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Journal Articles

EGFR Mediates Responses to Small-Molecule Drugs Targeting Oncogenic Fusion Kinases

Free
Aria Vaishnavi, Laura Schubert, Uwe Rix, Lindsay A. Marek, Anh T. Le, Stephen B. Keysar, Magdalena J. Glogowska, Matthew A. Smith, Severine Kako, Natalia J. Sumi, Kurtis D. Davies, Kathryn E. Ware, Marileila Varella-Garcia, Eric B. Haura, Antonio Jimeno, Lynn E. Heasley, Dara L. Aisner, Robert C. Doebele
Journal: Cancer Research
Cancer Res (2017) 77 (13): 3551–3563.
https://doi.org/10.1158/0008-5472.CAN-17-0109
Published: 02 July 2017
View articletitled, EGFR Mediates Responses to Small-Molecule Drugs Targeting Oncogenic Fusion Kinases
Open the PDF for EGFR Mediates Responses to Small-Molecule Drugs Targeting Oncogenic Fusion Kinases in another window
Includes: Supplementary data
Journal Articles

Abstract 5064: CORO1B amplification and expression status identifies an aggressive subset of chromosome 11q13 amplified HNSCC

Free
Jessica L. Allen, Elyse L. Walk, Kristen L. Rhodes, Colleen J. Beatty, Steven M. Markwell, Brenen W. Papenberg, Erik T. Interval, Hong Wu, Marileila Varella Garcia, James E. Bear, Scott A. Weed
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 5064.
https://doi.org/10.1158/1538-7445.AM2016-5064
Published: 15 July 2016
View articletitled, Abstract 5064: CORO1B amplification and expression status identifies an aggressive subset of chromosome 11q13 amplified HNSCC
Journal Articles

Abstract 5605: Spectral karyotyping characterization of ovarian adenocarcinomas and corresponding cell lines and xenografts

Free
Marileila Varella-Garcia, Isabel M. Bernal, Sakshi Mahale, Evelyn M. Musselwhite, Victor Stastny, Mahboubeh Papari-Zareei, Jayanthi Lea, Tito Woodburn, Patrick Reynolds, Adi F. Gazdar
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5605.
https://doi.org/10.1158/1538-7445.AM2014-5605
Published: 01 October 2014
View articletitled, Abstract 5605: Spectral karyotyping characterization of ovarian adenocarcinomas and corresponding cell lines and xenografts
Journal Articles

Abstract 5255: EGFR is a conspiring kinase in gene fusion positive lung cancer

Free
Aria Vaishnavi, Anh T. Le, Stephen B. Keysar, Christine M. Lovly, Severine Kako, Marileila Varella-Garcia, Antonio Jimeno, Robert C. Doebele
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5255.
https://doi.org/10.1158/1538-7445.AM2014-5255
Published: 01 October 2014
View articletitled, Abstract 5255: EGFR is a conspiring kinase in gene fusion positive lung cancer
Journal Articles

Abstract 894: Targeting ROS1 receptor tyrosine kinase gene fusions in non-small cell lung cancer

Free
Kurtis D. Davies, Anh T. Le, Margaret C. Skokan, Mariana F. Theodoro, Marileila Varella-Garcia, D. Ross Camidge, Robert C. Doebele
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 894.
https://doi.org/10.1158/1538-7445.AM2012-894
Published: 15 April 2012
View articletitled, Abstract 894: Targeting ROS1 receptor tyrosine kinase gene fusions in non-small cell lung cancer
Journal Articles

Increased VEGFR-2 Gene Copy Is Associated with Chemoresistance and Shorter Survival in Patients with Non–Small-Cell Lung Carcinoma Who Receive Adjuvant Chemotherapy

Free
Fei Yang, Ximing Tang, Erick Riquelme, Carmen Behrens, Monique B. Nilsson, Uma Giri, Marileila Varella-Garcia, Lauren A. Byers, Heather Y. Lin, Jing Wang, Maria G. Raso, Luc Girard, Kevin Coombes, J. Jack Lee, Roy S. Herbst, John D. Minna, John V. Heymach, Ignacio I. Wistuba
Journal: Cancer Research
Cancer Res (2011) 71 (16): 5512–5521.
https://doi.org/10.1158/0008-5472.CAN-10-2614
Published: 11 August 2011
View articletitled, Increased VEGFR-2 Gene Copy Is Associated with Chemoresistance and Shorter Survival in Patients with Non–Small-Cell Lung Carcinoma Who Receive Adjuvant Chemotherapy
Open the PDF for Increased VEGFR-2 Gene Copy Is Associated with Chemoresistance and Shorter Survival in Patients with Non–Small-Cell Lung Carcinoma Who Receive Adjuvant Chemotherapy in another window
Includes: Supplementary data
Journal Articles

Abstract 5190: Biomarkers of sensitivity to PF-03084014, a γ-secretase Inhibitor, in a preclinical model of colorectal cancer

Free
Rebecca W. Powell, Aik Choon Tan, Marileila Varella-Garcia, Basel Touban, Arvind Dasari, Lauren Puls, Todd Pitts, Gillian Kulikowski, Kevin Quackenbush, Wells Messersmith, John J. Arcaroli
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5190.
https://doi.org/10.1158/1538-7445.AM2011-5190
Published: 15 April 2011
View articletitled, Abstract 5190: Biomarkers of sensitivity to PF-03084014, a γ-secretase Inhibitor, in a preclinical model of colorectal cancer
Journal Articles

Abstract 1492: Histological and molecular characteristics of 29 cases of carcinoma in situ from a prospective bronchoscopic cohort

Free
Steinn Jonsson, York E. Miller, Tim C. Kennedy, Marileila Varella-Garcia, Margaret Skokan, Holly Wolf, William Feser, Tim Byers, Jerry Haney, Dan Merrick, Paul A. Bunn, Robert L. Keith, Fred R. Hirsch, Wilbur A. Franklin
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1492.
https://doi.org/10.1158/1538-7445.AM10-1492
Published: 15 April 2010
View articletitled, Abstract 1492: Histological and molecular characteristics of 29 cases of carcinoma in situ from a prospective bronchoscopic cohort
Journal Articles

Abstract 812: Lack of intra-tumoral heterogeneity in lung adenocarcinoma supports gene fusions involving ALK as early clonal events

Free
Marileila Varella-Garcia, Antonella Flacco, Yong Gon Cho, Aik-Choon Tan, Scott Kono, Wilbur Franklin, Federico Cappuzzo, Lucio Crino, Robert Doebele, D. Ross Camidge
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 812.
https://doi.org/10.1158/1538-7445.AM10-812
Published: 15 April 2010
View articletitled, Abstract 812: Lack of intra-tumoral heterogeneity in lung adenocarcinoma supports gene fusions involving ALK as early clonal events
Journal Articles

Abstract #1302: Integrated study of chromosome 7 numeric alterations and EGFR, MET and BRAF expression in non-small-cell lung cancer

Free
Ilse Valencia, William Lockwood, Wan Lam, Marileila Varella-Garcia, Adi Gazdar
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 1302.
Published: 01 May 2009
View articletitled, Abstract #1302: Integrated study of chromosome 7 numeric alterations and EGFR, MET and BRAF expression in non-small-cell lung cancer
Journal Articles

Abstract #4327: Gene fusions in prostate carcinoma cell lines: An investigation by fluorescence in situ hybridization (FISH)

Free
Margaret Skokan, Sujatha Gajapathy, L. Michael Glode, M. Scott Lucia, Marileila Varella-Garcia, Adrie van Bokhoven
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4327.
Published: 01 May 2009
View articletitled, Abstract #4327: Gene fusions in prostate carcinoma cell lines: An investigation by fluorescence in situ hybridization (FISH)
Journal Articles

Abstract #4933: Multi-genetic events collaboratively contribute to Pten null leukemia stem cell formation

Free
Wei Guo, Joseph Lasky, James Chen, Suzanne Schubbert, Chun-Ju Chang, Sherly Mosessian, Bahram Valamehr, Hubing Shi, Xiaoman Lewis, Yun Xiao, Jennifer Yeh, Luisa Iruela-Arispe, Marileila Varella-Garcia, Hong Wu
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4933.
Published: 01 May 2009
View articletitled, Abstract #4933: Multi-genetic events collaboratively contribute to Pten null leukemia stem cell formation
Journal Articles

EGFR increased copy number is frequent in non-small cell lung cancer with brain metastasis

Free
Menghong Sun, Erminia Massarelli, Natalie Ozburn, Ximing Tang, Ludmila Prudkin, Ritsuko Komaki, Waun Ki Hong, Cesar Moran, Kenneth Aldape, Marileila Varella-Garcia, Ignacio Wistuba
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2163.
Published: 01 May 2008
View articletitled, EGFR increased copy number is frequent in non-small cell lung cancer with brain metastasis
Journal Articles

Identification of biomarkers in squamous cell carcinoma tumor cell lines of the head and neck that predict for in vitro sensitivity to gefitinib

Free
D Hickinson, Gayle Marshall, Garry Beran, Andrew Cassidy, Marileila Varella-Garcia, Elizabeth Mills, Marie South, Kerry Acheson, Gael McWalter, Rose McCormack, Graham Alex, Paul Bunn, Tim French, Brian Holloway, Fred Hirsch, Georgina Speake
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2754.
Published: 01 May 2008
View articletitled, Identification of biomarkers in squamous cell carcinoma tumor cell lines of the head and neck that predict for in vitro sensitivity to gefitinib
Journal Articles

TITF-1 gene amplification and protein expression pattern identify adenocarcinoma of lung with worse prognosis

Free
Ximing Tang, Menghong Sun, Carmen Behrens, Ludmina Prudkin, Natalie Ozburn, Adi Gazdar, Cesar Moran, Marileila Varella-Garcia, Ignacio Wistuba
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4952.
Published: 01 May 2008
View articletitled, TITF-1 gene amplification and protein expression pattern identify adenocarcinoma of lung with worse prognosis
Journal Articles

Coordinated Epidermal Growth Factor Receptor Pathway Gene Overexpression Predicts Epidermal Growth Factor Receptor Inhibitor Sensitivity in Pancreatic Cancer

Free
Antonio Jimeno, Aik Choon Tan, Jordy Coffa, N.V. Rajeshkumar, Peter Kulesza, Belen Rubio-Viqueira, Jenna Wheelhouse, Begoña Diosdado, Wells A. Messersmith, Christine Iacobuzio-Donahue, Anirban Maitra, Marileila Varella-Garcia, Fred R. Hirsch, Gerrit A. Meijer, Manuel Hidalgo
Journal: Cancer Research
Cancer Res (2008) 68 (8): 2841–2849.
https://doi.org/10.1158/0008-5472.CAN-07-5200
Published: 15 April 2008
View articletitled, Coordinated Epidermal Growth Factor Receptor Pathway Gene Overexpression Predicts Epidermal Growth Factor Receptor Inhibitor Sensitivity in Pancreatic Cancer
Open the PDF for Coordinated Epidermal Growth Factor Receptor Pathway Gene Overexpression Predicts Epidermal Growth Factor Receptor Inhibitor Sensitivity in Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Six1 Overexpression in Mammary Cells Induces Genomic Instability and Is Sufficient for Malignant Transformation

Free
Ricardo D. Coletta, Kimberly L. Christensen, Douglas S. Micalizzi, Paul Jedlicka, Marileila Varella-Garcia, Heide L. Ford
Journal: Cancer Research
Cancer Res (2008) 68 (7): 2204–2213.
https://doi.org/10.1158/0008-5472.CAN-07-3141
Published: 01 April 2008
View articletitled, Six1 Overexpression in Mammary Cells Induces Genomic Instability and Is Sufficient for Malignant Transformation
Open the PDF for Six1 Overexpression in Mammary Cells Induces Genomic Instability and Is Sufficient for Malignant Transformation in another window
Includes: Supplementary data
Journal Articles

MicroRNAs predicted to regulate highly expressed genes in non-small cell lung cancer (NSCLC) and small-cell lung cancer (SCLC) are localized to 19q.

Free
Glen Weiss, Lynne Bemis, Michio Sugita, Marileila Varella-Garcia, Jerry Haney, Paul Bunn, Wilbur Franklin
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 4517.
Published: 01 May 2007
View articletitled, MicroRNAs predicted to regulate highly expressed genes in non-small cell lung cancer (NSCLC) and small-cell lung cancer (SCLC) are localized to 19q.
Journal Articles

Cortactin Overexpression Regulates Actin-Related Protein 2/3 Complex Activity, Motility, and Invasion in Carcinomas with Chromosome 11q13 Amplification

Free
Brian L. Rothschild, Ann H. Shim, Amanda Gatesman Ammer, Laura C. Kelley, Kimberly B. Irby, Julie A. Head, Lin Chen, Marileila Varella-Garcia, Peter G. Sacks, Barbara Frederick, David Raben, Scott A. Weed
Journal: Cancer Research
Cancer Res (2006) 66 (16): 8017–8025.
https://doi.org/10.1158/0008-5472.CAN-05-4490
Published: 15 August 2006
View articletitled, Cortactin Overexpression Regulates Actin-Related Protein 2/3 Complex Activity, Motility, and Invasion in Carcinomas with Chromosome 11q13 Amplification
Open the PDF for Cortactin Overexpression Regulates Actin-Related Protein 2/3 Complex Activity, Motility, and Invasion in Carcinomas with Chromosome 11q13 Amplification in another window
Journal Articles

Spontaneous Fusion with, and Transformation of Mouse Stroma by, Malignant Human Breast Cancer Epithelium

Free
Britta M. Jacobsen, J. Chuck Harrell, Paul Jedlicka, Virginia F. Borges, Marileila Varella-Garcia, Kathryn B. Horwitz
Journal: Cancer Research
Cancer Res (2006) 66 (16): 8274–8279.
https://doi.org/10.1158/0008-5472.CAN-06-1456
Published: 15 August 2006
View articletitled, Spontaneous Fusion with, and Transformation of Mouse Stroma by, Malignant Human Breast Cancer Epithelium
Open the PDF for Spontaneous Fusion with, and Transformation of Mouse Stroma by, Malignant Human Breast Cancer Epithelium in another window
Includes: Multimedia, Supplementary data