of action

Lenka Oplustil O'Connor, Gregory Hamm, Maria Udriste, Stephanie Ling, Joanne Wilson, Steve Durant, Gareth Hughes, Sabina Cosulich, Wenlin Shao, Martin Pass, Gemma Jones, Andrew Pierce, Richard Goodwin, Mark O'Connor, Carl Barrett, Elizabeth Harrington
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6168.
DOI: https://doi.org/10.1158/1538-7445.AM2020-6168
Published: 15 August 2020
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Journal Articles

Abstract 4868: A preclinical PK/PD model based on a mouse glioblastoma survival model for AZD1390, a novel, brain-penetrant ATM kinase inhibitor, to predict the inhibition of DNA damage response induced by radiation and the human efficacious dose

Venkatesh Pilla Reddy, Andy Sykes, Nicola Colclough, Stephen T. Durant, Lenka Oplustil O'Connor, Matthias Hoch, Nuria Buil Bruna, Serena De Vita, Melinda Merchant, Martin Pass
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4868.
DOI: https://doi.org/10.1158/1538-7445.AM2019-4868
Published: 01 July 2019
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Journal Articles

Abstract 4909: Adaptive oncology phase 1 study of first-in-class inhibitor of ataxia telangiectasia mutated protein kinase (ATM), in combination with olaparib

Yingxue Chen, Martin Pass, Nuria Bui Bruna, Christine Stephens, Andrew Pierce, Wouter Hanekom, Hani Gabra, Helen Tomkinson, Nidal Al-Huniti
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4909.
DOI: https://doi.org/10.1158/1538-7445.AM2018-4909
Published: 01 July 2018
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Journal Articles

Abstract 3041: Blood-brain barrier penetrating ATM inhibitor (AZ32) radiosensitises intracranial gliomas in mice

Steve T. Durant, Jeremy Karlin, Kurt Pike, Nicola Colclough, N Mukhopadhyay, S F. Ahmad, J M. Bekta, M Tokarz, Catherine Bardelle, Gareth Hughes, Bhavika Patel, Andrew Thomason, Elaine Cadogan, Ian Barrett, Alan Lau, Martin Pass, Kristoffer Valerie
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3041.
DOI: https://doi.org/10.1158/1538-7445.AM2016-3041
Published: 15 July 2016
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Journal Articles

Abstract CT010: Phase I trial combining the PARP inhibitor olaparib (Ola) and AKT inhibitor AZD5363 (AZD) in germline (g)BRCA and non-BRCA mutant (m) advanced cancer patients (pts) incorporating noninvasive monitoring of cancer mutations

Vasiliki Michalarea, Desam Roda, Yvette Drew, Suzanne Carreira, Brent S. O’Carrigan, Heather Shaw, Rene Roux, Sanjeev Kumar, Sarah Ward, Mona Parmar, Alison Turner, Emma Hall, Sonia Serrano Fandos, Raquel Perez, Nina Tunariu, Florence Raynaud, Marie Cullberg, Andrew Foxley, Justin PO Lindemann, Martin Pass, Paul Rugman, Juanita S. Lopez, Udai Banerji, Bristi Basu, Ruth Plummer, Rebecca Kristeleit, Johann S. de Bono, Timothy A. Yap
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): CT010.
DOI: https://doi.org/10.1158/1538-7445.AM2016-CT010
Published: 15 July 2016
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Journal Articles

Abstract 3343: The pre-clinical in vitro and in vivo activity of AZD6738: A potent and selective inhibitor of ATR kinase.

Sylvie M. Guichard, Elaine Brown, Rajesh Odedra, Adina Hughes, Dan Heathcote, Jen Barnes, Alan Lau, Steve Powell, Clifford D. Jones, Willem Nissink, Kevin M. Foote, Philip J. Jewsbury, Martin Pass
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3343.
DOI: https://doi.org/10.1158/1538-7445.AM2013-3343
Published: 15 April 2013
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Journal Articles

Abstract 917: AZD2014, a dual mTORC1 and mTORC2 inhibitor is differentiated from allosteric inhibitors of mTORC1 in ER+ breast cancer

Sylvie M. Guichard, Zoe Howard, Dan Heathcote, Mark Roth, Gareth Hughes, Jon Curwen, James Yates, Armelle Logie, Sarah Holt, Christine M. Chresta, Barry R. Davies, Karine Malagu, Marc Hummersone, Sarah L. Pass, Stephen Green, Martin Pass
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 917.
DOI: https://doi.org/10.1158/1538-7445.AM2012-917
Published: 15 April 2012
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Journal Articles

Abstract 4477: Characterization of AZD5363, an orally bioavailable, potent ATP-competitive inhibitor of AKT kinases with pharmacodynamic and antitumor activity in preclinical models

Barry R. Davies, Richard Luke, Phillippa Dudley, Hannah Greenwood, Claire Crafter, Sabina Cosulich, Ken Page, James Yates, Clare Lane, Derek Yu, Jingchuan Zhang, Martin Pass
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4477.
DOI: https://doi.org/10.1158/1538-7445.AM2011-4477
Published: 15 April 2011
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Journal Articles

AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity

Christine M. Chresta, Barry R. Davies, Ian Hickson, Tom Harding, Sabina Cosulich, Susan E. Critchlow, John P. Vincent, Rebecca Ellston, Darren Jones, Patrizia Sini, Dominic James, Zoe Howard, Phillippa Dudley, Gareth Hughes, Lisa Smith, Sharon Maguire, Marc Hummersone, Karine Malagu, Keith Menear, Richard Jenkins, Matt Jacobsen, Graeme C.M. Smith, Sylvie Guichard, Martin Pass
Journal: Cancer Research
Cancer Res (2010) 70 (1): 288–298.
DOI: https://doi.org/10.1158/0008-5472.CAN-09-1751
Published: 04 January 2010
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Includes: Supplementary data
Journal Articles

Abstract #4770: Characterization of AZD8055, a potent selective inhibitor of mTORC1 and mTORC2 kinase

Christine Chresta, Barry Davies, Tom Harding, Ian Hickson, Sabina Cosulich, Susan Critchlow, Patrizia Sini, Dominic James, Karine Malagu, Marc Hummersone, Graeme Smith, Martin Pass, Sylvie Guichard
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4770.
Published: 01 May 2009
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Journal Articles

Characterisation of a novel and highly selective kinase inhibitor of the mammalian target of rapamycin (mTOR)

Ian Hickson, Lisa Smith, Sharon Maguire, Heather Duggan, Karine Malagu, Marc Hummersone, Keith Menear, Christine Chresta, Barry Davies, Martin Pass, Niall Martin, Graeme Smith
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1422.
Published: 01 May 2008
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Journal Articles

Cellular differentiation of rapamycin, PI3 kinase and TOR kinase inhibitors

Christine Chresta, Sam Butterworth, Sabina Cosulich, Nicola Curtis, Sara Davenport, Barry Davies, Rebecca Ellston, Tom Harding, Eric Newboult, Donald Ogilvie, Paul Smith, Martin Pass, Ian Hickson, Karine Malagu, Marc Hummersone, Kurt Pike, Lisa Drew, Lihua Yu, David Brandon
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 3564.
Published: 01 May 2008
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