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Marina Konopleva
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Journal Articles

BCL-xL Targeting to Induce Apoptosis and to Eliminate Chemotherapy-Induced Senescent Tumor Cells: From Navitoclax to Platelet-Sparing BCL-xL PROTACs

Anna Skwarska, Marina Konopleva
Journal: Cancer Research
Cancer Res (2023) 83 (21): 3501–3503.
https://doi.org/10.1158/0008-5472.CAN-23-2804
Published: 01 November 2023
View article titled, BCL-xL Targeting to Induce Apoptosis and to Eliminate Chemotherapy-Induced Senescent Tumor Cells: From Navitoclax to Platelet-Sparing BCL-xL PROTACs
Open the PDF for BCL-xL Targeting to Induce Apoptosis and to Eliminate Chemotherapy-Induced Senescent Tumor Cells: From Navitoclax to Platelet-Sparing BCL-xL PROTACs in another window
Journal Articles

Abstract 5927: Leveraging single cell RNA profiling to uncover intra-tumor heterogeneity across cytogenetic subgroups in acute myeloid leukemia

Bofei Wang, Christopher Ly, Fatima Zahra Jelloul, Enes Dasdemir, Guilin Tang, Sonali Jindal, Yulong Chen, Sreyashi Basu, Poonam Desai, Pamella Borges, Preethi Gunaratne, Natalia Baran, Qing Deng, Dapeng Hao, Sean Post, Michael Green Green, Marina Konopleva, Andy Futreal, Padmanee Sharma, Hussein A. Abbas
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5927.
https://doi.org/10.1158/1538-7445.AM2023-5927
Published: 04 April 2023
View article titled, Abstract 5927: Leveraging single cell RNA profiling to uncover intra-tumor heterogeneity across cytogenetic subgroups in acute myeloid leukemia
Journal Articles

Abstract 3455: Transcriptional and phenotypic heterogeneity underpinning venetoclax resistance

Vakul Mohanty, Natalia Baran, Yuefan Huang, Shan He, Ramiz Iqbal, CTD2 consortium, Jeffrey Tyner, Gordon Mills, Marina Konopleva, Ken Chen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3455.
https://doi.org/10.1158/1538-7445.AM2023-3455
Published: 04 April 2023
View article titled, Abstract 3455: Transcriptional and phenotypic heterogeneity underpinning venetoclax resistance
Journal Articles

Abstract 2530: DELE1 loss and dysfunctional integrated stress signaling in TP53 mutated AML is a novel pathway for venetoclax resistance

David Sharon, Paul Jung, Yan Sun, Weiguo Feng, Ziping Yang, Valerie Robinson, Diya Mitra, Wei Liu, Pingping Zheng, Tamar Uziel, Lloyd Lam, Mark D. Minden, Jeremy Ross, Wellington Mendes, Jalaja Potluri, Andrew H. Wei, Marina Konopleva, Monique Dail, Brenda Chyla, PK Epling-Burnette
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2530.
https://doi.org/10.1158/1538-7445.AM2023-2530
Published: 04 April 2023
View article titled, Abstract 2530: DELE1 loss and dysfunctional integrated stress signaling in <em>TP53</em> mutated AML is a novel pathway for venetoclax resistance
Journal Articles

Abstract 6314: Novel granzyme B-based fusion constructs targeting FRα on liquid and solid tumors

Ana Alvarez-Cienfuegos, Lawrence H. Cheung, Khalid A. Mohamedali, Natalia Baran, Marina Konopleva, Michael G. Rosenblum
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6314.
https://doi.org/10.1158/1538-7445.AM2023-6314
Published: 04 April 2023
View article titled, Abstract 6314: Novel granzyme B-based fusion constructs targeting FRα on liquid and solid tumors
Journal Articles

Abstract 3785: ME-344, a novel isoflavone mitochondrial inhibitor, in combination with venetoclax constitutes a new metabolism-targeted approach to overcome resistance to Bcl-2 inhibition and standard of care treatment in AML

Katie H. Hurrish, Yongwei Su, Shraddha Patel, Sandra E. Wiley, Zhanjun Hou, Jenna Carter, Hasini Kalpage, Maik Hüttemann, Connie Weng, Holly Edwards, Lisa Polin, Jing Li, Jay Yang, Larry H. Matherly, Sergej Naumovich Konoplev, Jeffrey W. Taub, Marina Konopleva, Yubin Ge, Natalia Baran
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3785.
https://doi.org/10.1158/1538-7445.AM2022-3785
Published: 15 June 2022
View article titled, Abstract 3785: ME-344, a novel isoflavone mitochondrial inhibitor, in combination with venetoclax constitutes a new metabolism-targeted approach to overcome resistance to Bcl-2 inhibition and standard of care treatment in AML
Journal Articles

Abstract 726: Effects of diet composition and timing on treatment for FLT3 positive acute myeloid leukemia

Megan Rodriguez, Mary Figueroa, Brianna Murphy, Tiewei Cheng, Baharan Fekry, Kendra Allton, Michelle Barton, Marina Konopleva, Kristin Mahan, Joya Chandra
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 726.
https://doi.org/10.1158/1538-7445.AM2022-726
Published: 15 June 2022
View article titled, Abstract 726: Effects of diet composition and timing on treatment for FLT3 positive acute myeloid leukemia
Journal Articles

Abstract 3075: Anti-leukemic activity of BCL-2/BCL-XL dual inhibitor - AZD0466 in T-acute lymphoblastic leukemia preclinical models

Sankaranarayanan Kannan, Sanaz Ghotbaldini, Julia E. Wells, Qi Zhang, Srividya Balachander, Justin Cidado, Marina Konopleva
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3075.
https://doi.org/10.1158/1538-7445.AM2020-3075
Published: 15 August 2020
View article titled, Abstract 3075: Anti-leukemic activity of BCL-2/BCL-XL dual inhibitor - AZD0466 in T-acute lymphoblastic leukemia preclinical models
Journal Articles

Abstract 6417: LY3410738, a novel inhibitor of mutant IDH1 is more effective than Ivosidenib and potentiates antileukemic activity of standard chemotherapy in preclinical models of acute myeloid leukemia (AML)

Vivian Salama, Nathan Brooks, Anna Skwarska, Lisa Kays, Paul Milligan, Katherine Newell, Kenneth Roth, Sandaruwan Geeganage, Raymond Gilmour, Steven M. Chan, Jean-Emmanuel Sarry, Mary Sabatier, Courtney DiNardo, Marina Konopleva
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6417.
https://doi.org/10.1158/1538-7445.AM2020-6417
Published: 15 August 2020
View article titled, Abstract 6417: LY3410738, a novel inhibitor of mutant IDH1 is more effective than Ivosidenib and potentiates antileukemic activity of standard chemotherapy in preclinical models of acute myeloid leukemia (AML)
Journal Articles

Abstract 342: S63845, a novel BH3 mimetic Mcl-1 inhibitor synergizes with midostaurin to induce potent apoptosis in acute myeloid leukemia cells carrying FLT3-ITD mutations

Anna Skwarska, Qi Zhang, Shelley M. Herbrich, Natalia Baran, Ensar Halilovic, Peter Ruvolo, Vivian Ruvolo, Erick Morris, Andrew Wei, Donia Moujalled, Michael Andreff, Marina Konopleva
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 342.
https://doi.org/10.1158/1538-7445.AM2019-342
Published: 01 July 2019
View article titled, Abstract 342: S63845, a novel BH3 mimetic Mcl-1 inhibitor synergizes with midostaurin to induce potent apoptosis in acute myeloid leukemia cells carrying FLT3-ITD mutations
Journal Articles

Abstract 2725: The single-cell atlas of driver mutations in acute myeloid leukemia

Kiyomi Morita, Feng Wang, Katharina Jahn, Yuanqing Yan, Robert Durruthy-Durruthy, Anup Parikh, Jairo Matthews, Latasha Little, Curtis Gumbs, Jianhua Zhang, Xingzhi Song, Erika Thompson, Keyur Patel, Carlos Bueso-Ramos, Courtney DiNardo, Farhad Ravandi, Elias Jabbour, Michael Andreeff, Jorge Cortes, Marina Konopleva, Guillermo Garcia-Manero, Hagop Kantarjian, Dennis J. Eastburn, P Andrew Futreal, Niko Beerenwinkel, Koichi Takahashi
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2725.
https://doi.org/10.1158/1538-7445.AM2019-2725
Published: 01 July 2019
View article titled, Abstract 2725: The single-cell atlas of driver mutations in acute myeloid leukemia
Journal Articles

Abstract 3831: Selective targeting BET family BDII bromodomain with ABBV-744 and BCL-2 with venetoclax (ABT-199) is synergistic in primary acute myeloid leukemia models

Tianyu Cai, Vinitha Kuruvilla, Xiaoyu Lin, Tamar Uziel, Xin Lu, Lu Zhang, Qi Zhang, Lina Han, Antonio Cavazos, Yu Shen, Marina Konopleva
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3831.
https://doi.org/10.1158/1538-7445.AM2019-3831
Published: 01 July 2019
View article titled, Abstract 3831: Selective targeting BET family BDII bromodomain with ABBV-744 and BCL-2 with venetoclax (ABT-199) is synergistic in primary acute myeloid leukemia models
Journal Articles

Abstract LB-222: Polyfunctionality determined by single-cell proteomics of bone marrow-derived CD4 T cells from patients with acute myeloid leukemia identifies patients responding to anti-PD-1-based therapy and discovers profound T cell defect in mutant TP53 disease

Naval Daver, Hagop Kantarjian, Sean Mackay, Brianna Flynn, Sreyashi Basu, Guillermo Garcia-Manero, Mansour Alfayez, Marina Konopleva, Jairo Matthews, Steven Kornblau, Ellias Jabbour, Jing Zhou, Michael Andreeff
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-222.
https://doi.org/10.1158/1538-7445.AM2019-LB-222
Published: 01 July 2019
View article titled, Abstract LB-222: Polyfunctionality determined by single-cell proteomics of bone marrow-derived CD4 T cells from patients with acute myeloid leukemia identifies patients responding to anti-PD-1-based therapy and discovers profound T cell defect in mutant TP53 disease
Journal Articles

Abstract 1655: Discovery and development of IACS-010759, a novel inhibitor of Complex I currently in phase I studies to exploit oxidative phosphorylation dependency in acute myeloid leukemia and solid tumors

Maria Emilia Di Francesco, Joseph R. Marszalek, Timothy McAfoos, Christopher L. Carroll, Zhijun Kang, Gang Liu, Jay P. Theroff, Jennifer P. Bardenhager, Madhavi L. Bandi, Jennifer R. Molina, Sonal Gera, Marina Protopopova, Yuting Sun, Mary K. Geck Do, Ningping Feng, Jason P. Gay, Florian Muller, Marina Konopleva, Funda Meric-Bernstam, Carlo Toniatti, Timothy P. Heffernan, Giulio F. Draetta, Philip Jones
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1655.
https://doi.org/10.1158/1538-7445.AM2018-1655
Published: 01 July 2018
View article titled, Abstract 1655: Discovery and development of IACS-010759, a novel inhibitor of Complex I currently in phase I studies to exploit oxidative phosphorylation dependency in acute myeloid leukemia and solid tumors
Journal Articles

Abstract 1875: Oxidative metabolism as a novel therapeutic target to eradicate T-ALL with mitochondrial complex I inhibitor IACS-010759

Natalia Baran, Alessia Lodi, Shannon Sweeney, Vinitha Mary Kuruvilla, Antonio Cavazos, Anna Skwarska, Sriram Shanmuga Velandy, Karine Harutyunyan, Ningping Feng, Jason Gay, Marcin Kaminski, Elias J. Jabbour, Adolfo Ferrando, M. Emilia Di Francesco, Joseph R. Marszalek, Stefano Tiziani, Marina Konopleva
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1875.
https://doi.org/10.1158/1538-7445.AM2018-1875
Published: 01 July 2018
View article titled, Abstract 1875: Oxidative metabolism as a novel therapeutic target to eradicate T-ALL with mitochondrial complex I inhibitor IACS-010759
Journal Articles

Abstract 2856: Targeting OXPHOS with IACS-010759 to eliminate standard of care resistant tumor cells

Joseph R. Marszalek, Sahil Seth, Denise Corti, Qi Zhang, Gloria V. Echeverria, Lina Han, Yuting Sun, Jennifer Molina, Sonal Gera, Edward Chang, Tin O. Khor, Mikhila Mahendra, Ningping Feng, Jason P. Gay, Timothy McAfoos, Virginia Giuliani, Xi Shi, Sabrina Jeter-Jones, Sarah Loponte, Chieh-Yuan Li, Christopher A. Bristow, Maria Emilia Di Francesco, Helen Piwnica-Worms, Marina Konopleva, Alessandro Carugo, Andrea Viale, Philip Jones, Timothy P. Heffernan, Giulio F. Draetta
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2856.
https://doi.org/10.1158/1538-7445.AM2018-2856
Published: 01 July 2018
View article titled, Abstract 2856: Targeting OXPHOS with IACS-010759 to eliminate standard of care resistant tumor cells
Journal Articles

Abstract 2560: Preclinical efficacy of allogeneic anti-CD123 CAR T-cells for the therapy of blastic plasmacytoid dendritic cell neoplasm (BPDCN)

Tianyu Cai, Kathryn L. Black, Ammar Naqvi, Roman Galetto, Agnès Gouble, Julianne Smith, Antonio Cavazos, Lina Han, Qi Zhang, Vinitha Kuruvilla, Sergej Naumovich Sergej Konoplev, Sattva S. Neelapu, Andrew A. Lane, Monica L. Guzman, Hagop Kantarjian, Andrei Thomas-Tikhonenko, Naveen Pemmaraju, Marina Konopleva
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2560.
https://doi.org/10.1158/1538-7445.AM2018-2560
Published: 01 July 2018
View article titled, Abstract 2560: Preclinical efficacy of allogeneic anti-CD123 CAR T-cells for the therapy of blastic plasmacytoid dendritic cell neoplasm (BPDCN)
Journal Articles

Abstract LB-261: Targeting BET Family Bromodomain with ABBV-075 and BCL-2 with venetoclax (ABT-199) is synergistic in primary acute myeloid leukemia models

Tianyu Cai, Vinitha Mary Kuruvilla, Tamar Uziel, Qi Zhang, Lina Han, Antonio Cavazos, Yu Shen, Marina Konopleva
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-261.
https://doi.org/10.1158/1538-7445.AM2018-LB-261
Published: 01 July 2018
View article titled, Abstract LB-261: Targeting BET Family Bromodomain with ABBV-075 and BCL-2 with venetoclax (ABT-199) is synergistic in primary acute myeloid leukemia models
Journal Articles

Abstract 4323: Metabolic reprogramming in acute myeloid leukemia cells by mesenchymal stromal cell-derived exosomes induces chemoresistance

Hongyun Zhao, Abhinav Achreja, Ziwen Zhu, Ahmed N. Rawi, Marina Konopleva, Michael Andreeff, Deepak Nagrath
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4323.
https://doi.org/10.1158/1538-7445.AM2017-4323
Published: 01 July 2017
View article titled, Abstract 4323: Metabolic reprogramming in acute myeloid leukemia cells by mesenchymal stromal cell-derived exosomes induces chemoresistance
Journal Articles

Abstract 876: Imaging the interaction of leukemia and bone marrow microenvironment in murine model of ALL

Karine G. Harutyunyan, Saradhi Mallampati, Anna Zal, Mateusz Rytelewski, Michael C. Gutkin, Jason M. Butler, Tomasz Zal, Marina Konopleva
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 876.
https://doi.org/10.1158/1538-7445.AM2017-876
Published: 01 July 2017
View article titled, Abstract 876: Imaging the interaction of leukemia and bone marrow microenvironment in murine model of ALL