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Maria Teresa Landi
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Journal Articles

Abstract C055: Unraveling pancreatic cancer susceptibility at 5p15.33: Functional characterization of a novel VNTR element

Aidan O'Brien, Hyunkyung Kong, Minal Patel, Katelyn E Connelly, Mai Xu, Irene Collins, Jun Zhong, Jason Hoskins, Michelle Ho, Brenen Papenburg, Mark M Iles, Matthew H Law, Maria-Teresa Landi, Rachael Stolzenber- Solomon, Brian M Wolpin, Alison P Klein, Nick Orr, Stephen J Chanock, Sara Lindström, Marc-Henri Stern, Ludmila Prokunina-Olsson, Jieyon Choi, Kevin M Brown, Laufey T Amundadottir
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): C055.
https://doi.org/10.1158/1538-7445.PANCREATIC24-C055
Published: 15 September 2024
View article titled, Abstract C055: Unraveling pancreatic cancer susceptibility at 5p15.33: Functional characterization of a novel VNTR element
Journal Articles

Abstract LB231: The mutagenic forces shaping the genomic landscape of lung cancer in never smokers

Marcos Diaz-Gay, Tongwu Zhang, Azhar Khandekar, Burçak Otlu, Shuvro Nandi, Christopher D. Steele, Nathaniel Rothman, Stephen J. Chanock, Qing Lan, Ludmil B. Alexandrov, Maria Teresa Landi
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB231.
https://doi.org/10.1158/1538-7445.AM2024-LB231
Published: 05 April 2024
View article titled, Abstract LB231: The mutagenic forces shaping the genomic landscape of lung cancer in never smokers
Journal Articles

Abstract LB228: Evolutionary trajectories of lung cancer in never smokers

Christopher Wirth, Tongwu Zhang, Wei Zhao, Phuc Hoang, Jian Sang, Nathaniel Rothman, Marcos Díaz-Gay, Ruxandra Teslo, Naser Ansari-Pour, Máire Ní Leathlobhair, Iliana Peneva, William Eagles, Lixing Yang, Ludmil Alexandrov, David C. Wedge, Maria Teresa Landi
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB228.
https://doi.org/10.1158/1538-7445.AM2024-LB228
Published: 05 April 2024
View article titled, Abstract LB228: Evolutionary trajectories of lung cancer in never smokers
Journal Articles

Abstract LB243: Deep learning-based molecular characterization of lung cancers from never smokers using hematoxylin and eosin-stained whole slide images

Monjoy Saha, Tongwu Zhang, Praphulla Bhawsar, Wei Zhao, Jianxin Shi, Soo Ryum Yang, Jonas Almeida, Maria Teresa Landi
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB243.
https://doi.org/10.1158/1538-7445.AM2024-LB243
Published: 05 April 2024
View article titled, Abstract LB243: Deep learning-based molecular characterization of lung cancers from never smokers using hematoxylin and eosin-stained whole slide images
Journal Articles

Abstract LB226: Deciphering lung adenocarcinoma evolution and the role of LINE-1 retrotransposition

Tongwu Zhang, Wei Zhao, Christopher Wirth, Marcos Díaz-Gay, Jinhu Yin, Phuc H. Hoang, Jian Sang, John McElderry, Alyssa Klein, Azhar Khandekar, Caleb Hartman, Jennifer Rosenbaum, Frank Colon-Matos, Kristine M. Jones, Neil E. Caporaso, Robert Homer, Angela C. Pesatori, Dario Consonni, Lixing Yang, Bin Zhu, Jianxin Shi, Kevin Brown, Nathaniel Rothman, Stephen J. Chanock, Ludmil B. Alexandrov, Jiyeon Choi, Maurizio Cardelli, Qing Lan, Martin A. Nowak, David C. Wedge, Maria Teresa Landi
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB226.
https://doi.org/10.1158/1538-7445.AM2024-LB226
Published: 05 April 2024
View article titled, Abstract LB226: Deciphering lung adenocarcinoma evolution and the role of LINE-1 retrotransposition
Journal Articles

Abstract 5672: Transcriptomic profiling of lung adenocarcinoma from never-smokers reveals molecular subtypes with clinical implications

Wei Zhao, Tongwu Zhang, Phuc H. Hoang, Jian Sang, Maria Teresa Landi
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5672.
https://doi.org/10.1158/1538-7445.AM2024-5672
Published: 22 March 2024
View article titled, Abstract 5672: Transcriptomic profiling of lung adenocarcinoma from never-smokers reveals molecular subtypes with clinical implications
Journal Articles

Abstract 6250: The RNA editing landscape of lung cancer in never smokers

Jian Sang, Wei Zhao, Tongwu Zhang, Maria Teresa Landi
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6250.
https://doi.org/10.1158/1538-7445.AM2024-6250
Published: 22 March 2024
View article titled, Abstract 6250: The RNA editing landscape of lung cancer in never smokers
Journal Articles

CYP2A6 Activity and Cigarette Consumption Interact in Smoking-Related Lung Cancer Susceptibility

Mulong Du, Junyi Xin, Rui Zheng, Qianyu Yuan, Zhihui Wang, Hongliang Liu, Hanting Liu, Guoshuai Cai, Demetrius Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Stig E. Bojesen, Maria Teresa Landi, Mattias Johansson, Angela Risch, Heike Bickeböller, H-Erich Wichmann, Gad Rennert, Susanne Arnold, Paul Brennan, John K. Field, Sanjay S. Shete, Loïc Le Marchand, Geoffrey Liu, Angeline S. Andrew, Lambertus A. Kiemeney, Shan Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil E. Caporaso, Angela Cox, Yun-Chul Hong, Jian-Min Yuan, Matthew B. Schabath, Melinda C. Aldrich, Meilin Wang, Hongbing Shen, Feng Chen, Zhengdong Zhang, Rayjean J. Hung, Christopher I. Amos, Qingyi Wei, Philip Lazarus, David C. Christiani
Journal: Cancer Research
Cancer Res (2024) 84 (4): 616–625.
https://doi.org/10.1158/0008-5472.CAN-23-0900
Published: 15 February 2024
View article titled, CYP2A6 Activity and Cigarette Consumption Interact in Smoking-Related Lung Cancer Susceptibility
Open the PDF for CYP2A6 Activity and Cigarette Consumption Interact in Smoking-Related Lung Cancer Susceptibility in another window
Includes: Supplementary data
Journal Articles

Abstract 1166: APOBEC deaminases compete with tobacco smoking mutagenesis and affect age at onset of lung cancer

Tongwu Zhang, Jian Sang, Phuc H. Hoang, Wei Zhao, Jennifer Rosenbaum, Leszek J. Klimczak, John McElderry, Alyssa Klein, Christopher Wirth, Erik N. Bergstrom, Marcos Díaz-Gay, Raviteja Vangara, Amy Hutchinson, Scott M. Lawrence, Nathan Cole, Bin Zhu, Teresa M. Przytycka, Jianxin Shi, Neil E. Caporaso, Robert Homer, Angela C. Pesatori, Dario Consonni, Stephen J. Chanock, David C. Wedge, Dmitry A. Gordenin, Ludmil B. Alexandrov, Reuben S. Harris, Maria Teresa Landi
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1166.
https://doi.org/10.1158/1538-7445.AM2023-1166
Published: 04 April 2023
View article titled, Abstract 1166: APOBEC deaminases compete with tobacco smoking mutagenesis and affect age at onset of lung cancer
Journal Articles

Abstract 2088: gCNV-Seeker: A comprehensive germline CNV calling pipeline based on whole genome sequencing data

Jian Sang, Tongwu Zhang, David Wedge, Maria Teresa Landi
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2088.
https://doi.org/10.1158/1538-7445.AM2023-2088
Published: 04 April 2023
View article titled, Abstract 2088: <em>gCNV-Seeker</em>: A comprehensive germline CNV calling pipeline based on whole genome sequencing data
Journal Articles

Abstract 2087: Sherlock-Genome: a R shiny app for genomic analysis and visualization

Alyssa Klein, Maria Teresa Landi, Tongwu Zhang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2087.
https://doi.org/10.1158/1538-7445.AM2023-2087
Published: 04 April 2023
View article titled, Abstract 2087: <em>Sherlock-Genome</em>: a R shiny app for genomic analysis and visualization
Journal Articles

Abstract 5722: The mutational signatures of 100,477 targeted sequenced tumors

Donghyuk Lee, Min Hua, Difei Wang, Lei Song, Tongwu Zhang, Kai Yu, Xiaohong R. Yang, Jianxin Shi, Stephen J. Chanock, Maria Teresa Landi, Bin Zhu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5722.
https://doi.org/10.1158/1538-7445.AM2023-5722
Published: 04 April 2023
View article titled, Abstract 5722: The mutational signatures of 100,477 targeted sequenced tumors
Journal Articles

Abstract 5909: Characterization of the lung cancer microbiome using whole genome sequencing

John McElderry, Tongwu Zhang, Jianxin Shi, Maria Teresa Landi
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5909.
https://doi.org/10.1158/1538-7445.AM2023-5909
Published: 04 April 2023
View article titled, Abstract 5909: Characterization of the lung cancer microbiome using whole genome sequencing
Journal Articles

Abstract 865: Genomic and evolutionary classification of lung cancer in never smokers from the Sherlock-Lung study

Tongwu Zhang, Ludmil B. Alexandrov, Wei Zhao, Jian Sang, Jianxin Shi, Bin Zhu, Dmitry A. Gordenin, Montserrat Garcia-Closas, Qing Lan, Nathaniel Rothman, Stephen J. Chanock, David C. Wedge, Maria Teresa Landi
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 865.
https://doi.org/10.1158/1538-7445.AM2021-865
Published: 01 July 2021
View article titled, Abstract 865: Genomic and evolutionary classification of lung cancer in never smokers from the Sherlock-<em>Lung</em> study
Journal Articles

Abstract 211: Integrative mutational signature portal (mSigPortal) for cancer genomic study

Tongwu Zhang, Jian Sang, Phyllip Cho, Kevin Jiang, Maria Teresa Landi
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 211.
https://doi.org/10.1158/1538-7445.AM2021-211
Published: 01 July 2021
View article titled, Abstract 211: Integrative mutational signature portal (mSigPortal) for cancer genomic study
Journal Articles

Assessing Lung Cancer Absolute Risk Trajectory Based on a Polygenic Risk Model

Rayjean J. Hung, Matthew T. Warkentin, Yonathan Brhane, Nilanjan Chatterjee, David C. Christiani, Maria Teresa Landi, Neil E. Caporaso, Geoffrey Liu, Mattias Johansson, Demetrius Albanes, Loic Le Marchand, Adonina Tardon, Gad Rennert, Stig E. Bojesen, Chu Chen, John K. Field, Lambertus A. Kiemeney, Philip Lazarus, Shanbeth Zienolddiny, Stephen Lam, Angeline S. Andrew, Susanne M. Arnold, Melinda C. Aldrich, Heike Bickeböller, Angela Risch, Matthew B. Schabath, James D. McKay, Paul Brennan, Christopher I. Amos
Journal: Cancer Research
Cancer Res (2021) 81 (6): 1607–1615.
https://doi.org/10.1158/0008-5472.CAN-20-1237
Published: 15 March 2021
View article titled, Assessing Lung Cancer Absolute Risk Trajectory Based on a Polygenic Risk Model
Open the PDF for Assessing Lung Cancer Absolute Risk Trajectory Based on a Polygenic Risk Model in another window
Includes: Supplementary data
Journal Articles

Abstract 1601: Genetic and epigenetic intratumor heterogeneity of lung adenocarcinoma

Wei Zhao, Xing Hua, Tongwu Zhang, Dario Consonni, Angela Cecilia Pesatori, Jianxin Shi, Maria Teresa Landi
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1601.
https://doi.org/10.1158/1538-7445.AM2019-1601
Published: 01 July 2019
View article titled, Abstract 1601: Genetic and epigenetic intratumor heterogeneity of lung adenocarcinoma
Journal Articles

Abstract SY26-02: Sherlock-Lung: Tracing lung cancer mutational processes in never smokers

Maria Teresa Landi, Tongwu Zhang, Montserrat Garcia-Closas, Yohan Bossé, Jianxin Shi, Bin Zhu, Qing Lan, Nathaniel Rothman, Jiyeon Choi, Neil E. Caporaso, Wei Zhao, Chongyi Chen, Eytan Ruppin, Jennifer Rosenbaum, Dmitry Gordenin, Sai Yendamuri, Chris Amos, Paul Brennan, David C. Christiani, Geoff Liu, Bonnie Gould Rothberg, Matthew Schabath, Han Liang, Ludmil Alexandrov, David Wedge, Stephen Chanock
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): SY26-02.
https://doi.org/10.1158/1538-7445.AM2019-SY26-02
Published: 01 July 2019
View article titled, Abstract SY26-02: <em>Sherlock-Lung</em>: Tracing lung cancer mutational processes in never smokers
Journal Articles

Abstract 1187: Comparison of intra-tumor heterogeneity and clonal evolution across lung cancer subtypes by multi-region whole genome sequencing

Tongwu Zhang, Joshua Sampson, Pier Alberto Bertazzi, Angela Pesatori, Dario Consonni, Bin Zhu, Belynda Hicks, Xing Hua, Jianxin Shi, Kevin Brown, Stephen Chanock, Maria Teresa Landi
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1187.
https://doi.org/10.1158/1538-7445.AM2018-1187
Published: 01 July 2018
View article titled, Abstract 1187: Comparison of intra-tumor heterogeneity and clonal evolution across lung cancer subtypes by multi-region whole genome sequencing
Journal Articles

Abstract 2185: Multiple region whole-genome sequencing reveals intratumor heterogeneity and branching clonal architecture of non-clear-cell renal cell carcinoma

Bin Zhu*, Luana Poeta*, Manuela Costantini*, Tongwu Zhang*, Steno Sentinelli, Jianxin Shi, Kevin Brown, Xing Hua, Meredith Yeager, Mingyi Wang, Belynda Hicks, Stephen Chanock*, Michele Gallucci*, Vito Fazio*, Maria Teresa Landi*
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2185.
https://doi.org/10.1158/1538-7445.AM2018-2185
Published: 01 July 2018
View article titled, Abstract 2185: Multiple region whole-genome sequencing reveals intratumor heterogeneity and branching clonal architecture of non-clear-cell renal cell carcinoma