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Marion Dorsch
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Journal Articles

Abstract 1467: BLU-945, a fourth-generation, potent and highly selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with intracranial activity, demonstrates robust in vivo antitumor activity in models of osimertinib-resistant non-small cell lung cancer (NSCLC)

Sun Min Lim, Chae Won Park, Zhuo Zhang, Rich Woessner, Tom Dineen, Faith Stevison, John Hsieh, Meredith Eno, Doug Wilson, John Campbell, Caitlin Utt, Faris Albayya, Nicolas Lamontagne, Marion Dorsch, Klaus Hoeflich, Byoung Chul Cho, Stefanie Schalm
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1467.
https://doi.org/10.1158/1538-7445.AM2021-1467
Published: 01 July 2021
View article titled, Abstract 1467: BLU-945, a fourth-generation, potent and highly selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with intracranial activity, demonstrates robust <em>in vivo</em> antitumor activity in models of osimertinib-resistant non-small cell lung cancer (NSCLC)
Journal Articles

Abstract 1717: MAP4K1 inhibition enhances immune cell activation and anti-tumor immunity in preclinical tumor models

Kerrie Faia, Alberto Toso, Kristina Fetalvero, Marly Roche, Steven Bench, Erin O'Hearn, Qiongfang Cao, Kerry-Ann Bright, Debora Paduraru, Andrea Romagnani, Weifan Weng, Tina Zimmermann, Michael Burke, Joshua Close, Luke Green, Joseph Kim, Chandra Miduturu, Alison Ribeiro, Marina Bacac, Sylvia Herter, Emanuele Perola, Michael Sheets, Jan Eckmann, Gordon Heidkamp, Tary Traore, Erik Gerson, Rich Woessner, Carsten Wolter, Felix Scheuplein, Nisha Perez, Timothy LaBranche, Grace Silva, Chaoyang Ye, Caitlin Utt, Stefan Gross, James R. Bischoff, Marion Dorsch, Tim Guzi, Klaus Hoeflich, Jason Brubaker
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1717.
https://doi.org/10.1158/1538-7445.AM2021-1717
Published: 01 July 2021
View article titled, Abstract 1717: MAP4K1 inhibition enhances immune cell activation and anti-tumor immunity in preclinical tumor models
Journal Articles

Abstract 1279: Development of a selective CDK2-E inhibitor in CCNE driven cancers

Yoon J. Choi, Steve Wenglowsky, Victoria Brown, Neil Bifulco, Yeon S. Choi, Jian Guo, Megan Hatlen, Joseph Kim, Tim LaBranche, Riadh Lobbardi, Emanuele Perola, Emily Rozsahegyi, Michelle Maynard, Phil Ramsden, Grace Silva, Faith Stevison, Richard Vargas, Ruduan Wang, Doug Wilson, Rich Woessner, Dean Zhang, Rob Meissner, Klaus Hoeflich, Marion Dorsch
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1279.
https://doi.org/10.1158/1538-7445.AM2021-1279
Published: 01 July 2021
View article titled, Abstract 1279: Development of a selective CDK2-E inhibitor in CCNE driven cancers
Journal Articles

Abstract 1262: BLU-701 is a highly potent, brain-penetrant and WT-sparing next-generation EGFR TKI for the treatment of sensitizing (ex19del, L858R) and C797S resistance mutations in metastatic NSCLC

Chiara Conti, John Campbell, Rich Woessner, Jian Guo, Yoav Timsit, Maria Iliou, Scott Wardwell, Alison Davis, Sharon Chicklas, John Hsieh, Meredith Eno, Omar Ahmad, Dilinie Fernando, Kevin Barvian, Joseph Kim, Steven Kazmirski, Emanuele Perola, Tom Dineen, Victoria Brown, Timothy Guzi, Ayşegül Özen, Faith Stevison, Caitlin Utt, Clare Medendorp, Robert Meissner, Marion Dorsch, Klaus Hoeflich
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1262.
https://doi.org/10.1158/1538-7445.AM2021-1262
Published: 01 July 2021
View article titled, Abstract 1262: BLU-701 is a highly potent, brain-penetrant and WT-sparing next-generation EGFR TKI for the treatment of sensitizing (ex19del, L858R) and C797S resistance mutations in metastatic NSCLC
Journal Articles

Abstract 2296: IDH2 mutation induced histone and DNA hypermethylation is progressively reversed by small molecule inhibition

Andrew Kernytsky, Fang Wang, Erica Hansen, Stefanie Schalm, Kimberly Straley, Camelia Gliser, Hua Yang, Jeremy Travins, Stuart Murray, Marion Dorsch, Sam Agresta, David P. Schenkein, Scott A. Biller, Shinsan M. Su, Wei Liu, Katharine E. Yen
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2296.
https://doi.org/10.1158/1538-7445.AM2014-2296
Published: 01 October 2014
View article titled, Abstract 2296: IDH2 mutation induced histone and DNA hypermethylation is progressively reversed by small molecule inhibition
Journal Articles

Abstract 1194: IDH1 mutant inhibitor induces cellular differentiation and offers a combination benefit with Ara-C in a primary human Idh1 mutant AML xenograft model

Kate Ellwood-Yen, Yue Chen, Fang Wang, Rene Lemieux, Janeta Popovici-Muller, Hua Yang, Kimberly Straley, Sung Choe, Marion Dorsch, Sam Agresta, David Schenkein, Scott Biller, Michael Su
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1194.
https://doi.org/10.1158/1538-7445.AM2014-1194
Published: 01 October 2014
View article titled, Abstract 1194: IDH1 mutant inhibitor induces cellular differentiation and offers a combination benefit with Ara-C in a primary human Idh1 mutant AML xenograft model
Journal Articles

Abstract 3116: AG-221 offers a survival advantage in a primary human IDH2 mutant AML xenograft model

Kate Ellwood-Yen, Fang Wang, Jeremy Travins, Yue Chen, Hua Yang, Kim Straley, Sung Choe, Marion Dorsch, Sam Agresta, David Schenkein, Scott Biller, Michael Su
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3116.
https://doi.org/10.1158/1538-7445.AM2014-3116
Published: 01 October 2014
View article titled, Abstract 3116: AG-221 offers a survival advantage in a primary human IDH2 mutant AML xenograft model
Journal Articles

Abstract 4376: Evaluation of PRP4 kinase as a potential drug target in cancer.

Qiang Gao, Ingrid Mechin, Nayantara Kothari, Zhuyan Guo, Gejing Deng, Anlai Wang, Dmitri Wiederschain, Jennifer Rocnik, Werngard Czechtizky, Feng Liu, Tahir Majid, Vinod Patel, Christoph Lengauer, Carlos Garcia-Echeverria, Bailin Zhang, Hong Cheng, Marion Dorsch, Shih-Min A. Huang
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4376.
https://doi.org/10.1158/1538-7445.AM2013-4376
Published: 15 April 2013
View article titled, Abstract 4376: Evaluation of PRP4 kinase as a potential drug target in cancer.
Journal Articles

Abstract 4553: Design and validation of a screening strategy for the identification of novel inhibitors of wild type and mutant CARD11 mediated BCR/NF-κB signaling.

Julia Zhu, Joshua C. Murtie, Rita Greco, Hongyun Wang, Monsif Bouaboula, Marion Dorsch, Francisco Adrian
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4553.
https://doi.org/10.1158/1538-7445.AM2013-4553
Published: 15 April 2013
View article titled, Abstract 4553: Design and validation of a screening strategy for the identification of novel inhibitors of wild type and mutant CARD11 mediated BCR/NF-κB signaling.
Journal Articles

Abstract 4406: CARD11 is critical for in vitro and in vivo growth of ABC-DLBCL cells.

Joshua C. Murtie, Julia Zhu, Hongyun Wang, Beatriz Ospina, May Cindhuchao, Dietmar Hoffman, Rita Greco, Marion Dorsch, Francisco Adrian
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4406.
https://doi.org/10.1158/1538-7445.AM2013-4406
Published: 15 April 2013
View article titled, Abstract 4406: CARD11 is critical for in vitro and in vivo growth of ABC-DLBCL cells.
Journal Articles

Abstract 1135: Chemical Proteomics effort identifies PKN1 as a key player in the canonical NF-κB signaling pathway.

Katherine Tang, Michael Lampa, Tieu-Binh Le, Matthieu Barrague, Ronald Tomlinson, Brittain Scott, Tahir Majid, Marion Dorsch, Hong Cheng, Christoph Lengauer, Carlos Garcia-Echeverria, Francisco Adrian, Mikhail Levit, Balin Zhang, Kin Yu, Ivan Cornella-Taracido, Lakshmi Srinivasan
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1135.
https://doi.org/10.1158/1538-7445.AM2013-1135
Published: 15 April 2013
View article titled, Abstract 1135: Chemical Proteomics effort identifies PKN1 as a key player in the canonical NF-κB signaling pathway.
Journal Articles

Abstract 1796: SAR302503: A Jak2 inhibitor with antitumor activity in solid tumor models

Rita Greco, Raelene Hurley, Fangxian Sun, Lu Yang, Qunyan Yu, Juliet Williams, Marion Dorsch, Pamela Cohen, Francisco Adrián
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1796.
https://doi.org/10.1158/1538-7445.AM2012-1796
Published: 15 April 2012
View article titled, Abstract 1796: SAR302503: A Jak2 inhibitor with antitumor activity in solid tumor models
Journal Articles

The Polycomb Group Protein Bmi-1 Is Essential for the Growth of Multiple Myeloma Cells

Zainab Jagani, Dmitri Wiederschain, Alice Loo, Dan He, Rebecca Mosher, Paul Fordjour, John Monahan, Michael Morrissey, Yung-Mae Yao, Christoph Lengauer, Markus Warmuth, William R. Sellers, Marion Dorsch
Journal: Cancer Research
Cancer Res (2010) 70 (13): 5528–5538.
https://doi.org/10.1158/0008-5472.CAN-09-4229
Published: 30 June 2010
View article titled, The Polycomb Group Protein Bmi-1 Is Essential for the Growth of Multiple Myeloma Cells
Open the PDF for The Polycomb Group Protein Bmi-1 Is Essential for the Growth of Multiple Myeloma Cells in another window
Includes: Supplementary data
Journal Articles

Abstract 4290: The smoothened antagonist NVP-LDE225 targets stroma and cancer stem cells in primary human pancreatic tumor xenografts

Silvia Buonamici, Beatriz E. Ospina, Julia Xing Zhu, Jing Yuan, Kathy Hsiao, Anthony Vattay, Fang Li, James Deeds, Lance Ostrom, John Monahan, Juliet Williams, Joseph Kelleher, Stefan Peukert, Shifeng Pan, Xu Wu, Markus Warmuth, Rebecca Mosher, Yung-mae Yao, William R. Sellers, Marion Dorsch
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4290.
https://doi.org/10.1158/1538-7445.AM10-4290
Published: 15 April 2010
View article titled, Abstract 4290: The smoothened antagonist NVP-LDE225 targets stroma and cancer stem cells in primary human pancreatic tumor xenografts
Journal Articles

Abstract 4498: Biological characterization of NVP-BKM120, a novel inhibitor of phosphoinosotide 3-kinase in Phase I/II clinical trials

charles F. Voliva, Sabina Pecchi, Matthew Burger, Tobi Nagel, Christian Schnell, christine Fritsch, saskia Brachmann, Daniel Menezes, Mark Knapp, Kevin Shoemaker, Marion Wiesmann, kay Huh, Isabel Zaror, Marion Dorsch, William R. Sellers, Carlos Garcia-Echeverria, Michel Maira
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4498.
https://doi.org/10.1158/1538-7445.AM10-4498
Published: 15 April 2010
View article titled, Abstract 4498: Biological characterization of NVP-BKM120, a novel inhibitor of phosphoinosotide 3-kinase in Phase I/II clinical trials
Journal Articles

Abstract 1976: The discovery of mechanisms of resistance to SMO antagonists and the therapeutic implications

Marion Dorsch, Silvia Buonamici, Juliet Williams, Anlai Wang, Ribo Guo, Anthony Vattay, Kathy Hsiao, Jing Yuan, Lance Ostrom, Paul Fordjour, Dustin Anderson, Michael Morrissey, John Monahan, Joseph Kelleher, Stefan Peukert, Shifeng Pan, Xu Wu, Sauver-Michel Maira, Carlos Garcia-Echeverria, Kimberly Briggs, Neil Watkins, Yung-mae Yao, Christoph Lengauer, Markus Warmuth, William Sellers
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1976.
https://doi.org/10.1158/1538-7445.AM10-1976
Published: 15 April 2010
View article titled, Abstract 1976: The discovery of mechanisms of resistance to SMO antagonists and the therapeutic implications
Journal Articles

PI3K Pathway Activation Mediates Resistance to MEK Inhibitors in KRAS Mutant Cancers

Susan Wee, Zainab Jagani, Kay Xiaoqin Xiang, Alice Loo, Marion Dorsch, Yung-Mae Yao, William R. Sellers, Christoph Lengauer, Frank Stegmeier
Journal: Cancer Research
Cancer Res (2009) 69 (10): 4286–4293.
https://doi.org/10.1158/0008-5472.CAN-08-4765
Published: 15 May 2009
View article titled, PI3K Pathway Activation Mediates Resistance to MEK Inhibitors in KRAS Mutant Cancers
Open the PDF for PI3K Pathway Activation Mediates Resistance to MEK Inhibitors in KRAS Mutant Cancers in another window
Includes: Supplementary data
Journal Articles

Abstract #288: A primary xenograft model of small cell lung cancer reveals irreversible changes in gene expression imposed by culture in-vitro

Luigi Marchionni, Vincent Daniel, Jared Hierman, Jonathan Rhodes, Wendy Devereux, Charles Rudin, Rex Yung, Marion Dorsch, Giovanni Parmigani, Craig Peacock, Neil Watkins
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 288.
Published: 01 May 2009
View article titled, Abstract #288: A primary xenograft model of small cell lung cancer reveals irreversible changes in gene expression imposed by culture in-vitro
Journal Articles

A Primary Xenograft Model of Small-Cell Lung Cancer Reveals Irreversible Changes in Gene Expression Imposed by Culture In vitro

Vincent C. Daniel, Luigi Marchionni, Jared S. Hierman, Jonathan T. Rhodes, Wendy L. Devereux, Charles M. Rudin, Rex Yung, Giovanni Parmigiani, Marion Dorsch, Craig D. Peacock, D. Neil Watkins
Journal: Cancer Research
Cancer Res (2009) 69 (8): 3364–3373.
https://doi.org/10.1158/0008-5472.CAN-08-4210
Published: 15 April 2009
View article titled, A Primary Xenograft Model of Small-Cell Lung Cancer Reveals Irreversible Changes in Gene Expression Imposed by Culture <em>In vitro</em>
Open the PDF for A Primary Xenograft Model of Small-Cell Lung Cancer Reveals Irreversible Changes in Gene Expression Imposed by Culture <em>In vitro</em> in another window
Includes: Supplementary data
Journal Articles

Vaccinations with Tumor Cells Genetically Engineered to Produce Different Cytokines: Effectivity not Superior to a Classical Adjuvant

Hanno Hock, Marion Dorsch, Ulrich Kunzendorf, Klaus Überla, Zhihai Qin, Tibor Diamantstein, Thomas Blankenstein
Journal: Cancer Research
Cancer Res (1993) 53 (4): 714–716.
Published: 01 February 1993
View article titled, Vaccinations with Tumor Cells Genetically Engineered to Produce Different Cytokines: Effectivity not Superior to a Classical Adjuvant
Open the PDF for Vaccinations with Tumor Cells Genetically Engineered to Produce Different Cytokines: Effectivity not Superior to a Classical Adjuvant in another window