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Marketa Zvelebil
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Journal Articles

Abstract 671: BKM120-mediated G2 arrest: Structural and functional segregation of off-target action and PI3K inhibition

Thomas Bohnacker, Florent Beaufils, Andrea E. Prota, John E. Burke, Anna Melone, Alison J. Inglis, Ludovico Fusco, Vladimir Cmiljanovic, Natasa Cmiljanovic, Denise Rageot, Katja Bargsten, Gonzalo Saez-Calvo, Olivier Pertz, Amol B. Aher, Anna Akhmanova, Fernando J. Diaz, Doriano Fabbro, Marketa Zvelebil, Roger L. Williams, Michel O. Steinmetz, Matthias P. Wymann
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 671.
DOI: https://doi.org/10.1158/1538-7445.AM2015-671
Published: 01 August 2015
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Journal Articles

Abstract 2664: PQR309: Structure-based design, synthesis and biological evaluation of a novel, selective, dual pan-PI3K/mTOR inhibitor

Vladimir Cmiljanovic, Natasa Cmiljanovic, Romina Marone, Florent Beaufils, Xuxiao Zhang, Marketa Zvelebil, Paul Hebeisen, Marc Lang, Juergen Mestan, Anna Melone, Thomas Bohnacker, Eugenio Gaudio, Chiara Tarantelli, Francesco Bertoni, Reto Ritschard, Vincent Pretre, Andreas Wicki, Doriano Fabbro, Petra Hillmann, Roger Williams, Bernd Giese, Matthias P. Wymann
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2664.
DOI: https://doi.org/10.1158/1538-7445.AM2015-2664
Published: 01 August 2015
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Journal Articles

GDNF–RET Signaling in ER-Positive Breast Cancers Is a Key Determinant of Response and Resistance to Aromatase Inhibitors

Andrea Morandi, Lesley-Ann Martin, Qiong Gao, Sunil Pancholi, Alan Mackay, David Robertson, Marketa Zvelebil, Mitch Dowsett, Ivan Plaza-Menacho, Clare M. Isacke
Journal: Cancer Research
Cancer Res (2013) 73 (12): 3783–3795.
DOI: https://doi.org/10.1158/0008-5472.CAN-12-4265
Published: 13 June 2013
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Includes: Supplementary data
Journal Articles

Abstract 4761: Glial cell derived neurotrophic factor (GDNF)-RET signaling as a target in aromatase inhibitor resistant ER-positive breast cancers.

Andrea Morandi, Lesley-Ann Martin, Qiong Gao, Alan Mackay, David Robertson, Marketa Zvelebil, Mitch Dowsett, Ivan Plaza-Menacho, Clare M. Isacke
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4761.
DOI: https://doi.org/10.1158/1538-7445.AM2013-4761
Published: 15 April 2013
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Journal Articles

Abstract 3417: An in vivo functional screen to identify metastasis suppressor genes

Nirupa Murugaesu, Marjan Iravani, Damian Johnson, Aristotelis Antonopoulos, David Sims, Kerry Fenwick, Costas Mitsopoulos, Qiong Gao, Nick Orr, Marketa Zvelebil, Stuart Haslam, Anne Dell, Christopher Lord, Alan Ashworth, Clare Isacke
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3417.
DOI: https://doi.org/10.1158/1538-7445.AM2012-3417
Published: 15 April 2012
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Journal Articles

The Vascular Endothelial Growth Factor Receptor Inhibitor PTK787/ZK222584 Inhibits Aromatase

Susana Banerjee, Marketa Zvelebil, Pascal Furet, Ursula Mueller-Vieira, Dean B. Evans, Mitch Dowsett, Lesley-Ann Martin
Journal: Cancer Research
Cancer Res (2009) 69 (11): 4716–4723.
DOI: https://doi.org/10.1158/0008-5472.CAN-08-4711
Published: 01 June 2009
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Includes: Supplementary data
Journal Articles

The discovery of GDC-0941: A potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer

Adrian Folkes, Stewart Baker, Irina Chuckowree, Suzanne Eccles, Angela Hayes, Timothy Hancox, Mohammed Latif, Alan Olivero, Sonal Patel, Giles Pergl-Wilson, Florence Raynaud, Anthony Robson, Nahid Saghir, Sukhjit Sohal, Nan Chi Wan, Christian Weissman, Paul Workman, Marketa Zvelebil, Stephen Shuttleworth
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): LB-146.
Published: 01 May 2008
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Journal Articles

Gene and Protein Expression Profiling of Human Ovarian Cancer Cells Treated with the Heat Shock Protein 90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin

Alison Maloney, Paul A. Clarke, Soren Naaby-Hansen, Rob Stein, Jens-Oliver Koopman, Akunna Akpan, Alice Yang, Marketa Zvelebil, Rainer Cramer, Lindsay Stimson, Wynne Aherne, Udai Banerji, Ian Judson, Swee Sharp, Marissa Powers, Emmanuel deBilly, Joanne Salmons, Michael Walton, Al Burlingame, Michael Waterfield, Paul Workman
Journal: Cancer Research
Cancer Res (2007) 67 (7): 3239–3253.
DOI: https://doi.org/10.1158/0008-5472.CAN-06-2968
Published: 04 April 2007
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Includes: Supplementary data