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Mark D. Minden
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Journal Articles

Abstract 3806: Single-cell transcriptional mapping reveals genetic and non-genetic determinants of aberrant differentiation in AML

Free
Andy G. Zeng, Ilaria Iacobucci, Sayyam Shah, Amanda Mitchell, Gordon Wong, Suraj Bansal, David Chen, Qingsong Gao, Hyerin Kim, James A. Kennedy, Andrea Arruda, Mark D. Minden, Torsten Haferlach, Charles G. Mullighan, John E. Dick
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3806.
https://doi.org/10.1158/1538-7445.AM2025-3806
Published: 22 May 2025
View articletitled, Abstract 3806: Single-cell transcriptional mapping reveals genetic and non-genetic determinants of aberrant differentiation in AML
Journal Articles

Abstract 5411: The IL-23 receptor localizes intracellularly in AML and stem cells where it regulates mitotic spindle formation to maintain cell viability

Free
Nathan Duong, Dilshad H. Khan, Geethu E. Thomas, Yue Feng, Rose Hurren, Jong Bok Lee, Jonathan St-Germain, Lily Drimmer, Yongran Yan, Lan Xin Zhang, Dakai Ling, Mary L. Ma, Neil MacLean, Marcela Gronda, Vincent Rondeau, Brandon D. Brown, Laura Matellán, Courtney L. Jones, Hong Chang, Andrea Arruda, Stephanie Xie, Laurence Pelletier, Mark D. Minden, Li Zhang, Steven M. Kornblau, Brian Raught, Kevin Jacobs, Max G. Jacobs, Daniel Goede, Vito Spadavecchio, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5411.
https://doi.org/10.1158/1538-7445.AM2025-5411
Published: 21 April 2025
View articletitled, Abstract 5411: The IL-23 receptor localizes intracellularly in AML and stem cells where it regulates mitotic spindle formation to maintain cell viability
Journal Articles

Abstract 5431: The mitochondrial protease, YME1L regulates interferon signaling and is essential for AML growth and differentiation

Free
Yihe Zhang, Rose Hurren, Yongran Yan, Marcela Gronda, Dakai Ling, Karen Kai-Lin Fang, Andrea Arruda, Mark D. Minden, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5431.
https://doi.org/10.1158/1538-7445.AM2025-5431
Published: 21 April 2025
View articletitled, Abstract 5431: The mitochondrial protease, YME1L regulates interferon signaling and is essential for AML growth and differentiation
Journal Articles

Abstract 3033: Increased mitochondrial protein import necessitates greater reliance on the mitochondrial unfolded protein response (UPRmt) and the protease LONP1 to maintain mitochondrial protein solubility and cell viability in acute myeloid leukemia (AML)

Free
Matthew Tcheng, Veronique Voisin, Marcela Gronda, Rose Hurren, Lan Xin Zhang, Yue Feng, Zaynab Mamai, Brady Stock, Yulia Jitkova, Andrea Arruda, Steven M. Kornblau, Mark D. Minden, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3033.
https://doi.org/10.1158/1538-7445.AM2025-3033
Published: 21 April 2025
View articletitled, Abstract 3033: Increased mitochondrial protein import necessitates greater reliance on the mitochondrial unfolded protein response (UPRmt) and the protease LONP1 to maintain mitochondrial protein solubility and cell viability in acute myeloid leukemia (AML)
Journal Articles

Abstract 1792: A novel lipid nanoparticle formulation transfects acute myeloid leukemia cells and primary AML samples with high efficiency and low toxicity

Free
Lan Xin Zhang, Yongran Yan, Jingan Chen, Rose Hurren, Jiachuan Bu, Juan Chen, Dakai Ling, Nathan Duong, Andrea Arruda, Hansen He, Mark D. Minden, Rod Bremner, Gang Zheng, Bowen Li, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1792.
https://doi.org/10.1158/1538-7445.AM2025-1792
Published: 21 April 2025
View articletitled, Abstract 1792: A novel lipid nanoparticle formulation transfects acute myeloid leukemia cells and primary AML samples with high efficiency and low toxicity
Journal Articles

Abstract 5898: Inhibition of the LONP1 ATPase domain induces mitochondrial proteotoxic stress and is cytotoxic to acute myeloid leukemia cells

Free
Matthew Tcheng, Marcela Gronda, Rose Hurren, Lan Xin Zhang, Chaitra Sarathy, Yongran Yan, Andrea Arruda, Mark D. Minden, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5898.
https://doi.org/10.1158/1538-7445.AM2024-5898
Published: 22 March 2024
View articletitled, Abstract 5898: Inhibition of the LONP1 ATPase domain induces mitochondrial proteotoxic stress and is cytotoxic to acute myeloid leukemia cells
Journal Articles

Abstract 1646: IL-23R is a regulator of the mitotic spindle and is critical for cell viability in AML

Free
Nathan Duong, Dilshad H. Khan, Geethu E. Thomas, Rose Hurren, Jong Bok Lee, Jonathan St-Germain, Lily Drimmer, Yongran Yan, Neil Maclean, Marcela Gronda, Vincent Rondeau, Brandon D. Brown, Courtney L. Jones, Hong Chang, Andrea Arruda, Mark D. Minden, Li Zhang, Steven M. Kornblau, Brian Raught, Vito Spadavecchio, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1646.
https://doi.org/10.1158/1538-7445.AM2024-1646
Published: 22 March 2024
View articletitled, Abstract 1646: IL-23R is a regulator of the mitotic spindle and is critical for cell viability in AML
Journal Articles

Abstract 4833: Inhibiting the mitochondrial RNA degradosome complex SUV3 and PNPase increases dsRNA in the cytoplasm, triggers a viral mimicry response and kills AML cells and progenitors

Free
Geethu Emily Thomas, Kazem Nouri, Jong Bok Lee, Rose Hurren, Yongran Yan, Neil MacLean, Yulia Jitkova, Li Ma, Xiao Ming Wang, Chaitra Sarathy, Andrea Arruda, Mark D. Minden, Li Zhang, Vito Spadavecchio, Aaron Schimmer
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4833.
https://doi.org/10.1158/1538-7445.AM2023-4833
Published: 04 April 2023
View articletitled, Abstract 4833: Inhibiting the mitochondrial RNA degradosome complex SUV3 and PNPase increases dsRNA in the cytoplasm, triggers a viral mimicry response and kills AML cells and progenitors
Journal Articles

Abstract 2530: DELE1 loss and dysfunctional integrated stress signaling in TP53 mutated AML is a novel pathway for venetoclax resistance

Free
David Sharon, Paul Jung, Yan Sun, Weiguo Feng, Ziping Yang, Valerie Robinson, Diya Mitra, Wei Liu, Pingping Zheng, Tamar Uziel, Lloyd Lam, Mark D. Minden, Jeremy Ross, Wellington Mendes, Jalaja Potluri, Andrew H. Wei, Marina Konopleva, Monique Dail, Brenda Chyla, PK Epling-Burnette
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2530.
https://doi.org/10.1158/1538-7445.AM2023-2530
Published: 04 April 2023
View articletitled, Abstract 2530: DELE1 loss and dysfunctional integrated stress signaling in TP53 mutated AML is a novel pathway for venetoclax resistance
Journal Articles

Abstract 333: Interleukin 23 receptor is a critical regulator of the mitotic spindle and necessary for AML viability

Free
Nathan Duong, Dilshad H. Khan, Geethu E. Thomas, Rose Hurren, Jong Bok Lee, Jonathan St-Germain, Lily Drimmer, Yongran Yan, Neil MacLean, Marcela Gronda, Brandon D. Brown, Brian Raught, Andrea Arruda, Hong Chang, Mark D. Minden, Li Zhang, Steven M. Kornblau, Vito Spadavecchio, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 333.
https://doi.org/10.1158/1538-7445.AM2023-333
Published: 04 April 2023
View articletitled, Abstract 333: Interleukin 23 receptor is a critical regulator of the mitotic spindle and necessary for AML viability
Journal Articles

Targeting STAT5 Signaling Overcomes Resistance to IDH Inhibitors in Acute Myeloid Leukemia through Suppression of Stemness

Available to Purchase
Alex C.H. Liu, Severine Cathelin, Yitong Yang, David L. Dai, Dhanoop Manikoth Ayyathan, Mohsen Hosseini, Mark D. Minden, Anne Tierens, Steven M. Chan
Journal: Cancer Research
Cancer Res (2022) 82 (23): 4325–4339.
https://doi.org/10.1158/0008-5472.CAN-22-1293
Published: 02 December 2022
View articletitled, Targeting STAT5 Signaling Overcomes Resistance to IDH Inhibitors in Acute Myeloid Leukemia through Suppression of Stemness
Open the PDF for Targeting STAT5 Signaling Overcomes Resistance to IDH Inhibitors in Acute Myeloid Leukemia through Suppression of Stemness in another window
Includes: Supplementary data
Journal Articles

Abstract CT537: A phase 2, multicenter, randomized, double-blind trial of maintenance therapy with FLT3 inhibitor gilteritinib (ASP2215) in patients with FLT3/ITD AML (GOSSAMER study)

Free
Mark D. Minden, Jacob M. Rowe, Emmanuel Gyan, Kohmei Kubo, Nahla Hasabou, David Delgado, Wensheng He, Stanley C. Gill, Jason E. Hill, Ramon Tiu
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT537.
https://doi.org/10.1158/1538-7445.AM2022-CT537
Published: 15 June 2022
View articletitled, Abstract CT537: A phase 2, multicenter, randomized, double-blind trial of maintenance therapy with FLT3 inhibitor gilteritinib (ASP2215) in patients with FLT3/ITD AML (GOSSAMER study)
Journal Articles

TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors

Available to Purchase
Silvia Maifrede, Bac Viet Le, Margaret Nieborowska-Skorska, Konstantin Golovine, Katherine Sullivan-Reed, Wangisa M.B. Dunuwille, Joseph Nacson, Michael Hulse, Kelsey Keith, Jozef Madzo, Lisa Beatrice Caruso, Zachary Gazze, Zhaorui Lian, Antonella Padella, Kumaraswamy N. Chitrala, Boris A. Bartholdy, Ksenia Matlawska-Wasowska, Daniela Di Marcantonio, Giorgia Simonetti, Georg Greiner, Stephen M. Sykes, Peter Valent, Elisabeth M. Paietta, Martin S. Tallman, Hugo F. Fernandez, Mark R. Litzow, Mark D. Minden, Jian Huang, Giovanni Martinelli, George S. Vassiliou, Italo Tempera, Katarzyna Piwocka, Neil Johnson, Grant A. Challen, Tomasz Skorski
Journal: Cancer Research
Cancer Res (2021) 81 (19): 5089–5101.
https://doi.org/10.1158/0008-5472.CAN-20-3761
Published: 01 October 2021
View articletitled, TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors
Open the PDF for TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors in another window
Includes: Supplementary data
Journal Articles

Diminished AHR Signaling Drives Human Acute Myeloid Leukemia Stem Cell Maintenance

Free
Michelle Ly, Stefan Rentas, Ana Vujovic, Nicholas Wong, Steven Moreira, Joshua Xu, Nicholas Holzapfel, Sonam Bhatia, Damian Tran, Mark D. Minden, Jonathan S. Draper, Kristin J. Hope
Journal: Cancer Research
Cancer Res (2019) 79 (22): 5799–5811.
https://doi.org/10.1158/0008-5472.CAN-19-0274
Published: 15 November 2019
View articletitled, Diminished AHR Signaling Drives Human Acute Myeloid Leukemia Stem Cell Maintenance
Open the PDF for Diminished AHR Signaling Drives Human Acute Myeloid Leukemia Stem Cell Maintenance in another window
Includes: Supplementary data
Journal Articles

Abstract 2720: Mitochondrial ClpP-mediated proteolysis induces selective cancer cell lethality

Free
Jo Ishizawa, Sarah F. Zarabi, R Eric Davis, Ondrej Halgas, Takenobu Nii, Yulia Jitkova, Ran Zhao, Jonathan St-Germain, Lauren E. Heese, Grace Egan, Vivian R. Ruvolo, Samir H. Barghout, Yuki Nishida, Rose Hurren, Wencai Ma, Marcela Gronda, Todd Link, Keith Wong, Mark Mabanglo, Kensuke Kojima, Gautam Borthakur, Neil MacLean, John Man Chun Ma, Andrew B. Leber, Mark D. Minden, Walid Houry, Hagop Kantarjian, Martin Stogniew, Brian Raught, Emil F. Pai, Aaron D. Schimmer, Michael Andreeff
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2720.
https://doi.org/10.1158/1538-7445.AM2019-2720
Published: 01 July 2019
View articletitled, Abstract 2720: Mitochondrial ClpP-mediated proteolysis induces selective cancer cell lethality
Journal Articles

Abstract 3003: Inhibiting the mitochondrial enzyme phosphatidylserine decarboxylase (PISD) reduces stemness and increases differentiation in acute myeloid leukemia (AML)

Free
Mingjing Xu, Ayesh Seneviratne, Val A. Fajardo, Geethu E. Thomas, G. Wei Xu, Rose Hurren, S. Kim, Neil MacLean, Xiaoming Wang, Marcela Gronda, Danny Jeyaraju, Yulia Jitkova, David Sharon, Ahmed Aman, Rima Al-awar, Steven Chan, Mark D. Minden, Paul LeBlanc, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3003.
https://doi.org/10.1158/1538-7445.AM2019-3003
Published: 01 July 2019
View articletitled, Abstract 3003: Inhibiting the mitochondrial enzyme phosphatidylserine decarboxylase (PISD) reduces stemness and increases differentiation in acute myeloid leukemia (AML)
Journal Articles

Abstract 2991: Cytoplasmic mislocalization of CTCF by NPM1c in acute myeloid leukemia resulting in inhibited CTCF regulatory functions generating aberrant genetic and epigenetic profiles

Free
Atom Wang, Youqi Han, Peikun Chen, Nanyang Jia, Mark D. Minden
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2991.
https://doi.org/10.1158/1538-7445.AM2018-2991
Published: 01 July 2018
View articletitled, Abstract 2991: Cytoplasmic mislocalization of CTCF by NPM1c in acute myeloid leukemia resulting in inhibited CTCF regulatory functions generating aberrant genetic and epigenetic profiles
Journal Articles

Abstract 819: High response rates with entospletinib in patients with t(v;11q23.3);KMT2A rearranged acute myeloid leukemia and acute lymphoblastic leukemia

Free
Alison R. Walker, John C. Byrd, William Blum, Tara Lin, Howland E. Crosswell, Danjie Zhang, Jie Gao, Arati V. Rao, Mark D. Minden, Wendy Stock
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 819.
https://doi.org/10.1158/1538-7445.AM2018-819
Published: 01 July 2018
View articletitled, Abstract 819: High response rates with entospletinib in patients with t(v;11q23.3);KMT2A rearranged acute myeloid leukemia and acute lymphoblastic leukemia
Journal Articles

Abstract LB-341: Evolving functional heterogeneity in B-acute lymphoblastic leukemia

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Stephanie M. Dobson, Robert Vanner, Esmé Waanders, Olga I. Gan, Jessica McLeod, Ildiko Grandal, Debbie Payne-Turner, Michael Edmonson, Zhaohui Gu, Xioatu Ma, Yiping Fan, Pankaj Gupta, Sagi Abelson, Michael Rusch, Ying Shao, Scott Olsen, Geoffrey Neale, John Easton, Cynthia J. Guidos, Jayne S. Danska, Jinghui Zhang, Mark D. Minden, Charles G. Mullighan, John E. Dick
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-341.
https://doi.org/10.1158/1538-7445.AM2016-LB-341
Published: 15 July 2016
View articletitled, Abstract LB-341: Evolving functional heterogeneity in B-acute lymphoblastic leukemia
Journal Articles

Abstract A25: Evolving functional heterogeneity in B-acute lymphoblastic leukemia

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Stephanie M. Dobson, Robert Vanner, Esmé Waanders, Jessica McLeod, Olga I. Gan, Zhaohui Gu, Debbie Payne-Turner, Xiaotu Ma, Yiping Fan, Pankaj Gupta, Michael Rusch, John Easton, Cynthia J. Guidos, Jayne S. Danska, Jinghui Zhang, Mark D. Minden, Charles G. Mullighan, John E. Dick
Journal: Cancer Research
Cancer Res (2016) 76 (3_Supplement): A25.
https://doi.org/10.1158/1538-7445.FBCR15-A25
Published: 07 April 2016
View articletitled, Abstract A25: Evolving functional heterogeneity in B-acute lymphoblastic leukemia