1-20 of 21
Martin O. Leach
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Abstract 4108: Longitudinal diffusion-weighted MRI assessment of NRAS mutant melanoma response to dual RAF-MEK inhibition reveals differences associated with collagen deposition

Teresa Delgado-Goni, Slawomir Wantuch, Teresa Casals-Galobart, Udai Banerji, Nina Tunariu, Simon P. Robinson, Martin O. Leach, Mounia Beloueche-Babari
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4108.
https://doi.org/10.1158/1538-7445.AM2018-4108
Published: 01 July 2018
View article titled, Abstract 4108: Longitudinal diffusion-weighted MRI assessment of NRAS mutant melanoma response to dual RAF-MEK inhibition reveals differences associated with collagen deposition
Journal Articles

MCT1 Inhibitor AZD3965 Increases Mitochondrial Metabolism, Facilitating Combination Therapy and Noninvasive Magnetic Resonance Spectroscopy

Mounia Beloueche-Babari, Slawomir Wantuch, Teresa Casals Galobart, Markella Koniordou, Harold G. Parkes, Vaitha Arunan, Yuen-Li Chung, Thomas R. Eykyn, Paul D. Smith, Martin O. Leach
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (21): 5913–5924.
https://doi.org/10.1158/0008-5472.CAN-16-2686
Published: 31 October 2017
View article titled, MCT1 Inhibitor AZD3965 Increases Mitochondrial Metabolism, Facilitating Combination Therapy and Noninvasive Magnetic Resonance Spectroscopy
Open the PDF for MCT1 Inhibitor AZD3965 Increases Mitochondrial Metabolism, Facilitating Combination Therapy and Noninvasive Magnetic Resonance Spectroscopy in another window
Includes: Supplementary data
Journal Articles

Abstract 444: Monocarboxylate transporter 1 inhibition with AZD3965 increases cancer cell dependence on bioenergetic metabolism predicating combination therapy with mitochondrial inhibitors

Mounia Beloueche-Babari, Teresa Casals Galobart, Slawomir Wantuch, Paul D. Smith, Martin O. Leach
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 444.
https://doi.org/10.1158/1538-7445.AM2017-444
Published: 01 July 2017
View article titled, Abstract 444: Monocarboxylate transporter 1 inhibition with AZD3965 increases cancer cell dependence on bioenergetic metabolism predicating combination therapy with mitochondrial inhibitors
Journal Articles

Abstract 2897: Phosphatidylcholine synthesis is required for autophagosome membrane formation and maintenance during autophagy

Gabriela Andrejeva, Gigin Lin, Harry G. Parkes, James Mui, Anne-Christine LF Wong Te Fong, Gema Vizcay-Barrena, Roland Fleck, Martin O. Leach, Yuen-Li Chung
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2897.
https://doi.org/10.1158/1538-7445.AM2015-2897
Published: 01 August 2015
View article titled, Abstract 2897: Phosphatidylcholine synthesis is required for autophagosome membrane formation and maintenance during autophagy
Journal Articles

Abstract 1158: Real-time assessment of uptake and utilization of lactate in intact human breast cancer cells using a 1H-NMR-based assay

Emily G. Wholey, Harold G. Parkes, Paul Workman, Martin O. Leach, Mounia Beloueche-Babari
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1158.
https://doi.org/10.1158/1538-7445.AM2015-1158
Published: 01 August 2015
View article titled, Abstract 1158: Real-time assessment of uptake and utilization of lactate in intact human breast cancer cells using a 1H-NMR-based assay
Journal Articles

Abstract 2451: Insulin-like growth factor-1 receptor (IGF-1R) inhibitors downregulate p53 expression and upregulate the Warburg effect in paediatric glioblastoma cells

Anne-Christine Wong Te Fong, Gabriela Andrejeva, Aleksandra Bielen, Chris Jones, John Griffiths, Martin O. Leach, Yuen-Li Chung
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2451.
https://doi.org/10.1158/1538-7445.AM2014-2451
Published: 01 October 2014
View article titled, Abstract 2451: Insulin-like growth factor-1 receptor (IGF-1R) inhibitors downregulate p53 expression and upregulate the Warburg effect in paediatric glioblastoma cells
Journal Articles

MEK1/2 Inhibition Decreases Lactate in BRAF-Driven Human Cancer Cells

Maria Falck Miniotis, Vaitha Arunan, Thomas R. Eykyn, Richard Marais, Paul Workman, Martin O. Leach, Mounia Beloueche-Babari
Journal: Cancer Research
Cancer Res (2013) 73 (13): 4039–4049.
https://doi.org/10.1158/0008-5472.CAN-12-1969
Published: 30 June 2013
View article titled, MEK1/2 Inhibition Decreases Lactate in BRAF-Driven Human Cancer Cells
Open the PDF for MEK1/2 Inhibition Decreases Lactate in BRAF-Driven Human Cancer Cells in another window
Includes: Supplementary data
Journal Articles

Abstract 5399: Inhibition of the PI3K/mTOR pathway potentiates irradiation effects in paediatric glioblastoma inducing metabolic alterations detected by MRS.

Alice Agliano, Geetha Balaragah, Daniela M. Ciobota, Florence l. Raynaud, Paul A. Clarke, Chris Jones, Paul Workman, Andrew D. Pearson, Martin O. Leach, Nada M.S. Al-Saffar
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5399.
https://doi.org/10.1158/1538-7445.AM2013-5399
Published: 15 April 2013
View article titled, Abstract 5399: Inhibition of the PI3K/mTOR pathway potentiates irradiation effects in paediatric glioblastoma inducing metabolic alterations detected by MRS.
Journal Articles

Abstract 5640: Picropodophyllin downregulates p53 and increases the Warburg effect in pediatric glioblastoma cells.

Anne-Christine LF Wong Te Fong, Chris Jones, John R. Griffiths, Martin O. Leach, Yuen-Li Chung
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5640.
https://doi.org/10.1158/1538-7445.AM2013-5640
Published: 15 April 2013
View article titled, Abstract 5640: Picropodophyllin downregulates p53 and increases the Warburg effect in pediatric glioblastoma cells.
Journal Articles

Histone Deacetylase Inhibition Increases Levels of Choline Kinase α and Phosphocholine Facilitating Noninvasive Imaging in Human Cancers

Mounia Beloueche-Babari, Vaitha Arunan, Helen Troy, Robert H. te Poele, Anne-Christine Wong Te Fong, L. Elizabeth Jackson, Geoffrey S. Payne, John R. Griffiths, Ian R. Judson, Paul Workman, Martin O. Leach, Yuen-Li Chung
Journal: Cancer Research
Cancer Res (2012) 72 (4): 990–1000.
https://doi.org/10.1158/0008-5472.CAN-11-2688
Published: 14 February 2012
View article titled, Histone Deacetylase Inhibition Increases Levels of Choline Kinase α and Phosphocholine Facilitating Noninvasive Imaging in Human Cancers
Open the PDF for Histone Deacetylase Inhibition Increases Levels of Choline Kinase α and Phosphocholine Facilitating Noninvasive Imaging in Human Cancers in another window
Includes: Supplementary data
Journal Articles

Abstract 3788: Autophagy induced by DCA, PI3K inhibition or starvation results in reduced lactate production measured in real-time by DNP 13C MRS

Yuen-Li Chung, Gigin Lin, Helen Troy, Anne-Christine Wong Te Fong, L Elizabeth Jackson, Deborah K. Hill, Matthew Orton, Dow-Mu Koh, Simon P. Robinson, Ian R. Judson, John R. Griffiths, Martin O. Leach, Thomas R. Eykyn
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3788.
https://doi.org/10.1158/1538-7445.AM2011-3788
Published: 15 April 2011
View article titled, Abstract 3788: Autophagy induced by DCA, PI3K inhibition or starvation results in reduced lactate production measured in real-time by DNP 13C MRS
Journal Articles

Abstract 5277: Non-invasive metabolic biomarkers of histone deacetylase inhibition in human colon cancer cells and tumors

Mounia Beloueche-Babari, Vaitha Arunan, Helen Troy, L Elizabeth Jackson, Anne-Christine Wong, Paul Workman, Ian Judson, John R. Griffiths, Martin O. Leach, Yuen-Li Chung
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5277.
https://doi.org/10.1158/1538-7445.AM2011-5277
Published: 15 April 2011
View article titled, Abstract 5277: Non-invasive metabolic biomarkers of histone deacetylase inhibition in human colon cancer cells and tumors
Journal Articles

The Phosphoinositide 3-Kinase Inhibitor PI-103 Downregulates Choline Kinase α Leading to Phosphocholine and Total Choline Decrease Detected by Magnetic Resonance Spectroscopy

Nada M.S. Al-Saffar, L. Elizabeth Jackson, Florence I. Raynaud, Paul A. Clarke, Ana Ramírez de Molina, Juan C. Lacal, Paul Workman, Martin O. Leach
Journal: Cancer Research
Cancer Res (2010) 70 (13): 5507–5517.
https://doi.org/10.1158/0008-5472.CAN-09-4476
Published: 30 June 2010
View article titled, The Phosphoinositide 3-Kinase Inhibitor PI-103 Downregulates Choline Kinase α Leading to Phosphocholine and Total Choline Decrease Detected by Magnetic Resonance Spectroscopy
Open the PDF for The Phosphoinositide 3-Kinase Inhibitor PI-103 Downregulates Choline Kinase α Leading to Phosphocholine and Total Choline Decrease Detected by Magnetic Resonance Spectroscopy in another window
Includes: Supplementary data
Journal Articles

Abstract 5083: Inhibition of MEK1/2 signaling in human BRAFV600E melanoma cells reduces glucose uptake and lactate dehydrogenase activity resulting in a time-dependent decrease in lactate production

Maria Falck Miniotis, Thomas R. Eykyn, Paul Workman, Martin O. Leach, Mounia Beloueche-Babari
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5083.
https://doi.org/10.1158/1538-7445.AM10-5083
Published: 15 April 2010
View article titled, Abstract 5083: Inhibition of MEK1/2 signaling in human <em>BRAF</em><sup>V600E</sup> melanoma cells reduces glucose uptake and lactate dehydrogenase activity resulting in a time-dependent decrease in lactate production
Journal Articles

Abstract LB-48: Non-invasive imaging of response to MEK Inhibition with AZD6244 (ARRY-142886) in a human melanoma xenograft monitored by diffusion-weighted MRI

Mounia Beloueche-Babari, Yann Jamin, Vaitha Arunan, Simon Walker-Samuel, Paul D. Smith, John C. Waterton, Jane Halliday, Paul Workman, Martin O. Leach, Simon P. Robinson
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): LB-48.
https://doi.org/10.1158/1538-7445.AM10-LB-48
Published: 15 April 2010
View article titled, Abstract LB-48: Non-invasive imaging of response to MEK Inhibition with AZD6244 (ARRY-142886) in a human melanoma xenograft monitored by diffusion-weighted MRI
Journal Articles

Phase I study of SR4554 as a non-invasive probe of tumor hypoxia detected by magnetic resonance spectroscopy

Chooi P. Lee, Geoffrey S. Payne, Alain Oregioni, Ruth R. Ruddle, Florence I. Raynaud, David A. Eaton, Kathryn Cross, Michael Tracy, James P. McNamara, Martin O. Leach, Ian R. Judson, Paul Workman
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 232.
Published: 15 April 2006
View article titled, Phase I study of SR4554 as a non-invasive probe of tumor hypoxia detected by magnetic resonance spectroscopy
Journal Articles

Noninvasive Magnetic Resonance Spectroscopic Pharmacodynamic Markers of the Choline Kinase Inhibitor MN58b in Human Carcinoma Models

Nada M.S. Al-Saffar, Helen Troy, Ana Ramírez de Molina, Laura E. Jackson, Basetti Madhu, John R. Griffiths, Martin O. Leach, Paul Workman, Juan C. Lacal, Ian R. Judson, Yuen-Li Chung
Journal: Cancer Research
Cancer Res (2006) 66 (1): 427–434.
https://doi.org/10.1158/0008-5472.CAN-05-1338
Published: 05 January 2006
View article titled, Noninvasive Magnetic Resonance Spectroscopic Pharmacodynamic Markers of the Choline Kinase Inhibitor MN58b in Human Carcinoma Models
Open the PDF for Noninvasive Magnetic Resonance Spectroscopic Pharmacodynamic Markers of the Choline Kinase Inhibitor MN58b in Human Carcinoma Models in another window
Journal Articles

SR4554 as a non-invasive probe of tumor hypoxia detected by Magnetic Resonance Spectroscopy: Update of a Phase I Trial

Chooi P. Lee, Geoffrey S. Payne, Ruth R. Ruddle, Florence I. Raynaud, Siew K. Tan, Maeli J. Campbell, Michael Tracy, James P. McNamara, Martin O. Leach, Ian R. Judson, Paul Workman
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 897.
Published: 01 May 2005
View article titled, SR4554 as a non-invasive probe of tumor hypoxia detected by Magnetic Resonance Spectroscopy: Update of a Phase I Trial
Journal Articles

Magnetic Resonance Spectroscopy Monitoring of Mitogen-Activated Protein Kinase Signaling Inhibition

Mounia Beloueche-Babari, L. Elizabeth Jackson, Nada M.S. Al-Saffar, Paul Workman, Martin O. Leach, Sabrina M. Ronen
Journal: Cancer Research
Cancer Res (2005) 65 (8): 3356–3363.
https://doi.org/10.1158/10.1158/0008-5472.CAN-03-2981
Published: 15 April 2005
View article titled, Magnetic Resonance Spectroscopy Monitoring of Mitogen-Activated Protein Kinase Signaling Inhibition
Open the PDF for Magnetic Resonance Spectroscopy Monitoring of Mitogen-Activated Protein Kinase Signaling Inhibition in another window
Journal Articles

Metabolites of 2′-Fluoro-2′-deoxy-d-glucose Detected by 19F Magnetic Resonance Spectroscopy in Vivo Predict Response of Murine RIF-1 Tumors to 5-Fluorouracil1

Paul M. J. McSheehy, Martin O. Leach, Ian R. Judson, John R. Griffiths
Journal: Cancer Research
Cancer Res (2000) 60 (8): 2122–2127.
Published: 01 April 2000
View article titled, Metabolites of 2′-Fluoro-2′-deoxy-<sc>d</sc>-glucose Detected by <sup>19</sup>F Magnetic Resonance Spectroscopy <em>in Vivo</em> Predict Response of Murine RIF-1 Tumors to 5-Fluorouracil1
Open the PDF for Metabolites of 2′-Fluoro-2′-deoxy-<sc>d</sc>-glucose Detected by <sup>19</sup>F Magnetic Resonance Spectroscopy <em>in Vivo</em> Predict Response of Murine RIF-1 Tumors to 5-Fluorouracil1 in another window