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Journal Articles

Abstract 6379: Identification of selective, orally bioavailable aurora A degraders for treatment of pediatric and adult cancers

Cancer Res (2025) 85 (8_Supplement_1): 6379.

https://doi.org/10.1158/1538-7445.AM2025-6379

Published: 21 April 2025

View articletitled, Abstract 6379: Identification of selective, orally bioavailable aurora A degraders for treatment of pediatric and adult cancers

Journal Articles

MYC- and MIZ1-Dependent Vesicular Transport of Double-Strand RNA Controls Immune Evasion in Pancreatic Ductal Adenocarcinoma

Bastian Krenz, Anneli Gebhardt-Wolf, Carsten P. Ade, Abdallah Gaballa, Florian Roehrig, Emilia Vendelova, Apoorva Baluapuri, Ursula Eilers, Peter Gallant, Luana D'Artista, Armin Wiegering, Georg Gasteiger, Mathias T. Rosenfeldt, Stefan Bauer, Lars Zender, Elmar Wolf, Martin Eilers

Cancer Res (2021) 81 (16): 4242–4256.

https://doi.org/10.1158/0008-5472.CAN-21-1677

Published: 15 August 2021

View articletitled, MYC- and MIZ1-Dependent Vesicular Transport of Double-Strand RNA Controls Immune Evasion in Pancreatic Ductal Adenocarcinoma

Includes: Supplementary data

Journal Articles

Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers

Cancer Res (2021) 81 (7): 1627–1632.

https://doi.org/10.1158/0008-5472.CAN-20-3108

Published: 01 April 2021

View articletitled, Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers

Journal Articles

UBR5 Is Coamplified with MYC in Breast Tumors and Encodes an Ubiquitin Ligase That Limits MYC-Dependent Apoptosis

Xi Qiao, Ying Liu, Maria Llamazares Prada, Aravind K. Mohan, Abhishekh Gupta, Alok Jaiswal, Mukund Sharma, Joni Merisaari, Heidi M. Haikala, Kati Talvinen, Laxman Yetukuri, Joanna W. Pylvänäinen, Juha Klefström, Pauliina Kronqvist, Annika Meinander, Tero Aittokallio, Ville Hietakangas, Martin Eilers, Jukka Westermarck

Cancer Res (2020) 80 (7): 1414–1427.

https://doi.org/10.1158/0008-5472.CAN-19-1647

Published: 02 April 2020

View articletitled, UBR5 Is Coamplified with MYC in Breast Tumors and Encodes an Ubiquitin Ligase That Limits MYC-Dependent Apoptosis

Includes: Supplementary data

Journal Articles

Abstract LB-189: Pharmacological reactivation of MYC-dependent apoptosis cooperates with anti-PD1 immunotherapy

Heidi M. Haikala, Johanna M. Anttila, Mariel Savelius, Elsa Marques, Tiina Raatikainen, Mette Ilander, Henna Hakanen, Johanna Mattson, Paivi Heikkila, Marjut Leidenius, Heikki Joensuu, Satu Mustjoki, Panu Kovanen, Martin Eilers, Joel D. Leverson, Juha T. Klefström

Cancer Res (2019) 79 (13_Supplement): LB-189.

https://doi.org/10.1158/1538-7445.AM2019-LB-189

Published: 01 July 2019

View articletitled, Abstract LB-189: Pharmacological reactivation of MYC-dependent apoptosis cooperates with anti-PD1 immunotherapy

Journal Articles

Abstract LB-335: Induction of Ribosomal Checkpoint Induced Senescence (RCIS) for the treatment of liver cancer

Cancer Res (2017) 77 (13_Supplement): LB-335.

https://doi.org/10.1158/1538-7445.AM2017-LB-335

Published: 01 July 2017

View articletitled, Abstract LB-335: Induction of Ribosomal Checkpoint Induced Senescence (RCIS) for the treatment of liver cancer

Journal Articles

Abstract 2943: MYC functions as a master switch for natural killer cell-mediated immune surveillance of lymphoid malignancies

Srividya Swaminathan, Adriane Mosley, Crista Horton, Daniel F. Liefwalker, Anja Deutzmann, Renumathy Dhanasekaran, Arvin Gouw, Andrew Gentles, Martin Eilers, Holden T. Maecker, Dean W. Felsher

Cancer Res (2017) 77 (13_Supplement): 2943.

https://doi.org/10.1158/1538-7445.AM2017-2943

Published: 01 July 2017

View articletitled, Abstract 2943: MYC functions as a master switch for natural killer cell-mediated immune surveillance of lymphoid malignancies

Journal Articles

Abstract 5170: HDAC inhibitors and the mechanism of resistance in colorectal cancer: RAS and MYC - the partners in crime

Sylvia S. Ispasanie, Lena Boehme, Martin Eilers, Tilman Brummer, Kathleen Klotz-Noack, Natalia Kuhn, Bastian Gastl, Christine Sers

Cancer Res (2017) 77 (13_Supplement): 5170.

https://doi.org/10.1158/1538-7445.AM2017-5170

Published: 01 July 2017

View articletitled, Abstract 5170: HDAC inhibitors and the mechanism of resistance in colorectal cancer: RAS and MYC - the partners in crime

Journal Articles

Abstract B07: Loss of APC induces a dependence on elevated eIF2B5 function in colorectal cancer

Stefanie Peter, Friedrich-Wilhelm Uthe, Martin Eilers, Christoph-Thomas Germer, Armin Wiegering

Cancer Res (2017) 77 (6_Supplement): B07.

https://doi.org/10.1158/1538-7445.Transcontrol16-B07

Published: 14 March 2017

View articletitled, Abstract B07: Loss of APC induces a dependence on elevated eIF2B5 function in colorectal cancer

Journal Articles

Abstract 1257: A MYC-Aurka protein complex represents an actionable target in p53 altered liver cancer

Dauch Daniel, Ramona Rudalska, Giacomo Cossa, Jean Charles Nault, Sandrine Imbeaud, Nisar P. Malek, Thomas Longerich, Stefan Laufer, Antti Poso, Jessica Zucman-Rossi, Martin Eilers, Lars Zender

Cancer Res (2016) 76 (14_Supplement): 1257.

https://doi.org/10.1158/1538-7445.AM2016-1257

Published: 15 July 2016

View articletitled, Abstract 1257: A MYC-Aurka protein complex represents an actionable target in p53 altered liver cancer

Journal Articles

Abstract 887: N-Myc drives neuroendocrine prostate cancer

Cancer Res (2016) 76 (14_Supplement): 887.

https://doi.org/10.1158/1538-7445.AM2016-887

Published: 15 July 2016

View articletitled, Abstract 887: N-Myc drives neuroendocrine prostate cancer

Journal Articles

Abstract LB-072: The N-Myc transcriptional program driving the neuroendocrine prostate cancer phenotype

Etienne Dardenne, Kaitlyn Gayvert, Adeline Berger, Andrea Sboner, Brian Robinson, Kenneth Hennrick, Juan Miguel Mosquera, Cynthia Cheung, Martin Eilers, Himisha Beltran, Mark A. Rubin, Olivier Elemento, David S. Rickman

Cancer Res (2015) 75 (15_Supplement): LB-072.

https://doi.org/10.1158/1538-7445.AM2015-LB-072

Published: 01 August 2015

View articletitled, Abstract LB-072: The N-Myc transcriptional program driving the neuroendocrine prostate cancer phenotype

Journal Articles

Usp28 Counteracts Fbw7 in Intestinal Homeostasis and Cancer

Markus E. Diefenbacher, Atanu Chakraborty, Sophia M. Blake, Richard Mitter, Nikita Popov, Martin Eilers, Axel Behrens

Cancer Res (2015) 75 (7): 1181–1186.

https://doi.org/10.1158/0008-5472.CAN-14-1726

Published: 31 March 2015

View articletitled, Usp28 Counteracts Fbw7 in Intestinal Homeostasis and Cancer

Includes: Supplementary data

Journal Articles

Abstract PR08: Drugging MYCN protein stability through an allosteric transition in Aurora kinase A

W. Clay Gustafson, Justin G. Meyerowitz, Erin A. Nekritz, Elise Charron, Katherine K. Matthay, Nicholas T. Hertz, Martin Eilers, Kevan M. Shokat, William A. Weiss

Cancer Res (2014) 74 (20_Supplement): PR08.

https://doi.org/10.1158/1538-7445.PEDCAN-PR08

Published: 09 October 2014

View articletitled, Abstract PR08: Drugging MYCN protein stability through an allosteric transition in Aurora kinase A

Journal Articles

Abstract 2977: Myc and Miz1 in medulloblastoma

BaoHan T. Vo, Elmar Wolf, Daisuke Kawauchi, Jerold Rehg, David Finkelstein, Brian Murphy, Martin Eilers, Martine F. Roussel

Cancer Res (2014) 74 (19_Supplement): 2977.

https://doi.org/10.1158/1538-7445.AM2014-2977

Published: 01 October 2014

View articletitled, Abstract 2977: Myc and Miz1 in medulloblastoma

Journal Articles

A SP1/MIZ1/MYCN Repression Complex Recruits HDAC1 at the TRKA and p75NTR Promoters and Affects Neuroblastoma Malignancy by Inhibiting the Cell Response to NGF

Nunzio Iraci, Daniel Diolaiti, Antonella Papa, Antonio Porro, Emanuele Valli, Samuele Gherardi, Steffi Herold, Martin Eilers, Roberto Bernardoni, Giuliano Della Valle, Giovanni Perini

Cancer Res (2011) 71 (2): 404–412.

https://doi.org/10.1158/0008-5472.CAN-10-2627

Published: 13 January 2011

View articletitled, A SP1/MIZ1/MYCN Repression Complex Recruits HDAC1 at the TRKA and p75NTR Promoters and Affects Neuroblastoma Malignancy by Inhibiting the Cell Response to NGF

Includes: Supplementary data

Journal Articles

Abstract #609: Colon cancer HCT116 cells deficient in p21/Cip1 are hypersensitive to tyrosine kinase inhibitors imatinib and gefitinib through a mechanism unrelated to p21 and dependent on p53 hyperactivity

Nuria Ferrandiz, Jorge Martin-Perez, Rosa Blanco, Derya Donertas, Axel Weber, Dotto Paolo, Martin Eilers, M. Dolores Delgado, Javier Leon

Cancer Res (2009) 69 (9_Supplement): 609.

Published: 01 May 2009

View articletitled, Abstract #609: Colon cancer HCT116 cells deficient in p21/Cip1 are hypersensitive to tyrosine kinase inhibitors imatinib and gefitinib through a mechanism unrelated to p21 and dependent on p53 hyperactivity

Journal Articles

Abstract #4647: In vivo validation of HectH9 as a cancer target via gene silencing in established orthotopic xenografts.

Jennyfer Bultinck, Martin Eilers, Michel Aguet

Cancer Res (2009) 69 (9_Supplement): 4647.

Published: 01 May 2009

View articletitled, Abstract #4647: In vivo validation of HectH9 as a cancer target via gene silencing in established orthotopic xenografts.

Journal Articles

N-myc Regulates Oncogenic microRNAs in neuroblastoma

Johannes Schulte, Sebastian Horn, Birgit Samans, Lukas Heukamp, Ursula-Christa Eilers, Tobias Otto, Michael Krause, Kathy Astrahantseff, Reinhard Buettner, Alexander Schramm, Holger Christiansen, Martin Eilers, Angelika Eggert, Bernd Berwanger

Cancer Res (2007) 67 (9_Supplement): 4512.

Published: 01 May 2007

View articletitled, N-myc Regulates Oncogenic microRNAs in neuroblastoma

Journal Articles

Loss of Caspase-8 Expression Does Not Correlate with MYCN Amplification, Aggressive Disease, or Prognosis in Neuroblastoma

Simone Fulda, Christopher Poremba, Bernd Berwanger, Sabine Häcker, Martin Eilers, Holger Christiansen, Barbara Hero, Klaus-Michael Debatin

Cancer Res (2006) 66 (20): 10016–10023.

https://doi.org/10.1158/0008-5472.CAN-05-4079

Published: 17 October 2006

View articletitled, Loss of Caspase-8 Expression Does Not Correlate with MYCN Amplification, Aggressive Disease, or Prognosis in Neuroblastoma

Includes: Supplementary data

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Abstract 6379: Identification of selective, orally bioavailable aurora A degraders for treatment of pediatric and adult cancers

MYC- and MIZ1-Dependent Vesicular Transport of Double-Strand RNA Controls Immune Evasion in Pancreatic Ductal Adenocarcinoma

Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers

UBR5 Is Coamplified with MYC in Breast Tumors and Encodes an Ubiquitin Ligase That Limits MYC-Dependent Apoptosis

Abstract LB-189: Pharmacological reactivation of MYC-dependent apoptosis cooperates with anti-PD1 immunotherapy

Abstract LB-335: Induction of Ribosomal Checkpoint Induced Senescence (RCIS) for the treatment of liver cancer

Abstract 2943: MYC functions as a master switch for natural killer cell-mediated immune surveillance of lymphoid malignancies

Abstract 5170: HDAC inhibitors and the mechanism of resistance in colorectal cancer: RAS and MYC - the partners in crime

Abstract B07: Loss of APC induces a dependence on elevated eIF2B5 function in colorectal cancer

Abstract 1257: A MYC-Aurka protein complex represents an actionable target in p53 altered liver cancer

Abstract 887: N-Myc drives neuroendocrine prostate cancer

Abstract LB-072: The N-Myc transcriptional program driving the neuroendocrine prostate cancer phenotype

Usp28 Counteracts Fbw7 in Intestinal Homeostasis and Cancer

Abstract PR08: Drugging MYCN protein stability through an allosteric transition in Aurora kinase A

Abstract 2977: Myc and Miz1 in medulloblastoma

A SP1/MIZ1/MYCN Repression Complex Recruits HDAC1 at the TRKA and p75NTR Promoters and Affects Neuroblastoma Malignancy by Inhibiting the Cell Response to NGF

Abstract #609: Colon cancer HCT116 cells deficient in p21/Cip1 are hypersensitive to tyrosine kinase inhibitors imatinib and gefitinib through a mechanism unrelated to p21 and dependent on p53 hyperactivity

Abstract #4647: In vivo validation of HectH9 as a cancer target via gene silencing in established orthotopic xenografts.

N-myc Regulates Oncogenic microRNAs in neuroblastoma

Loss of Caspase-8 Expression Does Not Correlate with MYCN Amplification, Aggressive Disease, or Prognosis in Neuroblastoma

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