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Journal Articles

Abstract 402: Dual RAF/MEK inhibitor VS-6766 enhances antitumor efficacy of KRAS G12C inhibitors through vertical inhibition of RAS, RAF and MEK

Silvia Coma, Sanjib Chowdhury, Julien Dilly, Monica Musteanu, Mariano Barbacid, Andrew J. Aguirre, Jonathan A. Pachter

Cancer Res (2022) 82 (12_Supplement): 402.

DOI: https://doi.org/10.1158/1538-7445.AM2022-402

Published: 15 June 2022

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Journal Articles

Dynamic Regulation of Expression of KRAS and Its Effectors Determines the Ability to Initiate Tumorigenesis in Pancreatic Acinar Cells

Mohamad Assi, Younes Achouri, Axelle Loriot, Nicolas Dauguet, Hajar Dahou, Jonathan Baldan, Maxime Libert, Jean S. Fain, Carmen Guerra, Luc Bouwens, Mariano Barbacid, Frédéric P. Lemaigre, Patrick Jacquemin

Cancer Res (2021) 81 (10): 2679–2689.

DOI: https://doi.org/10.1158/0008-5472.CAN-20-2976

Published: 15 May 2021

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Includes: Supplementary data

Journal Articles

Abstract IA11: The use of GEM tumor models to identify effective therapies against KRAS mutant tumors

Mariano Barbacid

Cancer Res (2020) 80 (11_Supplement): IA11.

DOI: https://doi.org/10.1158/1538-7445.CAMODELS2020-IA11

Published: 02 June 2020

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Journal Articles

Abstract 395: Activation mechanisms of cancer associated MEK1 mutants

Yijun Gao, Matthew T. Chang, Daniel McKay, Rona D. Yaeger, Merna Torres, Keven Muniz, Drosten Matthias, Omar I. Abdel-Wahab, Mariano Barbacid, Giordano Caponigro, Darrin Stuart, David Solit, Barry S. Taylor, Zhan Yao, Neal Rosen

Cancer Res (2017) 77 (13_Supplement): 395.

DOI: https://doi.org/10.1158/1538-7445.AM2017-395

Published: 01 July 2017

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Journal Articles

Abstract 4078: Tumors with class 3 BRAF mutants are sensitive to the inhibition of activated RAS

Zhan Yao, Rona Yaeger, Vanessa S. Rodrik-Outmezguine, Anthony Tao, Neilawattie M. Torres, Matthew T. Chang, Matthias Drosten, Huiyong Zhao, Fabiola Cecchi, Todd Hembrough, Judith Michels, Hervé Baumert, Linde Miles, Naomi M. Campbell, Elisa de Stanchina, David B. Solit, Mariano Barbacid, Barry S. Taylor, Neal Rosen

Cancer Res (2017) 77 (13_Supplement): 4078.

DOI: https://doi.org/10.1158/1538-7445.AM2017-4078

Published: 01 July 2017

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Journal Articles

H-Ras and K-Ras Oncoproteins Induce Different Tumor Spectra When Driven by the Same Regulatory Sequences

Matthias Drosten, Lucía Simón-Carrasco, Isabel Hernández-Porras, Carmen G. Lechuga, María T. Blasco, Harrys K.C. Jacob, Salvatore Fabbiano, Nicoletta Potenza, Xosé R. Bustelo, Carmen Guerra, Mariano Barbacid

Cancer Res (2017) 77 (3): 707–718.

DOI: https://doi.org/10.1158/0008-5472.CAN-16-2925

Published: 31 January 2017

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Includes: Supplementary data

Journal Articles

Abstract A44: Targeting cancer-associated fibroblasts in pancreatic ductal adenocarcinoma: Identification and characterization of therapeutic candidates

Magdolna Djurec, Osvaldo Grana, David Pisano, Albert Lee, Raul Rabadan, Carmen Guerra, Mariano Barbacid

Cancer Res (2015) 75 (13_Supplement): A44.

DOI: https://doi.org/10.1158/1538-7445.PANCA2014-A44

Published: 30 June 2015

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Journal Articles

Abstract IA25: Targeting K-Ras signaling in pancreatic cancer

Mariano Barbacid

Cancer Res (2015) 75 (13_Supplement): IA25.

DOI: https://doi.org/10.1158/1538-7445.PANCA2014-IA25

Published: 30 June 2015

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Journal Articles

Modeling Lung Cancer Evolution and Preclinical Response by Orthotopic Mouse Allografts

Chiara Ambrogio, Francisco J. Carmona, August Vidal, Mattia Falcone, Patricia Nieto, Octavio A. Romero, Sara Puertas, Miguel Vizoso, Ernest Nadal, Teresa Poggio, Montserrat Sánchez-Céspedes, Manel Esteller, Francisca Mulero, Claudia Voena, Roberto Chiarle, Mariano Barbacid, David Santamaría, Alberto Villanueva

Cancer Res (2014) 74 (21): 5978–5988.

DOI: https://doi.org/10.1158/0008-5472.CAN-14-1606

Published: 30 October 2014

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Includes: Supplementary data

Journal Articles

Cdk2 deficiency decrease Ras/Cdk4-dependent malignant progression, but not c-Myc-induced tumorigenesis

Everardo Macias, Yongbaek Kim, Andres Klein-Szanto, Mariano Barbacid, Marcelo Rodriguez-Puebla

Cancer Res (2007) 67 (9_Supplement): 5694.

Published: 01 May 2007

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Journal Articles

Target validation of cyclin-dependent kinases in cancer.

Mariano Barbacid

Cancer Res (2006) 66 (8_Supplement): 1362.

Published: 15 April 2006

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Journal Articles

Cdk2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication

Anette Duensing, Ying Liu, Marcos Malumbres, Mariano Barbacid, Stefan Duensing

Cancer Res (2006) 66 (8_Supplement): 753–754.

Published: 15 April 2006

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Journal Articles

Spontaneous and UV Radiation–Induced Multiple Metastatic Melanomas in Cdk4^R24C/R24C/TPras Mice

Elke Hacker, H. Konrad Muller, Nicole Irwin, Brian Gabrielli, Douglas Lincoln, Sandra Pavey, Marianne Broome Powell, Marcos Malumbres, Mariano Barbacid, Nicholas Hayward, Graeme Walker

Cancer Res (2006) 66 (6): 2946–2952.

DOI: https://doi.org/10.1158/0008-5472.CAN-05-3196

Published: 15 March 2006

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Includes: Supplementary data

Journal Articles

Cooperation between Cdk4 and p27^kip1 in Tumor Development: A Preclinical Model to Evaluate Cell Cycle Inhibitors with Therapeutic Activity

Rocío Sotillo, Oliver Renner, Pierre Dubus, Jesús Ruiz-Cabello, Juan Martín-Caballero, Mariano Barbacid, Amancio Carnero, Marcos Malumbres

Cancer Res (2005) 65 (9): 3846–3852.

DOI: https://doi.org/10.1158/0008-5472.CAN-04-4195

Published: 02 May 2005

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Includes: Supplementary data

NARROW

Abstract 402: Dual RAF/MEK inhibitor VS-6766 enhances antitumor efficacy of KRAS G12C inhibitors through vertical inhibition of RAS, RAF and MEK

Dynamic Regulation of Expression of KRAS and Its Effectors Determines the Ability to Initiate Tumorigenesis in Pancreatic Acinar Cells

Abstract IA11: The use of GEM tumor models to identify effective therapies against KRAS mutant tumors

Abstract 395: Activation mechanisms of cancer associated MEK1 mutants

Abstract 4078: Tumors with class 3 BRAF mutants are sensitive to the inhibition of activated RAS

H-Ras and K-Ras Oncoproteins Induce Different Tumor Spectra When Driven by the Same Regulatory Sequences

Abstract A44: Targeting cancer-associated fibroblasts in pancreatic ductal adenocarcinoma: Identification and characterization of therapeutic candidates

Abstract IA25: Targeting K-Ras signaling in pancreatic cancer

Modeling Lung Cancer Evolution and Preclinical Response by Orthotopic Mouse Allografts

Cdk2 deficiency decrease Ras/Cdk4-dependent malignant progression, but not c-Myc-induced tumorigenesis

Target validation of cyclin-dependent kinases in cancer.

Cdk2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication

Spontaneous and UV Radiation–Induced Multiple Metastatic Melanomas in Cdk4^R24C/R24C/TPras Mice

Cooperation between Cdk4 and p27^kip1 in Tumor Development: A Preclinical Model to Evaluate Cell Cycle Inhibitors with Therapeutic Activity

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