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Martin E. Gleave
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Journal Articles

Abstract 6962: Shed Trop2 drives prostate cancer progression and Trop2 is a novel tissue prognostic biomarker and a candidate urinary marker for prostate cancer

Free
Shiqin Liu, Sarah Hawley, Christian Kunder, En-Chi Hsu, Michelle Shen, Merve Aslan, Fernando J. Marques, Chung S. Lee, Abel Bermudez, Lennart Westphalen, Heidi Auman, Lisa F. Newcomb, Daniel W. Lin, Peter S. Nelson, Ziding Feng, Maria S. Tretiakova, Lawrence D. True, Funda Vakar-Lopez, Peter R. Carroll, Jeffry Simko, Martin E. Gleave, Dean A. Troyer, Jesse K. McKenney, Donna Peehl, Sharon J. Pitteri, James D. Brooks, Michael A. Liss, Tanya Stoyanova
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6962.
https://doi.org/10.1158/1538-7445.AM2024-6962
Published: 22 March 2024
View articletitled, Abstract 6962: Shed Trop2 drives prostate cancer progression and Trop2 is a novel tissue prognostic biomarker and a candidate urinary marker for prostate cancer
Journal Articles

Abstract B048: Performance of diagnostic biomarkers in the Canary Prostate cancer Active Surveillance Study (PASS)

Free
Lisa F. Newcomb, Yingye Zheng, Menghan Liu, James D. Brooks, Peter R. Carroll, Atreya Dash, William J. Ellis, Christopher J. Filson, Martin E. Gleave, Michael A. Liss, Frances M. Martin, Todd M. Morgan, Peter S. Nelson, Andrew A. Wagner, Daniel W. Lin
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): B048.
https://doi.org/10.1158/1538-7445.PRCA2023-B048
Published: 02 June 2023
View articletitled, Abstract B048: Performance of diagnostic biomarkers in the Canary Prostate cancer Active Surveillance Study (PASS)
Journal Articles

Abstract 3625: Clonal architecture and evolution of treatment-resistant prostate cancer via deep whole-genome ctDNA sequencing

Free
Cameron Herberts, Matti Annala, Joonatan Sipola, Sarah W. Ng, Xinyi E. Chen, Anssi Nurminen, Olga Korhonen, Aslı D. Munzur, Kevin Beja, Elena Schönlau, Cecily Q. Bernales, Elie Ritch, Jack V. Bacon, Nathan A. Lack, Matti Nykter, Rahul Aggarwal, Eric J. Small, Martin E. Gleave, David A. Quigley, Felix Y. Feng, Kim N. Chi, Alexander W. Wyatt
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3625.
https://doi.org/10.1158/1538-7445.AM2022-3625
Published: 15 June 2022
View articletitled, Abstract 3625: Clonal architecture and evolution of treatment-resistant prostate cancer via deep whole-genome ctDNA sequencing
Journal Articles

Abstract 2367: Characterizing the reciprocal regulation of an ABI1-dependent androgen receptor axis in prostate cancer

Free
Baylee A. Porter-Hansen, Alaji Bah, Alfonso Urbanucci, Konsta Kukkonen, Fan Zhang, Sonia Kung, Ladan Fazli, Martin E. Gleave, Gennady Bratslavsky, Leszek Kotula
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2367.
https://doi.org/10.1158/1538-7445.AM2022-2367
Published: 15 June 2022
View articletitled, Abstract 2367: Characterizing the reciprocal regulation of an ABI1-dependent androgen receptor axis in prostate cancer
Journal Articles

Abstract 5729: Dynamic phase separation of the androgen receptor and its coactivators to regulate gene expression

Free
Fan Zhang, Maitree Biswas, Joseph Lee, Shreyas Lingadahalli, Samantha Wong, Christopher Wells, Neetu Saxena, Bei Sun, Ana K. Parra-Nuñez, Christophe Sanchez, Jane Foo, Novia Chan, Lauren Ung, Nabeel Khan, Umut Berkay Altıntaş, Jennifer M. Bui, Yuzhuo Wang, Ladan Fazli, Paul S. Rennie, Nathan Lack, Artem Cherkasov, Martin E. Gleave, Joerg Gsponer, Nada Lallous
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5729.
https://doi.org/10.1158/1538-7445.AM2022-5729
Published: 15 June 2022
View articletitled, Abstract 5729: Dynamic phase separation of the androgen receptor and its coactivators to regulate gene expression
Journal Articles

SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer

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Rafael S. Martinez, Mark J. Salji, Linda Rushworth, Chara Ntala, Giovanny Rodriguez Blanco, Ann Hedley, William Clark, Paul Peixoto, Eric Hervouet, Elodie Renaude, Sonia H.Y. Kung, Laura C.A. Galbraith, Colin Nixon, Sergio Lilla, Gillian M. MacKay, Ladan Fazli, Luke Gaughan, David Sumpton, Martin E. Gleave, Sara Zanivan, Arnaud Blomme, Hing Y. Leung
Journal: Cancer Research
Cancer Res (2021) 81 (13): 3664–3678.
https://doi.org/10.1158/0008-5472.CAN-20-3694
Published: 01 July 2021
View articletitled, SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer
Open the PDF for SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 340: ABI1 and androgen dependence in prostate cancer

Free
Leszek Kotula, Baylee A. Porter, Xiang Li, Maria A. Ortiz, Rakesh Khanna, Fan Zhang, Sonia H. Kung, Ladan Fazli, Martin E. Gleave, Gennady Bratslavsky, Jeffrey S. Ross
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 340.
https://doi.org/10.1158/1538-7445.AM2020-340
Published: 15 August 2020
View articletitled, Abstract 340: ABI1 and androgen dependence in prostate cancer
Journal Articles

p300-Mediated Acetylation of Histone Demethylase JMJD1A Prevents Its Degradation by Ubiquitin Ligase STUB1 and Enhances Its Activity in Prostate Cancer

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Songhui Xu, Lingling Fan, Hee-Young Jeon, Fengbo Zhang, Xiaolu Cui, McKayla B. Mickle, Guihong Peng, Arif Hussain, Ladan Fazli, Martin E. Gleave, Xuesen Dong, Jianfei Qi
Journal: Cancer Research
Cancer Res (2020) 80 (15): 3074–3087.
https://doi.org/10.1158/0008-5472.CAN-20-0233
Published: 04 August 2020
View articletitled, p300-Mediated Acetylation of Histone Demethylase JMJD1A Prevents Its Degradation by Ubiquitin Ligase STUB1 and Enhances Its Activity in Prostate Cancer
Open the PDF for p300-Mediated Acetylation of Histone Demethylase JMJD1A Prevents Its Degradation by Ubiquitin Ligase STUB1 and Enhances Its Activity in Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 1018: GnRH antagonists have direct inhibitory effects on castration-resistant prostate cancer via intracrine androgen and AR-V7 expression

Free
Vito Cucchiara, Joy C. Yang, Chengfei Liu, Hans Adomat, Emma Guns, Martin E. Gleave, Allen C. Gao, Christopher P. Evans
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1018.
https://doi.org/10.1158/1538-7445.AM2019-1018
Published: 01 July 2019
View articletitled, Abstract 1018: GnRH antagonists have direct inhibitory effects on castration-resistant prostate cancer via intracrine androgen and AR-V7 expression
Journal Articles

Abstract 773: A heterochromatin gene signature unveils HP1α mediating neuroendocrine prostate cancer development and aggressiveness

Free
Xinpei Ci, Jun Hao, Xin Dong, Stephen Y. Choi, Hui Xue, Sifeng Qu, Ladan Fazli, Francesco Crea, Christopher Ong, Amina Zoubeidi, Housheng H. He, Martin E. Gleave, Colin C. Collins, Dong Lin, Yuzhuo Wang
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 773.
https://doi.org/10.1158/1538-7445.AM2018-773
Published: 01 July 2018
View articletitled, Abstract 773: A heterochromatin gene signature unveils HP1α mediating neuroendocrine prostate cancer development and aggressiveness
Journal Articles

Abstract 1087: Semaphorin 3C drives invasiveness in prostate cells through epithelial-to-mesenchymal transition and stemness

Free
Kevin J. Tam, Daniel H. Hui, Wilson C. Lee, Mingshu Dong, Tabitha Tombe, Ivy Z. Jiao, Shahram Khosravi, Ario Takeuchi, James W. Peacock, Larissa Ivanova, Igor Moskalev, Martin E. Gleave, Ralph Buttyan, Michael E. Cox, Christopher J. Ong
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1087.
https://doi.org/10.1158/1538-7445.AM2018-1087
Published: 01 July 2018
View articletitled, Abstract 1087: Semaphorin 3C drives invasiveness in prostate cells through epithelial-to-mesenchymal transition and stemness
Journal Articles

Abstract 1918: Patient-derived hormone-naive prostate cancer xenograft models reveal GRB10 as an AR-repressed gene driving the development of castration-resistant prostate cancer

Free
Jun Hao, Xinpei Ci, Hui Xue, Rebecca Wu, Xin Dong, Fang Zhang, Sifeng Qu, Fan Zhang, Anne M. Haegert, Peter W. Gout, Colin Collins, Martin E. Gleave, Dong Lin, Yuzhuo Wang
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1918.
https://doi.org/10.1158/1538-7445.AM2018-1918
Published: 01 July 2018
View articletitled, Abstract 1918: Patient-derived hormone-naive prostate cancer xenograft models reveal GRB10 as an AR-repressed gene driving the development of castration-resistant prostate cancer
Journal Articles

Heterochromatin Protein 1α Mediates Development and Aggressiveness of Neuroendocrine Prostate Cancer

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Xinpei Ci, Jun Hao, Xin Dong, Stephen Y. Choi, Hui Xue, Rebecca Wu, Sifeng Qu, Peter W. Gout, Fang Zhang, Anne M. Haegert, Ladan Fazli, Francesco Crea, Christopher J. Ong, Amina Zoubeidi, Housheng H. He, Martin E. Gleave, Colin C. Collins, Dong Lin, Yuzhuo Wang
Journal: Cancer Research
Cancer Res (2018) 78 (10): 2691–2704.
https://doi.org/10.1158/0008-5472.CAN-17-3677
Published: 14 May 2018
View articletitled, Heterochromatin Protein 1α Mediates Development and Aggressiveness of Neuroendocrine Prostate Cancer
Open the PDF for Heterochromatin Protein 1α Mediates Development and Aggressiveness of Neuroendocrine Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 1576: UGT2B17 promotes castration-resistant prostate cancer progression through enhancing ligand-independent AR signaling

Free
Haolong Li, Ning Xie, Ruiqi Chen, Mélanie Verreault, Ladan Fazli, Martin E. Gleave, Olivier Barbier, Xuesen Dong
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1576.
https://doi.org/10.1158/1538-7445.AM2017-1576
Published: 01 July 2017
View articletitled, Abstract 1576: UGT2B17 promotes castration-resistant prostate cancer progression through enhancing ligand-independent AR signaling
Journal Articles

UGT2B17 Expedites Progression of Castration-Resistant Prostate Cancers by Promoting Ligand-Independent AR Signaling

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Haolong Li, Ning Xie, Ruiqi Chen, Mélanie Verreault, Ladan Fazli, Martin E. Gleave, Olivier Barbier, Xuesen Dong
Journal: Cancer Research
Cancer Res (2016) 76 (22): 6701–6711.
https://doi.org/10.1158/0008-5472.CAN-16-1518
Published: 14 November 2016
View articletitled, UGT2B17 Expedites Progression of Castration-Resistant Prostate Cancers by Promoting Ligand-Independent AR Signaling
Open the PDF for UGT2B17 Expedites Progression of Castration-Resistant Prostate Cancers by Promoting Ligand-Independent AR Signaling in another window
Includes: Supplementary data
Journal Articles

Abstract 1834: Semaphorin 3C is an androgen receptor-regulated gene

Free
Kevin J. Tam, Kush Dalal, Michael Hsing, Chi Wing Cheng, Yan Ting Chiang, Aishwariya Sharma, James W. Peacock, Artem Cherkasov, Yuzhuo Wang, Martin E. Gleave, Paul S. Rennie, Christopher J. Ong
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1834.
https://doi.org/10.1158/1538-7445.AM2016-1834
Published: 15 July 2016
View articletitled, Abstract 1834: Semaphorin 3C is an androgen receptor-regulated gene
Journal Articles

Abstract 1810: Heterogeneous activation of PP-1 and Akt determines AR-v7 protein expression in prostate cancer cells under AR inhibition

Free
Yinan Li, Ning Xie, Martin E. Gleave, Paul Rennie, Xuesen Dong
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1810.
https://doi.org/10.1158/1538-7445.AM2016-1810
Published: 15 July 2016
View articletitled, Abstract 1810: Heterogeneous activation of PP-1 and Akt determines AR-v7 protein expression in prostate cancer cells under AR inhibition
Journal Articles

High Fidelity Patient-Derived Xenografts for Accelerating Prostate Cancer Discovery and Drug Development

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Dong Lin, Alexander W. Wyatt, Hui Xue, Yuwei Wang, Xin Dong, Anne Haegert, Rebecca Wu, Sonal Brahmbhatt, Fan Mo, Lina Jong, Robert H. Bell, Shawn Anderson, Antonio Hurtado-Coll, Ladan Fazli, Manju Sharma, Himisha Beltran, Mark Rubin, Michael Cox, Peter W. Gout, James Morris, Larry Goldenberg, Stanislav V. Volik, Martin E. Gleave, Colin C. Collins, Yuzhuo Wang
Journal: Cancer Research
Cancer Res (2014) 74 (4): 1272–1283.
https://doi.org/10.1158/0008-5472.CAN-13-2921-T
Published: 16 February 2014
View articletitled, High Fidelity Patient-Derived Xenografts for Accelerating Prostate Cancer Discovery and Drug Development
Open the PDF for High Fidelity Patient-Derived Xenografts for Accelerating Prostate Cancer Discovery and Drug Development in another window
Includes: Supplementary data
Journal Articles

Abstract 4062: Clusterin downregulation sensitize prostate cancer cells to taxane by modulating mitosis.

Free
Nader Al Nakouzi, Eliana Beraldi, Stuart Shepherd, Yohann Loriot, Soojin Kim, Lauren Leichmann, Amina Zoubeidi, Martin E Gleave
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4062.
https://doi.org/10.1158/1538-7445.AM2013-4062
Published: 15 April 2013
View articletitled, Abstract 4062: Clusterin downregulation sensitize prostate cancer cells to taxane by modulating mitosis.
Journal Articles

Abstract 5359: Predictive significance of EZH2 expression and H3K27me3 intensity in therapy-naïve and neoadjuvant therapy-treated metastatic prostate cancer.

Free
Mitali Pandey, Ladan Fazli, Antonio Hurtado-Coll, Martin E. Gleave, Michael E. Cox
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5359.
https://doi.org/10.1158/1538-7445.AM2013-5359
Published: 15 April 2013
View articletitled, Abstract 5359: Predictive significance of EZH2 expression and H3K27me3 intensity in therapy-naïve and neoadjuvant therapy-treated metastatic prostate cancer.