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Marie Evangelista
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Journal Articles

Abstract LB296: Anti-cancer effect of Cyclin A/B RxL inhibitors is mediated in part by disruption of the ATR/Chk1 DNA repair pathway

Free
Catherine E. Gleason, Ranya Odeh, Frances Hamkins-Indik, Iolanda Vendrell, Roman Fischer, Benedikt Kessler, Shilpa Singh, Matthew Oser, David J. Earp, Marie Evangelista, Pablo D. Garcia
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): LB296.
https://doi.org/10.1158/1538-7445.AM2025-LB296
Published: 25 April 2025
View articletitled, Abstract LB296: Anti-cancer effect of Cyclin A/B RxL inhibitors is mediated in part by disruption of the ATR/Chk1 DNA repair pathway
Journal Articles

Abstract 7133: Phenomics-enabled discovery and optimization of small-molecule RBM39 degraders as an alternative to CDK12 targeting in high-grade serous ovarian cancer (HGSOC)

Free
Chase Neumann, Harish Shankaran, Kiran Nadella, Kelly Biette, Shane Rowley, Ethan Gardner, Shadi Swaidani, Vamshi Manda, Lu Chen, Daria Beshnova, Ashraf Saeed, Christopher Bailey, Janet Paulsen, Paul Rearden, Carl Brooks, Ashish Bhandari, Chris Gibson, Laura Schaevitz, Imran Haque, Hayley Donnella, Michael Cuccarese, Marie Evangelista
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7133.
https://doi.org/10.1158/1538-7445.AM2024-7133
Published: 22 March 2024
View articletitled, Abstract 7133: Phenomics-enabled discovery and optimization of small-molecule RBM39 degraders as an alternative to CDK12 targeting in high-grade serous ovarian cancer (HGSOC)
Journal Articles

Abstract LB071: A phenomics platform combining imaging and artificial intelligence for rapid validation and advancement of novel oncology targets

Free
Jenny Rudnick, Kiran Nadella, Chase Neumann, Shane Rowley, Ethan Gardner, Shadi Swaidani, Aimee Iberg, Lu Chen, Daria Beshnova, Aurora Blucher, Rebecca Sarto Basso, Malini Rajan, Kevin Fales, Ashraf Saeed, Christopher Bailey, Weston Judd, Chrissy Egbert, Joel Ellis, John Ansede, Pouya Hadipour, Kevin Jessing, Janet Paulsen, Paul Rearden, Vamshi Manda, Sashi Kasimsetty, Sashi Kasimsetty, Michael Hancock, Harish Shankaran, Bryan Ellis, Meenakshy Iyer, Carl Brooks, Ashish Bhandari, Chris Gibson, Irit Rappley, Laura Schaevitz, Imran Haque, Hayley Donnella, Michael Cuccarese, Marie Evangelista
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB071.
https://doi.org/10.1158/1538-7445.AM2023-LB071
Published: 14 April 2023
View articletitled, Abstract LB071: A phenomics platform combining imaging and artificial intelligence for rapid validation and advancement of novel oncology targets
Journal Articles

Abstract 3327: Discovery and characterization of the potent, allosteric SHP2 inhibitor GDC-1971 for the treatment of RTK/RAS driven tumors

Free
Bret Williams, Alexander Taylor, Olivia Orozco, Christopher Owen, Elizabeth Kelley, Andre Lescarbeau, Kelley Shortsleeves, Randy Kipp, Vy Nguyen, Erin Brophy, Jeremy Wilbur, Yong Tang, David Lanzetta, Nigel Waters, Sherri Smith, Fabrizio Giordanetto, Paul Maragakis, Jack Greismann, Lindsay Willmore, Eric Therrien, Yang Xiao, Marie Evangelista, Luca Gerosa, Eva Lin, Mark Merchant, Alfonso Arrazate, Emily Chan, Pablo Sáenz-López Larrocha, Stefan Chun, Thomas Hunsaker, Gauri Deshmukh, Christine M. Bowman, David E. Shaw, Mark Murcko, Mahesh Padval, W Patrick Walters, James Watters, Donald A. Bergstrom
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3327.
https://doi.org/10.1158/1538-7445.AM2022-3327
Published: 15 June 2022
View articletitled, Abstract 3327: Discovery and characterization of the potent, allosteric SHP2 inhibitor GDC-1971 for the treatment of RTK/RAS driven tumors
Journal Articles

Abstract 3601: Discovery of novel dual-acting KRASG12C inhibitors that target both the active and inactive forms of the protein

Free
Philamer Calses, Sam Clark, Jacob Corpuz, Susan Fong, Phil Gerkin, Mohammad Hekmatnejad, Evan McMahon, Megan Murray, Truc Nguyen, Tony Phan, Allison Roberts, Phillip Schwartz, Mikayla Shanafelt, Hiroko Tanaka, Jennifer Tomczyk, John Widen, Monika Williams, John Eksterowicz, Daniel Erlanson, Marie Evangelista, Johannes Hermann, Richard M. Neve, Snahel Patel, Kevin R. Webster
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3601.
https://doi.org/10.1158/1538-7445.AM2022-3601
Published: 15 June 2022
View articletitled, Abstract 3601: Discovery of novel dual-acting KRASG12C inhibitors that target both the active and inactive forms of the protein
Journal Articles

Abstract 2917: High complexity molecular indexing reveals that time-dependent cell plasticity underpins response to EGFR targeted therapy

Free
Aaron Boudreau, Richard Bourgon, Marie Evangelista
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2917.
https://doi.org/10.1158/1538-7445.AM2017-2917
Published: 01 July 2017
View articletitled, Abstract 2917: High complexity molecular indexing reveals that time-dependent cell plasticity underpins response to EGFR targeted therapy
Journal Articles

Abstract 944: Development of predictive and pharmacodynamic biomarker strategies for GDC-0425, a checkpoint kinase 1 inhibitor, in combination with gemcitabine

Free
Sami Mahrus, Kelly DuPree, Kaska Kowanetz, Jenille Tan, Jarrod Tremayne, Diana Jakubiak, Peter Haverty, Yuda Zhu, Franklin Peale, Elizabeth Blackwood, Richard Bourgon, Robert Yauch, Mark Lackner, Marie Evangelista
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 944.
https://doi.org/10.1158/1538-7445.AM2015-944
Published: 01 August 2015
View articletitled, Abstract 944: Development of predictive and pharmacodynamic biomarker strategies for GDC-0425, a checkpoint kinase 1 inhibitor, in combination with gemcitabine
Journal Articles

Abstract CT139: Phase I study of GDC-0425, a checkpoint kinase 1 inhibitor, in combination with gemcitabine in patients with refractory solid tumors

Free
Jeffrey R. Infante, Antoine Hollebecque, Sophie Postel-Vinay, Todd Bauer, Beth Blackwood, Marie Evangelista, Sami Mahrus, Frank Peale, Xuyang Lu, Srikumar Sahasranaman, Rui Zhu, Yuan Chen, Xiao Ding, Elaine Murray, Jennifer Schutzman, Jennifer Lauchle, Jean-Charles Soria, Patricia LoRusso
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): CT139.
https://doi.org/10.1158/1538-7445.AM2015-CT139
Published: 01 August 2015
View articletitled, Abstract CT139: Phase I study of GDC-0425, a checkpoint kinase 1 inhibitor, in combination with gemcitabine in patients with refractory solid tumors
Journal Articles

Abstract 1423: Resistance to LDHA inhibitors requires signaling through the AMPK/mTOR/S6K pathway leading to increased oxidative phosphorylation

Free
Aaron Boudreau, David Peterson, John Moffat, Bonnie Liu, Mandy Kwong, Min Gao, Hans Purkey, Thomas O'Brien, Georgia Hatzivassiliou, Anneleen Daemen, Marie Evangelista
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1423.
https://doi.org/10.1158/1538-7445.AM2014-1423
Published: 01 October 2014
View articletitled, Abstract 1423: Resistance to LDHA inhibitors requires signaling through the AMPK/mTOR/S6K pathway leading to increased oxidative phosphorylation
Journal Articles

Abstract 964: Inhibiting glycolysis with an LDHA inhibitor: A new solution to an old problem

Free
Thomas O'Brien, Hans Purkey, Anna Hitz, Dave Peterson, Aaron Boudreau, Christopher Delnagro, Mandy Kwong, Rebecca Hong, Min Gao, Jodi Pang, Alex Vanderbilt, Simon Williams, Laurent Salphati, Deepak Sampath, Georgia Hatzivassiliou, Marie Evangelista
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 964.
https://doi.org/10.1158/1538-7445.AM2014-964
Published: 01 October 2014
View articletitled, Abstract 964: Inhibiting glycolysis with an LDHA inhibitor: A new solution to an old problem
Journal Articles

The Cancer Stem Cell Marker Aldehyde Dehydrogenase Is Required to Maintain a Drug-Tolerant Tumor Cell Subpopulation

Free
Debasish Raha, Timothy R. Wilson, Jing Peng, David Peterson, Peng Yue, Marie Evangelista, Catherine Wilson, Mark Merchant, Jeff Settleman
Journal: Cancer Research
Cancer Res (2014) 74 (13): 3579–3590.
https://doi.org/10.1158/0008-5472.CAN-13-3456
Published: 30 June 2014
View articletitled, The Cancer Stem Cell Marker Aldehyde Dehydrogenase Is Required to Maintain a Drug-Tolerant Tumor Cell Subpopulation
Open the PDF for The Cancer Stem Cell Marker Aldehyde Dehydrogenase Is Required to Maintain a Drug-Tolerant Tumor Cell Subpopulation in another window
Includes: Supplementary data
Journal Articles

Abstract 4618: Elucidating the role of distinct glutaminase isoforms in cancer.

Free
Bonnie Liu, Kyung Song, Mandy Kwong, Min Gao, Rebecca Hong, Michelle Nannini, Deepak Sampath, Marcia Belvin, David Peterson, Marie Evangelista, Anneleen Daemen, Ron Firestein, Georgia Hatzivassiliou
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4618.
https://doi.org/10.1158/1538-7445.AM2013-4618
Published: 15 April 2013
View articletitled, Abstract 4618: Elucidating the role of distinct glutaminase isoforms in cancer.
Journal Articles

Abstract 943: RRM2: a key contributor in tamoxifen resistance in breast cancer.

Free
Khyati Niral Shah, David Peterson, Marie Evangelista, Jesika Faridi
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 943.
https://doi.org/10.1158/1538-7445.AM2013-943
Published: 15 April 2013
View articletitled, Abstract 943: RRM2: a key contributor in tamoxifen resistance in breast cancer.
Journal Articles

An Integrated Genomic Screen Identifies LDHB as an Essential Gene for Triple-Negative Breast Cancer

Free
Mark L. McCleland, Adam S. Adler, Yonglei Shang, Thomas Hunsaker, Tom Truong, David Peterson, Eric Torres, Li Li, Benjamin Haley, Jean-Philippe Stephan, Marcia Belvin, Georgia Hatzivassiliou, Elizabeth M. Blackwood, Laura Corson, Marie Evangelista, Jiping Zha, Ron Firestein
Journal: Cancer Research
Cancer Res (2012) 72 (22): 5812–5823.
https://doi.org/10.1158/0008-5472.CAN-12-1098
Published: 14 November 2012
View articletitled, An Integrated Genomic Screen Identifies LDHB as an Essential Gene for Triple-Negative Breast Cancer
Open the PDF for An Integrated Genomic Screen Identifies LDHB as an Essential Gene for Triple-Negative Breast Cancer in another window
Includes: Supplementary data