1-20 of 32
Mark R. Kelley
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Abstract C028: Challenging PDAC adaptability: Uncovering therapeutic vulnerabilities in APE1 DNA repair mechanisms

Eyram K Kpenu, Randall Wireman, Mahmut Mijiti, Silpa Gampala, Melissa L Fishel, Mark R Kelley
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): C028.
https://doi.org/10.1158/1538-7445.PANCREATIC24-C028
Published: 15 September 2024
View article titled, Abstract C028: Challenging PDAC adaptability: Uncovering therapeutic vulnerabilities in APE1 DNA repair mechanisms
Journal Articles

Abstract 478: Targeted combination nano-drug delivery system to enhance anti-cancer efficacy and reduce side effects

Niloufar Rashidi, Majid Davidson, Vasso Apostolopoulos, Mark R. Kelley, Kulmira Nurgali
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 478.
https://doi.org/10.1158/1538-7445.AM2024-478
Published: 22 March 2024
View article titled, Abstract 478: Targeted combination nano-drug delivery system to enhance anti-cancer efficacy and reduce side effects
Journal Articles

Abstract 2009: Elucidating the mechanistic effect of targeting Ref-1 redox function on MPNST survival signaling using patient-derived xenolines

Silpa Gampala, Olivia Babb, Nikkitha Umesh Ganesh, Steven D. Rhodes, Reza M. Saadatzadeh, Kai Pollard, Christine Pratilas, Jing-Ruey Joanna Yeh, Karen E. Pollok, Wade D. Clapp, Mark R. Kelley, Chi Zhang, Melissa L. Fishel
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2009.
https://doi.org/10.1158/1538-7445.AM2022-2009
Published: 15 June 2022
View article titled, Abstract 2009: Elucidating the mechanistic effect of targeting Ref-1 redox function on MPNST survival signaling using patient-derived xenolines
Journal Articles

Abstract 2366: Inhibition of Ref-1/APE1 redox activity with APX3330 enhances Ref-1/APE1 protein unfolded conformation in human PDAC cells

Mahmut Mijit, Olivia Babb, Silpa Gampala, Randall Wireman, Millie M. Georgiadis, Melissa L. Fishel, Mark R. Kelley
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2366.
https://doi.org/10.1158/1538-7445.AM2022-2366
Published: 15 June 2022
View article titled, Abstract 2366: Inhibition of Ref-1/APE1 redox activity with APX3330 enhances Ref-1/APE1 protein unfolded conformation in human PDAC cells
Journal Articles

Abstract 2475: Differential sensitivity of mouse PDAC KrasG12D cells to Ref-1/APE1 redox signalling inhibitors: Role of NFkB as a primary target of Ref-1/APE1 in Kras driven pancreatic ductal adenocarcinoma

Rachel A. Caston, Randy Wireman, Lee Armstrong, Silpa Gampala, Olivia Babb, Nayela Chowdhury, Zonera Hassan, Christian Schneeweis, Gunter Schneider, Melissa L. Fishel, Mark R. Kelley
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2475.
https://doi.org/10.1158/1538-7445.AM2021-2475
Published: 01 July 2021
View article titled, Abstract 2475: Differential sensitivity of mouse PDAC Kras<sup>G12D</sup> cells to Ref-1/APE1 redox signalling inhibitors: Role of NFkB as a primary target of Ref-1/APE1 in <em>Kras</em> driven pancreatic ductal adenocarcinoma
Journal Articles

Abstract 1452: Deciphering mechanisms of Ref-1 signaling and its inhibition in aggressive tumor-stroma PDAC models

Silpa Gampala, Nayela Chowdhury, Olivia Babb, Rachel A. Caston, Randall S. Wireman, Hye-ran Moon, George Sandusky, Emily Hulsey, Bumsoo Han, Millie M. Georgiadis, Sara K. Quinney, Andi R. Masters, James H. Wikel, Mark R. Kelley, Melissa L. Fishel
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1452.
https://doi.org/10.1158/1538-7445.AM2021-1452
Published: 01 July 2021
View article titled, Abstract 1452: Deciphering mechanisms of Ref-1 signaling and its inhibition in aggressive tumor-stroma PDAC models
Journal Articles

Abstract PO025: Ref-1 redox function identified as mitochondrial metabolic regulator in pancreatic cancer cells but not in CAFs

Silpa Gampala, Fenil Shah, Xiaoyu Lu, Hye-ran Moon, George E. Sandusky, Emily Hulsey, Amber L. Mosley, Bamsoo Han, Chi Zhang, Mark R. Kelley, Melissa L. Fishel
Journal: Cancer Research
Cancer Res (2021) 81 (5_Supplement): PO025.
https://doi.org/10.1158/1538-7445.TME21-PO025
Published: 01 March 2021
View article titled, Abstract PO025: Ref-1 redox function identified as mitochondrial metabolic regulator in pancreatic cancer cells but not in CAFs
Journal Articles

Abstract 2941: APE1/Ref-1 redox signaling regulates HIF1a-mediated CA9 expression in hypoxic pancreatic cancer cells: Combination treatment in patient-derived pancreatic tumor models

Derek Logsdon, Fenil Shah, Fabrizio Carta, Claudiu Supuran, Melissa Fishel, Mark R. Kelley
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2941.
https://doi.org/10.1158/1538-7445.AM2018-2941
Published: 01 July 2018
View article titled, Abstract 2941: APE1/Ref-1 redox signaling regulates HIF1a-mediated CA9 expression in hypoxic pancreatic cancer cells: Combination treatment in patient-derived pancreatic tumor models
Journal Articles

Abstract 4802: Combination therapy in PDAC involving blockade of the APE1/Ref-1 signaling pathway: An investigation into drug synthetic lethality and anti-neuropathy therapeutic approach

Fenil L. Shah, Nadia Atallah, Michelle Grimard, Chunlu Guo, Chi Zhang, Jill Fehrenbacher, Mark R. Kelley, Melissa Fishel
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4802.
https://doi.org/10.1158/1538-7445.AM2018-4802
Published: 01 July 2018
View article titled, Abstract 4802: Combination therapy in PDAC involving blockade of the APE1/Ref-1 signaling pathway: An investigation into drug synthetic lethality and anti-neuropathy therapeutic approach
Journal Articles

Abstract B88: Clinical trials targeting APE1/Ref-1 in pancreatic cancer with APX3330

Mark R. Kelley, Safi Shahda, Bert H. O'Neil, Homer Pearce, Jackie Walling
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): B88.
https://doi.org/10.1158/1538-7445.PANCA16-B88
Published: 14 December 2016
View article titled, Abstract B88: Clinical trials targeting APE1/Ref-1 in pancreatic cancer with APX3330
Journal Articles

Abstract B51: Regulation of HIF1α under hypoxia by APE1/Ref-1 impacts CA9 expression: Dual-targeting in patient-derived 3D pancreatic cancer models

Derek P. Logsdon, Michelle Grimard, Safi Shahda, Nicholas Zyromski, Ernestina Schipani, Fabrizio Carta, Claudiu T. Supuran, Murray Korc, Mircea Ivan, Mark R. Kelley, Melissa L. Fishel
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): B51.
https://doi.org/10.1158/1538-7445.PANCA16-B51
Published: 14 December 2016
View article titled, Abstract B51: Regulation of HIF1α under hypoxia by APE1/Ref-1 impacts CA9 expression: Dual-targeting in patient-derived 3D pancreatic cancer models
Journal Articles

Abstract 1246: Development of STAT3 dual-targeting strategies for the treatment of pancreatic cancer

Melissa L. Fishel, Michelle L. Grimard, Mark R. Kelley, David A. Rosa, Andrew Shouksmith, Gary Tin, Ji Park, Patrick T. Gunning
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1246.
https://doi.org/10.1158/1538-7445.AM2016-1246
Published: 15 July 2016
View article titled, Abstract 1246: Development of STAT3 dual-targeting strategies for the treatment of pancreatic cancer
Journal Articles

Abstract 4740: Targeting Ref-1/APE1 pathway inhibition in pancreatic cancer using APX3330 for clinical trials

Melissa L. Fishel, Derek P. Logsdon, Michelle L. Grimard, Claudiu T. Supuran, Nicholas Zyromski, Mircea Ivan, Mark R. Kelley, Fenil Shah
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4740.
https://doi.org/10.1158/1538-7445.AM2016-4740
Published: 15 July 2016
View article titled, Abstract 4740: Targeting Ref-1/APE1 pathway inhibition in pancreatic cancer using APX3330 for clinical trials
Journal Articles

Abstract 5183: Efficacy study of APX3330, a Ref-1 redox inhibitor, and Gemcitabine in a mouse pancreatic ductal adenocarcinoma model

Kyle C. McElyea, Max H. Jacobsen, Max Schmidt, Huiwen Cheng, Mark R. Kelley, George E. Sandusky, Melissa L. Fishel
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 5183.
https://doi.org/10.1158/1538-7445.AM2016-5183
Published: 15 July 2016
View article titled, Abstract 5183: Efficacy study of APX3330, a Ref-1 redox inhibitor, and Gemcitabine in a mouse pancreatic ductal adenocarcinoma model
Journal Articles

Abstract B19: Redox factor 1 (Ref-1) signaling in the interaction between pancreatic tumor cells and cancer-associated fibroblasts

Melissa L. Fishel, Huiwen Cheng, Murray Korc, Mark R. Kelley
Journal: Cancer Research
Cancer Res (2015) 75 (13_Supplement): B19.
https://doi.org/10.1158/1538-7445.PANCA2014-B19
Published: 30 June 2015
View article titled, Abstract B19: Redox factor 1 (Ref-1) signaling in the interaction between pancreatic tumor cells and cancer-associated fibroblasts
Journal Articles

Abstract B32: First-in-class Ref-1 redox inhibitors for the multipathway targeting of survival signals for relapsed childhood acute lymphoblastic leukemia

Angelo A. Cardoso, James H. Wikel, Jixin Ding, April M. Reed, Meihua Luo, Mark R. Kelley
Journal: Cancer Research
Cancer Res (2014) 74 (20_Supplement): B32.
https://doi.org/10.1158/1538-7445.PEDCAN-B32
Published: 09 October 2014
View article titled, Abstract B32: First-in-class Ref-1 redox inhibitors for the multipathway targeting of survival signals for relapsed childhood acute lymphoblastic leukemia
Journal Articles

Abstract 4961: Longitudinal bioluminescence imaging of primary versus abdominal metastatic tumor growth in orthotopic pancreatic tumor models in NOD/SCIDγ(-/-) mice

Harlan E. Shannon, Melissa L. Fishel, Jingwu Xie, Dongsheng Gu, Brian P. McCarthy, Amanda A. Riley, Anthony L. Sinn, Jayne M. Silver, Mark R. Kelley, Helmut Hanenberg, Murray Korc, Karen E. Pollok, Paul R. Territo
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4961.
https://doi.org/10.1158/1538-7445.AM2014-4961
Published: 01 October 2014
View article titled, Abstract 4961: Longitudinal bioluminescence imaging of primary versus abdominal metastatic tumor growth in orthotopic pancreatic tumor models in NOD/SCIDγ(-/-) mice
Journal Articles

Abstract 1769: Significant in vivo activity of an APE1/Ref-1 redox inhibitor, E3330, alone and in combination with Bevacizumab in a glioblastoma mouse model analyzed by a whole slide digital imaging system and quantitative immunohistochemistry

Krishan Kumar, Jessica L. Jackson, Mark R. Kelley, Mircea Ivan, George Sandsuky
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1769.
https://doi.org/10.1158/1538-7445.AM2012-1769
Published: 15 April 2012
View article titled, Abstract 1769: Significant in vivo activity of an APE1/Ref-1 redox inhibitor, E3330, alone and in combination with Bevacizumab in a glioblastoma mouse model analyzed by a whole slide digital imaging system and quantitative immunohistochemistry
Journal Articles

Abstract 1963: Novel small molecule inhibitor of the endonuclease function of the APE1 DNA repair and redox signaling enzyme blocks proliferation and reduces viability of glioblastoma cells

Aditi Bapat, LaTeca S. Glass, Meihua Luo, Melissa L. Fishel, April Reed, Eric C. Long, Millie M. Georgiadis, Mark R. Kelley
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1963.
https://doi.org/10.1158/1538-7445.AM10-1963
Published: 15 April 2010
View article titled, Abstract 1963: Novel small molecule inhibitor of the endonuclease function of the APE1 DNA repair and redox signaling enzyme blocks proliferation and reduces viability of glioblastoma cells
Journal Articles

Implications of Apurinic/Apyrimidinic Endonuclease in Reactive Oxygen Signaling Response after Cisplatin Treatment of Dorsal Root Ganglion Neurons

Yanlin Jiang, Chunlu Guo, Michael R. Vasko, Mark R. Kelley
Journal: Cancer Research
Cancer Res (2008) 68 (15): 6425–6434.
https://doi.org/10.1158/0008-5472.CAN-08-1173
Published: 01 August 2008
View article titled, Implications of Apurinic/Apyrimidinic Endonuclease in Reactive Oxygen Signaling Response after Cisplatin Treatment of Dorsal Root Ganglion Neurons
Open the PDF for Implications of Apurinic/Apyrimidinic Endonuclease in Reactive Oxygen Signaling Response after Cisplatin Treatment of Dorsal Root Ganglion Neurons in another window